KEGG   ENZYME: 4.1.1.111
Entry
EC 4.1.1.111                Enzyme                                 

Name
siroheme decarboxylase;
sirohaem decarboxylase;
nirDLHG (gene name);
ahbAB (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
siroheme carboxy-lyase
Reaction(IUBMB)
siroheme = 12,18-didecarboxysiroheme + 2 CO2 [RN:R12000]
Reaction(KEGG)
R12000
Substrate
siroheme [CPD:C00748]
Product
12,18-didecarboxysiroheme [CPD:C21835];
CO2 [CPD:C00011]
Comment
The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway.
History
EC 4.1.1.111 created 2018
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22225  siroheme decarboxylase
Genes
PAE: PA0512 PA0513 PA0514(nirL) PA0515
PAEV: N297_524 N297_525 N297_526 N297_527
PAEI: N296_524 N296_525 N296_526 N296_527
PAU: PA14_06680(nirH) PA14_06690(nirG) PA14_06700(nirL) PA14_06710(nirD)
PAP: PSPA7_0613 PSPA7_0614 PSPA7_0615(nirL) PSPA7_0616
PAG: PLES_05091(nirH) PLES_05101 PLES_05111(nirL) PLES_05121
PAF: PAM18_0511(nirH) PAM18_0512 PAM18_0513(nirL) PAM18_0514
PNC: NCGM2_5681(nirD) NCGM2_5682(nirL) NCGM2_5683(nirG) NCGM2_5684(nirH)
PAEB: NCGM1900_0524(nirH) NCGM1900_0525(nirG) NCGM1900_0526(nirL) NCGM1900_0527(nirD)
PDK: PADK2_02575 PADK2_02580 PADK2_02585 PADK2_02590
PFE: PSF113_3747(nirH) PSF113_3748(nirG) PSF113_3749(nirL) PSF113_3750(nirD)
PMAN: OU5_0461(nirD) OU5_0462(nirL) OU5_0463(nirG) OU5_0464(nirH) OU5_P0211 OU5_P0212(nirL) OU5_P0214
PSA: PST_3523(nirH) PST_3524(nirG) PST_3525(nirL) PST_3526(nirD)
PSZ: PSTAB_3497(nirH) PSTAB_3498(nirG) PSTAB_3499(nirL) PSTAB_3500(nirD)
PSR: PSTAA_3620(nirH) PSTAA_3621(nirG) PSTAA_3622(nirL) PSTAA_3623(nirD)
MHC: MARHY3065(nirD) MARHY3066(nirL) MARHY3067(nirG) MARHY3068(nirH)
TNI: TVNIR_1644(nirD_[H]) TVNIR_1645(nirL_[H]) TVNIR_1646(nirG_[H]) TVNIR_1647(nirH_[H])
OAI: OLEAN_C22280(nirH) OLEAN_C22290(nirG) OLEAN_C22300(nirL) OLEAN_C22310(nirD)
GPB: HDN1F_37020(nirH)
ENM: EBS_1576(nirGH) EBS_1577(nirL) EBS_1578(nirD)
PSE: NH8B_1426(nirG) NH8B_1427(nirH)
REH: H16_B2280(nirD) H16_B2281(nirG) H16_B2282(nirH)
CNC: CNE_2c22480(nirD2) CNE_2c22490(nirG) CNE_2c22500(nirH)
RME: Rmet_2081(nirG) Rmet_4937 Rmet_6507(nirH)
CTI: RALTA_B2052(nirD) RALTA_B2053(nirG) RALTA_B2054(nirH)
BPT: Bpet4059(nirD) Bpet4060(nirL) Bpet4061(nirG) Bpet4062(nirH)
RGE: RGE_06620(nirDL) RGE_06630(nirG) RGE_06640(nirH)
DOE: DENOEST_2948(nirH) DENOEST_2949(nirG) DENOEST_2950(nirD)
SLAC: SKTS_25500(nirH) SKTS_25510(nirG) SKTS_25520
