KEGG   ENZYME: 4.1.1.103
Entry
EC 4.1.1.103                Enzyme                                 

Name
gamma-resorcylate decarboxylase;
graF (gene name);
tsdA (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2,6-dihydroxybenzoate carboxy-lyase
Reaction(IUBMB)
2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 [RN:R11353]
Reaction(KEGG)
R11353
Substrate
2,6-dihydroxybenzoate [CPD:C21298]
Product
1,3-dihydroxybenzene [CPD:C01751];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.
History
EC 4.1.1.103 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20941  gamma-resorcylate decarboxylase
Genes
KPN: KPN_04278
KPU: KP1_0140
KPM: KPHS_01250
KPP: A79E_4910
KPZ: KPNIH27_00690
KPV: KPNIH29_00645
KPY: KPNIH31_00680
KPG: KPNIH32_00680
KPT: VK055_3197
KPO: KPN2242_24405
KPR: KPR_0232
KPJ: N559_5007
KPNK: BN49_4581
KVA: Kvar_4950
KPE: KPK_5401
EAE: EAE_07765
EAR: CCG32448
AGU: AS4_34920
BTQ: BTQ_5450
BTJ: BTJ_4106
BTZ: BTL_4919
BTV: BTHA_5304
BTHE: BTN_4575
BTHM: BTRA_4840
BTHA: DR62_4685
BTHL: BG87_4907
BSEM: WJ12_23745
PPNO: DA70_09465
PPNM: LV28_21345
PUD: G9Q38_01855(tsdA)
POL: Bpro_2061
AAA: Acav_4140
ATU: Atu2529
ARA: Arad_7160
RLE: pRL120216
ROY: G3A56_13315(tsdA)
RII: FFM53_025675(tsdA)
RHID: FFM81_029540(tsdA)
RBQ: J2J99_28410(tsdA)
RRG: J3P73_26395(tsdA)
BARH: WN72_15315
MSL: Msil_3500
MABB: MASS_3600
TPR: Tpau_1503
GLJ: GKIL_0975
 » show all
Reference
1  [PMID:15466039]
  Authors
Yoshida M, Fukuhara N, Oikawa T
  Title
Thermophilic, reversible gamma-resorcylate decarboxylase from Rhizobium sp. strain MTP-10005: purification, molecular characterization, and expression.
  Journal
J Bacteriol 186:6855-63 (2004)
DOI:10.1128/JB.186.20.6855-6863.2004
  Sequence
Reference
2  [PMID:15474471]
  Authors
Ishii Y, Narimatsu Y, Iwasaki Y, Arai N, Kino K, Kirimura K
  Title
Reversible and nonoxidative gamma-resorcylic acid decarboxylase: characterization and gene cloning of a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene, from Rhizobium radiobacter.
  Journal
Biochem Biophys Res Commun 324:611-20 (2004)
DOI:10.1016/j.bbrc.2004.09.091
Reference
3  [PMID:16683134]
  Authors
Matsui T, Yoshida T, Yoshimura T, Nagasawa T
  Title
Regioselective carboxylation of 1,3-dihydroxybenzene by 2,6-dihydroxybenzoate decarboxylase of Pandoraea sp. 12B-2.
  Journal
Appl Microbiol Biotechnol 73:95-102 (2006)
DOI:10.1007/s00253-006-0437-z
Reference
4  [PMID:16963440]
  Authors
Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T
  Title
Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.
  Journal
J Biol Chem 281:34365-73 (2006)
DOI:10.1074/jbc.M607270200
Reference
5  [PMID:26319878]
  Authors
Kasai D, Araki N, Motoi K, Yoshikawa S, Iino T, Imai S, Masai E, Fukuda M
  Title
gamma-Resorcylate catabolic-pathway genes in the soil actinomycete Rhodococcus jostii RHA1.
  Journal
Appl Environ Microbiol 81:7656-65 (2015)
DOI:10.1128/AEM.02422-15
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.103
IUBMB Enzyme Nomenclature: 4.1.1.103
ExPASy - ENZYME nomenclature database: 4.1.1.103
BRENDA, the Enzyme Database: 4.1.1.103

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