KEGG   ENZYME: 4.1.1.115
Entry
EC 4.1.1.115                Enzyme                                 
Name
indoleacetate decarboxylase;
IAD
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
(1H-indol-3-yl)acetate carboxy-lyase (skatole-forming)
Reaction(IUBMB)
(1H-indol-3-yl)acetate = skatole + CO2 [RN:R12303]
Reaction(KEGG)
R12303
Substrate
(1H-indol-3-yl)acetate [CPD:C00954]
Product
skatole [CPD:C08313];
CO2 [CPD:C00011]
Comment
This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces.
History
EC 4.1.1.115 created 2019
Pathway
ec00380  Tryptophan metabolism
Orthology
K23384  indoleacetate decarboxylase
Genes
CBN: CbC4_1610
CSQ: CSCA_1772
CDRK: B9W14_10435
AFT: BBF96_06495
OLS: Olsu_0124
Reference
1  [PMID:30310076]
  Authors
Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y
  Title
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.
  Journal
Nat Commun 9:4224 (2018)
DOI:10.1038/s41467-018-06627-x
  Sequence
[csq:CSCA_1772]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.115
IUBMB Enzyme Nomenclature: 4.1.1.115
ExPASy - ENZYME nomenclature database: 4.1.1.115
BRENDA, the Enzyme Database: 4.1.1.115

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (5)   
All databases (13)   

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