EBA: ebA878(nirH) ebA880(nirG) ebA881(nirD)
APET: ToN1_15110(nirH) ToN1_15120(nirG) ToN1_15130(nirD2)
AZA: AZKH_3542(nirH) AZKH_3543(nirG) AZKH_3544
SUA: Saut_0825
SULC: CVO_00335
ATP: ATR_0633
ACRE: ACRYA_1448
ALK: ALEK_0523
AMYT: AMYT_0450
PACO: AACT_0546
HYO: NNO_0554
SUN: SUN_0294
NIS: NIS_1776
DTR: RSDT_0964(ahbA) RSDT_1048(ahbB)
LIP: LI0207(nirD) LI0907(nirH)
SAT: SYN_02265
SFU: Sfum_4037
PSF: PSE_2204 PSE_2205(nirG)
SIL: SPOA0224 SPOA0225(nirG) SPOA0226(nirH)
RDE: RD1_1569(nirD) RD1_1570(nirG) RD1_1571(nirH)
DSH: Dshi_3174(nirH) Dshi_3175(nirG) Dshi_3176(nirD)
PAMN: pAMV3p0217(nirH) pAMV3p0218(nirG) pAMV3p0219(nirD)
MAGX: XM1_2033(nirD) XM1_2034(nirL) XM1_2035(nirG) XM1_2036(nirH)
PPOY: RE92_24465
PSAB: PSAB_13040
BTS: Btus_0655
CAE: SMB_G2829(nirH) SMB_G2830
SWO: Swol_0692
SLP: Slip_1422
SALQ: SYNTR_0463
DSY: DSY2220
DHD: Dhaf_3349
PTH: PTH_0977(Lrp) PTH_0978(Lrp)
SGY: Sgly_1409
TACI: TDSAC_1392
MHG: MHY_22630
RXY: Rxyl_0505
CWO: Cwoe_5931
ELE: Elen_2066
DGE: Dgeo_2287
KST: KSMBR1_2939(nirD_nirG) KSMBR1_2940(nirH_nirL)
HTH: HTH_0209(nirD)
MOX: DAMO_2409
MAC: MA_0574(nirD) MA_0575(nirH)
MMA: MM_1727(nirD) MM_1728(nirH) MM_1738(nirD) MM_1739(nirH)
MHI: Mhar_0167
HAL: VNG_1776G(nirH) VNG_1911G(nirD)
HSL: OE_3500R(ahbB) OE_3689R(ahbA)
HHB: Hhub_3077(ahbB) Hhub_3245(ahbA)
HMA: rrnAC1711(nirH) rrnAC3307(nirD)
HHI: HAH_0544(nirH1) HAH_2245(nirH3)
NPH: NP_3064A(ahbA) NP_4498A(ahbB)
NMO: Nmlp_2396(ahbA) Nmlp_3268(ahbB)
HWA: HQ_3121A(ahbA) HQ_3334A(ahbB)
HWC: Hqrw_3659(ahbA) Hqrw_3863(ahbB)
HVO: HVO_2227(ahbA) HVO_2313(ahbB)
HME: HFX_2279(nirD) HFX_2323(nirH)
NMG: Nmag_1221(ahbB) Nmag_2894(ahbA)
NMR: Nmar_0512
NCT: NMSP_1162
NEV: NTE_01248
NCV: NCAV_0216
NBV: T478_0462
NDV: NDEV_0469
LOKI: Lokiarch_30580(lrpA_2)
 » show all
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Reference
3  [PMID:24865947]
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
  Sequence
Reference
4  [PMID:25083922]
  Authors
Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G
  Title
The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues.
  Journal
J Mol Biol 426:3272-3286 (2014)
DOI:10.1016/j.jmb.2014.07.021
  Sequence
[hth:HTH_0209]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.111
IUBMB Enzyme Nomenclature: 4.1.1.111
ExPASy - ENZYME nomenclature database: 4.1.1.111
BRENDA, the Enzyme Database: 4.1.1.111

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