KEGG   ENZYME: 4.1.1.110Help
Entry
EC 4.1.1.110                Enzyme                                 

Name
bisphosphomevalonate decarboxylase;
mevalonate 3,5-bisphosphate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)
Reaction(IUBMB)
(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate [RN:R10781]
Reaction(KEGG)
Substrate
(R)-3,5-bisphosphomevalonate [CPD:C20848]
Product
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011];
phosphate [CPD:C00009]
Comment
The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.
History
EC 4.1.1.110 created 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K22813  bisphosphomevalonate decarboxylase
Genes
TAC: Ta0893
TVO: TVG0411662(TVG0411662)
PTO: PTO0478
FAC: FACI_IFERC01G1792
FAI: FAD_0762
CDIV: CPM_0958
MARH: Mia14_0535
Taxonomy
Reference
1  [PMID:28004831]
  Authors
Vinokur JM, Cummins MC, Korman TP, Bowie JU.
  Title
An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.
  Journal
Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737
  Sequence
[tac:Ta0893]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.110
IUBMB Enzyme Nomenclature: 4.1.1.110
ExPASy - ENZYME nomenclature database: 4.1.1.110
BRENDA, the Enzyme Database: 4.1.1.110

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