KEGG   ENZYME: 4.1.1.21
Entry
EC 4.1.1.21                 Enzyme                                 

Name
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]
Reaction(KEGG)
R04209
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]
Product
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]
Comment
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
History
EC 4.1.1.21 created 1961, modified 2000, modified 2006
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K11808  phosphoribosylaminoimidazole carboxylase
Genes
HSA: 10606(PAICS)
PTR: 471236(PAICS)
PPS: 100993147(PAICS)
GGO: 101132763(PAICS)
PON: 100190835(PAICS)
NLE: 100580950
MCC: 694743
MCF: 101864855(PAICS)
CSAB: 103237366
RRO: 104655715(PAICS)
RBB: 108513484(PAICS)
CJC: 100390231(PAICS)
SBQ: 101031274(PAICS) 104651700
MMU: 67054(Paics)
MCAL: 110293933(Paics)
MPAH: 110330578(Paics)
RNO: 100910308 140946(Paics)
MUN: 110565016(Paics)
CGE: 100758991(Paics)
NGI: 103734378(Paics)
HGL: 101721606(Paics)
CCAN: 109697886(Paics)
OCU: 100343740(PAICS)
TUP: 102484181(PAICS)
CFA: 100855769
VVP: 112923709
AML: 100482672(PAICS)
UMR: 103672750(PAICS)
UAH: 113262521(PAICS)
ORO: 101383279(PAICS)
ELK: 111149362
FCA: 101084705
PTG: 102951236(PAICS)
PPAD: 109278673
AJU: 106971666
BTA: 404170(PAICS)
BOM: 102281546(PAICS)
BIU: 109560492
BBUB: 102392736
CHX: 102182773(PAICS)
SSC: 100521281(PAICS)
CFR: 102522524
CDK: 105091550
BACU: 103009147(PAICS)
LVE: 103076533(PAICS)
OOR: 101287712(PAICS)
DLE: 111169417
PCAD: 102994548(PAICS)
ECB: 100058501(PAICS)
EPZ: 103556488(PAICS)
EAI: 106841680(PAICS)
MYB: 102239537(PAICS)
MYD: 102757395(PAICS)
MNA: 107532951(PAICS)
HAI: 109373280 109394361(PAICS)
DRO: 112320919(PAICS) 112322805
PALE: 102899036(PAICS)
RAY: 107517721(PAICS)
MJV: 108395834
LAV: 100658417
TMU: 101346245
MDO: 100012535(PAICS)
SHR: 100923019(PAICS)
PCW: 110200170(PAICS)
OAA: 100086365
GGA: 396534(PAICS)
MGP: 100539860(PAICS)
CJO: 107313717(PAICS) 116653347
NMEL: 110398445
APLA: 101797218
ACYG: 106048608 106048610(PAICS)
TGU: 100225152(PAICS)
LSR: 110471777
SCAN: 103825290(PAICS) 103826194
GFR: 102043382 102043552(PAICS)
FAB: 101807763 101808142(PAICS)
PHI: 102111686(PAICS) 106628861
PMAJ: 107202963 107203210(PAICS)
CCAE: 111928008 111928009(PAICS)
CCW: 104690617(PAICS) 104690618
ETL: 114058312 114058315(PAICS)
FPG: 101919014(PAICS)
FCH: 102045839 102046009(PAICS)
CLV: 102085431 102094220(PAICS)
EGZ: 104129452
NNI: 104020782
ACUN: 113479039 113479040(PAICS)
AAM: 106490207(PAICS)
ASN: 102380243
AMJ: 102565809(PAICS)
PSS: 102446966(PAICS) 102447225
CMY: 102937919(PAICS)
CPIC: 101942651(PAICS)
ACS: 100566555(paics)
PVT: 110077009 110077010(PAICS)
PBI: 103060841(PAICS)
PMUR: 107297224(PAICS)
TSR: 106554316(PAICS) 106554752
PMUA: 114603707
GJA: 107123142(PAICS)
XLA: 379855(paics) 431975(paics.2.L) 444677(paics.1.S)
XTR: 100036662(paics.2) 100488155(paics.1)
NPR: 108794756(PAICS)
DRE: 321193(paics)
CCAR: 109113011
IPU: 108257759
PHYP: 113545223(paics)
AMEX: 103037884
EEE: 113586370
TRU: 101073764(paics)
LCO: 104919099(paics)
NCC: 104947087(paics)
OLA: 101171736(paics)
XMA: 102236450
XCO: 114151174(paics)
PRET: 103463823
CVG: 107091569
NFU: 107393397
KMR: 108243405
ALIM: 106534470
AOCE: 111569591(paics)
CSEM: 103376690(paics)
POV: 109646212(paics)
LCF: 108879073(paics)
SDU: 111226365(paics)
HCQ: 109532211(paics)
BPEC: 110154796(paics)
MALB: 109962065
ELS: 105011850
SFM: 108922797
PKI: 111834756(paics)
LCM: 102354332(PAICS)
CMK: 103178180(paics)
RTP: 109915470(paics)
CIN: 100177417
SPU: 575874
APLC: 110988626
DME: Dmel_CG3989(Paics)
DER: 6551233
DSI: Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)
DYA: Dyak_GE16201(Dyak_ade5)
DSR: 110180572
