KEGG ENZYME: 4.1.1.12

ENZYME: 4.1.1.12

Entry

EC 4.1.1.12 Enzyme

Name

aspartate 4-decarboxylase;
desulfinase;
aminomalonic decarboxylase;
aspartate beta-decarboxylase;
aspartate omega-decarboxylase;
aspartic omega-decarboxylase;
aspartic beta-decarboxylase;
L-aspartate beta-decarboxylase;
cysteine sulfinic desulfinase;
L-cysteine sulfinate acid desulfinase;
L-aspartate 4-carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

L-aspartate 4-carboxy-lyase (L-alanine-forming)

Reaction(IUBMB)

L-aspartate = L-alanine + CO2 [RN:R00397]

Reaction(KEGG)

R00397;
(other) R00863

Substrate

L-aspartate [CPD:C00049]

Product

L-alanine [CPD:C00041];
CO2 [CPD:C00011]

Comment

A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.

History

EC 4.1.1.12 created 1961, modified 1976 (EC 4.1.1.10 created 1961, incorporated 1972)

Pathway

ec00250

Alanine, aspartate and glutamate metabolism

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K09758

aspartate 4-decarboxylase

Genes

PGE:	LG71_16775

SGOE:

A8O29_009805

EBI:	EbC_05500(asdA)

EGE:	EM595_p0259(asD)

PAGC:

BEE12_19545

XCZ:	EBN15_14105

DCS:	ISN74_02670

VPF:	M634_10470

VAG:

N646_0788

VOW:	A9237_22760

VBR:	A6E01_18540

VSH:	BSZ05_17320

VNL:	D3H41_09020

VCC:	FAZ90_22230

VAS:	GT360_19455

POR:	APT59_06490

PPSL:

BJP27_21240

ABC:	ACICU_02407

ABX:

ABK1_1281

ABR:	ABTJ_01313

ABD:	ABTW07_2602

ABH:

M3Q_2677

ABJ:	BJAB07104_02567

ABAJ:

BJAB0868_02449

ABK:	LX00_11905

ABW:	BL01_18405

ACC:	BDGL_001724(asdA)

ANO:	RR32_06650

ALC:	OTEC02_06155

ACAL:

BUM88_12690

ASEI:

I8T81_06570

ACD:	AOLE_05980

ACW:	A0J50_05920

ARJ:	DOM24_06685

AGU:

AS4_34620

AUG:

URS_3215

ADS:	FPL17_02705

ABER:

BSR55_16730

ABOU:

ACBO_17400(asdA)

SJA:	SJ2017_0934

SPSW:

SAES:

SPSH:

FTQ:

FTW:

FTL:

FTH:	FTH_0320(aspD)

FTA:

FTA_0339

FTS:

F92_01720

FTI:	FTS_0320(aspD)

FTC:	DA46_389(aspD)

FTV:	CH67_605(aspD)

FTZ:	CH68_339(aspD)

FTM:

FTM_0420

FTN:

FTN_0343

FTX:	AW25_1696(aspD)

FTD:	AS84_347(aspD)

FTY:	CH70_1724(aspD)

FCF:	FNFX1_0347

FCN:	FN3523_0319

FHI:	FSC454_01590

FPH:

Fphi_0481

FPT:	BZ13_1555(aspD)

FPI:	BF30_676(aspD)

FPM:	LA56_1696(aspD)

FPX:	KU46_878(aspD)

FPZ:	LA55_350(aspD)

FPJ:	LA02_93(aspD)

FNL:	M973_02125

FRX:	F7310_01935

FMI:	F0R74_00170

FSR:	KQR59_01715

GAP:	GAPWK_0604

FPP:	FPB0191_01217

SALV:

SALWKB2_1178

JEU:	BJP62_06550

RMN:	TK49_17160

RIN:	ACS15_4642(aspD)

REH:	H16_A3009(asdA)

CUH:	BJN34_16100

REU:	Reut_A2709

RME:	Rmet_1984(asdA)

CTI:	RALTA_A2486

CPAU:

EHF44_03735 EHF44_08790

BDL:	AK34_5158(aspD)

