KEGG   ENZYME: 4.1.1.112Help
Entry
EC 4.1.1.112                Enzyme                                 

Name
oxaloacetate decarboxylase;
oxaloacetate beta-decarboxylase;
oxalacetic acid decarboxylase;
oxalate beta-decarboxylase;
oxaloacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
oxaloacetate carboxy-lyase (pyruvate-forming)
Reaction(IUBMB)
oxaloacetate = pyruvate + CO2 [RN:R00217]
Reaction(KEGG)
R00217;
(other) R00995
Show
Substrate
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011]
Comment
Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport.
History
EC 4.1.1.112 created 1961 as EC 4.1.1.3, modified 1986, modified 2000, part transferred 2018 to EC 4.1.1.112
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01003  oxaloacetate decarboxylase
Genes
PAE: PA4872
PAEV: N297_5042
PAEI: N296_5042
PAU: PA14_16740 PA14_64440(bcpA)
PAP: PSPA7_5594
PAG: PLES_52581
PAF: PAM18_4984
PNC: NCGM2_0654(bcpA)
PAEB: NCGM1900_5613(bcpA)
PDK: PADK2_25850
PAEP: PA1S_26460
PAEM: U769_26725
PAEL: T223_26920
PAEG: AI22_07535
PAEC: M802_5040
PAEO: M801_4907
PMY: Pmen_0689
PMK: MDS_0774
PPSE: BN5_0574
PPU: PP_1389
PPF: Pput_4334
PPT: PPS_4264
PPI: YSA_02878
PPUH: B479_21440
PPUT: L483_26510
PPUN: PP4_09380
PPUD: DW66_4652
PMON: X969_20985
PMOT: X970_20620
PSB: Psyr_1256
PSYR: N018_19415
PSP: PSPPH_1328(bcpA)
PFL: PFL_2455
PPRO: PPC_2494
PFS: PFLU_3105
PFB: VO64_0355
PMAN: OU5_5864
PEN: PSEEN4356
PSA: PST_3733(bcpA)
PSZ: PSTAB_3695(bcpA)
PSR: PSTAA_3825(bcpA)
PSTT: CH92_18585
PKC: PKB_5190
PSES: PSCI_0548
PSEM: TO66_12015
PSOS: POS17_2450
PANR: A7J50_2850
PSIL: PMA3_17455
CSA: Csal_0251
EME: CEM_228
BXE: Bxe_B2147
BXB: DR64_4476
BJA: bll5266
BRA: BRADO3250
BBT: BBta_4901
BRS: S23_30220
AOL: S58_31240
BRAD: BF49_6364
BRO: BRAD285_3147(OAD)
RPA: RPA3174
RPB: RPB_2368
RPC: RPC_3351
RPD: RPD_3092
RPE: RPE_3438
RPT: Rpal_3584
SHUM: STHU_15720
 » show all
Taxonomy
Reference
1  [PMID:5972993]
  Authors
Schmitt A, Bottke I, Siebert G.
  Title
[Properties of oxaloacetate decarboxylase from codfish muscles]
  Journal
Hoppe Seylers Z Physiol Chem 347:18-34 (1966)
Reference
2
  Authors
Herbert, D.
  Title
Oxalacetic carboxylase of Micrococcus lysodeikticus.
  Journal
Methods Enzymol 1:753-757 (1955)
Reference
3  [PMID:14205502]
  Authors
HORTON AA, KORNBERG HL.
  Title
OXALOACETATE 4-CARBOXY-LYASE FROM PSEUDOMONAS OVALIS CHESTER.
  Journal
Biochim Biophys Acta 89:381-3 (1964)
Reference
4  [PMID:15251467]
  Authors
Sender PD, Martin MG, Peiru S, Magni C
  Title
Characterization of an oxaloacetate decarboxylase that belongs to the malic enzyme family.
  Journal
FEBS Lett 570:217-22 (2004)
DOI:10.1016/j.febslet.2004.06.038
Reference
5  [PMID:18081320]
  Authors
Narayanan BC, Niu W, Han Y, Zou J, Mariano PS, Dunaway-Mariano D, Herzberg O.
  Title
Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
  Journal
Biochemistry 47:167-82 (2008)
DOI:10.1021/bi701954p
  Sequence
[pae:PA4872]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.112
IUBMB Enzyme Nomenclature: 4.1.1.112
ExPASy - ENZYME nomenclature database: 4.1.1.112
BRENDA, the Enzyme Database: 4.1.1.112
CAS: 9024-98-0

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