KEGG   ENZYME: 4.1.1.113Help
Entry
EC 4.1.1.113                Enzyme                                 

Name
trans-aconitate decarboxylase;
TAD1 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
trans-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
trans-aconitate = itaconate + CO2 [RN:R11749]
Reaction(KEGG)
Substrate
trans-aconitate [CPD:C02341]
Product
itaconate [CPD:C00490];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase.
History
EC 4.1.1.113 created 2018
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01100  Metabolic pathways
Orthology
K22004  trans-aconitate decarboxylase
Genes
UMA: UMAG_05076
Taxonomy
Reference
1  [PMID:26639528]
  Authors
Geiser E, Przybilla SK, Friedrich A, Buckel W, Wierckx N, Blank LM, Bolker M.
  Title
Ustilago maydis produces itaconic acid via the unusual intermediate trans-aconitate.
  Journal
Microb Biotechnol 9:116-26 (2016)
DOI:10.1111/1751-7915.12329
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.113
IUBMB Enzyme Nomenclature: 4.1.1.113
ExPASy - ENZYME nomenclature database: 4.1.1.113
BRENDA, the Enzyme Database: 4.1.1.113

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