KEGG   ENZYME: 4.1.1.18
Entry
EC 4.1.1.18                 Enzyme                                 
Name
lysine decarboxylase;
L-lysine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-lysine carboxy-lyase (cadaverine-forming)
Reaction(IUBMB)
L-lysine = cadaverine + CO2 [RN:R00462]
Reaction(KEGG)
R00462
Substrate
L-lysine [CPD:C00047]
Product
cadaverine [CPD:C01672];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also acts on 5-hydroxy-L-lysine.
History
EC 4.1.1.18 created 1961
Pathway
ec00310  Lysine degradation
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K01582  lysine decarboxylase
Genes
ECOb0186(ldcC) b4131(cadA)
ECJJW0181(ldcC) JW4092(cadA)
ECDECDH10B_0166(ldcC) ECDH10B_4324(cadA)
EBWBWG_0178(ldcC) BWG_3845(cadA)
ECOKECMDS42_0173(ldcC) ECMDS42_3571(cadA)
ECEZ0198(ldcC) Z5734(cadA)
ECSECs_0188(cadA_1) ECs_5113(cadA)
ECFECH74115_0196(ldcC1) ECH74115_5647(ldcC2)
ETWECSP_0185(ldcC) ECSP_5231(cadA)
ELXCDCO157_0186 CDCO157_4798
EOIECO111_0187(ldcC)
EOJECO26_0188(ldcC) ECO26_5243(cadA)
EOHECO103_0184(ldcC) ECO103_4883(cadA)
ECOOECRM13514_0194(ldcC) ECRM13514_5348(cadA)
ECOHECRM13516_0196(ldcC) ECRM13516_5016(cadA)
ESLO3K_20640 O3K_23215
ESOO3O_02145 O3O_04740
ESMO3M_20540 O3M_23135
ECKEC55989_0180(ldcC) EC55989_4624(cadA)
ECGE2348C_0191(ldcC) E2348C_4458(cadA)
EOKG2583_0189(ldcC) G2583_4958(cadA)
ELRECO55CA74_00910 ECO55CA74_23770
ELHETEC_0181 ETEC_4442
ECWEcE24377A_0190(ldcC) EcE24377A_4686
EUNUMNK88_191 UMNK88_4998
ECPECP_0194 ECP_0327 ECP_4375
ENAECNA114_0176(ldcC) ECNA114_4317(cadA)
ECOSEC958_0332(ldcC) EC958_4620(cadA)
ECVAPECO1_1801(ldcC) APECO1_2322(cadA)
ECOAAPECO78_01590 APECO78_04360
ECXEcHS_A0188(ldcC1) EcHS_A4372(ldcC2)
ECMEcSMS35_0197(ldcC1) EcSMS35_4600(ldcC2)
ECYECSE_0185 ECSE_4431
ECRECIAI1_0186(ldcC) ECIAI1_4364(cadA)
ECQECED1_0192(ldcC) ECED1_4867(cadA)
EUMECUMN_0183(ldcC) ECUMN_4665(cadA)
ECTECIAI39_0189(ldcC) ECIAI39_4560(cadA)
EOCCE10_0188(ldcC) CE10_4850(cadA)
EBRECB_00184(ldcC) ECB_04002(cadA)
EBLECD_00184(ldcC) ECD_04002(cadA)
EBEB21_00183(ldcC) B21_03964(cadA)
EBDECBD_3433 ECBD_3899
ECIUTI89_C0201(ldcC) UTI89_C4728(cadA)
EIHECOK1_4643(ldcL)
ECZECS88_0197(ldcC) ECS88_4635(cadA)
ECCc0224(ldcC) c5140(cadA)
ELOEC042_0184(ldcC) EC042_4497(cadA)
ELNNRG857_00950 NRG857_20725
ESEECSF_0201 ECSF_4020
ECLEcolC_3474 EcolC_3896
EKOEKO11_3732 EKO11_4187
EKFKO11_00900(ldcC) KO11_01675(cadA)
EABECABU_c01990(ldcC) ECABU_c46850(cadA)
EDHEcDH1_3417 EcDH1_3860
EDJECDH1ME8569_0179(ldcC) ECDH1ME8569_3991(cadA)
ELUUM146_20895 UM146_23735
ELWECW_m0182(ldcC) ECW_m4492(cadA)
