KEGG   ENZYME: 4.1.1.22
Entry
EC 4.1.1.22                 Enzyme                                 
Name
histidine decarboxylase;
L-histidine decarboxylase;
L-histidine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-histidine carboxy-lyase (histamine-forming)
Reaction(IUBMB)
L-histidine = histamine + CO2 [RN:R01167]
Reaction(KEGG)
R01167
Substrate
L-histidine [CPD:C00135]
Product
histamine [CPD:C00388];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.
History
EC 4.1.1.22 created 1961
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01590  histidine decarboxylase
Genes
HSA3067(HDC)
PTR453425(HDC)
PPS100968932(HDC)
GGO101133251(HDC)
PON100435706(HDC)
NLE100583943(HDC)
MCC715287(HDC)
MCF102140159(HDC)
CSAB103245641(HDC)
CATY105588221(HDC)
PANU101023980 116268502
TGE112627767(HDC)
RRO104656909(HDC)
RBB108544824(HDC)
TFN117070674(HDC)
PTEH111552806(HDC)
CJC100407107(HDC)
SBQ101028065(HDC)
MMUR105870716(HDC)
OGA100948057(HDC)
MMU15186(Hdc)
MCAL110285423(Hdc)
MPAH110318815(Hdc)
RNO24443(Hdc)
MCOC116092343(Hdc)
MUN110551948(Hdc)
CGE100753889(Hdc)
PLEU114709080(Hdc)
NGI103733044(Hdc)
HGL101711940(Hdc)
CPOC100719978(Hdc)
CCAN109699102(Hdc)
DORD105981108(Hdc)
DSP122114434(Hdc)
NCAR124977495
OCU100352602(HDC)
OPI101535008(HDC)
TUP102473985(HDC)
CFA487551(HDC)
VVP112920057(HDC)
VLG121477960(HDC)
AML100483602(HDC)
UMR103676731(HDC)
UAH113269608(HDC)
UAR123801866(HDC)
ELK111140259
LLV125105599
MPUF101692154(HDC)
ORO101379199(HDC)
EJU114206458(HDC)
ZCA113909833(HDC)
MLX118003227(HDC)
FCA101096483(HDC)
PYU121041686(HDC)
PBG122468659(HDC)
PTG102958176(HDC)
PPAD109263003(HDC)
AJU106967229(HDC)
HHV120235025(HDC)
BTA515950(HDC)
BOM102288176(HDC)
BIU109565138(HDC)
BBUB102400426(HDC)
CHX102176332(HDC)
OAS101108052(HDC)
ODA120852975(HDC)
CCAD122443619 122443620
SSC100156724(HDC)
CFR102515254(HDC)
CBAI105077015(HDC)
CDK105102455(HDC)
VPC102525879(HDC)
BACU103017595(HDC)
LVE103084683(HDC)
OOR101285813(HDC)
DLE111181547(HDC)
PCAD102987046(HDC)
PSIU116749973(HDC)
ECB100069939(HDC)
EPZ103546940(HDC)
EAI106838475(HDC)
MYB102259283(HDC)
MYD102758428(HDC)
MMYO118651667(HDC)
MLF102426149(HDC)
MNA107534892(HDC)
PKL118721476(HDC)
HAI109394261(HDC)
DRO112311591(HDC)
SHON118992611(HDC)
AJM119057623(HDC)
PDIC114492872(HDC)
PHAS123808492(HDC)
MMF118618840(HDC)
RFQ117022779(HDC)
PALE102886268(HDC)
PGIG120623113(HDC)
PVP105288742(HDC)
RAY107502016(HDC)
TOD119237924(HDC)
SARA101554581(HDC)
LAV100655681(HDC)
TMU101361713
DNM101440241(HDC)
MDO100031203(HDC)
GAS123235997(HDC)
SHR100928753(HDC)
PCW110203020(HDC)
OAA100075371(HDC)
GGA415454(HDC)
PCOC116225336(HDC)
MGP100538642(HDC)
CJO107318706(HDC)
NMEL110403614(HDC)
APLA101793174(HDC)
ACYG106043373(HDC)
AFUL116493508(HDC)
TGU100229258(HDC)
LSR110474176(HDC)
SCAN103816036(HDC)
PMOA120508873(HDC)
OTC121343644(HDC)
PRUF121354401(HDC)
GFR102039864(HDC)
FAB101813047(HDC)
PHI102107166(HDC)
PMAJ107209245(HDC)
CCAE111934090(HDC)
CCW104683975(HDC)
ETL114059937(HDC)
ZAB102070884(HDC)
FPG101923835(HDC)