BGL:	bglu_1g10380

BGU:	KS03_1969(aspD)

BUG:	BC1001_0495

BGF:	BC1003_0509

BGD:	bgla_1g34720

BGO:	BM43_966(aspD)

BYI:	BYI23_B001880 BYI23_B009610

BUE:	BRPE67_BCDS04300 BRPE67_BCDS13690

BUQ:	AC233_02730 AC233_21280

BGP:	BGL_1c10730

BPLA:

bpln_1g10290

BUI:	AX768_27835

BXE:

Bxe_A3891

BXB:	DR64_1567(aspD)

BPX:	BUPH_04382

BPY:	Bphyt_0790

BUZ:	AYM40_02735

BFN:	OI25_910(aspD)

BCAI:

PARA:

PARB:

PTER:

PGP:	CUJ91_02890 CUJ91_22250

PCJ:	CUJ87_02565

PTRO:

PGIS:

PACP:

PACS:

PEW:	KZJ38_05240

PPK:	U875_16620

PPNO:

DA70_08515

PPNM:

LV28_22125

PRB:	X636_17850

PPUL:

RO07_16525

PSPU:

NA29_20650

PAPI:

SG18_15360

PVE:	UC34_07725

POX:	MB84_12100

PFG:	AB870_18430

PNR:	AT302_26280

PFIB:

PI93_020105

CABA:

SBC2_59080(asD)

BUO:	BRPE64_BCDS03460

BGM:	CAL15_04880

AXY:	AXYL_01733(asdA)

AXO:	NH44784_003501

AXN:	AX27061_1634

AXX:	ERS451415_01627

ADT:	APT56_07650

AIS:	BUW96_17710

ASW:	CVS48_27420

ACHB:

DVB37_06875 DVB37_19495

ADY:	HLG70_14320

PIG:	EGT29_14105

PACR:

FXN63_11900

AANT:

HUK68_19395

DAC:

Daci_3914

DEL:	DelCs14_2898

DTS:	BI380_05570

DHK:	BO996_17860

DLA:	I6G47_04575

VBO:	CKY39_13670

CTT:	CtCNB1_2315

CTES:

O987_14975

OTK:	C6570_11340

MMS:	mma_1084(asdA)

JAZ:	YQ44_16560

JAL:	BZG29_11315

JSV:	CNX70_11725

JAS:	FJQ89_00355

JLV:	G3257_11780

HEE:	hmeg3_11990

CFU:	CFU_0143(asdA)

CARE:

LT85_0123

CPRA:

CPter91_0121(aspD)

RGU:	A4W93_20110

SUN:

SUN_0877

DSD:	GD606_11240

DAS:

Daes_0274

PSEL:

GM415_11140

MSD:	MYSTI_04286

MFB:	MFUL124B02_23065

CCX:	COCOR_02790

LLU:	AKJ09_07676

PLA:

Plav_0095

SMER:

DU99_31685

EAH:	FA04_09150

ATA:	AWN88_07440

AGT:	EYD00_17740

RIR:	BN877_II0817

RPUS:

CFBP5875_17910

RHL:	LPU83_pLPU83c0641(asdA)

KAI:

K32_37910

OAN:

Oant_3483

OAH:	DR92_3003(aspD)

OCR:	HGK82_19905

OCL:	GTN27_17960

BJA:	blr3477(blr3477)

BRS:

S23_35870

BEL:	BE61_65300

BOI:	BLM15_13525

BOF:	FQV39_12980

MET:

M446_1557

AALA:

IGS74_01595

NOH:	G5V57_02800

CMB:	CSW64_14790

RUA:	D1823_08915

RUT:	FIU92_18350(asD)

PSHQ:

F3W81_02265

HDH:	G5B40_15560

ZMO:

ZMN:

ZMM:

ZMB:

ZMI:

ZMC:	A265_01479

ZMR:	A254_01478

KSC:	CD178_01686(asD)

APT:	APA01_04430 APA01_15490

APW:	APA42C_04430 APA42C_15490

APF:	APA03_04430 APA03_15490

APU:	APA07_04430 APA07_15490

APG:	APA12_04430 APA12_15490

APQ:	APA22_04430 APA22_15490

APX:	APA26_04430 APA26_15490

APZ:	APA32_04430 APA32_15490

APK:	APA386B_1928(asdA) APA386B_482

ASZ:

ASN_851

ASV:	WG31_02660 WG31_08065

AACE:

A0U92_00615

APER:

A0U91_10830

APOM:

CPF11_05090 CPF11_12475

ATO:	CIW82_07840

AASC:

A4S02_09960

ACET:

DS739_02335 DS739_07955

AOT:	AcetOri_orf02602 AcetOri_orf04014

AOY:	EOV40_002210 EOV40_007185

KBA:	A0U89_15935

RGI:	RGI145_16190

ROS:	CTJ15_14925

RMUC:

FOB66_04270

BOMB:

GT348_07755

ABS:	AZOBR_p430032

ABQ:	ABAZ39_32690

ABF:	AMK58_23540

AZT:	TSH58p_19950

BDC:	DOE51_04330

BDZ:	DOM22_15740

PRD:	F7984_03280(aspD)

AAD:

TC41_0858

AFX:	JZ786_08480(aspD)

LGR:

LGV:

LAC:

LAD:

LAF:

LHL:

LTA:	H1A07_02740

LCA:

LSEI_2747

LCZ:	LCAZH_2752

LCS:

LCBD_2960

LCE:

LC2W_2934

LCW:	BN194_28750

LCL:	LOCK919_3003

LPI:	LBPG_01343

LCB:	LCABL_29320(asdA)

LCX:	LCA12A_0440

LPR:	LBP_p3g040

LPZ:

Lp16_F030

LOR:	AYI71_02915

LHO:	LOOC260_121710

LSA:	LCA_0306(aspD)

LCV:	FBA2_01670

LGM:	LG542_07710

EFA:

EF1037

EFL:

EF62_1474

EFI:	OG1RF_10770

EFD:	EFD32_0849

EFS:	EFS1_0865(asdA)

EFN:	DENG_01170

EFQ:	DR75_96(aspD)

ENE:

ENT_30620

EGV:	EGCR1_11780 EGCR1_18225(aspD)

EAV:	EH197_06745(aspD) EH197_21350

ERAF:

J9537_19820(aspD)

MPS:	MPTP_0441 MPTP_0995

MPX:	MPD5_0951 MPD5_1465

THL:	TEH_22060(aspD)

VTE:	BHY08_01720 BHY08_05240

VPI:	BW732_03295

MARR:

BKP56_00640

DPM:	FNV33_08145(aspD)

CPE:	CPE0341 CPE1001

CPF:	CPF_0325 CPF_1258(aspD)

CPR:

CPR_0327

CBO:	CBO1166(asdA)

CBA:	CLB_1197(asdA)

CBH:	CLC_1209(asdA)

CBY:

CLM_1317

CBL:

CLK_0601

CBB:

CLD_3403

CBI:	CLJ_B1207(aspD)

CBF:	CLI_1247(aspD)

CBJ:	H04402_01235

CBE:

CBZ:

CBEI:

CKL:

CKR:

CLJ:	CLJU_c33270

CSB:	CLSA_c16110

CAH:	CAETHG_1226

CBV:	U729_1867(aspD)

CSQ:

CSCA_1714

CLD:	CLSPO_c11660(asd1)

CCK:	Ccar_06140

CTYK:

CTK_C07120

CEU:	A7L45_04535

CDRK:

B9W14_10705

CSEP:

CP523_01580(aspD)

CDY:	F3K33_09545(aspD)

CFER:

D4Z93_01615(aspD)

CLOS:

DMR38_16645(aspD)

SARJ:

HH195_05955(aspD)

PBIF:

KXZ80_04485(aspD)

CLE:	Clole_2227

CEW:	EKH84_13810(aspD)

CDF:	CD630_25150

PDC:	CDIF630_02764(aspD)

CDC:	CD196_2360(aspD)

CDL:	CDR20291_2407(aspD)

