KEGG   ENZYME: 4.1.1.25
Entry
EC 4.1.1.25                 Enzyme                                 
Name
tyrosine decarboxylase;
L-tyrosine decarboxylase;
L-(-)-tyrosine apodecarboxylase;
L-tyrosine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-tyrosine carboxy-lyase (tyramine-forming)
Reaction(IUBMB)
L-tyrosine = tyramine + CO2 [RN:R00736]
Reaction(KEGG)
R00736;
(other) R02080
Substrate
L-tyrosine [CPD:C00082]
Product
tyramine [CPD:C00483];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
History
EC 4.1.1.25 created 1961
Pathway
ec00350  Tyrosine metabolism
ec00680  Methane metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01592  tyrosine decarboxylase
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase
K22329  tyrosine decarboxylase
K22330  tyrosine decarboxylase
Genes
SPU594040
APLC110976950 110976951 110977004 110986576
SKO100370006
DMEDmel_CG30446(Tdc2)
DER6541166 6541418
DSE6607876
DSIDsimw501_GD10312(Dsim_GD10312) Dsimw501_GD10313(Dsim_GD10313)
DYADyak_GE24598 Dyak_GE24609
DAN6496636
DSR110189728 110189729
DPO4803425 4803426
DPE6591119 6591121
DMN108158753 108158754 117189880
DWI6652207 6652208
DGR6560599
DMODmoj_GI20238 Dmoj_GI20239
DAZ108616233 108616237
DNV108654279 108654288
DHE111597635 111597637
DVI6626705
CCAT101461091
BOD106623497
BDR105230617
RZE108354027 108382375
AOQ129245625
TDA119674230 119684975
MDE101895890 101896057
SCAC106091739
LCQ111679179 111685422
LSQ119615281
GFS119641193
ECOE129949501
CLON129607436
HIS119646852
AGA1269865 1269867
ACOZ120961689 120961690
AARA120895114 120895348
AMER121591456
ASTE118510594
AFUN125771293
AMOU128302292
AALI118463316
AAG5578207 5578213
AALB109407816 109407818
ASUA134217920 134217929
CQUCpipJ_CPIJ010562 CpipJ_CPIJ010568
CPII120422861 120422869 120425223
CNS116350804
BCOO119081376
AME410947 410948
ACER107997295 107997296
ALAB122712337 122712338
ADR102679261 102679553
AFLR100868557 100868783
BIM100749914 100750035
BBIF117206081 117206082
BVK117235367 117235368
BVAN117154201 117154202
BTER100644997 100645237
BAFF126915976 126915987
BPYO122577981 122577983
BPAS132905572 132905575
FVI122536462 122536463
CCAL108626254 108626255
OBB114878213 114878214
OLG117605374 117605375
MGEN117218014 117218015
NMEA116430689 116430700
CGIG122400854 122400855
SOC105195564 105195565
MPHA105835873 105835874
AEC105150198 105150199
ACEP105618319 105618436
PBAR105431663 105431664
VEM105569721 105569722
HST105181332 105183006
DQU106752145 106752152
CFO105253891 105253892
FEX115234425 115234506
LHU105673960 105673962
PGC109854155 109854156
OBO105275026 105275066
PCF106787311 106787312
PFUC122514815 122514816
VPS122636668 122636670
VCRB124429890 124429892
