KEGG   ENZYME: 4.1.1.109Help
Entry
EC 4.1.1.109                Enzyme                                 

Name
phenylacetaldehyde synthase;
PAAS (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-phenylalanine carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-phenylalanine + O2 + H2O = phenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11918]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
phenylacetaldehyde [CPD:C00601];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plants Petunia hybrida and a Rosa hybrid, catalyses the production of phenylacetaldehyde directly from L-phenylalanine. The enzyme is specific for L-phenylalanine and does not accept other aromatic amino acids as substrates.
History
EC 4.1.1.109 created 2017
Pathway
ec00360  Phenylalanine metabolism
Orthology
K22328  phenylacetaldehyde synthase
Genes
SLY: 101266606
SPEN: 107012915 107028028
SOT: 102580311 102592302 102594238
CANN: 107866061 107868087
NTA: 107774317 107824118
NSY: 104223628
NTO: 104115885
Taxonomy
Reference
1  [PMID:16766535]
  Authors
Kaminaga Y, Schnepp J, Peel G, Kish CM, Ben-Nissan G, Weiss D, Orlova I, Lavie O, Rhodes D, Wood K, Porterfield DM, Cooper AJ, Schloss JV, Pichersky E, Vainstein A, Dudareva N
  Title
Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation.
  Journal
J Biol Chem 281:23357-66 (2006)
DOI:10.1074/jbc.M602708200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.109
IUBMB Enzyme Nomenclature: 4.1.1.109
ExPASy - ENZYME nomenclature database: 4.1.1.109
BRENDA, the Enzyme Database: 4.1.1.109

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