KEGG ENZYME: 4.1.1.116

ENZYME: 4.1.1.116

Entry

EC 4.1.1.116                Enzyme

Name

D-ornithine/D-lysine decarboxylase;
dokD (gene name);
DOKDC

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

D-ornithine/D-lysine carboxy-lyase

Reaction(IUBMB)

(1) D-ornithine = putrescine + CO2 [RN:R12304];
(2) D-lysine = cadaverine + CO2 [RN:R12305]

Reaction(KEGG)

R12304 R12305

Substrate

D-ornithine [CPD:C00515];
D-lysine [CPD:C00739]

Product

putrescine [CPD:C00134];
CO2 [CPD:C00011];
cadaverine [CPD:C01672]

Comment

The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate.

History

EC 4.1.1.116 created 2019

Pathway

ec00310

Lysine degradation

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K23385

D-ornithine/D-lysine decarboxylase

Genes

STY:

STY2590

STT:

t0504

SEX:	STBHUCCB_5420

SENT:

TY21A_02565

STM:

STM2360

SEO:	STM14_2907

SEV:	STMMW_23821

SEY:	SL1344_2329

SEM:	STMDT12_C23820

SEJ:	STMUK_2390

SEB:	STM474_2458

SEF:	UMN798_2547

SETU:

STU288_08185

SETC:

CFSAN001921_04990

SENR:

STMDT2_23291

SEND:

DT104_24161

SENI:

CY43_12630

SEEN:

SE451236_18000

SPT:

SPA0504

SEK:

SSPA0468

SPQ:	SPAB_00611

SEI:

SPC_1346

SEC:	SCH_2362(dcdA)

SEH:	SeHA_C2602

SHB:

SU5_02955

SENH:

CFSAN002069_20050

SEEH:

SEEH1578_21075

SEE:	SNSL254_A2548

SENN:

SN31241_34670

SEW:	SeSA_A2590

SEA:	SeAg_B2502

SENS:

Q786_11650

SED:

SeD_A2711

SEG:

SG2389

SEL:

SPUL_0525

SEGA:

SPUCDC_0525

SET:

SEN2342

SENA:

AU38_11845

SENO:

AU37_11860

SENV:

AU39_11855

SENQ:

AU40_13270

SENL:

IY59_12180

SENJ:

CFSAN001992_21780

SEEC:

CFSAN002050_18730

SEEB:

SEEB0189_007775

SEEP:

I137_02420

SENB:

BN855_24460

SENE:

IA1_11770

SENC:

SEET0819_18895

SES:	SARI_00539

SALZ:

EOS98_07210

KPY:	KPNIH31_17990

KQV:	B8P98_08245

KAR:	LGL98_07250

CARS:

E1B03_18525

YRE:	HEC60_10965

EBB:

F652_2879

BIZ:	HC231_15555(lysA)

MINT:

C7M51_04183(lysA_2)

MTHI:

C7M52_02873(lysA_2)

ETD:

ETAF_2803

ETE:	ETEE_1297(lysA)

ETR:

ETAE_3108

ETC:	ETAC_14815

EDW:	QY76_05080

EDL:	AAZ33_16125

HAV:	AT03_19525

HPAR:

AL518_07035(lysA)

PMAO:

PMYSY11_3569

PCAV:

D3880_05700(lysA)

PLAU:

I0D68_14580(lysA)

MPAF:

R5R33_10215(lysA)

GAP:	GAPWK_0408

GAQ:	RAM11_03315(lysA)

AMAH:

DLM_1427

AQS:	DKK66_15610(lysA)

SWS:	I6J16_08305(lysA)

HTQ:	FRZ44_28070 FRZ44_40730

HADH:

FRZ61_19510(lysA) FRZ61_38830

PBRU:

LZC95_01585(lysA)

PRUE:

LVJ94_01565(lysA)

BTS:

Btus_0317

KYR:	CVV65_03090

CNO:	NT01CX_2116(lysA)

AMIJ:

EQM06_04195

AMIC:

Ami3637_02380

ABUT:

Ami103574_10075

AHAD:

FRZ06_17030(lysA)

LEPT:

JVX88_12865(lysA)

» show all

Reference

1 [PMID:29024617]

Authors

Phillips RS, Poteh P, Miller KA, Hoover TR

Title

STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.

Journal

Arch Biochem Biophys 634:83-87 (2017)
DOI:10.1016/j.abb.2017.09.010

Sequence

[stm:STM2360]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.116

IUBMB Enzyme Nomenclature:

4.1.1.116

ExPASy - ENZYME nomenclature database:

4.1.1.116

BRENDA, the Enzyme Database:

4.1.1.116

All links

Gene (59)   
   MGENES (59)   
Protein sequence (1220)   
   UniProt (7)   
   SWISS-PROT (1)   
   RefSeq(pep) (1202)   
   PDBSTR (10)   
DNA sequence (5711)   
   RefSeq(nuc) (4887)   
   GenBank (414)   
   EMBL (410)   
3D Structure (6)   
   PDB (6)   
All databases (6996)   

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