VVE124956037 124956042
NVI100117476 100118460
CSOL105365904 105365905
TPRE106652664 106656585
LHT122509216 122509217
LBD127278913 127278916
MDL103572145 103572208
CGLO123264542 123264543
FAS105263014 105263015
DAM107044580 107044582
AGIF122857291 122857296
CINS118073596 118073597
VCAN122408678 122408679
CCIN107267354 107267366
NPT124219920 124219922
NFB124183537 124183542
NLO107221190 107221191
NVG124305259 124305260
AROA105691671 105691672
TCA661439 661480
DPA109535230 109535237
SOY115886525 115886598
AGRG126748260 126748262
ATD109601574 109601585
CSET123312907 123313105
AGB108904229 108904230
LDC111512316 111513877
DVV126884135 126884142
NVL108556585 108564884
APLN108741933 108741935 108741943 112906014
PPYR116176997 116176998
OTU111429248 111429256 111429260
BMOR101745224
BMAN114250590
MSEX115443168
DPLKGM_205057A KGM_205057B
BANY112054855
MJU123880826
NIQ126769883
VCD124533633
MCIX123653583
PMAC106710721
PPOT106109234
PXU106128287
PRAP110996474 110996505
PBX123710866
PNAP125053377
ZCE119835054
CCRC123691497
LSIN126970438 126970696
AAGE121732095
HAW110375714
HZE124630951
TNL113504421
SLIU111351870
OFU114356729
ATRA106131818
GMW113521119
PXY105380584
PGW126367245
LGLY125228178
CFEL113363211 113379557
CCRN123296971 123296972
API100164582
DNX107166908
AGS114120413
RMD113549264
ACOO126847434
DVT126903201
BTAB109044218
DCI103506036
CLEC106662160
HHAL106690416 106690418
NLU111051897 111052314 111060835 111062184 120354157
HVI124365810 124365811 124365812
MQU129001973 129002570
PHUPhum_PHUM258570 Phum_PHUM515460
FOC113208884 113208915
TPAL117649422 117649515
ZNE110836469 110836473
CSEC111867565 111867567
SGRE126353933 126354113 126354115 126355886
BROR134536690 134536691
IEL124159574 124159576
FCD110845906 110862305
DPXDAPPUDRAFT_188046 DAPPUDRAFT_221579
DMK116929054 116930857
DPZ124311096 124348806
PVM113823929
PJA122254329
PCHN125034577
PMOO119589276
HAME121870628
PCLA123773630
CQD128695652
PTRU123508410
ESN126986955
MNZ135223460
HAZT108665985
EAF111709425
LSM121118689 121122148
TCF131882314
PPOI119096463 119096674
DSV119445928
RSAN119390348
RMP119172270
VDE111244865
VJA111264444
TUT107364473
DPTE113797060
DFR124498012
CSCU111621558 111636165 111636185
PTEP107437980 107437984 107437985 107440533 107448396
ABRU129960890 129962910
UDV129216621 129231199
SDM118197056
LPOL106473048
PMEO129583889
CELCELE_K01C8.3(tdc-1)
CBRCBG_00668(Cbr-tdc-1)
CRQGCK72_005038
NAINECAME_12827
BMYBM_BM4724(Bma-tdc-1)
LOALOAG_07708
HROHELRODRAFT_101612 HELRODRAFT_84403 HELRODRAFT_84539
LGILOTGIDRAFT_139922
PVUL126828019
PCAN112557030
GAE121389952
HRF124124275
HRJ124257477
CRG105343976
CANU128189530
CVN111138313
OED125669695
