KEGG   ENZYME: 4.1.1.107
Entry
EC 4.1.1.107                Enzyme                                 

Name
3,4-dihydroxyphenylacetaldehyde synthase;
DHPAA synthase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-dopa carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11916]
Reaction(KEGG)
R11916
Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
3,4-dihydroxyphenylacetaldehyde [CPD:C04043];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.
History
EC 4.1.1.107 created 2017
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K01618  3,4-dihydroxyphenylacetaldehyde synthase
Genes
DME: Dmel_CG10501(amd)
DER: 6549501
DSE: 6614648
DSI: Dsimw501_GD24184(Dsim_amd)
DYA: Dyak_GE13232
DAN: 6497523
DSR: 110181428
DPO: Dpse_GA10357(Dpse_amd)
DPE: 6597981 6597983
DMN: 108161124 117189005
DWI: 6644459
DGR: 6566401
DAZ: 108611006
DNV: 108658087
DHE: 111600249
DVI: 6634249
MDE: 101888467
LCQ: 111685139
ACOZ: 120959634
AARA: 120904565
AAG: 5573809
CPII: 120415581
BBIF: 117206393
CGIG: 122400485
AGB: 108909329
PPYR: 116172347
 » show all
Reference
1  [PMID:21283636]
  Authors
Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J
  Title
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.
  Journal
PLoS One 6:e16124 (2011)
DOI:10.1371/journal.pone.0016124
  Sequence
[aag:5573809]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.107
IUBMB Enzyme Nomenclature: 4.1.1.107
ExPASy - ENZYME nomenclature database: 4.1.1.107
BRENDA, the Enzyme Database: 4.1.1.107

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