KEGG   ENZYME: 4.1.1.102
Entry
EC 4.1.1.102                Enzyme                                 
Name
phenacrylate decarboxylase;
FDC1 (gene name);
ferulic acid decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
3-phenylprop-2-enoate carboxy-lyase
Reaction(IUBMB)
(1) 4-coumarate = 4-vinylphenol + CO2 [RN:R02952];
(2) trans-cinnamate = styrene + CO2 [RN:R11070];
(3) ferulate = 4-vinylguaiacol + CO2 [RN:R11071]
Reaction(KEGG)
R02952 R11070 R11071;
(other) R03367
Substrate
4-coumarate [CPD:C00811];
trans-cinnamate [CPD:C00423];
ferulate [CPD:C01494]
Product
4-vinylphenol [CPD:C05627];
CO2 [CPD:C00011];
styrene [CPD:C07083];
4-vinylguaiacol [CPD:C17883]
Comment
The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
History
EC 4.1.1.102 created 2015
Pathway
ec00940  Phenylpropanoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20039  phenacrylate decarboxylase
Genes
PXY105396714
QSU111991215
SCEYDR539W(FDC1)
SEUBDI49_4416
SPAOSPAR_D07100
ZROZYRO0E10428g
ZMKHG535_0A09030
DHADEHA2G00682g
CALCAALFM_C603620CA(CaO19.5730)
CDUCD36_64160
FGRFGSG_04669 FGSG_06434
FPUFPSE_08154
FVRFVEG_03405 FVEG_05792 FVEG_10483 FVEG_11829
FOXFOXG_02622 FOXG_04719 FOXG_13395 FOXG_14356 FOXG_15126
NHENECHADRAFT_52948 NECHADRAFT_55997 NECHADRAFT_73218 NECHADRAFT_81268
MAWMAC_08104
MAJMAA_01631 MAA_06752
PLJVFPFJ_04155
CFJCFIO01_10372
CLUPCLUP02_14534
CHIGCH63R_09745
SAPOSAPIO_CDS7959
ELAUCREL1_1236
PFYPFICI_01973 PFICI_11103
BFUBCIN_15g05150
ANIAN7164.2
NFINFIA_026010
AORAO090001000093 AO090003000424
ANGANI_1_1576034(An03g06590) ANI_1_918084(An09g00030)
AFVAFLA_001267 AFLA_008428
ALUCAKAW2_51012A(FDC1)
ACHEACHE_80178A(FDC1)
APUUAPUU_80780S(FDC1)
PCSPc22g03390
PDPPDIP_44190
TRGTRUGW13939_02308 TRUGW13939_08274
BZECOCCADRAFT_30049
BSCCOCSADRAFT_160246
BORCOCMIDRAFT_29078
NPAUCRNP2_4413
CNECNH00230
CNGCNAG_03519
CGICGB_G5620W CGB_H0280W
MPRMPER_02256
MRRMoror_16770
PSOJPHYSODRAFT_258069
 » show all
Reference
1  [PMID:20471595]
  Authors
Mukai N, Masaki K, Fujii T, Kawamukai M, Iefuji H
  Title
PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
  Journal
J Biosci Bioeng 109:564-9 (2010)
DOI:10.1016/j.jbiosc.2009.11.011
  Sequence
[sce:YDR539W]
Reference
2  [PMID:25862228]
  Authors
Bhuiya MW, Lee SG, Jez JM, Yu O
  Title
Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
  Journal
Appl Environ Microbiol 81:4216-23 (2015)
DOI:10.1128/AEM.00762-15
  Sequence
[sce:YDR539W]
Reference
3  [PMID:26083754]
  Authors
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D
  Title
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
  Journal
Nature 522:497-501 (2015)
DOI:10.1038/nature14560
  Sequence
[sce:YDR539W] [cdu:CD36_64160] [ang:ANI_1_1576034]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.102
IUBMB Enzyme Nomenclature: 4.1.1.102
ExPASy - ENZYME nomenclature database: 4.1.1.102
BRENDA, the Enzyme Database: 4.1.1.102

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