Entry |
|
Name |
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase;
sbnH (gene name)
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Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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Sysname |
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
|
Reaction(IUBMB) |
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 [RN: R12309]
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Reaction(KEGG) |
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Substrate |
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD: C22072]
|
Product |
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD: C22073];
CO2 [CPD: C00011]
|
Comment |
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.
|
History |
EC 4.1.1.117 created 2019
|
Pathway |
ec00997 | Biosynthesis of various other secondary metabolites |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K23373 | 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase |
|
Genes |
TACT: | SG35_002330 SG35_003620 |
MAQU: | Maq22A_c25460(lysA) |
MIWA: | SS37A_35480(sbnH_1) SS37A_39120(sbnH_2) |
SAX: | USA300HOU_0134(lysA1) |
SUF: | SARLGA251_00980(sbnH) |
SDP: | NCTC12225_02334(lysA_2) |
SSH: | NCTC13712_00076(lysA_1) |
SSTE: | SAMEA4384403_0108(lysA_1) |
TUM: | CBW65_11365 CBW65_11415 |
BLUI: | Blut17040_33070(sbnH) |
EBM: | SG0102_00780(lysA_1) |
SGF: | HEP81_00355 HEP81_07705 |
ACTR: | Asp14428_06990(sbnH) |
CATI: | CS0771_66390(lysA_2) |
LET: | O77CONTIG1_03927(btrK) |
» show all
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Reference |
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Authors |
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE |
Title |
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 4.1.1.117 |
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