KEGG   ENZYME: 4.1.1.12
Entry
EC 4.1.1.12                 Enzyme                                 
Name
aspartate 4-decarboxylase;
desulfinase;
aminomalonic decarboxylase;
aspartate beta-decarboxylase;
aspartate omega-decarboxylase;
aspartic omega-decarboxylase;
aspartic beta-decarboxylase;
L-aspartate beta-decarboxylase;
cysteine sulfinic desulfinase;
L-cysteine sulfinate acid desulfinase;
L-aspartate 4-carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-aspartate 4-carboxy-lyase (L-alanine-forming)
Reaction(IUBMB)
L-aspartate = L-alanine + CO2 [RN:R00397]
Reaction(KEGG)
R00397;
(other) R00863
Substrate
L-aspartate [CPD:C00049]
Product
L-alanine [CPD:C00041];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.
History
EC 4.1.1.12 created 1961, modified 1976 (EC 4.1.1.10 created 1961, incorporated 1972)
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K09758  aspartate 4-decarboxylase
Genes
PGE: LG71_16775
SGOE: A8O29_009805
CARU: P0E69_20280
EBI: EbC_05500(asdA)
EGE: EM595_p0259(asD)
PAGC: BEE12_19545
XCZ: EBN15_14105
DCS: ISN74_02670
VPF: M634_10470
VAG: N646_0788
VOW: A9237_22760
VBR: A6E01_18540
VSH: BSZ05_17320
VNL: D3H41_09020
VCC: FAZ90_22230
VAS: GT360_19455
VGI: MID13_20680
VSL: LTQ54_19605 LTQ54_20980
VPG: LZI70_16825
VCRA: IS519_20025
VLE: ISX51_17775
VSY: K08M4_37400(asD)
POR: APT59_06490
PPSL: BJP27_21240
ABC: ACICU_02407
ABX: ABK1_1281
ABR: ABTJ_01313
ABD: ABTW07_2602
ABH: M3Q_2677
ABJ: BJAB07104_02567
ABAJ: BJAB0868_02449
ABK: LX00_11905
ABW: BL01_18405
ACC: BDGL_001724(asdA)
ANO: RR32_06650
ALC: OTEC02_06155
ACAL: BUM88_12690
ASEI: I8T81_06570
ACD: AOLE_05980
ACW: A0J50_05920
ARJ: DOM24_06685
AGU: AS4_34620
AUG: URS_3215
ADS: FPL17_02705
ABER: BSR55_16730
ABOU: ACBO_17400(asdA)
AGYL: FPL18_19165
AVZ: HWI77_10025
ATZ: M5E07_10930
APRL: PY247_13965
ACOI: NQU59_15115
SJA: SJ2017_0934
SPSW: Sps_02671
SAES: HBH39_15210
SPSH: FM037_05185
AGZ: M0C34_10675 M0C34_15950
FTQ: RO31_0955
FTW: FTW_1358
FTL: FTL_0320
FTH: FTH_0320(aspD)
FTA: FTA_0339
FTS: F92_01720
FTI: FTS_0320(aspD)
FTC: DA46_389(aspD)
FTV: CH67_605(aspD)
FTZ: CH68_339(aspD)
FTM: FTM_0420
FTN: FTN_0343
FTX: AW25_1696(aspD)
FTD: AS84_347(aspD)
FTY: CH70_1724(aspD)
FCF: FNFX1_0347
FCN: FN3523_0319
FHI: FSC454_01590
FPH: Fphi_0481
FPT: BZ13_1555(aspD)
FPI: BF30_676(aspD)
FPM: LA56_1696(aspD)
FPX: KU46_878(aspD)
FPZ: LA55_350(aspD)
FPJ: LA02_93(aspD)
FNL: M973_02125
FRX: F7310_01935