ELLWFL_00900(ldcC) WFL_21855(cadA)
ELCi14_0206(ldcC) i14_4725(cadA)
ELDi02_0206(ldcC) i02_4725(cadA)
ELPP12B_c0174(ldcC) P12B_c4231(cadA)
ELFLF82_0254(cadA) LF82_1172(ldcC)
ECOLLY180_00900 LY180_21700
ECOIECOPMV1_00192(ldcC) ECOPMV1_04591(cadA)
ECOJP423_00990 P423_23025
EFEEFER_0209(ldcC) EFER_1900(cadA)
EALEAKF1_ch2295c(ldcC2)
EMAC1192_19340
ESZFEM44_12485
STYSTY0259(ldcC) STY2806(cadA)
STTt0236(ldcC) t0297(cadA)
SEXSTBHUCCB_2580 STBHUCCB_3190
SENTTY21A_01215 TY21A_01510
STMSTM0234(ldcC) STM2559(cadA)
SEOSTM14_0276(ldcC) STM14_3138(cadA)
SEVSTMMW_02401 STMMW_25761
SEYSL1344_0235(ldcC) SL1344_2521(cadA)
SEMSTMDT12_C02350 STMDT12_C25790
SEJSTMUK_0236(ldcC) STMUK_2591(cadA)
SEBSTM474_0243(ldcC) STM474_2664(cadA)
SEFUMN798_0255(ldcC) UMN798_2763(cadA)
SETUSTU288_01180 STU288_09155
SETCCFSAN001921_03975 CFSAN001921_16230
SENRSTMDT2_02361(ldcC) STMDT2_25201(cadA)
SENDDT104_02391(ldcC) DT104_26111(cadA)
SENICY43_01175 CY43_13655
SEENSE451236_07190 SE451236_19020
SPTSPA0241(ldcC) SPA0307(cadA)
SEKSSPA0233 SSPA0290
SPQSPAB_00299 SPAB_00369
SEISPC_0250(ldcC) SPC_1091(cadA)
SECSCH_0234(ldcC) SCH_2554(cadA)
SEHSeHA_C0272 SeHA_C2822
SHBSU5_03156 SU5_0883
SENHCFSAN002069_07975 CFSAN002069_18970
SEEHSEEH1578_10290 SEEH1578_22120
SEESNSL254_A0256 SNSL254_A2760
SENNSN31241_12290 SN31241_36690
SEWSeSA_A0261 SeSA_A2801
SEASeAg_B0275 SeAg_B2718
SENSQ786_01230 Q786_12670
SEDSeD_A0256(ldcC) SeD_A2935
SEGSG0238(ldcC) SG2596(cadA)
SELSPUL_0254(ldcC) SPUL_0315(cadA)
SEGASPUCDC_0254(ldcC) SPUCDC_0315(cadA)
SETSEN0241(ldcC) SEN2539(cadA)
SENAAU38_01195 AU38_12865
SENOAU37_01195 AU37_12875
SENVAU39_01195 AU39_12875
SENQAU40_01360 AU40_14470
SENLIY59_01220 IY59_13215
SENJCFSAN001992_09805 CFSAN001992_20740
SEECCFSAN002050_07710 CFSAN002050_19745
SEEBSEEB0189_006755 SEEB0189_018135
SEEPI137_01135 I137_01445
SENBBN855_2500(ldcC) BN855_26490
SENEIA1_01260 IA1_12795
SENCSEET0819_08100 SEET0819_20250
SESSARI_00317 SARI_02768
SBGSBG_0225(ldcC) SBG_2334(cadA)
SBZA464_239 A464_2671
SBVN643_01095 N643_11355
SALZEOS98_06150 EOS98_18035
SFLSF0176(ldcC)
SFXS0179(ldcC)
SFVSFV_0169(ldcC)
SFESFxv_0186(ldcC)
SFNSFy_0240
SFSSFyv_0244
SFTNCTC1_00182(ldcC1)
SSNSSON_0199(ldcC)
SBCSbBS512_E0179(ldcC1)
SDZAsd1617_00249 Asd1617_05863
SHQA0259_02295 A0259_04775
ENCECL_00989
ENLA3UG_04145
ECLGEC036_08150
ECLEECNIH2_05080
ECLNECNIH4_18610
ECLIECNIH5_04145
ECLXLI66_04155
ECLYLI62_04670
ECLZLI64_04330
ECLOENC_47090
EHMAB284_20805
EXFBFV63_04115
ECLAECNIH3_04135
ECLCECR091_04115
EAUDI57_14485
EKBBFV64_03920
ENOECENHK_04380
EECEcWSU1_00798(ldcC)
ELGBH714_18810
ECANCWI88_18000
