KEGG   ENZYME: 4.1.1.111Help
Entry
EC 4.1.1.111                Enzyme                                 

Name
siroheme decarboxylase;
sirohaem decarboxylase;
nirDLHG (gene name);
ahbAB (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
siroheme carboxy-lyase
Reaction(IUBMB)
siroheme = 12,18-didecarboxysiroheme + 2 CO2 [RN:R12000]
Reaction(KEGG)
Substrate
siroheme [CPD:C00748]
Product
12,18-didecarboxysiroheme [CPD:C21835];
CO2 [CPD:C00011]
Comment
The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway.
History
EC 4.1.1.111 created 2018
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K22225  siroheme decarboxylase
Genes
KST: KSMBR1_2939(nirD_nirG) KSMBR1_2940(nirH_nirL)
MMD: GYY_03120
MAC: MA_0574(nirD) MA_0575(nirH)
MBA: Mbar_A1459 Mbar_A1460
MBY: MSBRM_0433 MSBRM_0434
MBW: MSBRW_3267 MSBRW_3268
MBAR: MSBR2_1948 MSBR2_1949
MBAK: MSBR3_1993 MSBR3_1994
MMA: MM_1727(nirD) MM_1728(nirH)
MMAZ: MmTuc01_1817 MmTuc01_1818
MHI: Mhar_0167
MEMA: MMAB1_3018
MBN: Mboo_0956
MPL: Mpal_2628
 » show all
Taxonomy
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G.
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Reference
3  [PMID:24865947]
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with  structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
  Sequence
Reference
4  [PMID:25083922]
  Authors
Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G
  Title
The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues.
  Journal
J Mol Biol 426:3272-3286 (2014)
DOI:10.1016/j.jmb.2014.07.021
  Sequence
[hth:HTH_0209]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.111
IUBMB Enzyme Nomenclature: 4.1.1.111
ExPASy - ENZYME nomenclature database: 4.1.1.111
BRENDA, the Enzyme Database: 4.1.1.111

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