FCH102051866(HDC)
CLV102098924(HDC)
EGZ104130933(HDC)
NNI104017114
ACUN113484020(HDC)
TALA104359584(HDC)
PADL103922735(HDC)
ACHC115342300(HDC)
AAM106496427(HDC)
AROW112963513(HDC)
NPD112952813(HDC)
DNE112995985(HDC)
ASN102388705(HDC)
AMJ102567703(HDC)
CPOO109309069(HDC)
GGN109288566(HDC)
PSS102445403(HDC)
CMY102939386(HDC)
CPIC101938873(HDC)
TST117884418(HDC)
CABI116830925(HDC)
MRV120372756(HDC)
ACS100558434(hdc)
PVT110077265(HDC)
SUND121934314(HDC)
PBI103064200(HDC)
PMUR107302508(HDC)
TSR106544979
PGUT117675750(HDC)
VKO123027598(HDC)
PMUA114584406(HDC)
ZVI118092716(HDC)
GJA107122719(HDC)
XLA108712469
XTR100497702(hdc)
NPR108804808(HDC)
RTEM120931288(HDC)
BBUF120987159(HDC)
BGAR122929627(HDC)
DRE793609(hdc)
SRX107727402(hdc)
SANH107703948(hdc)
SGH107569986
CCAR109070931
CAUA113118435
PHYP113526698(hdc)
SMEO124395440(hdc)
TFD113638761(hdc)
AMEX103025570(hdc)
EEE113585359
TRU101064778(hdc)
TNGGSTEN00018049G001
LCO104919799(hdc)
NCC104953029(hdc)
CGOB115003687(hdc)
ELY117256878(hdc)
PLEP121945095(hdc)
SLUC116054504(hdc)
ECRA117947419(hdc)
GAT120811246
PPUG119225668(hdc)
MSAM119890795(hdc)
CUD121510975(hdc)
MZE101486176(hdc)
ONL100712505(hdc)
OAU116311714(hdc)
OLA101172886(hdc)
OML112160818(hdc)
XMA102221037(hdc)
XCO114143012(hdc)
XHE116718913(hdc)
PRET103462054(hdc)
PFOR103143585(hdc)
PLAI106952001(hdc)
PMEI106919684(hdc)
GAF122841198(hdc)
CVG107085331(hdc)
CTUL119771729(hdc)
GMU124867334(hdc)
NFU107381896(hdc)
KMR108251273(hdc)
ALIM106530921(hdc)
NWH119429295(hdc)
AOCE111577617(hdc)
CSEM103379072
POV109624805 109641325
SSEN122772466(hdc)
HHIP117754192(hdc)
LCF108887923(hdc)
SDU111223180(hdc)
SLAL111656878(hdc)
XGL120794369(hdc)
HCQ109525743(hdc)
BPEC110173045(hdc)
MALB109963375
SASA106587893 106595316
OMY110514654 118936597
OGO124035389 124035476
SNH120036179 120037157
ELS105025343(hdc)
SFM108940862(hdc)
PKI111844931(hdc)
AANG118215589(hdc)
LOC102698881(hdc)
PSPA121294326 121298899
ARUT117428518 117429746
LCM102353176(HDC)
RTP109917424(hdc)
BFO118412289
BBEL109468657
SPU548615
APLC110987761
SKO100313635
DMEDmel_CG3454(Hdc)
DER6543244
DSE6608476
DSIDsimw501_GD10721(Dsim_GD10721)
DYADyak_GE19346
DAN6495630
DSR110178288
DPODpse_GA17460
DPE6590521
DMN108159920 117191451
DWI6646037
DGR6561303
DMODmoj_GI19320
DAZ108615799
DNV108653725
DHE111592082 115483389
CCAT101452027
BOD106615337
MDE101901068
SCAC106084585
LCQ111674485
AGAAgaP_AGAP009001
ACOZ120957839
AARA120901262
AAG5564807
AALB109417567 109417775
CQUCpipJ_CPIJ009897
CPII120424415
CNS116336652
AME408587
ACER108003560
ALAB122720769
BIM100747061
BBIF117209704
BVK117238954
BVAN117164224
BTER100643518
BPYO122568756
CCAL108625613
OBB114872585
MGEN117229264
NMEA116424723
CGIG122400372
SOC105193202
MPHA105836992
AEC105152935
ACEP105622639
PBAR105425786
VEM105560846
HST105191881
DQU106744317
CFO105249475
FEX115244690
LHU105679173
PGC109856628
OBO105286450
PCF106791028
PFUC122515713
VPS122635251
NVI100119434
CSOL105359799
TPRE106658959
MDL103574233
CGLO123263347