MYI110450166
PMAX117344578
MCAF127720344
MMER123526517
RPHI132740677
DPOL127881846
MAEA128203273
OBI106872068
OSN115213324
LJP135465475
LAK106169254
SMMSmp_135230
SHXMS3_00010436(GAD2_4)
OVIT265_10505
LLON135496958
ATHAT4G28680(TYRDC)
ALY9305556
CRB17880524
CSAT104722011
BRP103854232
BNA106401881 111206442
BOE106301496
RSZ108840444
SRRSerAS9_4289
SRYM621_21860
SPLYQ5A_021830(ddc_3)
SRSSerAS12_4290
SRASerAS13_4290
PDDMNQ95_09545
LCICINQ41_11280
LAVIINQ42_10835
THEXICG51_002300
FSGLQ771_06950
FEDLQ772_08245
RTHLRK53_14545
TAMNN4264_12825
PPSYAOC04_17040
LLOLLO_2358
LSHCAB17_17095
MECQ7C_1781
MMEMarme_2120
SPLBSFPGR_25870
DTOTOL2_C15120
DTIDesti_1056
VIGBKP57_05785
VPNA21D_02269(ddc)
VPTKBP50_17275(tdc)
PLVERIC2_c03820 ERIC2_c03880
PAEER70331_07125
PDHB9T62_36425
PLUTEI981_13145(tdc)
LBRLVIS_2213
LBKLVISKB_2286
LKOABN16_05945
LZYLZ3411_0102
LSUAH3M12_04010(tdc)
LROSLROSL1_0287
LZHD1B17_03980
LFTFG051_11765(tdc)
EFAEF0634
EFLEF62_1003
EFIOG1RF_10367
EFDEFD32_0448
EFSEFS1_0482
EFNDENG_00663
EFQDR75_2583(tdc)
ENEENT_24840
EFCEFAU004_00402
EFAUEFAU085_00341
EFUHMPREF0351_10412
EFMM7W_577
EFTM395_01905
EHREHR_03460
EMUEMQU_0384
EDULIU_00045
ESSATZ33_01805
ETHCK496_01640(tdc)
ESGEsVE80_03990
ELACI4Q40_02120(tdc)
EDSPML78_05665(tdc)
EMSP3T75_11305(tdc)
MPXMPD5_1444
VCPH9L18_09730(tdc)
VFVK5K99_04370(tdc)
CMLBN424_2873(tdc)
CDJBFC22_00400
CBVU729_1871(tdc)
CCECcel_1039
SCYER2B67_12040(mfnA)
SHYSHJG_8487
SHOSHJGH_8247
STSIA4E84_01155
SDXC4B68_07225
STIRDDW44_21740(mfnA)
STUIGCM10017668_02080
SPRFK4G22_06385
GLJGKIL_0849
SKVNIES73_47590
MRIMal4_16360(ddc_2)
TPOLMal48_47350(ddc_2)
TSPHKIH39_04315
SACISinac_0199
SSMSpirs_1720
SPEREW093_04660(mfnA) EW093_08085(mfnA)
ACAACP_2295
ABASACPOL_2465
EDAGWR55_18060
ADINH7849_22275
TGIRBB81_02985
TPSCRBB77_00185
PFERIRI77_28470
ARBA9P82_09800
ARKD6B99_16810
AGIFSB73_08330
ARACE0W69_002380
SCNSolca_0125
BBDBelba_0914
EVIEchvi_1144
ESTDN752_12380
ECHIFKX85_04605
EMAIKZP23_05315
ALMAO498_15635
MDAIPZ59_03945
ALSDJ013_03305
MTTFtrac_2647
MHAAQ3Y49_04430
FLMMY04_4046
FLLEI427_21825
FYAKMW28_22245
FKAKM029_22935
FUVJR347_05650
FINKQS_13585
FGLEM308_03295
FALBHYN59_13485
FSEDI487_06335
FNKE1750_11755
FAKFUA48_14180
FCCLOS86_13350
FCBLOS89_00520
NOMAAT17_11255
NSDBST91_07530
LUTLupro_07405
LULLPB138_09290
FBUUJ101_00805(mfnA|adc)
OHOOweho_0805
CHYDH4K34_00630
MJAMJ_0050
MFEMefer_1281
MVUMetvu_1091
MFSMFS40622_0455
MIFMetin_0053
MJHJH146_0437
MESGMLAUSG7_1350(mfnA)
MESAMLASG1_0960(mfnA)
MIGMetig_1285
MMPMMP0131
MMQMmarC5_1547
MMXMmarC6_0821
MMZMmarC7_1130
MMDGYY_00665
MMAKMMKA1_01360(mfmA)
MMAOMMOS7_01620(mfmA)
MMADMMJJ_09550(ddc)
MAEMaeo_1008
MVNMevan_1136
MVOMvol_1332
MOKMetok_0539
