| Entry |
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| Name |
aspartate 4-decarboxylase;
desulfinase;
aminomalonic decarboxylase;
aspartate beta-decarboxylase;
aspartate omega-decarboxylase;
aspartic omega-decarboxylase;
aspartic beta-decarboxylase;
L-aspartate beta-decarboxylase;
cysteine sulfinic desulfinase;
L-cysteine sulfinate acid desulfinase;
L-aspartate 4-carboxy-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
L-aspartate 4-carboxy-lyase (L-alanine-forming)
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| Reaction(IUBMB) |
L-aspartate = L-alanine + CO2 [RN: R00397]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.
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| History |
EC 4.1.1.12 created 1961, modified 1976 (EC 4.1.1.10 created 1961, incorporated 1972)
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| Pathway |
| ec00250 | Alanine, aspartate and glutamate metabolism |
| ec00270 | Cysteine and methionine metabolism |
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| Orthology |
| K09758 | aspartate 4-decarboxylase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kakimoto T, Kato J, Shibatani T, Nishimura N, Chibata I. |
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| Title |
Crystalline L-aspartate beta-decarboxylase of Pseudomonas dacunhae. I. Crystallization and some physiocochemical properties. |
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| Journal |
J Biol Chem 244:353-8 (1969) |
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| Reference |
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| Authors |
NOVOGRODSKY A, MEISTER A. |
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| Title |
CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION. |
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| Journal |
J Biol Chem 239:879-88 (1964) |
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| Reference |
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| Authors |
Palekar AG, Tate SS, Meister A. |
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| Title |
Inhibition of aspartate beta-decarboxylase by aminomalonate. Stereospecific decarboxylation of aminomalonate to glycine. |
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| Journal |
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| Reference |
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| Authors |
WILSON EM, KORNBERG HL. |
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| Title |
PROPERTIES OF CRYSTALLINE L-ASPARTATE 4-CARBOXY-LYASE FROM ACHROMOBACTER SP. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.12 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.12 |
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