FAS105269473
DAM107048619
AGIF122853234
CCIN107264877
TCA664593
DPA109536318
SOY115889016
ATD109595135
CSET123307245
AGB108910565
LDC111518010
NVL108567253
APLN108735124
PPYR116170947 116171023
OTU111425586
BMOR101745115
BMAN114242029
MSEX115441582
DPLKGM_206235
BANY112050017
PMAC106715276
PPOT106101912
PXU106124531
PRAP110995341
ZCE119836418
HAW110384609
TNL113504121
OFU114365450
PXY105394466 105394720 105397280 105397281
API100159557
DNX107167737
AGS114129464
RMD113559422
BTAB109044724
DCI103514557
CLEC106664514
HHAL106691859 112211732 112211745
NLU111049406
FOC113206554
ZNE110836139
CSEC111870717
FCD110842279
DPXDAPPUDRAFT_304481
DMK116921661
PJA122260901
PCHN125038377
HAME121864112
PCLA123745308
PTRU123519628
HAZT108677699
EAF111705055
ISCIscW_ISCW012649
DSV119456021
RSAN119393852
VDE111249401
VJA111270048
TUT107364962
DPTE113795525
DFR124491035
CSCU111626285
PTEP107456663
SDM118180876
LGILOTGIDRAFT_119964
PCAN112556141
BGT106057991
GAE121373443
HRF124131219
HRJ124292334
CRG105338240
MYI110458956
PMAX117315931
MMER123542374
OBI106868611
OSN115219006
LAK106167343
DGT114526159
KPNKBN49_pI0079(hdc)
EAEEAE_02560
EARCCG33472
RORRORB6_18940
RAODSD31_00220
REEelectrica_00039(hdc)
CIFAL515_20490
CPARCUC49_16220
CITZE4Z61_19945
IZHFEM41_21745
PSHISAMEA2665130_1235(hdc_1) SAMEA2665130_2542(hdc_2)
SRZAXX16_0320
SRHZFO014_08885
DDDDda3937_00519
DZEDd1591_0272
DDCDd586_3787
DSOA4U42_07075
CEDLH89_14435
DFNCVE23_20465
DDQDDI_3894
DAQDAQ1742_04111
DDADd703_0354
LBQCKQ53_07495
EPECI789_14010
ERWIGN242_16690
PAOPat9b_5732
TCIA7K98_19280
PLUMA4R40_20620
PAYPAU_02211(hdc)
XPOXPG1_1072(hdc)
MMKMU9_3525
HIFHIBPF_17370
HILHICON_08330
HAYC3V42_04280
HAEGNCTC8502_00552(hdc)
VVUVV2_1425
VVMVVMO6_03218
VVLVV93_v1c32460
VHAVIBHAR_02100
VCAM892_02790
VNIVIBNI_A2877(hdc) VIBNI_A3076
LAGN175_19410
VAUVANGNB10_67p044(angH)
VCYIX92_23370
VCTJV59_16180
VTUIX91_08650
VEUIXK98_17340
VGABSQ33_18745
VTAB0460
VAQFIV01_05665(hdc1) FIV01_17635(hdc2)
VSRVspart_04269(hdc)
VNVIF132_05765
AWDAWOD_I_1509
PDSCAY62_02270
SKSFCN78_07785
PMOLCLJ08_25595
PFCPflA506_2784(pmsA)
PENPSEEN2506(pmsA)
PRHLT40_08460
PSECCCOS191_2635(hdc)
PMAMKSS90_12805
ACBA1S_2379
ABYABAYE1098(hdc)
ABCACICU_02576(basG)
ABNAB57_2808
ABBABBFA_01049(hdc)
ABXABK1_2695
ABZABZJ_02770
ABRABTJ_01137
ABDABTW07_2825(basG)
ABHM3Q_2843
ABADABD1_23740(basG)
ABJBJAB07104_02734
ABABBJAB0715_02782
ABAJBJAB0868_02616
ABAZP795_5030
ABKLX00_13110
ABAUIX87_08645
ABAAIX88_15190
ABWBL01_04695
ABALABLAC_10820
ACCBDGL_001867(hdc)
ACWA0J50_05180
SWDSwoo_0827
PTUPTUN_b0285(hdc)
CATEC2869_09130
MCELLPW13_14245
ASIPAQUSIP_12020(hdc)
MCAMCA2307
FTUFTT_0664c(hdc)
FTQRO31_0759
FTFFTF0664c(hdc)
FTWFTW_1064
FTRNE061598_03805
FTTFTV_0623(hdc)
FTGFTU_0707(hdc)
FTLFTL_0938
FTHFTH_0917(hdc)
FTAFTA_0986
FTSF92_05160
FTIFTS_0921(hdc)
FTOX557_04905
FTCDA46_1869
FTVCH67_1274
FTZCH68_1006
FTMFTM_1194(hdc)
FTNFTN_1019(hdc)
FTXAW25_988
FTDAS84_1504
FTYCH70_924
FCFFNFX1_1058
FCNFN3523_0651
FHIFSC454_06720
FPTBZ13_47
FNAOOM_1676
