KEGG   ENZYME: 4.1.1.102Help
Entry
EC 4.1.1.102                Enzyme                                 

Name
phenacrylate decarboxylase;
FDC1 (gene name);
ferulic acid decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
3-phenylprop-2-enoate carboxy-lyase
Reaction(IUBMB)
(1) 4-coumarate = 4-vinylphenol + CO2 [RN:R02952];
(2) trans-cinnamate = styrene + CO2 [RN:R11070];
(3) ferulate = 4-vinylguaiacol + CO2 [RN:R11071]
Reaction(KEGG)
Substrate
4-coumarate [CPD:C00811];
trans-cinnamate [CPD:C00423];
ferulate [CPD:C01494]
Product
4-vinylphenol [CPD:C05627];
CO2 [CPD:C00011];
styrene [CPD:C07083];
4-vinylguaiacol [CPD:C17883]
Comment
The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
History
EC 4.1.1.102 created 2015
Pathway
ec00940  Phenylpropanoid biosynthesis
Orthology
K20039  phenacrylate decarboxylase
Genes
PXY: 105396714
SCE: YDR539W(FDC1)
ZRO: ZYRO0E10428g
DHA: DEHA2G00682g
CAL: CAALFM_C603620CA(CaO19.5730)
CDU: CD36_64160
FGR: FGSG_04669 FGSG_06434
FPU: FPSE_08154
FVR: FVEG_03405 FVEG_05792 FVEG_10483 FVEG_11829
FOX: FOXG_02622 FOXG_04719 FOXG_13395 FOXG_14356 FOXG_15126
MAW: MAC_08104
ANI: AN7164.2
ANG: ANI_1_1576034(An03g06590) ANI_1_918084(An09g00030)
CNE: CNH00230
 » show all
Taxonomy
Reference
1  [PMID:20471595]
  Authors
Mukai N, Masaki K, Fujii T, Kawamukai M, Iefuji H
  Title
PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
  Journal
J Biosci Bioeng 109:564-9 (2010)
DOI:10.1016/j.jbiosc.2009.11.011
  Sequence
[sce:YDR539W]
Reference
2  [PMID:25862228]
  Authors
Bhuiya MW, Lee SG, Jez JM, Yu O
  Title
Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
  Journal
Appl Environ Microbiol 81:4216-23 (2015)
DOI:10.1128/AEM.00762-15
  Sequence
[sce:YDR539W]
Reference
3  [PMID:26083754]
  Authors
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D
  Title
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
  Journal
Nature 522:497-501 (2015)
DOI:10.1038/nature14560
  Sequence
[sce:YDR539W] [cdu:CD36_64160] [ang:ANI_1_1576034]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.102
IUBMB Enzyme Nomenclature: 4.1.1.102
ExPASy - ENZYME nomenclature database: 4.1.1.102
BRENDA, the Enzyme Database: 4.1.1.102

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