KEGG   ENZYME: 4.1.1.103Help
Entry
EC 4.1.1.103                Enzyme                                 

Name
gamma-resorcylate decarboxylase;
graF (gene name);
tsdA (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
2,6-dihydroxybenzoate carboxy-lyase
Reaction(IUBMB)
2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 [RN:R11353]
Reaction(KEGG)
Substrate
2,6-dihydroxybenzoate [CPD:C21298]
Product
1,3-dihydroxybenzene [CPD:C01751];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.
History
EC 4.1.1.103 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20941  gamma-resorcylate decarboxylase
Genes
KPK: A593_25530
KVD: KR75_23450
CHRO: CXB49_05340
CNC: CNE_BB1p12860
BUR: Bcep18194_B0258
BSEM: WJ12_23745
BUG: BC1001_0585
BGF: BC1003_5621
BGD: bgla_2g12820 bgla_2g18650
BGO: BM43_4095 BM43_4940 BM43_5584
PPNO: DA70_09465
PPNM: LV28_21345
POL: Bpro_2061
AAA: Acav_4140
ATU: Atu2529
ARA: Arad_7160
RLE: pRL120216
 » show all
Taxonomy
Reference
1  [PMID:15466039]
  Authors
Yoshida M, Fukuhara N, Oikawa T.
  Title
Thermophilic, reversible gamma-resorcylate decarboxylase from Rhizobium sp. strain MTP-10005: purification, molecular characterization, and expression.
  Journal
J Bacteriol 186:6855-63 (2004)
DOI:10.1128/JB.186.20.6855-6863.2004
  Sequence
Reference
2  [PMID:15474471]
  Authors
Ishii Y, Narimatsu Y, Iwasaki Y, Arai N, Kino K, Kirimura K
  Title
Reversible and nonoxidative gamma-resorcylic acid decarboxylase: characterization and gene cloning of a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene, from Rhizobium radiobacter.
  Journal
Biochem Biophys Res Commun 324:611-20 (2004)
DOI:10.1016/j.bbrc.2004.09.091
Reference
3  [PMID:16683134]
  Authors
Matsui T, Yoshida T, Yoshimura T, Nagasawa T
  Title
Regioselective carboxylation of 1,3-dihydroxybenzene by 2,6-dihydroxybenzoate decarboxylase of Pandoraea sp. 12B-2.
  Journal
Appl Microbiol Biotechnol 73:95-102 (2006)
DOI:10.1007/s00253-006-0437-z
Reference
4  [PMID:16963440]
  Authors
Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T
  Title
Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.
  Journal
J Biol Chem 281:34365-73 (2006)
DOI:10.1074/jbc.M607270200
Reference
5  [PMID:26319878]
  Authors
Kasai D, Araki N, Motoi K, Yoshikawa S, Iino T, Imai S, Masai E, Fukuda M
  Title
gamma-Resorcylate catabolic-pathway genes in the soil actinomycete Rhodococcus jostii RHA1.
  Journal
Appl Environ Microbiol 81:7656-65 (2015)
DOI:10.1128/AEM.02422-15
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.103
IUBMB Enzyme Nomenclature: 4.1.1.103
ExPASy - ENZYME nomenclature database: 4.1.1.103
BRENDA, the Enzyme Database: 4.1.1.103

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