FNLM973_06615
FRMBBG19_1035
FOOCGC45_05225
BLEPAL038_11940
THISHZT40_04285
HELHELO_2826(hdc)
MMWMmwyl1_1637
MMEMarme_2739
BSANCHH28_10065
AHDAI20_19915
AHIVU14_00745
ASAASA_4380(hdc)
AEOO23A_p3640
ADHCK627_03395
CRZD1345_00055
CHAECH06BL_00090(hdc)
IFLC1H71_02965
PTXABW99_12245
OURCEQ07_03535
ANTArnit_1162
SUNSUN_0880
SCUSCE1572_36655
DAODesac_2880
PACAID47_00865
MLOmlr6209
RLSHB780_09590
LABRCHH27_03250
YANAYJ57_22490
THAACFI11_08090
SSACI6I31_03740
LRELreu_1832
LRFLAR_1717
LRTLRI_1920
LVALV515_08410
LLEAYR59_06675
LFVLF543_00500
LPARFAM21731_00900
CPECPE0390
CPFCPF_0378
CPRCPR_0373
CTCCTC_01478
CTETBN906_01640
CBVU729_2405
CTHCthe_3028
CTXClo1313_0579
ANRAna3638_09050
PSORRSJ16_02400
NTPCRH09_23415
NAHF5544_38485
NIEKV110_17230
SCTSCAT_p0093
SCYSCATT_p16510
STRMM444_02955
SCLFBB341_30190
SSIAA7J05_00490 A7J05_36245
SSUBCP968_33130
SFUGCNQ36_34300
SPLACP981_31155
KSKKSE_09080(vlmD)
KITCFP65_4692
NALB005_4073
SESPBN6_39910
SSYIEKG83_20315
LEDBBK82_42310
MAUMicau_6135
MICBMicB006_4748
MTUACSH63_04380
MICHFJK98_21660
MTEMGCE86_15670
VMAVAB18032_16155
ACTNL083_0280
DVCDvina_41305
AEYCDG81_15220
ELEElen_2499
EGDGS424_014430
GPAGPA_07450
RTSCE91St31_15080
AMRAM1_6060(hdc)
LEPLepto7376_0439
LBOLBWT_7240
GVIgll2219
NPUNpun_F1479
NOSNos7107_1111
NSHGXM_05986
NEDHUN01_24655
FISFIS3754_44630
SCSSta7437_1197
STANSTA3757_05490(hdc)
LAMBKBB96_03670
VBCC5Q97_19650
FVAFV113G1_26110(hdc)
FULC4N20_10620
BFRBF1487
BFSBF9343_1349
BFGBF638R_1500
BFBVU15_06230
BNOK8P02_11330
ALQC7Y71_004095
CBAECOR50_16185
COYHF329_07585
FLASY85_24805
FLSGLV81_03340
FLCKJS93_02675
PEPAQ505_02510 AQ505_10545
PCMAY601_1282 AY601_2413
PSTYBFS30_07255
PEKFFJ24_024010
PROEH9L23_24475
SHGSph21_0649
SCNSolca_2061 Solca_2352
MGINFRZ54_04370
OLIFKG96_00105 FKG96_21605
SBXCA265_23415
CAMUCA2015_3965
GRLLPB144_07895
FCVAWN65_11245
MARMYQ22_11570
CLYCelly_1761
CLHIX49_08670
ZGAZOBELLIA_4435(hdc)
TDIAUW17_08620
TMARMARIT_0983(hdc)
TMPF9Y86_02545
FOPFNB79_16140
SMISLDL76_08000
ZSPMQE36_05565
FBUUJ101_01321(hdc|HDC)
ORHOrnrh_0964
ORIQ785_05410
CGNOK18_03110 OK18_08355
CIHATE47_09455
OHOOweho_0967
MBWMSBRW_1757
 » show all
Reference
1  [PMID:16747851]
  Authors
Epps HM
  Title
Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A.
  Journal
Biochem J 39:42-6 (1945)
DOI:10.1042/bj0390042
Reference
2  [PMID:5681461]
  Authors
Riley WD, Snell EE.
  Title
Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group.
  Journal
Biochemistry 7:3520-8 (1968)
DOI:10.1021/bi00850a029
Reference
3  [PMID:5216347]
  Authors
Rosenthaler J, Guirard BM, Chang GW, Snell EE.
  Title
Purification and properties of histidine decarboxylase from Lactobacillus 30a.
  Journal
Proc Natl Acad Sci U S A 54:152-8 (1965)
DOI:10.1073/pnas.54.1.152
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.22
IUBMB Enzyme Nomenclature: 4.1.1.22
ExPASy - ENZYME nomenclature database: 4.1.1.22
BRENDA, the Enzyme Database: 4.1.1.22
CAS: 9024-61-7

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