KEGG ENZYME: 4.1.1.117

ENZYME: 4.1.1.117

Entry

EC 4.1.1.117                Enzyme

Name

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase;
sbnH (gene name)

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)

Reaction(IUBMB)

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 [RN:R12309]

Reaction(KEGG)

R12309

Substrate

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22072]

Product

2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22073];
CO2 [CPD:C00011]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.

History

EC 4.1.1.117 created 2019

Pathway

ec00997

Biosynthesis of various other secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K23373

2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase

Genes

SDN:

Sden_0584

TACT:

SG35_002330 SG35_003620

PSAL:

PSLF89_1986

HSV:	HNO53_08405

RSO:	RSp0424(ssd)

RSE:

F504_3900

RPU:	CDC45_19750

RNC:	GO999_24090

RSL:	RPSI07_mp0385

RSN:	RSPO_m01404

RSM:	CMR15_mp10437

RSY:	RSUY_34920(btrK)

RSG:	JK151_14150

CNC:	CNE_2c14900(lysA)

CUH:	BJN34_08290

RME:	Rmet_1110(lysA)

CUK:	KB879_12600

BPLA:

bpln_2g05080

NET:

Neut_1742

NLC:	EBAPG3_006485

NIZ:	NNRS527_01543

ALEG:

CFBP4996_27415

MNO:

Mnod_6954

MAQU:

Maq22A_c25460(lysA)

MHAR:

L1P08_12095

MIWA:

SS37A_35480(sbnH_1) SS37A_39120(sbnH_2)

PPHR:

APZ00_12890

SBD:	ATN00_04605

MAES:

Ga0123461_0244

MFN:	Ga0123462_2021

CPEL:

CPEL_0305

BWH:	A9C19_09115

BBAD:

K7T73_21430

GCT:	GC56T3_0418

GJF:	M493_02155

GSR:	GS3922_13805

PCAL:

BV455_03917(btrK)

LGY:	T479_22375

HHD:	HBHAL_4879

HLI:

HLI_03735

SJE:	AAV35_000870

RUE:	DT065_14635

SALE:

EPH95_16140

MSEM:

GMB29_11065

ALKG:

MOJ78_16620

SAU:	SA0119(sbnH)

SAV:

SAV0123

SAW:

SAHV_0122

SAH:	SaurJH1_0114

SAJ:	SaurJH9_0110

SAM:	MW0096(sbnH)

SAS:

SAS0097

SAR:

SAR0126

SAC:

SACOL0107

SAX:	USA300HOU_0134(lysA1)

SAA:	SAUSA300_0125

SAO:	SAOUHSC_00082

SAE:	NWMN_0067(sbnH)

SAD:

SAAV_0091

SUU:	M013TW_0113(sbnH)

SUV:	SAVC_00355

SUE:

SAOV_0070

SUJ:	SAA6159_00106(sbnH)

SUK:	SAA6008_00101(sbnH)

SUC:

ECTR2_79

SUT:	SAT0131_00109

SUQ:	HMPREF0772_10374

SUZ:

MS7_0115

SUD:	ST398NM01_0135

SUX:	SAEMRSA15_00890

SUW:	SATW20_01350(sbnH)

SUG:

SAPIG0135

SUF:	SARLGA251_00980(sbnH)

SAUA:

SAAG_00607

SAUE:

RSAU_000077

SAUN:

SAKOR_00097

SAUS:

SA40_0090(sbnH)

SAUU:

SA957_0105(sbnH)

SAUG:

SA268_0102(sbnH)

SAUZ:

SAZ172_0134(sbnH)

SAUT:

SAI1T1_2000790

SAUJ:

SAI2T2_1000790

SAUK:

SAI3T3_1000790

SAUQ:

SAI4T8_1000790

SAUV:

SAI7S6_1000790

SAUW:

SAI5S5_1000790

SAUX:

SAI6T6_1000790

SAUY:

SAI8T7_1000790

SAUF:

X998_0102

SAB:

SAB0062

SUY:	SA2981_0124(sbnH)

SAUB:

C248_0111

SAUM:

BN843_1250

SAUC:

CA347_134

SAUR:

SABB_01717(sbnH)

SAUI:

AZ30_00640

SAUD:

CH52_05105

SAMS:

NI36_00535

SUH:	SAMSHR1132_00990

SSD:	SPSINT_0341

SDT:

SPSE_2117

SDP:	NCTC12225_02334(lysA_2)

SHU:	SHYC_00390(sbnH)

SSCH:

LH95_00390

SSCZ:

RN70_00610

SAGQ:

EP23_09735

SEQO:

SE1039_25040

SPET:

CEP67_08210

SLZ:	B5P37_07625

SARL:

SAP2_02100

SSH:	NCTC13712_00076(lysA_1)

SRAI:

LN051_00265

SSCU:

CEP64_13490

SFF:	FOB90_07400

SSTE:

SAMEA4384403_0108(lysA_1)

MVT:	I6J10_10610

MBRU:

MGG13_01660

BAGR:

BA6348_15320

BBOR:

RFB14_00515

PTA:	HPL003_19625

PPEO:

ABE82_04655

POW:	IJ21_46070

PXL:	BS614_08695

PKB:	B4V02_14030

PAIH:

ASL14_00105

PPSC:

EHS13_31645

PBAC:

HUB98_21850

PKA:	PQ456_10730

PMAH:

PTQ21_17795

PAMY:

P9222_32695

PMAE:

LMZ02_21530

ANX:	ACH33_02525

ATHE:

K3F53_16425

CCHL:

FPL14_15130

SACA:

FFV09_03650

TUM:	CBW65_11365 CBW65_11415

TAB:	CIG75_16800

PANA:

BBH88_04010

PANC:

E2636_16075

LFB:	C1X05_04265

KPUL:

GXN76_14210

PABS:

JIR001_05150

STU:	STH8232_0696

CSEP:

CP523_06275

CCT:

CC1_17280

ROB:

CK5_31170

BYL:	A4V09_07165

BLUI:

Blut17040_33070(sbnH)

MHW:	ACT01_03350

ERH:	ERH_0207(lysA)

ERS:	K210_08220

EIO:	H9L01_08060

EBM:	SG0102_00780(lysA_1)

NAH:	F5544_31195

SHY:

SHJG_0926

SHO:	SHJGH_0759

SGS:	AVL59_29350

SNW:	BBN63_16025

SALJ:

SMD11_0162(lysA)

SRJ:	SRO_0366 SRO_7379

SRK:	FGW37_30385

SVR:	CP971_06275

SFY:	GFH48_07845

SGF:	HEP81_00355 HEP81_07705

SBY:	H7H31_05365

SGOB:

test1122_12320

SYUN:

MOV08_35445

KAU:	B6264_01465

KIT:	CFP65_6208

RSA:	RSal33209_1689

NCG:	KGD84_12355

FRA:	Francci3_4053

FRE:	Franean1_0663

FAL:

FRAAL6420

FSY:	FsymDg_0715

SACG:

FDZ84_26465

PSEQ:

AD006_29035

PECQ:

AD017_29425

PMAD:

BAY61_28595

CROS:

N8J89_30765

ASE:	ACPL_4370(lysA)

AMS:	AMIS_41880

ACTN:

L083_3996(lysA)

AFS:

AFR_21240

ACTS:

ACWT_4241

AIH:	Aiant_88100(lysA_3)

ACTR:

Asp14428_06990(sbnH)

ACTL:

L3i22_055200(lysA)

ASIC:

Q0Z83_030800

PFLA:

Pflav_024170(sbnH)

PSUU:

Psuf_079620(sbnH)

PRY:	Prubr_61760(lysA_4)

CATI:

CS0771_66390(lysA_2)

DVC:	Dvina_27455

DFU:	Dfulv_25325

DROS:

Drose_20240

DAUR:

Daura_26770

DMAT:

Dmats_22890

CCAZ:

COUCH_21220

SNA:

Snas_3735

NAV:	JQS30_07790

GLY:	K3N28_09085

LET:	O77CONTIG1_03927(btrK)

TSU:	Tresu_1002

» show all

Reference

1 [PMID:19775248]

Authors

Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE

Title

Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.

Journal

Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.117

IUBMB Enzyme Nomenclature:

4.1.1.117

ExPASy - ENZYME nomenclature database:

4.1.1.117

BRENDA, the Enzyme Database:

4.1.1.117

DBGET integrated database retrieval system