| Entry |
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| Name |
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
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| Reaction(IUBMB) |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN: R04209]
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| Reaction(KEGG) |
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| Substrate |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD: C04751]
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| Product |
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD: C03373];
CO2 [CPD: C00011]
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| Comment |
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
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| History |
EC 4.1.1.21 created 1961, modified 2000, modified 2006
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01587 | phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase |
| K11808 | phosphoribosylaminoimidazole carboxylase |
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| Genes |
» show all
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| Reference |
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| Authors |
LUKENS LN, BUCHANAN JM. |
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| Title |
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide. |
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| Journal |
J Biol Chem 234:1799-805 (1959) |
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| Reference |
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| Authors |
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ. |
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| Title |
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. |
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| Journal |
Biochemistry 33:11927-34 (1994) |
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| Reference |
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| Authors |
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ. |
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| Title |
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.21 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.21 |
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