KEGG ENZYME: 4.1.1.21

ENZYME: 4.1.1.21

Entry

EC 4.1.1.21                 Enzyme

Name

phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]

Reaction(IUBMB)

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]

Reaction(KEGG)

R04209

Substrate

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]

Product

5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]

Comment

While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.

History

EC 4.1.1.21 created 1961, modified 2000, modified 2006

Pathway

ec00230

Purine metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K01587

phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase

K11808

phosphoribosylaminoimidazole carboxylase

Genes

HSA:	10606(PAICS)

PTR:	471236(PAICS)

PPS:

100993147

GGO:	101132763(PAICS)

PON:	100190835(PAICS)

PPYG:

129034893(PAICS)

NLE:

100580950

HMH:	116467849(PAICS) 116483296

SSYN:

129462621 129490997(PAICS)

MCC:

694743

MCF:	101864855(PAICS)

MTHB:

126955444

MNI:

105463551

CSAB:

103235649 103237366

CATY:

105591967 105591969(PAICS)

PANU:

101011883(PAICS) 103884449

TGE:	112625131(PAICS)

MLEU:

105552705(PAICS)

RRO:	104655715(PAICS)

RBB:	108513484(PAICS)

TFN:	117085582(PAICS) 117090262

PTEH:

111526496(PAICS)

CANG:

105507807 105525579(PAICS)

CJC:	100390231(PAICS)

SBQ:	101031274(PAICS) 104651700

CIMI:

108296113(PAICS) 108296114

ANAN:

105709234(PAICS)

CSYR:

103249285(PAICS)

MMUR:

105867854 105867855(PAICS)

LCAT:

123624098(PAICS) 123637056

PCOQ:

105807688(PAICS)

OGA:	100950463(PAICS)

MMU:	67054(Paics)

MCAL:

110293933

MPAH:

110330578(Paics)

RNO:	140946(Paics)

MCOC:

116071305(Paics)

ANU:	117712646(Paics)

ASYL:

127696683(Paics)

MUN:	110565016(Paics)

CGE:	100753190 100758991(Paics)

MAUA:

101829734(Paics) 121142783

PROB:

127232266(Paics)

PLEU:

114681836(Paics)

MORG:

121432328 121460627(Paics)

MFOT:

126506556 126515426

AAMP:

119808557(Paics) 119810165

NGI:	103734378(Paics)

HGL:	101721606(Paics)

CPOC:

100727779(Paics)

CCAN:

109697886(Paics)

DORD:

105980289(Paics)

DSP:	122106650(Paics)

DMER:

138821034(Paics)

PLOP:

125364939(Paics)

NCAR:

124985584 124994669

MMMA:

107139249(Paics)

ITI:

101961407

OCU:	100343740 127489901

OPI:	101534729(PAICS)

TUP:	102484181(PAICS)

GVR:	103606004(PAICS)

CFA:	100855769(PAICS)

CLUD:

112652356

VVP:

112923709

VLG:	121473255(PAICS)

NPO:	129519591(PAICS)

AML:	100482672(PAICS)

UMR:	103672750(PAICS)

UAH:	113262521(PAICS)

UAR:	123803985(PAICS)

ELK:

111149362

LLV:

125093749

MPUF:

101670430(PAICS) 106004002

MNP:	132006541(PAICS)

MLK:	131823800(PAICS)

NVS:	122889803(PAICS)

ORO:	101383279(PAICS)

EJU:	114206674(PAICS) 114206809

ZCA:	113924518 113924521(PAICS)

MLX:	118010506(PAICS)

NSU:	110588151 110590760(PAICS)

LWW:	102746659(PAICS)

FCA:	101084705(PAICS)

PYU:

121035341

PCOO:

112858402(PAICS)

PBG:	122497369(PAICS)

PVIV:

125163377(PAICS)

LRUF:

124520511

LGF:	123595955(PAICS)

AJU:

106971666

PTG:	102951236(PAICS)

PPAD:

109278673

PUC:

125922747

PLEZ:

122218208(PAICS)

HHV:	120243038(PAICS)

BTA:	404170(PAICS)

BOM:	102281546(PAICS)

BIU:

109560492

BBUB:

102392736(PAICS)

BBIS:

105002829 105002831

CHX:

102182773

OAS:	101115345 101117419(PAICS)

BTAX:

128050024(PAICS) 128054482

CSUM:

138078225 138081745(PAICS)

ODA:	120853000 120862146 120881137

CCAD:

122428484(PAICS)

MREE:

136153078(PAICS)

OVR:	110135551(PAICS)

MBEZ:

129554833 129561729(PAICS)

SSC:	100521281(PAICS)

CFR:

102522524

CBAI:

105077682(PAICS)

CDK:

105091550

VPC:	102531568(PAICS)

BACU:

103009147(PAICS)

BMUS:

118895967(PAICS)

LVE:	103076533(PAICS)

OOR:	101287712(PAICS)

LALB:

132519829(PAICS)

GMF:	115865656(PAICS)

DLE:

111169417

PCAD:

102994548(PAICS)

PSIU:

116754769(PAICS)

PPHC:

136123332(PAICS)

NASI:

112400791(PAICS)

ECB:	100058501(PAICS)

EPZ:	103556488(PAICS)

EAI:	106841680(PAICS)

MYB:	102239537(PAICS)

MYD:	102757395(PAICS)

MMYO:

118669110(PAICS)

MLF:	102437295(PAICS)

MDT:	132218788(PAICS)

MYUM:

138995631(PAICS)

PKL:	118706364(PAICS)

EFUS:

103284981(PAICS)

MNA:	107532951(PAICS)

DRO:	112320919(PAICS) 112322805

SHON:

118978572(PAICS)

AJM:	119061634(PAICS)

PDIC:

114492579(PAICS)

PHAS:

123815730(PAICS)

MMF:	118632016(PAICS)

PPAM:

129065527(PAICS)

HAI:	109373280 109394361(PAICS)

RFQ:	117019647 117022388(PAICS)

PALE:

102899036(PAICS)

PGIG:

120588101 120588103(PAICS)

PVP:	105293760(PAICS) 111741353

RAY:	107517721(PAICS)

MJV:	108395834(PAICS) 118969144

SARA:

101547712(PAICS)

SFUM:

130020741(PAICS)

SETR:

126028746 126032284(PAICS)

LAV:

100658417

TMU:

101346245

ETF:	101641703 101659036

DNM:	101418600(PAICS)

MDO:	100012535(PAICS)

GAS:	123231909 123250015 123250979(PAICS)

SHR:	100923019(PAICS)

AFZ:

127541800

PCW:	110200170(PAICS)

TVP:	118848492 118852716 118853100(PAICS)

PBRV:

138175027(PAICS)

OAA:

100086365

TACU:

119947589

GGA:	396534(PAICS)

PCOC:

116225927(PAICS)

MGP:	100539860(PAICS)

CJO:	107313717(PAICS) 116653347

TPAI:

128080320

NMEL:

110398445

APLA:

101797218

CATA:

118248082(PAICS)

TGU:	100225152(PAICS)

LSR:	110471777(PAICS)

SCAN:

103825290(PAICS) 103826194

PMOA:

120497414

OTC:	121335133(PAICS)

PRUF:

121358717(PAICS)

ATRC:

139592432(PAICS)

GFR:	102043382 102043552(PAICS)

FAB:	101807763 101808142(PAICS)

OMA:	130252536 130252539

PHI:	102111686(PAICS) 106628861

PMAJ:

107202963 107203210(PAICS)

CCAE:

111928008 111928009(PAICS)

CCW:	104690617(PAICS) 104690618

CBRC:

103622559(PAICS) 108449136

ACOE:

138109830(PAICS)

ETL:	114058312 114058315(PAICS)

ZAB:

102070226

ZLE:	135446541(PAICS)

ACHL:

103810554(PAICS)

SVG:	106851478(PAICS)

MMEA:

130579388 130579389

HRT:	120752708(PAICS)

CCIC:

134044340 134044343

FPG:	101919014(PAICS)

FCH:	102045839 102046009(PAICS)

CCRI:

104163262(PAICS)

NNT:

104400497

SHAB:

115610194

ACUN:

113479039 113479040(PAICS)

ACHC:

115348362 121232396

HALD:

104313976(PAICS)

HLE:	104836135(PAICS)

AGEN:

126035542 126035563

GCL:

127015555

CSTI:

104556851(PAICS) 104561187

LDI:	104348101(PAICS)

MNB:	103772148(PAICS)

DPUB:

104302244(PAICS)

PPUS:

135178389(PAICS)

AVIT:

104280921

BRHI:

104494915(PAICS) 104498823

EGZ:	104129452(PAICS)

NNI:

104020782

PCRI:

104024908

PCAO:

104050423(PAICS) 104051816

PADL:

103926281 103926342

AFOR:

103897396 103897432(PAICS)

FGA:	104070300(PAICS)

GSTE:

104251707(PAICS)

CBOY:

140652469(PAICS)

CLV:	102085431 102094220(PAICS)

CNIC:

135988403(PAICS)

MUI:

104534205

PGUU:

104463756(PAICS)

PLET:

104614437(PAICS)

EHS:	104505978(PAICS)

