KEGG   ENZYME: 4.1.1.21Help
Entry
EC 4.1.1.21                 Enzyme                                 

Name
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]
Reaction(KEGG)
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]
Product
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]
Comment
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
History
EC 4.1.1.21 created 1961, modified 2000, modified 2006
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01587  phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K11808  phosphoribosylaminoimidazole carboxylase
Genes
HSA: 10606(PAICS)
PTR: 471236(PAICS)
PPS: 100993147(PAICS)
GGO: 101132763(PAICS)
PON: 100190835(PAICS)
NLE: 100580950(PAICS)
MCC: 694743
MCF: 101864855(PAICS)
CSAB: 103235650 103237366
RRO: 104655715(PAICS)
RBB: 108513484(PAICS)
CJC: 100390231(PAICS)
SBQ: 101031274(PAICS) 104651700
MMU: 67054(Paics)
MCAL: 110293933(Paics)
MPAH: 110330578(Paics)
RNO: 140946(Paics)
MUN: 110565016(Paics)
CGE: 100758991(Paics)
NGI: 103734378(Paics)
HGL: 101721606(Paics)
CCAN: 109697886(Paics)
OCU: 100343740(PAICS)
TUP: 102484181(PAICS)
CFA: 100855769
VVP: 112923709
AML: 100482672(PAICS)
UMR: 103672750(PAICS)
UAH: 113262521(PAICS)
ORO: 101383279(PAICS)
FCA: 101084705
PTG: 102951236(PAICS)
AJU: 106971666
BTA: 404170(PAICS)
BOM: 102281546(PAICS)
BIU: 109560492
BBUB: 102392736
PHD: 102334474(PAICS) 102339573
CHX: 102182773(PAICS)
SSC: 100521281(PAICS)
CFR: 102522524(PAICS)
CDK: 105091550(PAICS)
BACU: 103009147(PAICS)
LVE: 103076533(PAICS)
OOR: 101287712(PAICS)
DLE: 111169417
ECB: 100058501(PAICS)
EPZ: 103556488(PAICS)
EAI: 106841680(PAICS)
MYB: 102239537(PAICS)
MYD: 102757395(PAICS)
MNA: 107532951(PAICS)
HAI: 109373280 109394361(PAICS)
RSS: 109451691(PAICS)
DRO: 112320919(PAICS) 112322805
PALE: 102899036(PAICS)
LAV: 100658417
TMU: 101346245
MDO: 100012535(PAICS)
SHR: 100923019(PAICS)
PCW: 110200170(PAICS)
OAA: 100086365
GGA: 396534(PAICS)
MGP: 100539860(PAICS)
CJO: 107313717
APLA: 101797218
ACYG: 106048610(PAICS)
TGU: 100225152(PAICS)
LSR: 110471777
SCAN: 103825290(PAICS)
GFR: 102043552(PAICS)
FAB: 101808142(PAICS)
PHI: 102111686(PAICS)
PMAJ: 107203210(PAICS)
CCAE: 111928009(PAICS)
CCW: 104690617(PAICS)
ETL: 114058315(PAICS)
FPG: 101919014(PAICS)
FCH: 102046009(PAICS)
CLV: 102094220(PAICS)
EGZ: 104129452
NNI: 104020782
ACUN: 113479040(PAICS)
AAM: 106490207(PAICS)
ASN: 102380243
AMJ: 102565809(PAICS)
PSS: 102446966(PAICS)
CMY: 102937919(PAICS)
CPIC: 101942651(PAICS)
ACS: 100566555(paics)
PVT: 110077010(PAICS)
PBI: 103060841(PAICS)
PMUR: 107297224(PAICS)
GJA: 107123142(PAICS)
XLA: 379855(paics) 431975(paics.2.L) 444677(paics.1.S)
XTR: 100036662(paics.2) 100488155(paics.1)
NPR: 108794756(PAICS)
DRE: 321193(paics)
IPU: 108257759
PHYP: 113545223(paics)
AMEX: 103037884
EEE: 113586370
TRU: 101073764
LCO: 104919099(paics)
NCC: 104947087(paics)
OLA: 101171736(paics)
XMA: 102236450
XCO: 114151174(paics)
PRET: 103463823
NFU: 107393397
KMR: 108243405
CSEM: 103376690(paics)
LCF: 108879073(paics)
SDU: 111226365(paics)
HCQ: 109532211(paics)
BPEC: 110154796(paics)
MALB: 109962065
ELS: 105011850
SFM: 108922797
PKI: 111834756(paics)
LCM: 102354332(PAICS)
CMK: 103178180(paics)
CIN: 100177417
SPU: 575874
APLC: 110988626
DME: Dmel_CG3989(Paics)
DER: 6551233
DPE: 6599097
DSI: Dsimw501_GD15919(Dsim_GD15919) Dsimw501_GD23841(Dsim_GD23841)
DYA: Dyak_GE16201(Dyak_ade5)
DAZ: 108619905
DNV: 108656029
DHE: 111602405
MDE: 101893760