METFCFE53_03665
MTHMTH_1116
MMGMTBMA_c15000(mfnA)
MWOMWSIV6_1508(mfnA)
MTEEMTTB_02960
METCMTCT_1010
METEtca_01072
METZMETMT2_1136
METKFVF72_06000(mfnA)
MTHMFZP57_07215(mfnA)
METJFZP68_03460(mfnA)
MSTMsp_0329(mfnA)
METBAW729_05440
MEISPXD04_05440(mfnA)
MRUmru_1896(mfnA)
MSIMsm_0987
MEBAbm4_1501(mfnA)
MMILsm9_1948(mfnA)
MEYETL18_09200
MOLYLM1_1352
MAROMarbSA_15800
METVK4897_06540(mfnA)
MELMetbo_0381
MEWMSWAN_2027
METHMBMB1_1647(mfnA)
MFCBRM9_0901(mfnA)
MFIDSM1535_0868(mfnA)
MCUBMCBB_1953(mfnA)
MSUBBK009_07245
METNBK008_02890
METTCIT01_03490
METOCIT02_09650
MEMEHYG87_04775(mfnA)
MFEGGCM10025860_02380 GCM10025860_06820
MFVMfer_0124
MKAMK1500
AFUAF_2004
AFGAFULGI_00022680
APOArcpr_0572
AVEArcve_0276
ASTAsulf_00822
FPLFerp_1624
GACGACE_1678
GAHGAH_00469
PFUPF1159
PFIPFC_05020
PHOPH0937(PH0937)
PABPAB1578
PYNPNA2_1618
PYAPYCH_06120
PYSPy04_1152
PYCTQ32_05860
TKOTK1814
TONTON_1710
TGATGAM_2137(mfnA)
TSITSIB_0460
TBATERMP_01938
THEGQS_06765
THATAM4_357
THMCL1_0978
TLTOCC_10103
THSTES1_1892
TNUBD01_1348
TEUTEU_02775
TGYX802_04065
THVADU37_CDS03910
TCHCHITON_0593
TPEPA0127_06075
TPIEA7C91_03515
TGGA3K92_00035
TCEA3L02_07045
TBSA3L01_09510
THHCDI07_09435
TSLA3L11_02945
TTDA3L14_00490
TPRFA3L09_01855
TRLA3L10_08935
TPAFA3L08_02375
THYA3L12_00195
TICFH039_01070(mfnA)
TCQTIRI35C_0025(mfnA)
THEMFPV09_09285(mfnA)
THEIK1720_05430(mfnA)
PPACPAP_09195
MBAMbar_A0977
MBYMSBRM_3518
MBWMSBRW_3745
MBARMSBR2_3469
MBAKMSBR3_3475
MACMA_0006
MMAMM_1317
MMAZMmTuc01_1364
MMJMSMAS_3345
MMACMSMAC_3369
MVCMSVAZ_3508
MEKMSKOL_3476
MLSMSLAZ_3221
METMMSMTP_3249
MEFMSWH1_3197
MEQMSWHS_3405
MSJMSSAC_4399
MSZMSSIH_3899
MSWMSSIT_3970
MTHRMSTHT_1822
MTHEMSTHC_1464
MHORMSHOH_4092
MFZAOB57_008380(mfnA)
MBUMbur_1732
MMETMCMEM_2203
MELOJ7W08_10035(mfnA)
MMHMmah_2032
MHAZBHR79_03475
MPOTBKM01_10435
MEVMetev_2260
MZHMzhil_2025
MPYMpsy_1730
MZIHWN40_01010(mfnA)
MMAVRE476_10080(mfnA)
MSEBRE474_06625(mfnA)
MHZMetho_2460
MEHFMmiHf6_12130(gadA)
MEESMmiEs2_14580(hdc)
MTPMthe_1636
MCJMCON_2882
MHIMhar_0758
MHUMhun_2611
MRTJKHC33_03555(mfnA)
MLAMlab_1545
MEMMemar_1848
MBGBN140_0541(mfnA)
MEMAMMAB1_0678(mfnA)
MCHKMchiMG62_21500
MSUMOH143_03490(mfnA)
MRCR6Y96_08920(mfnA)
MPIMpet_0341
MENDL6E24_06470(mfnA)
MEFWF1737_09315(mfnA)
MAQERJ40_09395(mfnA)
MFKE2N92_09590(mfnA)
MOUOU421_03840(mfnA)
MESBL1S32_07430(mfnA)
MANQL1994_09190(mfnA)
MBNMboo_2166
MFOMetfor_0587
MPLMpal_2080
MPDMCP_0399(mfnA)
MEZMtc_0699(mfnA)
RCIRCIX1543(mfnA)
MJKN2V74_01750(mfnA) N2V74_04110(mfnA)
HALVNG_0327G(gadD)
HSLOE_1498R(mfnA)
HANRLJ422_01425(mfnA)
HDLHALDL1_05815
HHBHhub_1472(mfnA)
HAGSJT689_02710(mfnA)
HABOJRZ79_01215(mfnA)
HNOLT974_02395(mfnA)
HLULT972_11145(mfnA)
HALHHTSR_1425(gadD)