FMI: F0R74_00170
FSR: KQR59_01715
TBOG: LT988_20810
HBH: E4T21_10470
HASO: B2G49_18225
EEI: NX720_01410
GAP: GAPWK_0604
GAQ: RAM11_09890
FPP: FPB0191_01217
SALV: SALWKB2_1178
SCOM: PYG29_06890
JEU: BJP62_06550
RMN: TK49_17160
RIN: ACS15_4642(aspD)
REH: H16_A3009(asdA)
CUH: BJN34_16100
REU: Reut_A2709
RME: Rmet_1984(asdA)
CTI: RALTA_A2486
CPAU: EHF44_03735 EHF44_08790
CCAM: M5D45_13465 M5D45_13595
BDL: AK34_5158(aspD)
BGL: bglu_1g10380
BGU: KS03_1969(aspD)
BUG: BC1001_0495
BGF: BC1003_0509
BGD: bgla_1g34720
BGO: BM43_966(aspD)
BYI: BYI23_B001880 BYI23_B009610
BUE: BRPE67_BCDS04300 BRPE67_BCDS13690
BUQ: AC233_02730 AC233_21280
BGP: BGL_1c10730
BPLA: bpln_1g10290
BUI: AX768_27835
BXE: Bxe_A3891
BXB: DR64_1567(aspD)
BPX: BUPH_04382
BPY: Bphyt_0790
BUZ: AYM40_02735
BFN: OI25_910(aspD)
BCAI: K788_0004943
PARA: BTO02_16975
PARB: CJU94_02295
PTER: C2L65_12530
PGP: CUJ91_02890 CUJ91_22250
PCJ: CUJ87_02565
PTRO: G5S35_02720
PGIS: I6I06_08795
PACP: FAZ97_02760
PACS: FAZ98_02735
PEW: KZJ38_05240
PDIO: PDMSB3_0651(asD)
PBRY: NDK50_03015
PSAA: QEN71_26105
PPK: U875_16620
PPNO: DA70_08515
PPNM: LV28_22125
PRB: X636_17850
PPUL: RO07_16525
PSPU: NA29_20650
PAPI: SG18_15360
PVE: UC34_07725
POX: MB84_12100
PFG: AB870_18430
PNR: AT302_26280
PFIB: PI93_020105
PCOM: NTU39_08800
CABA: SBC2_59080(asD)
BUO: BRPE64_BCDS03460
TVL: FAZ95_22685
BGM: CAL15_04880
BGV: CAL12_18975
AXY: AXYL_01733(asdA)
AXO: NH44784_003501
AXN: AX27061_1634
AXX: ERS451415_01627
ADT: APT56_07650
AIS: BUW96_17710
ASW: CVS48_27420
ACHB: DVB37_06875 DVB37_19495
ADY: HLG70_14320
ACHO: H4P35_07090
AMUI: PE062_03855
APES: FOC84_03915
AAEG: RA224_24140
PIG: EGT29_14105
PACR: FXN63_11900
DAC: Daci_3914
DEL: DelCs14_2898
DTS: BI380_05570
DHK: BO996_17860
DLA: I6G47_04575
VBO: CKY39_13670
CTT: CtCNB1_2315
CTES: O987_14975
AANT: HUK68_19395
OTK: C6570_11340
MMS: mma_1084(asdA)
JAZ: YQ44_16560
JAL: BZG29_11315
JSV: CNX70_11725
JAS: FJQ89_00355
JLV: G3257_11780
JAH: JAB4_024320(asD)
JRI: P9875_12080
HEE: hmeg3_11990
CFU: CFU_0143(asdA)
CARE: LT85_0123
CPRA: CPter91_0121(aspD)
OVB: NB640_09330
RGU: A4W93_20110
PLA: Plav_0095
SMER: DU99_31685
SKM: PZL22_006251
EAH: FA04_09150
ECAA: J3R84_34400
ENP: JVX98_10580
ATA: AWN88_07440
AGT: EYD00_17740
RIR: BN877_II0817
RPUS: CFBP5875_17910
RHL: LPU83_pLPU83c0641(asdA)
KAI: K32_37910
OAN: Oant_3483
OAH: DR92_3003(aspD)
OCR: HGK82_19905
OCL: GTN27_17960
BJA: blr3477(blr3477)
BRS: S23_35870
BEL: BE61_65300
BSEP: HAP48_0009735(aspD)
BAUT: QA635_06245 QA635_26070(aspD)
BBRA: QA636_27870(aspD)
BCOU: IC761_10245(aspD)
BPAH: QA639_05895(aspD)
BOI: BLM15_13525
BOF: FQV39_12980
MET: M446_1557
AALA: IGS74_01595
NOH: G5V57_02800
CMB: CSW64_14790
RUA: D1823_08915
RUT: FIU92_18350(asD)
RCON: K3740_22180
PSHQ: F3W81_02265
HDH: G5B40_15560
ZMO: ZMO1682
ZMN: Za10_1537
ZMM: Zmob_1458
ZMB: ZZ6_1435
ZMI: ZCP4_1480
ZMC: A265_01479
ZMR: A254_01478
KSC: CD178_01686(asD)
APT: APA01_04430 APA01_15490
APW: APA42C_04430 APA42C_15490
APF: APA03_04430 APA03_15490
APU: APA07_04430 APA07_15490
APG: APA12_04430 APA12_15490
APQ: APA22_04430 APA22_15490
APX: APA26_04430 APA26_15490
APZ: APA32_04430 APA32_15490
APK: APA386B_1928(asdA) APA386B_482
ASZ: ASN_851
ASV: WG31_02660 WG31_08065
AACE: A0U92_00615
APER: A0U91_10830
APOM: CPF11_05090 CPF11_12475
ATO: CIW82_07840
AASC: A4S02_09960
ACET: DS739_02335 DS739_07955
AOT: AcetOri_orf02602 AcetOri_orf04014
AOY: EOV40_002210 EOV40_007185
ACEK: FLP30_02220
KBA: A0U89_15935
RGI: RGI145_16190
ROS: CTJ15_14925
RMUC: FOB66_04270
BOMB: GT348_07755
ABS: AZOBR_p430032
ABQ: ABAZ39_32690
ABF: AMK58_23540
AZT: TSH58p_19950
AARE: D3093_28895
SUN: SUN_0877
DAS: Daes_0274
PSEL: GM415_11140
PNW: SYK_22330(asdA)
DSD: GD606_11240
MSD: MYSTI_04286
MFB: MFUL124B02_23065
CCX: COCOR_02790
LLU: AKJ09_07676
BDC: DOE51_04330
BDZ: DOM22_15740
BDK: HW988_14815
PRD: F7984_03280(aspD)
GCS: MUN88_00705(aspD)
PUK: PU629_10895(aspD)
AAD: TC41_0858
AFX: JZ786_08480(aspD)
AACO: K1I37_06695(aspD)
ACUR: JZ785_12650(aspD)
ADAU: NZD86_18095(aspD)
AFAS: NZD89_22440(aspD)
ACYC: JI721_11695(aspD)
LGR: LCGT_1281
LGV: LCGL_1302
LPET: lgb_00686(asD)
LFO: LMK00_03500
LAC: LBA1695
LAD: LA14_1696
LAF: SD55_1697
LHL: LBHH_1710
LTA: H1A07_02740
LIQ: KBW87_05945
LCA: LSEI_2747
LCZ: LCAZH_2752
LCS: LCBD_2960
LCE: LC2W_2934
LCW: BN194_28750
LCL: LOCK919_3003
LPI: LBPG_01343
LCB: LCABL_29320(asdA)
LCX: LCA12A_0440
LPR: LBP_p3g040
LPZ: Lp16_F030
LOR: AYI71_02915
LHO: LOOC260_121710
LSA: LCA_0306(aspD)
LCV: FBA2_01670
LGM: LG542_07710
BOG: MOO47_03240(aspD)
EFA: EF1037
EFL: EF62_1474
EFI: OG1RF_10770
EFD: EFD32_0849
EFS: EFS1_0865(asdA)
EFN: DENG_01170
EFQ: DR75_96(aspD)
ENE: ENT_30620
EGV: EGCR1_11780 EGCR1_18225(aspD)
EAV: EH197_06745(aspD) EH197_21350
ERAF: J9537_19820(aspD)
MPS: MPTP_0441 MPTP_0995
MPX: MPD5_0951 MPD5_1465
THL: TEH_22060(aspD)
VTE: BHY08_01720 BHY08_05240
VPI: BW732_03295
VLC: G314FT_15060(asD)
MARR: BKP56_00640
DPM: FNV33_08145(aspD)
CPE: CPE0341 CPE1001
CPF: CPF_0325 CPF_1258(aspD)
CPR: CPR_0327
CBO: CBO1166(asdA)
CBA: CLB_1197(asdA)
CBH: CLC_1209(asdA)
CBY: CLM_1317
CBL: CLK_0601
CBB: CLD_3403
CBI: CLJ_B1207(aspD)
CBF: CLI_1247(aspD)
CBJ: H04402_01235
CBE: Cbei_1924
CBZ: Cbs_1924
CBEI: LF65_02091
CKL: CKL_0699
CKR: CKR_0621
CLJ: CLJU_c33270
CSB: CLSA_c16110
CAH: CAETHG_1226(aspD)
CBV: U729_1867(aspD)
CSQ: CSCA_1714
CLD: CLSPO_c11660(asd1)
CCK: Ccar_06140
CTYK: CTK_C07120
CEU: A7L45_04535
CDRK: B9W14_10705
CSEP: CP523_01580(aspD)
CDY: F3K33_09545(aspD)
CFER: D4Z93_01615(aspD)
CLOS: DMR38_16645(aspD)
CCAA: KQH81_05490(aspD)
CMAH: C1I91_23255(aspD)
CGEL: psyc5s11_17570(asdA)
CTAG: LL095_09675(aspD)
SARJ: HH195_05955(aspD)
PBIF: KXZ80_04485(aspD)
CLE: Clole_2227
CEW: EKH84_13810(aspD)
CDF: CD630_25150
PDC: CDIF630_02764(aspD)
CDC: CD196_2360(aspD)
CDL: CDR20291_2407(aspD)
PDF: CD630DERM_25150
EAC: EAL2_c09600(aspD)
PSOR: RSJ16_04440
ROC: HF520_07485(aspD)
PHX: KGNDJEFE_01911(asD)
TEM: JW646_15505(aspD)
TGC: L0P85_12120(aspD)
TMY: TEMA_16830(asD)
IBR: NQ514_13205(aspD)
DMT: DESME_09070
DOR: Desor_4048
DAI: Desaci_1009
AMIC: Ami3637_00175(aspD)
ABUT: Ami103574_04740(aspD)
HHL: Halha_1158
MANA: MAMMFC1_00109(asD)
TUR: AT726_09355 AT726_11740
TSG: HLK68_09170(aspD) HLK68_11245(aspD)
TBB: J0J69_01790(aspD) J0J69_12600(aspD)
AEQ: AEQU_1726
AHAT: ADCFC_06340
MBOK: MBOE_49860(asdA)
NNO: NONO_c61950
SALB: XNR_4167
SGR: SGR_4732
SGB: WQO_11875
SFI: SFUL_2397
SANL: KZO11_12075
SVE: SVEN_2588
SVT: SVTN_13840
SCZ: ABE83_23965
SVU: B1H20_11125
SFK: KY5_2946
SKA: CP970_27805
SVN: CP980_06000
SNK: CP967_32090
SCAV: CVT27_10565
SSUB: CP968_06530
SCAL: I6J39_11340
SGJ: IAG43_26770
STRY: EQG64_11000
SDUR: M4V62_26875
SVIO: HWN34_21060
SGK: PET44_26555
KSK: KSE_63100
KAB: B7C62_10775
KIT: CFP65_6286
KIS: HUT16_29875
SALA: ESZ53_11080
AAQ: AOC05_08165
ASUN: KG104_09090
AGEG: MUG94_08410
BHQ: BRM3_06475
NCG: KGD84_08590
SESP: BN6_36290
PMAD: BAY61_13710
CAI: Caci_1946
SNA: Snas_3840
LSC: KIK02_20220
TRM: JO41_09340
TSK: HRI97_07595
CSOM: MKD34_00630
LBA: Lebu_0659
CPOR: BED41_13885
BTH: BT_0735
BTHO: Btheta7330_02355(asD)
BFR: BF1517
BFS: BF9343_1378
BFG: BF638R_1530
BFB: VU15_06365
BXY: BXY_02850
BOA: Bovatus_00911(asD)
BCEL: BcellWH2_01068(asD)
BCAC: CGC64_12685(aspD)
BIS: DXK01_019955(aspD)
BUN: Bun01g_20960
BEG: INE88_00537(asd_1)
