Entry
Name
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase;
COQ4
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
4-hydroxy-3-methoxy-5-all-trans-polyprenylbenzoate carboxy-lyase
Reaction(IUBMB)
4-hydroxy-3-methoxy- 5-all-trans-polyprenylbenzoate = 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2 [RN:
R08772 ]
Reaction(KEGG)
Substrate
4-hydroxy-3-methoxy- 5-all-trans-polyprenylbenzoate
Product
2-methoxy-6-(all-trans-polyprenyl)phenol [CPD:
C17552 ];
CO2 [CPD:
C00011 ]
Comment
Requires Zn2+. The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
History
EC 4.1.1.130 created 2024
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K18586 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase
Genes
MTHB : 126930050 126937060
CSAB : 103224310 103239803(COQ4)
CANG : 105504164(COQ4) 105517491
TOD : 119230393(COQ4) 119242609 119252019 119253165
TVP : 118839468 118841734(COQ4)
CGIB : 127958702 127958707 128025817
MASI : 127428793 127434091
SASA : 100196318(coq4) 106563305
STRU : 115159585 115204053
SALP : 111961629 111964521
CCLU : 121541655 121582540(coq4)
ARUT : 117396697 117396703
DSI : Dsimw501_GD12405(Dsim_GD12405)
AALB : 109430821 115253907 115263203
CQU : CpipJ_CPIJ006564 CpipJ_CPIJ019881
APLN : 108742497 108742505
PPOI : 119110716 119110742
CSCU : 111633737 111633781
CBR : CBG_11976(Cbr-coq-4.1)
BMY : BM_BM7871(Bma-coq-4)
SHX : MS3_00005991(COQ4_1)
CSAT : 104710282 104779687 104790127
BNA : 106382029 106382061 106396629 106396688
HSYR : 120158858 120163015
GMX : 100787101 100815878 102664386
MTR : 120577299 25493501 25493503 25499128
TPRA : 123889460 123906207 123906209 123908571 123908635
VVO : 131612484 131621719 131647607 131653188 131653189 131653191
LANG : 109327278 109340951
MSYL : 126594982 126607418
CSAV : 115694798 115701096
CMAX : 111492219 111496490
CMOS : 111454470 111462982
CPEP : 111798718 111805456
MEAN : 126687307 126688356
SSPL : 121794901 121798030
SMIL : 130995907 131016274 131016276 131016278
HAN : 110871895 110882145 110894385
CCAV : 112513242 112514566
CSIN : 114274799 114278560
ATRI : 130808518 130821402
PSOM : 113276028 113281575 113317125
DOSA : Os04g0674200 Os05g0188800
TAES : 123047355 123055156 123191007
MFLO : 136492750 136494074 136497959
PVIR : 120642092 120671466
ZOF : 122001780 122042212 122046742
SMO : SELMODRAFT_271567 SELMODRAFT_432317 SELMODRAFT_444766
CGR : 2887684(GVI51_F05049)
NCS : NCAS_0B02960(NCAS0B02960)
NDI : NDAI_0C04750(NDAI0C04750)
TPF : TPHA_0C02240(TPHA0C02240)
TBL : TBLA_0H00770(TBLA0H00770)
TDL : TDEL_0F05350(TDEL0F05350)
KAF : KAFR_0B06240(KAFR0B06240)
KNG : KNAG_0A04590(KNAG0A04590)
LBG : 92208080(LODBEIA_P28840)
CAL : CAALFM_C103160CA(COQ4)
ASAU : 88173480(PUMCH_002415)
YLI : 2907824(YALI2_E00964g)
NTE : NEUTE1DRAFT89102(NEUTE1DRAFT_89102)
SMP : 10801360(SMAC4_09067)
RTHE : 98122571(VTJ83DRAFT_1735)
PPEI : PpBr36_09689 PpBr36_11446
PGRI : PgNI_10660 PgNI_12304
FPOA : FPOAC1_005020(COQ4)
TATV : 25777210(TrAtP1_001934)
PLJ : 28882526(PLICBS_001452)
CDET : 87951050(CDEST_14550)
BFU : BCIN_01g01870(Bccoq4)
PTRR : 6345234(PtrM4_044370)
ADAC : 96085848(ACET3X_005526)
CDEC : 89991798(IAS62_005027)
CDEP : 91089545(L203_105336)
KMG : 30161447(I203_105823)
KNE : 92183305(IAR55_006047)
KDJ : 28964146(I303_100448)
KBI : 30206689(I302_103589)
CCAC : CcaHIS019_0205340(COQ4)
PCO : PHACADRAFT_194574 PHACADRAFT_194755 PHACADRAFT_208323 PHACADRAFT_208333
ABP : AGABI1DRAFT114485(AGABI1DRAFT_114485)
ABV : AGABI2DRAFT191524(AGABI2DRAFT_191524)
SCM : SCHCO_02642788(SCHCODRAFT_02642788)
PTRC : PtA15_11A98 PtA15_18A137
PLAG : 39742350(PADL01_1110400)
PMAL : PMUG01_09021700(COQ4)
PBRS : 92370808(MKS88_002720)
PREL : PRELSG_0909200(COQ4)
PTM : GSPATT00020312001 GSPATT00023557001
FCY : FRACYDRAFT_224960(COQ4_1)
TCR : 506753.170 510357.70
LMAT : 92517537(LSCM1_07663)
LOI : 92362682(LSCM4_06836)
LEIS : 94182583(GH5_07327)
LENR : 94174433(CUR178_07275)
LEIN : 94190535(JIQ42_06935)
PHET : 94292928(JKF63_06904)
» show all
Taxonomy
Reference
Authors
Nicoll CR, Alvigini L, Gottinger A, Cecchini D, Mannucci B, Corana F, Mascotti ML, Mattevi A.
Title
In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 4.1.1.130