ERNBFV67_03940
ECLSLI67_005085
ECHGFY206_04825
ESHC1N69_04025
ENTEnt638_0724
EASEntas_0783
ENRH650_19710
ENXNI40_003950
ENFAKI40_4103
LNICWR52_08040
EBGFAI37_02465
ENZG0034_04185
ENSHWQ15_12565
ENKLOC22_14965
EHUD5067_0018735
EMORL6Y89_03940
ENBELK40_04745
ESAESA_03153
CSKES15_3144(ldcC)
CSZCSSP291_14590
CSJCSK29544_00081
CCONAFK62_04100
CDMAFK67_04085
CSIP262_04644
CMJAFK66_015640
CUIAFK65_04025
CMWAFK63_14530
CTUCTU_08150(ldcC)
KPNKPN_00199(ldcC) KPN_00500(cadA)
KPUKP1_1043(ldcC) KP1_1410(cadA)
KPMKPHS_09330 KPHS_13090
KPPA79E_3758 A79E_4091
KPHKPNIH24_04670 KPNIH24_22225
KPZKPNIH27_04470 KPNIH27_06100
KPVKPNIH29_04865 KPNIH29_06750
KPWKPNIH30_04895 KPNIH30_06760
KPYKPNIH31_03155 KPNIH31_06665
KPGKPNIH32_04900 KPNIH32_06865
KPCKPNIH10_04645 KPNIH10_06580
KPQKPR0928_04655 KPR0928_06495
KPTVK055_2051(cadA) VK055_2366
KPOKPN2242_03445 KPN2242_05280
KPRKPR_1130(ldcC) KPR_4061
KPJN559_3848 N559_4214
KPID364_00960 D364_02570
KPAKPNJ1_04113 KPNJ1_04521
KPSKPNJ2_04136 KPNJ2_04473
KPXPMK1_02507(ldcC) PMK1_02826(cadA)
KPBFH42_21840 FH42_23450
KPNEKU54_019895
KPNULI86_19725 LI86_21690
KPNKBN49_1542 BN49_4138(ldcC)
KVAKvar_3879 Kvar_4182
KPEKPK_4092 KPK_4534(ldcC)
KPKA593_15410 A593_16900
KVDKR75_12790 KR75_14335
KVQSP68_19465 SP68_20990
KOXKOX_11535 KOX_13270
KOEA225_1471
KOYJ415_24280 J415_26175
KOMHR38_10265 HR38_12020
KMIVW41_03900
KOKKONIH1_05265 KONIH1_07220
KOCAB185_28820 AB185_30910
KQUAVR78_09245 AVR78_11005
EAEEAE_11730 EAE_13250
EARCCG31329 CCG31633
KQVB8P98_21020 B8P98_22610
KLLBJF97_05810 BJF97_07665
KLWDA718_21060 DA718_23200
KARLGL98_18840(cadA) LGL98_20420
KGRJJJ10_20840(cadA) JJJ10_22795
RORRORB6_12665 RORB6_14180
RONTE10_06740 TE10_08330
RPLNB1209_20335
RAODSD31_19215 DSD31_20850
RTGNCTC13098_06062(ldcC)
REEelectrica_03794(cadA) electrica_04147(ldcC)
CROROD_01941(ldcC)
CKOCKO_03180
CFDCFNIH1_10610
CBRAA6J81_12420(ldcC)
CWECO701_17500
CYOCD187_19555
CPOTFOB25_06660(ldcC)
CFQC2U38_04260
CSEDJY391_17405(ldcC)
CAMAF384_00965
CAFAL524_21535(ldcC)
CIFAL515_05675(ldcC)
CFARCI104_05380
CIRC2U53_03955
CIEAN232_25540(ldcC)
CPARCUC49_00925
CTELGBC03_24895(ldcC)
CITZE4Z61_12635(ldcC)
CARSE1B03_05430(ldcC)
EBTEBL_c28010(cadA1) EBL_c31760(cadA2)
CNTJT31_08370
CEMLH23_09355
CENLH86_09410
CLAPNCTC11466_03741(ldcC)
PGELG71_07875 LG71_10805
ESCEntcl_1196 Entcl_3519 Entcl_3551
KLEAO703_04185 AO703_15850
KSAC813_10860
KORAWR26_20590
KRDA3780_03150
KCOBWI95_01405
KOTEH164_18130
KPSEIP581_04170
KOBHF650_04670
KIENCTC12125_02837(ldcC)
KASKATP_11200(cadA) KATP_36880
LAXAPT61_18175
LEIC2U54_09175
LEHC3F35_07590
LEEDVA44_19705
LERGNG29_04390(ldcC)
LEAGNG26_03880(ldcC)
LPNUKQ929_16750
LAZA8A57_04115
LEFLJPFL01_0813
LEWDAI21_00310
BUFD8682_09495 D8682_11040
BAGEBADSM9389_33690
BFTMNO13_18190(cadA) MNO13_19710
METYMRY16398_46130
AHNNCTC12129_00982(ldcC) NCTC12129_00987(cadA)
ASUBNLZ15_17890
YREHEC60_13890(cadA) HEC60_22070
SGOEA8O29_018670
KINAB182_20835
PDZHHA33_23385
PSHISAMEA2665130_0737(cadA_1) SAMEA2665130_1220(cadA_2) SAMEA2665130_2471(cadA_4)
PSGCG163CM_17020(cadA) G163CM_27130(ldcC)
SCOLKFZ77_03940
EBFD782_2731 D782_3685
EBCC2U52_02475
EBUCUC76_08980 CUC76_10615
PSTSE05_03420
YENYE3267(ldcC)
YEPYE105_C0987
YEYY11_41191
YELLC20_01213
YEWCH47_276(ldcC)
YETCH48_717
YEFFORC2_0883
YEEYE5303_06261(ldcC)
YALAT01_1580
YINCH53_2737
YRUBD65_654(cadA)
YRBUGYR_03485
YCAF0T03_16955
YASN0H69_07935
SMARSM39_3366(cadA) SM39_3371(ldcC)
SMACSMDB11_3155(cadA) SMDB11_3161(ldcC)
SMWSMWW4_v1c38880 SMWW4_v1c38920
SPESpro_3767 Spro_3773
SRRSerAS9_3962
SRLSOD_c37380(ldcC)
SRYM621_20085
SPLYQ5A_019915(ldcC)
SRSSerAS12_3963
SRASerAS13_3963
SMAFD781_3508
SLQM495_19635 M495_19665
SERFL085_09230 L085_09250
SERSSERRSCBI_18820 SERRSCBI_18840
SFWWN53_01640 WN53_01660
SFGAV650_24400 AV650_24420
SRZAXX16_1568
SERMCLM71_18430
SQUE4343_21565 E4343_21595
SFJSAMEA4384070_3887(ldcC)
SOFNCTC11214_02873(ldcC_2) NCTC11214_02880(cadA)
SSURATE40_016110 ATE40_016130
SURIJ0X03_04535 J0X03_04555(cadA)
SRHZFO014_15790
SENPKHA73_18925
RAHRahaq_0880
RACEJHW33_21085
RAQRahaq2_0943
RAAQ7S_04150
ROXBV494_21355
RVCJ9880_12030
GQUAWC35_16875
EAMEGXP68_03665
RBADH2866_03815
SODSant_0913(ldcC)
PESSOPEG_3382(ldcC)
SLIGGTU79_05185
EAMEAMY_2742(cadA)
EAYEAM_0836(ldcC)
ETAETA_09070(cadA)
EPYEpC_08860
EPREPYR_00935(cadA)
EBIEbC_08270
ERJEJP617_02020
EGEEM595_0820(ldcC)
EPECI789_14375
ERWIGN242_17040(ldcC)
ERPLJN55_18775
PAMPANA_0810(ldcC)
PLFPANA5342_3498(ldcC)
PAJPAJ_0157(ldcC)
PAQPAGR_g3389
PVAPvag_0219(ldcC)
PAGGAL522_08045
PAOPat9b_0767
KLNLH22_18410
PANTPSNIH1_08785
PANPPSNIH2_13940
PAGCBEE12_10780
PSTWDSJ_06725
PALHB1H58_02985 B1H58_15020
PANSFCN45_03890
PEYEE896_15495(ldcC)
PDISD8B20_03730
PERLAC65_02975
PGZC2E15_04825
PCDC2E16_04750
MINTC7M51_00148(ldcC)
MTHIC7M52_02571(ldcC)
EICNT01EI_0291 NT01EI_0859 NT01EI_3413
ETRETAE_0284(cadA1) ETAE_0757(cadA2) ETAE_3006(cadA3)
ETDETAF_0246 ETAF_0700 ETAF_2734
ETEETEE_1240(ldcC) ETEE_2039(ldcC) ETEE_2518(ldcC)
ETCETAC_01205 ETAC_03665 ETAC_14470
EDWQY76_05325 QY76_16540
EDLAAZ33_01275 AAZ33_03585 AAZ33_15915
EHOA9798_12765 A9798_15210
HAVAT03_02990 AT03_17370
HPARAL518_02475 AL518_09050
OPODSM2777_07875 DSM2777_23350
