KEGG   ENZYME: 4.1.1.109
Entry
EC 4.1.1.109                Enzyme                                 
Name
phenylacetaldehyde synthase;
PAAS (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-phenylalanine carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-phenylalanine + O2 + H2O = phenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11918]
Reaction(KEGG)
R11918
Substrate
L-phenylalanine [CPD:C00079];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
phenylacetaldehyde [CPD:C00601];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plants Petunia hybrida and a Rosa hybrid, catalyses the production of phenylacetaldehyde directly from L-phenylalanine. The enzyme is specific for L-phenylalanine and does not accept other aromatic amino acids as substrates.
History
EC 4.1.1.109 created 2017
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
Orthology
K22328  phenylacetaldehyde synthase
Genes
SLY101266606
SPEN107012915 107028028
SOT102580311 102592302 102594238
CANN107866061 107868087
NTA107774317 107824118
NSY104223628
NTO104115885
NAU109238484
ITR115996425 115997242
EGT105948776
SSPL121783895 121786170 121790730
CSIN114268376 114290146 114306345
NCOL116265826
 » show all
Reference
1  [PMID:16766535]
  Authors
Kaminaga Y, Schnepp J, Peel G, Kish CM, Ben-Nissan G, Weiss D, Orlova I, Lavie O, Rhodes D, Wood K, Porterfield DM, Cooper AJ, Schloss JV, Pichersky E, Vainstein A, Dudareva N
  Title
Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation.
  Journal
J Biol Chem 281:23357-66 (2006)
DOI:10.1074/jbc.M602708200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.109
IUBMB Enzyme Nomenclature: 4.1.1.109
ExPASy - ENZYME nomenclature database: 4.1.1.109
BRENDA, the Enzyme Database: 4.1.1.109

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