KEGG   ENZYME: 4.1.1.107
Entry
EC 4.1.1.107                Enzyme                                 
Name
3,4-dihydroxyphenylacetaldehyde synthase;
DHPAA synthase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-dopa carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11916]
Reaction(KEGG)
R11916
Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
3,4-dihydroxyphenylacetaldehyde [CPD:C04043];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.
History
EC 4.1.1.107 created 2017
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K01618  3,4-dihydroxyphenylacetaldehyde synthase
Genes
DMEDmel_CG10501(amd)
DER6549501
DSE6614648
DSIDsimw501_GD24184(Dsim_amd)
DYADyak_GE13232
DAN6497523
DSR110181428
DPO117183959 4816707
DPE6597981 6597983
DMN108161124 117189005
DWI6644459
DGR6566401
DMODmoj_GI13977
DAZ108611006
DNV108658087
DHE111600249
DVI6634249
CCAT101454786 101462480
BOD106615364 106616425
MDE101888467
SCAC106085354
LCQ111685139
LSQ119607392
HIS119650590
AGAAgaP_AGAP009090
ACOZ120959634
AARA120904565
ASTE118509868
AAG5573809
AALB109404823 109423887
CQUCpipJ_CPIJ013308
CPII120415581
CNS116343658 116343942
BCOO119072247 119072248 119074606
TPRE106649945 106654040
CGLO123272459
FAS105273510
DAM107038037
SOY115875383
CSET123310893
AGB108909329
APLN108739719 108739728 108739729 112904224
PPYR116172347
MSEX115445053 115445067
BANY112044897 112044903
PRAP111000456
HZE124646041
OFU114354472 114354577
DCI103513799 108252376
 » show all
Reference
1  [PMID:21283636]
  Authors
Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J
  Title
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.
  Journal
PLoS One 6:e16124 (2011)
DOI:10.1371/journal.pone.0016124
  Sequence
[aag:5573809]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.107
IUBMB Enzyme Nomenclature: 4.1.1.107
ExPASy - ENZYME nomenclature database: 4.1.1.107
BRENDA, the Enzyme Database: 4.1.1.107

DBGET integrated database retrieval system