KEGG   ENZYME: 4.1.1.115
Entry
EC 4.1.1.115                Enzyme                                 

Name
indoleacetate decarboxylase;
IAD
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
(1H-indol-3-yl)acetate carboxy-lyase (skatole-forming)
Reaction(IUBMB)
(1H-indol-3-yl)acetate = skatole + CO2 [RN:R12303]
Reaction(KEGG)
R12303
Substrate
(1H-indol-3-yl)acetate [CPD:C00954]
Product
skatole [CPD:C08313];
CO2 [CPD:C00011]
Comment
This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces.
History
EC 4.1.1.115 created 2019
Pathway
ec00380  Tryptophan metabolism
Orthology
K23384  indoleacetate decarboxylase
Genes
CBN: CbC4_1610
CSQ: CSCA_1772
CDRK: B9W14_10435
AFT: BBF96_06495
OLS: Olsu_0124
Reference
1  [PMID:30310076]
  Authors
Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y
  Title
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.
  Journal
Nat Commun 9:4224 (2018)
DOI:10.1038/s41467-018-06627-x
  Sequence
[csq:CSCA_1772]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.115
IUBMB Enzyme Nomenclature: 4.1.1.115
ExPASy - ENZYME nomenclature database: 4.1.1.115
BRENDA, the Enzyme Database: 4.1.1.115

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