HHSRHSR6_1497(mfnA)
HSUHLASF_0642(gadD)
HSFHLASA_0638(gadD)
HAHSHSRCO_0991(mfnA)
SALRFQU85_02085(mfnA)
HALREFA46_006260(mfnA)
HJEHacjB3_13125
HDOMUK72_05145(mfnA)
HALXM0R89_11045(mfnA)
HAXZM0R88_11500(mfnA)
HAYCNGM10_05005(mfnA)
HAXYNGM07_17095(mfnA)
SALIL593_04020
SAIMK0C01_00870(mfnA)
HARAAArcS_2636(mfnA)
HMArrnAC1798(gadD)
HHIHAH_2325(gadB)
HHNHISP_11840
HABSG26_04170
HTABVU17_11320
HALJG9465_07335(mfnA)
HSINKDQ40_01800(mfnA)
NPHNP_1194A(panD)
NMONmlp_3238(mfnA)
NHOHWV23_12190(mfnA)
NSALHWV07_06010(mfnA)
HUTHuta_2743
HTIHTIA_2492
HALAHrd1104_02165(mfnA)
HASVSVXHr_1834(mfnA)
HABNHBNXHr_1822(mfnA)
HMUHmuk_2995
HALZE5139_02250(mfnA)
HALLLC1Hm_2418(mfnA)
HAZPGBQ70_02250(mfnA)
HALIBV210_05425
HSNDV733_10045(mfnA)
HDSHSR122_0241(mfnA)
HRRHZS55_08855(mfnA)
HPELHZS54_09975(mfnA)
HLTI7X12_05090(mfnA)
HARCHARCEL1_05395(mfnA)
SSAIN0B31_01285(mfnA)
HAADMW046_07175(mfnA)
HVOHVO_0811(panD)
HALEG3A49_04080(mfnA)
HLNSVXHx_0769(mfna)
HMEHFX_0780
HGIABY42_03880
HLSKU306_08615(mfnA)
HBOHbor_24050
HAERDU502_04300(mfnA)
HLMDV707_11510(mfnA)
HALMFCF25_10535(mfnA)
HLAHlac_0591
HALPDOS48_02805(mfnA)
HALBEKH57_08460(mfnA)
HEZZEO776_04065(mfnA)
HALQHrr1229_003030(mfnA)
HSSJ7656_12790(mfnA)
HSAIHPS36_03145(mfnA)
HAZZKI388_01525(mfnA)
HAEhalTADL_3067
HALGHUG10_01995(mfnA)
HALUHUG12_15070(mfnA)
HMPK6T50_00155(mfnA)
HREK6T36_00165(mfnA)
HRMK6T25_00945(mfnA)
HACBHbl1158_07480(mfnA)
HTUHtur_0805
HSALJMJ58_04880(mfnA)
HAKZJ0X25_11200(mfnA)
NMGNmag_2599(panD)
HXAHalxa_3903
NATNJ7G_4186
NPENatpe_3324
NVRFEJ81_16035(mfnA)
NPLFGF80_15110(mfnA)
NAYHYG81_12375(mfnA)
HALYHYG82_19550(mfnA)
HJTDVR14_06700(mfnA)
HLOJ0X27_12215(mfnA)
NGENatgr_3048
HRUHalru_1120
SAWLNGM29_07930(mfnA)
HALVNGM15_16840(mfnA)
NOUNatoc_0610
HLRHALLA_07900
HLCCHINAEXTREME00545
NAJB1756_06520
NAGAArcMg_0869
NANAArc1_2780
NARAQQ977_09645(mfnA)
NBGDV706_03355(mfnA)
NASGCU68_10160(mfnA)
HDABB347_01045
MELUMTLP_10440
MEUZKRP56_00750(mfnA)
ABIAboo_1436
ACFAciM339_1070
APEAPE_0412
ACJACAM_0297
SMRSmar_1292
SHCShell_1158
DKADKAM_0021
DFDDesfe_0121
DMUDesmu_0192
TAGTagg_0191
THGTCELL_0024
HBUHbut_0224
PDLPyrde_1453
PABIPABY_14200(mfnA)
PAREPYJP_07890
ASCASAC_0977
BARBAOA66_0496(mfnA)
LOKILokiarch_04140(mfnA_1) Lokiarch_53170(mfnA_2)
LOBNEF87_002612
PSYTDSAG12_00578(mfnA)
 » show all
Reference
1  [PMID:18871240]
  Authors
McGILVERY RW, COHEN PP
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J Biol Chem 174:813-6 (1948)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.25
IUBMB Enzyme Nomenclature: 4.1.1.25
ExPASy - ENZYME nomenclature database: 4.1.1.25
BRENDA, the Enzyme Database: 4.1.1.25
CAS: 9002-09-9

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