AAG: 5578622
AME: 551966
BIM: 100749872
BTER: 100649872
SOC: 105195586
MPHA: 105835135
AEC: 105144565
ACEP: 105618440
PBAR: 105431681
HST: 105184394
DQU: 106746186
CFO: 105253371
LHU: 105673924
PGC: 109857193
OBO: 105278330
PCF: 106787577
NVI: 100122105
MDL: 103569558
TCA: 656066
DPA: 109546155
NVL: 108561415
BMOR: 732910
HAW: 110379838
TNL: 113494584
API: 100169501
DNX: 107169969
AGS: 114121209
CLEC: 106673658
ZNE: 110838439
FCD: 110857027
TUT: 107361566
DPTE: 113792963
CEL: CELE_B0286.3(pacs-1)
CBR: CBG03675
TSP: Tsp_02239
CRG: 105333392
MYI: 110447155
OBI: 106881666
EPA: 110243452
ADF: 107351950
PDAM: 113666335
SPIS: 111338988
HMG: 100210246
ATH: AT2G37690
CRB: 17887570
CPAP: 110807756
TCC: 18600133
DZI: 111295264
EGR: 104421141
VRA: 106772452
CCAJ: 109795409
CAM: 101492527
LJA: Lj0g3v0036439.1(Lj0g3v0036439.1) Lj0g3v0036669.1(Lj0g3v0036669.1) Lj0g3v0076349.1(Lj0g3v0076349.1) Lj0g3v0078859.1(Lj0g3v0078859.1) Lj0g3v0078859.2(Lj0g3v0078859.2)
ADU: 107465696
AIP: 107618371
FVE: 101294659
PPER: 18774979
PMUM: 103318670
PAVI: 110754361
ZJU: 107412170
CSV: 101220975
CMO: 103485386
MCHA: 111020171
RCU: 8268191
JCU: 105647717
HBR: 110638277
MESC: 110600716
JRE: 108992651
VVI: 100250122
SPEN: 107004897
SOT: 102597319
CANN: 107851129
NTA: 107826110
NSY: 104210402
NAU: 109214079
OEU: 111390339
CCAV: 112510261
SOE: 110803454
OSA: 4327345
DOSA: Os01t0199900-01(Os01g0199900)
OBR: 102703081
BDI: 100840405
ATS: 109769837(LOC109769837)
SBI: 8084329
PDA: 103708454
EGU: 105040545
MUS: 103973031
DCT: 110098127
PEQ: 110034028
AOF: 109824587
ATR: 18438490
PPP: 112295424
APRO: F751_2359
SCE: YOR128C(ADE2)
ERC: Ecym_4634
KMX: KLMA_20598(ADE2)
NCS: NCAS_0H02150(NCAS0H02150)
NDI: NDAI_0C01500(NDAI0C01500)
TPF: TPHA_0J02670(TPHA0J02670)
TBL: TBLA_0A02680(TBLA0A02680)
TDL: TDEL_0D02460(TDEL0D02460)
KAF: KAFR_0D05120(KAFR0D05120)
PIC: PICST_81265(ADE2)
CAL: CAALFM_C304520CA(ADE2)
SLB: AWJ20_1637(ADE2)
NCR: NCU03194
NTE: NEUTE1DRAFT72443(NEUTE1DRAFT_72443)
MGR: MGG_01256
SSCK: SPSK_07276
MAW: MAC_00025
MAJ: MAA_01998
CMT: CCM_06867
BFU: BCIN_07g01690(Bcade2)
MBE: MBM_05356
ANI: AN3626.2
ANG: ANI_1_1076014(An01g08090)
PBN: PADG_12229(PADG_07036)
ABE: ARB_04901
TVE: TRV_05910
PTE: PTT_18788
SPO: SPCC1322.13(ade6)
CNE: CNE02500
CNB: CNBE2520
ABP: AGABI1DRAFT63686(AGABI1DRAFT_63686)
ABV: AGABI2DRAFT230061(AGABI2DRAFT_230061)
MGL: MGL_2675
DDI: DDB_G0283987(purC/E)
DFA: DFA_08571(purC/E)
SMIN: v1.2.002376.t1(symbB.v1.2.002376.t1) v1.2.002376.t2(symbB.v1.2.002376.t2) v1.2.002376.t3(symbB.v1.2.002376.t3) v1.2.002376.t4(symbB.v1.2.002376.t4)
SPAR: SPRG_11850
MPH: MLP_03890(purC)
 » show all
Taxonomy
Reference
1  [PMID:13672967]
  Authors
LUKENS LN, BUCHANAN JM.
  Title
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
  Journal
J Biol Chem 234:1799-805 (1959)
Reference
2  [PMID:7918411]
  Authors
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
  Title
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
  Journal
Biochemistry 33:11927-34 (1994)
Reference
3  [PMID:9500840]
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ.
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch Biochem Biophys 351:123-34 (1998)
DOI:10.1006/abbi.1997.0512
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.21
IUBMB Enzyme Nomenclature: 4.1.1.21
ExPASy - ENZYME nomenclature database: 4.1.1.21
BRENDA, the Enzyme Database: 4.1.1.21
CAS: 9032-04-6

DBGET integrated database retrieval system