DPE: 6599097
DMN: 108161668
DAZ: 108619905
DNV: 108656029
DHE: 111602405
DVI: 6633868
MDE: 101893760
LCQ: 111687676
AAG: 5578622
AME: 551966
BIM: 100749872
BTER: 100649872
CCAL: 108629228
OBB: 114879276
SOC: 105195586
MPHA: 105835135
AEC: 105144565
ACEP: 105618440
PBAR: 105431681
VEM: 105569749
HST: 105184394
DQU: 106746186
CFO: 105253371
LHU: 105673924
PGC: 109857193
OBO: 105278330
PCF: 106787577
NVI: 100122105
CSOL: 105364366
MDL: 103569558
TCA: 656066
DPA: 109546155
ATD: 109598511
NVL: 108561415
BMOR: 732910
BMAN: 114242655
PMAC: 106711899
HAW: 110379838
TNL: 113494584
API: 100169501
DNX: 107169969
AGS: 114121209
RMD: 113548300
CLEC: 106673658
ZNE: 110838439
FCD: 110857027
TUT: 107361566
DPTE: 113792963
CSCU: 111642214
PTEP: 107441412
CEL: CELE_B0286.3(paic-1)
CBR: CBG03675
TSP: Tsp_02239
CRG: 105333392
MYI: 110447155
OBI: 106881666
NVE: 5500615
EPA: 110243452
ADF: 107351950
AMIL: 114970396
PDAM: 113666335
SPIS: 111338988
DGT: 114527900
HMG: 100210246
ATH: AT2G37690
ALY: 9317611
CRB: 17887570
CPAP: 110807756
CIT: 102626933
TCC: 18600133
DZI: 111295264
EGR: 104421141
VRA: 106772452
VAR: 108323122
VUN: 114190497
CCAJ: 109795409
CAM: 101492527
LJA: Lj0g3v0078859.2(Lj0g3v0078859.2)
ADU: 107465696
AIP: 107618371
FVE: 101294659
RCN: 112193541
PPER: 18774979
PMUM: 103318670
PAVI: 110754361
ZJU: 107412170
CSV: 101220975
CMO: 103485386
MCHA: 111020171
RCU: 8268191
JCU: 105647717
HBR: 110638277
MESC: 110600716
PEU: 105109809
JRE: 108992651
VVI: 100250122
SPEN: 107004897
SOT: 102597319
NTA: 107826110
NSY: 104210402
NTO: 104116449
NAU: 109214079
LSV: 111878896
CCAV: 112510261
SOE: 110803454
OSA: 4327345
DOSA: Os01t0199900-01(Os01g0199900)
OBR: 102703081
BDI: 100840405
ATS: 109769837(LOC109769837)
SBI: 8084329
SITA: 101771655
PDA: 103708454
EGU: 105040545
MUS: 103973031
DCT: 110098127
PEQ: 110034028
AOF: 109824587
ATR: 18438490
PPP: 112295424
APRO: F751_2359
SCE: YOR128C(ADE2)
ERC: Ecym_4634
KMX: KLMA_20598(ADE2)
NCS: NCAS_0H02150(NCAS0H02150)
NDI: NDAI_0C01500(NDAI0C01500)
TPF: TPHA_0J02670(TPHA0J02670)
TBL: TBLA_0A02680(TBLA0A02680)
TDL: TDEL_0D02460(TDEL0D02460)
KAF: KAFR_0D05120(KAFR0D05120)
PIC: PICST_81265(ADE2)
CAL: CAALFM_C304520CA(ADE2)
SLB: AWJ20_1637(ADE2)
NCR: NCU03194
NTE: NEUTE1DRAFT72443(NEUTE1DRAFT_72443)
MGR: MGG_01256
SSCK: SPSK_07276
MAW: MAC_00025
MAJ: MAA_01998
CMT: CCM_06867
BFU: BCIN_07g01690(Bcade2)
MBE: MBM_05356
ANI: AN3626.2
ANG: ANI_1_1076014(An01g08090)
PBN: PADG_12229(PADG_07036)
ABE: ARB_04901
TVE: TRV_05910
PTE: PTT_18788
SPO: SPCC1322.13(ade6)
CNE: CNE02500
CNB: CNBE2520
TASA: A1Q1_06001
ABP: AGABI1DRAFT63686(AGABI1DRAFT_63686)
ABV: AGABI2DRAFT230061(AGABI2DRAFT_230061)
MGL: MGL_2675
MRT: MRET_2669
DDI: DDB_G0283987(purC/E)
DFA: DFA_08571(purC/E)
SMIN: v1.2.002376.t1(symbB.v1.2.002376.t1) v1.2.002376.t4(symbB.v1.2.002376.t4)
SPAR: SPRG_11850
 » show all
Reference
1  [PMID:13672967]
  Authors
LUKENS LN, BUCHANAN JM.
  Title
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
  Journal
J Biol Chem 234:1799-805 (1959)
Reference
2  [PMID:7918411]
  Authors
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
  Title
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
  Journal
Biochemistry 33:11927-34 (1994)
DOI:10.1021/bi00205a031
Reference
3  [PMID:9500840]
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ.
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch Biochem Biophys 351:123-34 (1998)
DOI:10.1006/abbi.1997.0512
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.21
IUBMB Enzyme Nomenclature: 4.1.1.21
ExPASy - ENZYME nomenclature database: 4.1.1.21
BRENDA, the Enzyme Database: 4.1.1.21
CAS: 9032-04-6

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