HSOHS_1007(cadA)
ADPNCTC12871_01111(cadA)
RHEYFEE42_02990
RHAEIHV77_11655
VCHVC_0281
VCFIR04_06305
VCSMS6_0145
VCEVch1786_I2565
VCQEN18_18275
VCJVCD_001340
VCIO3Y_01305
VCOVC0395_A2658(cadA)
VCRVC395_0310(cadA)
VCMVCM66_0266(cadA)
VCLVCLMA_A0246
VCXVAA049_3416
VCZVAB027_3565
VVUVV1_2060
VVYVV2381
VVMVVMO6_00934
VVLVV93_v1c20890
VPAVP2890
VPBVPBB_2740
VPKM636_22935
VPFM634_00980
VPHVPUCM_2987
VHAVIBHAR_00205
VCAM892_11625
VAGN646_1979
VEXVEA_002189
VDBAL552_23360
VHRAL538_08555
VOWA9237_09215
VROBSZ04_24370
VMIAL543_10425
VSHBSZ05_07320
VQICCZ37_12145
VAFD1115_00885
VNLD3H41_15720
VPLSA104470976_02458(cadA)
VFIVF_2057(cadA)
VFMVFMJ11_2162
VSAVSAL_I2491(cadA)
PDSCAY62_01575
MVSMVIS_4400(cadA)
MMAAFR932_18035(cadA)
LFALFA_0253(ldcC)
LCJNCTC11976_02922(cadA)
FTUFTT_0406(cadA)
FTQRO31_0456(cadA)
FTFFTF0406(cadA)
FTWFTW_1667(cadA)
FTRNE061598_02265
FTTFTV_0376(cadA)
FTGFTU_0460(cadA)
FTLFTL_0476
FTHFTH_0474(cadA)
FTAFTA_0502
FTSF92_02580
FTIFTS_0478(cadA)
FTOX557_02565
FTCDA46_219(cadA)
FTVCH67_777(cadA)
FTZCH68_511(cadA)
FTNFTN_0504
FTXAW25_1525(cadA)
FTDAS84_180(cadA)
FTYCH70_1559(cadA)
FCFFNFX1_0489
FCNFN3523_0462
FHIFSC454_02330
FPHFphi_0341
FPTBZ13_1733(cadA)
FPIBF30_519(cadA)
FPMLA56_1846(cadA)
FPXKU46_1035(cadA)
FPZLA55_502(cadA)
FPJLA02_1952(cadA)
FRTF7308_1833
FNAOOM_1068
FNLM973_02955
FRFLO80_08140
FHACDV26_08585
FRXF7310_08080
FRMBBG19_1293
FRCKX01_1834(cadA)
FADCDH04_07890
FMIF0R74_00925
FOOCGC45_06490
FNNFSC774_00820
FSRKQR59_02465
FGUSD28_06380
AFRIE3E15_03030(ldcC)
AIIE4K63_03290(ldcC)
AHAAHA_1192
AHYAHML_06345
AHDAI20_13250
AHRV428_06570
AHPV429_06570
AHJV469_16780
AHHRY45_06390
AHIVU14_16715
AAJBOQ57_05790
ASAASA_3141(cadA)
AEOO23A_p2424
AVRB565_3003
AVOAMS64_17760
ASRWL1483_1742(cadA)
ADHCK627_20175
AEMCK911_11755
AELNCTC12917_03192(cadA)
ASIMFE240_11630(cadA)
AALLI6G90_00025
AJDI6H43_05070
ECORSAMEA4412678_1910(cadA)
EEXEZJ17_05575
SUTKFG381_04680
SWSI6J16_01630
 » show all
Reference
1  [PMID:16747785]
  Authors
Gale EF, Epps HM.
  Title
Studies on bacterial amino-acid decarboxylases: 1. l(+)-lysine decarboxylase.
  Journal
Biochem J 38:232-42 (1944)
DOI:10.1042/bj0380232
Reference
2  [PMID:5762458]
  Authors
Soda K, Moriguchi M.
  Title
Crystalline lysine decarboxylase.
  Journal
Biochem Biophys Res Commun 34:34-9 (1969)
DOI:10.1016/0006-291X(69)90524-5
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.18
IUBMB Enzyme Nomenclature: 4.1.1.18
ExPASy - ENZYME nomenclature database: 4.1.1.18
BRENDA, the Enzyme Database: 4.1.1.18
CAS: 9024-76-4

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