BSTE: K6V31_16075(aspD)
BFE: K6V30_15685(aspD)
BNO: K8P02_11205(aspD)
BHUM: JXR92_009630(aspD)
BFC: BacF7301_19130(aspD)
BSAL: K6V25_18520(aspD)
BVU: BVU_2264
BDO: EL88_04250
BDH: GV66_11835
PDI: BDI_1073
PARC: CI960_09080
PMER: INE87_00972(asd_1)
PGOL: K6V26_07070
PJO: LK449_08285
PFAI: NXY11_09580
PII: NF347_11970
COPR: Cop2CBH44_09800
CFAS: Cfast33896_09520(aspD)
COY: HF329_12145(aspD)
PGO: FSB84_29235(aspD)
SCN: Solca_2046
FJG: BB050_04015(asD)
FBI: L0669_19825(aspD)
FHU: M0M44_16395(aspD)
CAO: Celal_4230
OLL: CW732_12970
PSYN: E9099_16455
APIB: G8C43_08895(aspD)
MEL: Metbo_1835
THA: TAM4_1721
THM: CL1_0496
ABI: Aboo_0621
ACF: AciM339_0098
 » show all
Reference
1  [PMID:5773301]
  Authors
Kakimoto T, Kato J, Shibatani T, Nishimura N, Chibata I.
  Title
Crystalline L-aspartate beta-decarboxylase of Pseudomonas dacunhae. I. Crystallization and some physiocochemical properties.
  Journal
J Biol Chem 244:353-8 (1969)
Reference
2  [PMID:14154469]
  Authors
NOVOGRODSKY A, MEISTER A.
  Title
CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION.
  Journal
J Biol Chem 239:879-88 (1964)
Reference
3  [PMID:5424207]
  Authors
Palekar AG, Tate SS, Meister A.
  Title
Inhibition of aspartate beta-decarboxylase by aminomalonate. Stereospecific decarboxylation of aminomalonate to glycine.
  Journal
Biochemistry 9:2310-5 (1970)
DOI:10.1021/bi00813a014
Reference
4  [PMID:14071532]
  Authors
WILSON EM, KORNBERG HL.
  Title
PROPERTIES OF CRYSTALLINE L-ASPARTATE 4-CARBOXY-LYASE FROM ACHROMOBACTER SP.
  Journal
Biochem J 88:578-87 (1963)
DOI:10.1042/bj0880578
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.12
IUBMB Enzyme Nomenclature: 4.1.1.12
ExPASy - ENZYME nomenclature database: 4.1.1.12
BRENDA, the Enzyme Database: 4.1.1.12
CAS: 9024-57-1

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Pathway (6)   
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Chemical reaction (5)   
   KEGG REACTION (2)   
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Gene (4589)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (522)   
   KEGG MGENES (3784)   
   RefGene (282)   
Protein sequence (5883)   
   UniProt (343)   
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   RefSeq(pep) (5518)   
   PDBSTR (20)   
DNA sequence (30580)   
   RefSeq(nuc) (27618)   
   GenBank (1787)   
   EMBL (1175)   
3D Structure (5)   
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