PDF:	CD630DERM_25150

EAC:	EAL2_c09600(aspD)

PSOR:

RSJ16_04440

ROC:	HF520_07485(aspD)

PHX:	KGNDJEFE_01911(asD)

TEM:	JW646_15505(aspD)

DMT:	DESME_09070

DOR:	Desor_4048

DAI:	Desaci_1009

AMIC:

Ami3637_00175(aspD)

ABUT:

Ami103574_04740(aspD)

HHL:	Halha_1158

MANA:

MAMMFC1_00109(asD)

TUR:	AT726_09355 AT726_11740

TSG:	HLK68_09170(aspD) HLK68_11245(aspD)

MBOK:

MBOE_49860(asdA)

NNO:	NONO_c61950

SALB:

SGR:

SGB:

SVE:

SFI:

SVT:	SVTN_13840

SCZ:	ABE83_23965

SVU:	B1H20_11125

SFK:

KY5_2946

SKA:	CP970_27805

SVN:	CP980_06000

SNK:	CP967_32090

SCAV:

SSUB:

SCAL:

KSK:

KAB:	B7C62_10775

KIT:	CFP65_6286

SALA:

ESZ53_11080

AAQ:	AOC05_08165

SESP:

PMAD:

CAI:

SNA:

AEQ:

AHAT:

LSC:	KIK02_20220

TRM:	JO41_09340

LBA:

Lebu_0659

CPOR:

BED41_13885

BTH:

BT_0735

BTHO:

Btheta7330_02355(asD)

BFR:

BF1517

BFS:	BF9343_1378

BFG:	BF638R_1530

BFB:	VU15_06365

BXY:

BXY_02850

BOA:	Bovatus_00911(asD)

BCEL:

BcellWH2_01068(asD)

BCAC:

CGC64_12685(aspD)

BIS:	DXK01_019955(aspD)

BUN:	Bun01g_20960

BEG:	INE88_00537(asd_1)

BVU:

BVU_2264

BDO:	EL88_04250

BDH:	GV66_11835

PDI:

BDI_1073

PARC:

CI960_09080

PMER:

INE87_00972(asd_1)

PGOL:

K6V26_07070

COPR:

Cop2CBH44_09800

COY:	HF329_12145(aspD)

PGO:	FSB84_29235(aspD)

SCN:	Solca_2046

FJG:	BB050_04015(asD)

CAO:	Celal_4230

OLL:	CW732_12970

PSYN:

E9099_16455

APIB:

G8C43_08895(aspD)

MEL:	Metbo_1835

THA:

TAM4_1721

THM:

CL1_0496

ABI:

Aboo_0621

ACF:	AciM339_0098

» show all

Reference

1 [PMID:5773301]

Authors

Kakimoto T, Kato J, Shibatani T, Nishimura N, Chibata I.

Title

Crystalline L-aspartate beta-decarboxylase of Pseudomonas dacunhae. I. Crystallization and some physiocochemical properties.

Journal

J Biol Chem 244:353-8 (1969)

Reference

2 [PMID:14154469]

Authors

NOVOGRODSKY A, MEISTER A.

Title

CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION.

Journal

J Biol Chem 239:879-88 (1964)

Reference

3 [PMID:5424207]

Authors

Palekar AG, Tate SS, Meister A.

Title

Inhibition of aspartate beta-decarboxylase by aminomalonate. Stereospecific decarboxylation of aminomalonate to glycine.

Journal

Biochemistry 9:2310-5 (1970)
DOI:10.1021/bi00813a014

Reference

4 [PMID:14071532]

Authors

WILSON EM, KORNBERG HL.

Title

PROPERTIES OF CRYSTALLINE L-ASPARTATE 4-CARBOXY-LYASE FROM ACHROMOBACTER SP.

Journal

Biochem J 88:578-87 (1963)
DOI:10.1042/bj0880578

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.12

IUBMB Enzyme Nomenclature:

4.1.1.12

ExPASy - ENZYME nomenclature database:

4.1.1.12

BRENDA, the Enzyme Database:

4.1.1.12

CAS:

9024-57-1

DBGET integrated database retrieval system