CMAC:

104473864(PAICS)

TEO:	104370341(PAICS)

BREG:

104641570(PAICS)

OHA:

104334899

ACAR:

104532390(PAICS)

CPEA:

104393033

CVF:	104286445 104286446

AAM:	106490207(PAICS)

AROW:

112976747(PAICS)

NPD:

112942546

TGT:

104572965

DNE:

112979521

SCAM:

104138555

ASN:

102380243

AMJ:	102565809(PAICS)

PSS:	102446966(PAICS) 102447225

CMY:	102937687(PAICS)

CCAY:

125635887(PAICS)

DCC:	119854539(PAICS)

CPIC:

101942651(PAICS)

TST:	117877973(PAICS) 117878023

CABI:

116834617(PAICS)

ACS:	100566555(paics)

ASAO:

132776662(PAICS)

PVT:	110077009 110077010(PAICS)

SUND:

121931240

PBI:	103060841(PAICS)

PMUR:

107297224(PAICS)

TSR:	106554316(PAICS) 106554752

PGUT:

117662104

PCAE:

139320473(PAICS)

APRI:

131203468 131203474

VKO:	123016987(PAICS)

PMUA:

114603707

PRAF:

128420983(PAICS)

ZVI:	118083784(PAICS)

GJA:	107123142(PAICS)

EMC:	129336478(PAICS)

XLA:	379855(paics.1.L) 431975(paics.2.L) 444677(paics.1.S)

XTR:	100036662(paics.2) 100488155(paics.1)

NPR:	108794756(PAICS)

ACAT:

141114579(PAICS)

BBUF:

120990191(PAICS) 120990192

BGAR:

122939229 122941977

DTC:	141096779 141096780(PAICS)

DRE:	321193(paics)

SRX:	107721365 107737306

SANH:

107665310 107683924

SGH:	107555752 107556158

CCAR:

109064121(paics) 109113011

CAUA:

113062925 113120971

CGIB:

127938623 127984087

PTET:

122325378(paics)

LROH:

127182968(paics)

GRF:	141348737(paics)

OMC:	131527253(paics)

PPRM:

120493429(paics)

RKG:	130091798(paics)

MAMB:

125277864(paics)

CIDE:

127502654

CERY:

137018942(paics)

MASI:

127410005 127415945

TROS:

130565424(paics)

TDW:	130434255(paics)

MANU:

129429251(paics)

PDAB:

135738874(paics) 135738879

IPU:	108257759(paics)

IFU:	128601397(paics)

PHYP:

113545223(paics)

SMEO:

124376692(paics)

TFD:	113642559(paics)

TVC:	132843443(paics)

CGAR:

128514679(paics)

NGRA:

132883632(paics)

AMEX:

103037884(paics)

CMAO:

118815403(paics)

EEE:

113586370

TRU:	101073764(paics)

TFS:	130528961 130528965(paics)

TNG:	GSTEN00032745G001

LCO:	104919099(paics)

NCC:	104947087(paics)

TBEN:

117495070(paics)

CGOB:

115007230(paics)

PGEO:

117444932 117444934

GACU:

117555197 117555199(paics)

EMAC:

134869549(paics)

ELY:	117253892(paics)

EFO:	125895511(paics)

PLEP:

121940268(paics)

SLUC:

116058805(paics)

ECRA:

117950144(paics)

ESP:

116695595

PFLV:

114562112

GAT:	120824171(paics)

PPUG:

119216565(paics)

AFB:	129094579(paics)

CLUM:

117729933 117729935(paics)

PSWI:

130193822(paics)

CVE:	137883707(paics)

MSAM:

119901058(paics)

SCHU:

122877194(paics)

CUD:	121511738(paics)

SPUL:

138607296(paics)

LMIX:

132955715(paics)

ALAT:

119029246 119029249(paics)

ASTR:

137599230(paics)

MZE:	101476340(paics) 101482534 106676564 112431584

ONL:	100704318 102077476 102078617 102079785 109194371 109199026 109199183

OAU:	116316740 116331053(paics) 116334329 120434429

OLA:	101171736(paics)

OML:	112136857(paics)

CSAI:

133458279(paics)

XMA:

102236450

XCO:	114151174(paics)

XHE:

116725943

PRET:

103463823

GAF:	122838035(paics)

PPRL:

129369792(paics)

CVG:

107091569

CTUL:

119780629(paics)

NFU:

107393397

KMR:	108243405(paics)

ALIM:

106534470

NWH:	119430855(paics)

AOCE:

111569591(paics)

EJA:	138198908(paics)

BFRE:

138621286(paics)

CSEM:

103376690(paics)

POV:	109646212(paics)

SSEN:

122762456(paics)

SSOE:

131465664(paics)

HHIP:

117760547(paics)

HSP:	118121417(paics)

PPLT:

128448130(paics)

SMAU:

118318436(paics)

LCF:

108879073

SDU:	111226365(paics)

XGL:	120791276 120791279(paics)

HCQ:	109532211(paics)

SSCV:

125994705(paics)

SBIA:

133503459(paics)

PEE:	133405976(paics)

PTAO:

133480896(paics)

BPEC:

110154796(paics)

ENY:	140353414 140354274

MALB:

109962065

BSPL:

114853784(paics)

SJO:	128362114(paics)

SSCO:

133984937(paics)

GMH:	115555973 115555976(paics)

SASA:

106560280 106584129

STRU:

115158545 115192372

OTW:	112249249(paics) 112251146

OMY:	110521683(paics) 110524564

OGO:	123996807 124037869(paics)

ONE:	115108542 115145144

OKI:	109898037 109902723

OKE:	118359024(paics) 118392653

OMM:	135513027 135556294

OCLA:

139406709 139409373

SALP:

111972328 111975271

SNH:	120052592(paics) 120054934

CCLU:

121533956 121540141(paics)

ELS:

105011850

OEP:	134011014(paics)

SFM:

108922797

PKI:	111834756(paics)

AANG:

118225698(paics)

AROT:

135254059(paics)

CCOG:

133126192(paics)

LOC:	102695780(paics) 107077190

PSPA:

121320173 121326752

ARUT:

117409359(paics) 117421369 117962728

PSEX:

120527461(paics)

LCM:	102354332(PAICS)

CMK:	103178180(paics)

RTP:	109915470(paics)

CPLA:

122550019(paics)

HOC:	132819206(paics)

LERI:

129697301(paics)

HAKA:

140737545 140737871

PMRN:

116943019(PAICS)

LRJ:	133343052(PAICS)

BFO:	118415422 118417541

BBEL:

109479396

CIN:

100177417

SCLV:

120331954

SPU:

575874

LPIC:

129261039

AJJ:

139979534

APLC:

110988626

ARUN:

117293910

AAMU:

139935784

AFIL:

140160865

AJC:

117108681

PFLL:

139130784

DME:	Dmel_CG3989(Paics)

DER:

6551233

DSE:	6617746 6618591

DSI:	Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)

DYA:	Dyak_GE16201(Dyak_ade5)

DAN:	6503583 6503584

DSR:

110180572

DPO:

4814561

DPE:

6599097

DMN:

108161668

DWI:

6644514

DGR:

6565145

DMO:	Dmoj_GI14693

DAZ:

108619905

DNV:

108656029

DHE:

111602405

DVI:	6633868(Paics)

CCAT:

101455100

BOD:

106625714

BDR:

105233168

RZE:	108371476 108380553

AOQ:

129238737

ALUD:

128858667

TDA:

119669080

MDE:	101893760 131804426

SCAC:

106092606

LCQ:

111687676

LSQ:	119602720 119613245 119615291 119615292

CVJ:	135956897(Paics)

GFS:

119633828

ECOE:

129944480

CLON:

129605353

HIS:

119656658

AGA:

1272084

ACOZ:

120947737

AARA:

120906513

AMER:

121591361

ASTE:

118513258

AMAP:

126558020

AFUN:

125767887

AMOU:

128306787

AMRS:

128707217

AALI:

118463640

ACOS:

131269484

AAG:

5578622

AALB:

109422142 109432621

ASUA:

134206446

CQU:	CpipJ_CPIJ009002

CPII:

120413362

CBRI:

134833770

CNS:

116341883

BCOO:

119068988

LLL:

129786097

PPAP:

129799420

AME:

551966

ACER:

108004086

ALAB:

122714131

ADR:

102671162

AFLR:

100872691

BIM:

100749872

BBIF:

117208120

BVK:

117235554

BVAN:

117154111

BHUN:

126864830

BTER:

100649872

BAFF:

126916404

BPYO:

122565783

BPAS:

132905409

FVI:

122534822

CCAL:

108629228

OBB:

114879276

OLG:

117610744

MGEN:

117227688

NMEA:

116432024

CGIG:

122398570

SOC:

105195586

MPHA:

105835135

AEC:

105144565

ACEP:

105618440

ACOC:

108685062

MZT:	108722389(Paics)

PBAR:

105431681

VEM:

105569749

COBS:

139103523(Paics)

TLN:	139819519(Paics)

HST:

105184394

DQU:

106746186

CFO:

105253371

FEX:

115234376

PMEC:

138941710(Paics)

LHU:	105673924(Paics)

PGC:

109857193

OBO:

105278330

PCF:

106787577

PFUC:

122525817

VPS:

122633239

VCRB:

124429674

VVE:

124953716

NVI:

100122105

CSOL:

105364366

TPRE:

106655517

LHT:	122509806 122509809

LBD:

127280069

MDL:

103569558

CGLO:

123272470

CTYP:

141536499(Paics)

FAS:

105273501

DAM:

107035651

AGIF:

122859183

CINS:

118073739

VCAN:

122410618

CCIN:

107270852

DSM:

124407665

NPT:	124214232(Paics)

NFB:

124177769

NLO:

107217478

NVG:

124300374

AROA:

105684598

TCA:

656066

TMOL:

138136498 138137500 138137504(Paics)

DPA:

109546155

ESIM:

136412211(Paics)

EFOR:

136341049(Paics)

SOY:

115884553

AGRG:

126734352

ATD:

109598511

CSET:

123316162

HAXR:

123676511

AGB:

108915132

LDC:

111512243

DVV:	114335014 126892770

NVL:

108561415

APLN:

108738575

PPYR:

116175172

OTU:

111417005

BMOR:

732910

BMAN:

114242655

MSEX:

115450465 119188545

DPL:	KGM_208829

BANY:

112055181

MJU:

123864941

NIQ:

126777364

VCD:

124539226

MCIX:

123661138

PMAC:

106711899

PXU:

106117402

BPHI:

137929426(Paics)

PRAP:

111000679

PBX:

123711880

PNAP:

125063530

ZCE:	119830235 119830386

CCRC:

123705114

LSIN:

126964659

AAGE:

121729263

HAW:

126055027

HZE:

124636806

TNL:

113494584

SLIU:

111351565

OFU:

114350954

ONU:

135079933

ATRA:

106130953

GMW:

113522778

PXY:

105393713

PGW:

126380449

LGLY:

125241630

CSTB:

134755173

CFUM:

141433627(Paics)

CFEL:

113373201 113373674

CCRN:

123294246

API:

100169501

DNX:

107169969

AGS:

114121209

RMD:

113548300

ACOO:

126847076

DVT:

126894157

BTAB:

109040170 109041589

CLEC:

106673658

HHAL:

106677324(Paics)

NLU:

111047647

MQU:

128991924

PHU:	Phum_PHUM430820

FOC:

113205894

TPAL:

117640819

ZNE:

110838439

CSEC:

111874922

PAME:

138713815(Paics)

SGRE:

126299365

BROR:

134545219

IEL:

124168472

HAMR:

139690937(Paics)

FCD:

110857027

PVM:	113818328(Paics)

PJA:

122255345

PCHN:

125031798

PMOO:

119593846

HAME:

121866313

PCLA:

123772116(Paics)

CQD:	128688414(Paics)

ESN:

126999937

MNZ:

135200147

MRJ:	136827980(Paics)

PORN:

139766528(Paics)

HAZT:

108672159

PPOI:

119091740

ISC:

8024797

DSV:

119449786

RSAN:

119382846

RMP:

119170043

VDE:

111245399

VJA:

111267570

GOE:

100897842

TUT:

107361566

DPTE:

113792963

DFR:

124493911

CSCU:

111642214

CVS:	136988126(Paics)

PTEP:

107441412

ABRU:

129962615

UDV:

129227709

SDM:

118187838

LPOL:

106471938

PMEO:

129594308

CEL:	CELE_B0286.3(paic-1)

CBR:

CBG_03675

CRQ:	GCK72_004561

NAI:	NECAME_06175

TSP:

Tsp_02239

HRO:	HELRODRAFT_186294

LGI:	LOTGIDRAFT_182233

PVUL:

126830190

PCAN:

112560932 112560933

LSAX:

138968667

BGT:

106051207

GAE:

121375145

HRF:

124132688

HRJ:

124279536

HASI:

137274450

HCRA:

139449731

CRG:

105333392

CANU:

128193132

CVN:

111127492

OED:

125682095

MYI:

110447155

PMAX:

117329261

AIRR:

138327724

MCAF:

127714300

RPHI:

132734889 132759339

DPOL:

127878162

MAEA:

128228258

OBI:

106881666

OSN:

115219101

LJP:

135473085

LAK:	106173523 106177955

LLON:

135494005

NVE:

5500615

EPA:

110243452

ATEN:

116293642

ADF:

107351950

AMIL:

114970396

MCAZ:

138016485

MFOO:

138000068

PDAM:

113666335

SPIS:

111338988

DGT:

114527900

XEN:

124446730

HMG:

100210246

HSY:	130654877 130655238

RES:

135686374

TAD:	TRIADDRAFT_56870

ATH:

AT2G37690

ALY:

9317611

CRB:

17887570

CSAT:

104782201 104785717 104792562

EUS:	EUTSA_v10016367mg

BRP:	103857728 103865624

BNA:	106392916 106410642 106427767 125585663 125601293

BOE:	106328958 106342429

RSZ:	108830244 108844546

THJ:	104799866 104808027

CPAP:

110807756

CIT:

102626933

CIC:	CICLE_v10003992mg CICLE_v10027983mg

PVY:	116111936 116128981

MINC:

123208675

TCC:

18600133

GRA:	105782260 105804662

GHI:	107889325 107926745 107949056 121225607

GAB:	108454374 108472012 108473667

HSYR:

120174201 120189750

DZI:

111295264

EGR:

104421141

RARG:

115727041 115755742

GMX:	100787182 100812377

GSJ:	114371965 114403281

PVU:

137829932

VRA:

106772452

VAR:

108323122

VUN:

114190497

VUM:

124826119

CCAJ:

109795409

APRC:

113872785

MTR:

11405596

TPRA:

123884336 123903144

CAM:

101492527

PSAT:

127098564

VVO:

131644161

LJA:

130718530

ADU:

107465696

AIP:

107618371

AHF:	112711008 112776399

LANG:

109345404 109355206

QSA:	O6P43_007650 O6P43_011231

FVE:

101294659

AANS:

126793871

RCN:

112193541

PPER:

18774979

PMUM:

103318670

PAVI:

110754361

PDUL:

117633014

MDM:	103434186 103451046

MSYL:

126594208 126619431

PXB:	103954378 103961338

PCOX:

137722686 137745286

ZJU:

107412170

MNT:

21407287

CSAV:

115719673

CSV:

101220975

CMO:

103485386

BHJ:

120076308

MCHA:

111020171

CMAX:

111487615 111489012

CMOS:

111444942 111456832

CPEP:

111808154 111808341

RCU:

8268191

MEAN:

126675457

HBR:

110638277

MESC:

110600716

POP:	18108079 7487686

PEU:

105109809

PALZ:

118037883 118038270 118044016

PNZ:	133669163 133706344

JRE:

108992651

CILL:

122318430

CAVE:

132172741

AGLU:

133852318

QSU:	111985940 112028403

QLO:	115953009 115986390

TWL:

119987566

VVI:

100250122

VRI:

117931118

SLY:

101255944

SPEN:

107004897

SOT:

102597319

SSTN:

125844841

SDUL:

129900437

CANN:

107851129

LBB:

132614254

NTA:

107826110

NSY:

104210402

NTO:

104116449

NAU:

109214079

INI:	109177453 109183529

ITR:	115999660 116021020 116027506

SIND:

105162621 105179969

EGT:

105958306

SSPL:

121747796 121787463

SMIL:

130985195

SHIS:

125208971

APAN:

127246807

HPUM:

140890521

PEBU:

140836948

HAN:	110936856 110941521

ECAD:

122581774

LSV:

111878896

CCAV:

112510261

DCR:	108200242 108209412

CSIN:

114266917

RVL:	131324585 131327049

AEW:	130759572 130764187

DLT:

127798224

BVG:	104884365 104902182

SOE:

110803454

CQI:	110712887 110716796

ATRI:

130814669

MOF:

131160176

NNU:	104589619 104610105

MING:

122072792 122081867

TSS:

122671416

PSOM:

113289538 113297995 113305505 113356177 113359473

OSA:

4327345

DOSA:

Os01g0199900

OBR:

102703081

OGL:

127770586

BDI:

100840405

ATS:

109769837

TDC:	119267456 119275372

TAES:

123060587 123069188 123077712

TUA:

125543128

LPER:

127341823

LRD:

124661925

SBI:

8084329

ZMA:	100501865 103630165

MFLO:

136449435 136461521

SITA:

101771655

SVS:

117857790

PVIR:

120673914 120705683

PHAI:

112894377

PAUA:

133898812 133916088

TANG:

140768784

PDA:

103708454

EGU:

105040545

ZOF:	122040602 122045131

DCT:

110098127

PEQ:

110034028

AOF:

109824587

MSIN:

131251449

ACAK:

137958524

NCOL:

116259327

ATR:

18438490

CJF:	131049869 131060514

SMO:	SELMODRAFT_121407 SELMODRAFT_123573 SELMODRAFT_79988

PPP:

112295424

CRE:	CHLRE_12g503300v5

VCN:	VOLCADRAFT_88132

MNG:	MNEG_15346

CSL:	COCSUDRAFT_56990

CVR:	CHLNCDRAFT_24868

APRO:

F751_2359

OLU:	OSTLU_33376

OTA:	OT_ostta09g00792

BPG:	Bathy10g03620

MIS:	MICPUN_98347

MPP:	MICPUCDRAFT_15308

SCE:	YOR128C(ADE2)

SEUB:

DI49_4963

SPAO:

SPAR_O02600

AGO:	AGOS_ACR210C

ERC:

Ecym_4634

KLA:	KLLA0_E02685g

KMX:	KLMA_20598(ADE2)

LTH:	KLTH0F15532g

VPO:	Kpol_440p3

ZRO:	ZYRO0G04400g

CGR:	2890129(ADE2)

NCS:	NCAS_0H02150(NCAS0H02150)

NDI:	NDAI_0C01500(NDAI0C01500)

TPF:	TPHA_0J02670(TPHA0J02670)

TBL:	TBLA_0A02680(TBLA0A02680)

TGB:	HG536_0F02600

TDL:	TDEL_0D02460(TDEL0D02460)

KAF:	KAFR_0D05120(KAFR0D05120)

KNG:	KNAG_0B04140(KNAG0B04140)

ZMK:	HG535_0C04380

SLUD:

SCDLUD_003240

DHA:	DEHA2G13772g

PIC:	PICST_81265(ADE2)

PGU:	PGUG_04377

SPAA:

SPAPADRAFT_62222

LEL:	PVL30_003512(ADE2)

LBG:	92208749(LODBEIA_P35530)

CAL:	CAALFM_C304520CA(ADE2)

CTP:	CTRG_02291

COT:	CORT_0C03210

CDU:	CD36_84460

CTEN:

18247287(ADE2)

CLU:	CLUG_04693

CLUS:

A9F13_11g01177

CAUR:

CJI96_0002528

ASAU:

88175112(PUMCH_004049)

PPA:	PAS_chr3_0085

PKZ:	C5L36_0A02730

BNN:	FOA43_000670(ADE1_2)

BBRX:

BRETT_003290(ADE2)

OPA:	HPODL_03845

YLI:	2906747(YALI2_C00602g)

SLB:	AWJ20_1637(ADE2)

NCR:

NCU03194

NTE:	NEUTE1DRAFT72443(NEUTE1DRAFT_72443)

SMP:	10805873(SMAC4_02914)

PAN:	PODANSg5612

PBEL:

QC761_109160

PPSD:

QC762_109160

PPSP:

QC763_109160

PPSA:

QC764_109160

TTT:	THITE_2122013

MTM:	MYCTH_2106437

CTHR:

CTHT_0054820

RTHE:

98127573(VTJ83DRAFT_624)

MGR:

MGG_01256

PPEI:

PpBr36_00763

TMN:	UCRPA7_8298

SSCK:

SPSK_07276

FGR:	FGSG_10669

FPU:	FPSE_05696

FPOA:

FPOAC1_003848

FVN:	FVRRES_04306

FVR:	FVEG_03306

FOX:	FOXG_04841

NHE:	NECHADRAFT_57703

FFC:	NCS54_00167900

FKR:	NCS57_00165400

FMU:	J7337_006208

TRE:	TRIREDRAFT_105832

TRR:	M419DRAFT_34104

TATV:

90959042(TrAtP1_002451)

TASP:

36611142(TrAFT101_000217)

MAW:	19244336(J3458_000133)

MAJ:

MAA_01998

MBRN:

26239590(ADE2)

PCHM:

VFPPC_01781

CMT:

CCM_06867

AMUS:

LMH87_002107

PLJ:	28885475(PLICBS_007033)

PTKZ:

JDV02_001700

VAL:	VDBG_04892

VDA:	VDAG_04435

CFJ:	CFIO01_08613

CLUP:

CLUP02_05480

CHIG:

CH63R_00671

CDET:

87939388(CDEST_02885)

SAPO:

SAPIO_CDS5738

ELA:	UCREL1_1956

PFY:	PFICI_00262

SSL:	SS1G_09902

BFU:	BCIN_07g01690(Bcade2)

MBE:

MBM_05356

PSCO:

LY89DRAFT_683580

GLZ:	GLAREA_02172

ANI:	ANIA_03626

AFM:	AFUA_4G12600

ACT:	ACLA_051590

NFI:	NFIA_103710

AOR:	AO090009000333

ANG:	An01g08090

AFV:	AFLA_011025

ALUC:

AKAW2_20869A(ADE2)

ACHE:

ACHE_10306A(ADE2)

APUU:

APUU_60252A(ADE2)

PCS:	N7525_005771

PDP:	PDIP_43260

POU:	POX_a01367

TMF:	EYB26_005226

TRG:	TRUGW13939_02718

CIM:	CIMG_00790

CPW:	9691758(ADE2)

