KEGG   ENZYME: 4.1.1.105Help
Entry
EC 4.1.1.105                Enzyme                                 

Name
L-tryptophan decarboxylase;
psiD (gene name);
TDC (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-tryptophan carboxy-lyase
Reaction(IUBMB)
L-tryptophan = tryptamine + CO2 [RN:R00685]
Reaction(KEGG)
R00685;
(other) R11932
Show
Substrate
L-tryptophan [CPD:C00078]
Product
tryptamine [CPD:C00398];
CO2 [CPD:C00011]
Comment
The enzyme has been characterized from bacteria, plants, and fungi. Unlike EC 4.1.1.28, aromatic-L-amino-acid decarboxylase, this enzyme is specific for L-tryptophan.
History
EC 4.1.1.105 created 2017
Pathway
ec00380  Tryptophan metabolism
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase
K22433  L-tryptophan decarboxylase
Genes
HSA: 1644(DDC)
PTR: 463409(DDC)
PPS: 100971531(DDC)
GGO: 101145222(DDC)
PON: 100435277(DDC)
NLE: 100597933(DDC)
MCC: 693677(DDC)
MCF: 102119567(DDC)
CSAB: 103226076(DDC)
RRO: 104657651(DDC)
RBB: 108527366(DDC)
CJC: 100402255(DDC)
SBQ: 101040684(DDC)
MMU: 13195(Ddc)
MCAL: 110305561(Ddc)
MPAH: 110330601(Ddc)
RNO: 24311(Ddc)
MUN: 110554532(Ddc)
CGE: 100761742(Ddc)
NGI: 103746991(Ddc)
HGL: 101697555(Ddc)
CCAN: 109689534(Ddc)
OCU: 100355492(DDC)
TUP: 102499553(DDC)
CFA: 606852(DDC)
VVP: 112925826(DDC)
AML: 100475392(DDC)
UMR: 103674553(DDC)
UAH: 113257543(DDC)
ORO: 101364177(DDC)
FCA: 101082989(DDC)
PTG: 102955370(DDC)
PPAD: 109267874 109267969(DDC)
AJU: 106968187(DDC)
BTA: 280762(DDC)
BOM: 102287020(DDC)
BIU: 109558177(DDC)
BBUB: 102405051(DDC)
CHX: 102169726(DDC)
OAS: 101106765(DDC)
SSC: 396857(DDC)
CFR: 102513068(DDC)
CDK: 105105292(DDC)
BACU: 102999539(DDC)
LVE: 103080634(DDC)
OOR: 101290071(DDC)
DLE: 111184555(DDC)
PCAD: 102988654(DDC)
ECB: 100052557(DDC)
EPZ: 103558736 103563419(DDC)
EAI: 106822940(DDC)
MYB: 102254659(DDC)
MYD: 102774614(DDC)
MNA: 107526019(DDC)
HAI: 109388356(DDC)
DRO: 112307000(DDC)
PALE: 102893985(DDC)
RAY: 107512420(DDC)
MJV: 108409738(DDC)
LAV: 100677538(DDC)
TMU: 101348227
MDO: 100030001(DDC)
SHR: 100917570(DDC)
PCW: 110205002(DDC)
OAA: 100074589(DDC)
GGA: 420947(DDC)
MGP: 100542576(DDC)
CJO: 107309491(DDC)
NMEL: 110393205(DDC)
APLA: 101796508(DDC)
ACYG: 106036562(DDC)
TGU: 100226623(DDC)
LSR: 110479536(DDC)
SCAN: 103824172(DDC)
GFR: 102032520(DDC)
FAB: 101811896(DDC)
PHI: 102104958(DDC)
PMAJ: 107216322(DDC)
CCAE: 111925383(DDC)
CCW: 104685862(DDC)
ETL: 114055148(DDC)
FPG: 101922826(DDC)
FCH: 102059671(DDC)
EGZ: 104126196(DDC)
NNI: 104017967 104018896(DDC)
ACUN: 113476218(DDC)
PADL: 103922341(DDC)
AAM: 106492855(DDC)
ASN: 102375703(DDC)
AMJ: 106736839(DDC)
PSS: 102452351(DDC)
CMY: 102937578(DDC)
CPIC: 101939746(DDC)
ACS: 100564794(ddc)
PVT: 110085760(DDC)
PBI: 103055744(DDC)
PMUR: 107287642(DDC)
TSR: 106538958(DDC)
PMUA: 114582385(DDC)
GJA: 107121867(DDC)
XLA: 100126640(ddc.L)
XTR: 496742(ddc)
NPR: 108788303(DDC)
DRE: 406651(ddc)
SANH: 107657571(ddc) 107704081
CCAR: 109066248 109071918(ddc)
IPU: 108275746(ddc)
PHYP: 113533710(ddc)
AMEX: 103039119(ddc)
EEE: 113586562(ddc)
TRU: 101070663(ddc)
LCO: 104939491(ddc)
NCC: 104957402
MZE: 101472888(ddc)
ONL: 100703971(ddc)
OLA: 100301599(ddc)
XMA: 102226428(ddc)
XCO: 114142376(ddc)
PRET: 103478360(ddc)
CVG: 107094111(ddc)
NFU: 107378764(ddc)
KMR: 108232186(ddc)
ALIM: 106514240(ddc)
AOCE: 111573425(ddc)
CSEM: 103388766(ddc)
POV: 109632088(ddc)
LCF: 108888820(ddc)
SDU: 111227826(ddc)
SLAL: 111655924(ddc)
HCQ: 109531054(ddc)
BPEC: 110171777(ddc)
MALB: 109958276(ddc)
ELS: 105025918(ddc)
SFM: 108940501(ddc)
PKI: 111840945(ddc)
CMK: 103181195(ddc)
CIN: 100101815(hdcl)
APLC: 110989624
SKO: 100374376
DME: Dmel_CG10697(Ddc)
DER: 6549499
DSI: Dsimw501_GD21778(Dsim_Ddc)
DSR: 110181456
DPO: Dpse_GA10503(Dpse_Ddc)
DPE: 6598065
DMN: 108163291
DWI: 6644461
DAZ: 108611630
DNV: 108658877
DHE: 111600378
DVI: Dvir_GJ17995(Dvir_Ddc)
LCQ: 111686140
AAG: 5563940
DPTE: 113795103
PTEP: 107451419
CEL: CELE_C05D2.3(basl-1) CELE_C05D2.4(bas-1)
CBR: CBG08967(Cbr-bas-1)
BMY: Bm1_24405
TSP: Tsp_00610
PCAN: 112576021
EGL: EGR_09525
ATH: AT2G20340(AAS)
LJA: Lj0g3v0211149.1(Lj0g3v0211149.1) Lj1g3v4528440.1(Lj1g3v4528440.1) Lj6g3v1679480.1(Lj6g3v1679480.1)
CSV: 101205061
CMO: 103489832
MCHA: 111022679
RCU: 8266698
CANN: 107842494(TDC2) 107878308
DOSA: Os07t0437500-01(Os07g0437500) Os08t0140300-01(Os08g0140300) Os08t0140500-00(Os08g0140500) Os10t0400500-00(Os10g0400500)
ATS: 109748394(LOC109748394) 109749204(LOC109749204) 109751651(LOC109751651) 109754049(LOC109754049) 109782055(LOC109782055)
SMO: SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
CRE: CHLREDRAFT_116869(DDC1)
APRO: F751_5176
NCR: NCU08275
NTE: NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
SSCK: SPSK_03252
MAW: MAC_06737
MAJ: MAA_01165
CMT: CCM_04742
MBE: MBM_06276
ANI: AN2357.2
ANG: ANI_1_2316014(An01g02000)
ABE: ARB_03722
TVE: TRV_07554
PTE: PTT_10253
CNE: CND00950
CNB: CNBD5350
ABP: AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV: AGABI2DRAFT185212(AGABI2DRAFT_185212)
MGL: MGL_3372
MRT: MRET_2673
SMIN: v1.2.008729.t1(symbB.v1.2.008729.t1)
SPAR: SPRG_03246
YPE: YPO1193
YPK: y2996(dcd)
YPH: YPC_3018
YPA: YPA_0905
YPN: YPN_2783
YPM: YP_0943(dcd1)
YPZ: YPZ3_1100
YPD: YPD4_1061
YPX: YPD8_1086
YPW: CH59_650
YPJ: CH55_1355
YPV: BZ15_2363
YPL: CH46_3938
YPS: YPTB1234
YPO: BZ17_1292
YPY: YPK_2867
YPB: YPTS_1322
YPQ: DJ40_1004
YPU: BZ21_503
YPR: BZ20_754
YPC: BZ23_833
YPF: BZ19_633
YRU: BD65_352
SRL: SOD_c40120(ddc)
PPU: PP_2552
PPF: Pput_3163
PPT: PPS_2093
PPI: YSA_00462
PPX: T1E_3359
PPUH: B479_10915
PPUT: L483_10035
PPUN: PP4_33460
PPUD: DW66_2355
PMON: X969_08790
PMOT: X970_08450
PFC: PflA506_1055(ddc)
PFB: VO64_4209
PEN: PSEEN2370
PSEC: CCOS191_3137(ELI5)
NOC: Noc_2983
DVU: DVU0867
DVL: Dvul_2115
DVM: DvMF_2916
DDE: Dde_1124
MLO: mll0712
ARA: Arad_0017
SHZ: shn_28130
NWI: Nwi_1102
XAU: Xaut_0071
MET: M446_1957
MNO: Mnod_1238
MAQU: Maq22A_c11740(gadB)
RVA: Rvan_3231
PLEO: OHA_1_02537(ddc)
RBM: TEF_10700
SIL: SPO3687
JAN: Jann_3501
PGD: Gal_00109
LAQU: R2C4_19610
RHC: RGUI_0736
SPSE: SULPSESMR1_00270(ddc)
RFA: A3L23_05009(ddc)
SALU: DC74_159
SALL: SAZ_01240
STRE: GZL_08019
GOB: Gobs_3209
BSD: BLASA_2287(tdcA)
MMAR: MODMU_3399(ELI)
SEN: SACE_2888
SACC: EYD13_18150(ddc)
PDX: Psed_3994
PSEA: WY02_04890
AMI: Amir_5685
SESP: BN6_68200
KAL: KALB_5849
ACTI: UA75_21780
ACAD: UA74_21300
AHG: AHOG_18795(ddc2)
RXY: Rxyl_1038
CAU: Caur_2842
CAG: Cagg_1126
MRB: Mrub_1738
GES: VT84_23180(ddc)
SUS: Acid_1182
ABAC: LuPra_06070(ddc_2)
GAU: GAU_3087
DORI: FH5T_14760
IAL: IALB_2412
MRO: MROS_1175
CABY: Cabys_2336
 » show all
Taxonomy
Reference
1  [PMID:24310513]
  Authors
Noe W, Mollenschott C, Berlin J
  Title
Tryptophan decarboxylase from Catharanthus roseus cell suspension cultures: purification, molecular and kinetic data of the homogenous protein.
  Journal
Plant Mol Biol 3:281-8 (1984)
DOI:10.1007/BF00017782
Reference
2  [PMID:4036551]
  Authors
Buki KG, Vinh DQ, Horvath I
  Title
Partial purification and some properties of tryptophan decarboxylase from a Bacillus strain.
  Journal
Acta Microbiol Hung 32:65-73 (1985)
Reference
3  [PMID:4441405]
  Authors
Nakazawa H, Kumagai H, Yamada H
  Title
Constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus.
  Journal
Biochem Biophys Res Commun 61:75-82 (1974)
DOI:10.1016/0006-291X(74)90536-1
Reference
4  [PMID:9225462]
  Authors
Lopez-Meyer M, Nessler CL
  Title
Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress.
  Journal
Plant J 11:1167-75 (1997)
DOI:10.1046/j.1365-313X.1997.11061167.x
  Sequence
Reference
5  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.105
IUBMB Enzyme Nomenclature: 4.1.1.105
ExPASy - ENZYME nomenclature database: 4.1.1.105
BRENDA, the Enzyme Database: 4.1.1.105

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