URE:	UREG_00756

ABE:

ARB_04901

TVE:

TRV_05910

PBL:	PAAG_06211

PBN:	PADG_12229

AJE:	HCAG_03809

BGH:	BDBG_05577

PNO:	SNOG_09661

PTE:

PTT_18788

PTRR:

6349752(PtrM4_001310)

BZE:	COCCADRAFT_86084

BSC:	COCSADRAFT_37238

BOR:	COCMIDRAFT_28685

AALT:

CC77DRAFT_1018523

ADAC:

96083534(ACET3X_003212)

ARAB:

EKO05_0000234

ZTR:	MYCGRDRAFT_73277

PFJ:	MYCFIDRAFT_215799

FFU:	CLAFUR5_09769

CBET:

CB0940_10644

BCOM:

BAUCODRAFT_506580

NPA:	UCRNP2_7084

TML:	GSTUM_00003827001

SPO:	2538734(ade6)

SOM:	SOMG_00727(ade6)

CNE:

CNE02500

CNB:

CNBE2520

CNG:	CNAG_02294

CGI:	CGB_E3300W

CDEU:

CNBG_4007

CDEC:

89991245(IAS62_004473)

CTEG:

91990121(I308_103265)

CBAS:

91984472(I312_104427)

CDEP:

91086248(L203_102036)

KMG:	30163353(I203_102555)

KNE:	92182198(IAR55_004940)

KDJ:	28971006(I303_108366)

KBI:	30212623(I302_109080)

KPIN:

30174456(I206_107754)

KSH:	87958723(IL334_006593)

KER:	91101377(V865_002573)

TMS:	TREMEDRAFT_42952

TASA:

A1Q1_06001

CCAC:

CcaHIS019_0406440(ADE2)

PPL:	POSPLDRAFT_90700

TVS:	TRAVEDRAFT_144724

DSQ:	DICSQDRAFT_94493

PCO:	PHACADRAFT_249143

SHS:	STEHIDRAFT_100223

HIR:	HETIRDRAFT_313681

PSQ:	PUNSTDRAFT_96255

ADL:	AURDEDRAFT_160414

FME:	FOMMEDRAFT_157872

GTR:	GLOTRDRAFT_71482

RSX:	RhiXN_04201

LBC:	LACBIDRAFT_318305

CCI:	CC1G_11091

ABP:	AGABI1DRAFT63686(AGABI1DRAFT_63686)

ABV:	AGABI2DRAFT230061(AGABI2DRAFT_230061)

PCUB:

JR316_0005281 JR316_0005292

MPR:	MPER_11161

MRR:	Moror_13808

E1B28_012184(ADE2)

SCM:	SCHCO_02496475(SCHCODRAFT_02496475)

CPUT:

CONPUDRAFT_164622

SLA:	SERLADRAFT_454448

WSE:	WALSEDRAFT_33155

WIC:	J056_000475

UMA:	UMAG_10790

PFP:	PFL1_01053

SGRA:

EX895_006207

MGL:

MGL_2675

MRT:

MRET_2669

MSYM:

MSY001_0173

PGR:	PGTG_13944

PTRC:

PtA15_10A435 PtA15_15A419

PSTR:

Pst134EA_027824

MLR:	MELLADRAFT_114877

RIE:	OCT59_016677

MBR:	MONBRDRAFT_34384 MONBRDRAFT_9068

DDI:	DDB_G0283987(purC/E)

DPP:	DICPUDRAFT_147031

DFA:	DFA_08571(purC/E)

ACAN:

ACA1_106300

PTI:	PHATRDRAFT_56626

FCY:	FRACYDRAFT_277172

TPS:	THAPSDRAFT_21670

PIF:	PITG_09726

PSOJ:

PHYSODRAFT_510589

BLAC:

94345388(CCR75_001615)

SPAR:

SPRG_11850

EHX:	EMIHUDRAFT_421581 EMIHUDRAFT_424259

RHZ:	RHPLAN_45860

BBGW:

UT28_C0001G0672

» show all

Reference

1 [PMID:13672967]

Authors

LUKENS LN, BUCHANAN JM.

Title

Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.

Journal

J Biol Chem 234:1799-805 (1959)

Reference

2 [PMID:7918411]

Authors

Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.

Title

Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.

Journal

Biochemistry 33:11927-34 (1994)
DOI:10.1021/bi00205a031

Reference

3 [PMID:9500840]

Authors

Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ

Title

Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.

Journal

Arch Biochem Biophys 351:123-34 (1998)
DOI:10.1006/abbi.1997.0512

Other DBs

ExplorEnz - The Enzyme Database: