Entry
Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:
R02080 ];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:
R02701 ]
Reaction(KEGG)
Substrate
Product
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
History
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
Pathway
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K01593 aromatic-L-amino-acid/L-tryptophan decarboxylase
Genes
EPZ : 103558736 103563419(DDC)
NNI : 104017967 104018896(DDC)
ASAO : 132778500(DDC) 132778501
BBUF : 121001140 121002046
BGAR : 122922544 122938153
SANH : 107657571(ddc) 107704081
CCAR : 109066248 109071918(ddc)
CAUA : 113060096 113116177
CGIB : 127974302 128030946
MASI : 127452567 127453616
TBEN : 117480093 117480719 117480720
SLUC : 116035306(ddc) 116055886
ECRA : 117946627(ddc) 117955333
ESP : 116691568(ddc) 116701058
PFLV : 114557608(ddc) 114567147
CLUM : 117745294 117745295 117745296 117745331
SBIA : 133500306 133500409
SASA : 106579919 106605416
STRU : 115177099 115180492
SALP : 111958643 111964972
CCLU : 121570070 121586246
PSPA : 121313363 121314798
ARUT : 117400633 117435476
LCM : 102350005(DDC) 102367294 102367556
LERI : 129710410 129710425
BFO : 118408309 118412535 118413499 118413500 118413733 118413734 118414917 118420118 118421733 118423460
BBEL : 109462022 109471696 109483075
CIN : 100101815(hdcl) 100182530
SCLV : 120344520 120346561 120346790 120346792 120346896
SPU : 577767 581752 593847 757080
LPIC : 129254435 129258521 129275950 129275951 129281727
ARUN : 117290426 117290891 117302638
AJC : 117100623 117112026 117116137
DSI : Dsimw501_GD21778(Dsim_Ddc)
CLON : 129608867 129612370
AALB : 109404792 109423885
ACER : 107999757 107999770
ALAB : 122713101 122713125
AFLR : 100868361 100868484
BBIF : 117206336 117206393
BVAN : 117163449 117163592
BTER : 100648451 100648688
BAFF : 126921167 126921170
BPYO : 122573414 122573606
BPAS : 132916077 132916078
NMEA : 116431039 116431041
CGIG : 122400484 122400485
SOC : 105197233 105197234 105204749 105204753
MPHA : 105829430 105839334
ACEP : 105623398 105623405
PBAR : 105424457 105424468
VEM : 105557138 105557373 105557374 105557375 105562055 105562056 105562059 105566600
PFUC : 122518115 122523221
VCRB : 124423514 124428878
CSOL : 105359909 105360065
TPRE : 106654761 106654798
MDL : 103570951 103575474 103575498
CGLO : 123273230 123274690
FAS : 105273511 105273514 105273550
AGIF : 122847350 122860147
CINS : 118064057 118067252
CCIN : 107266547 107271210 107271211 107271213
AROA : 105689590 105689604 105689616
TCA : 103313065 661842 662962(Ddc)
DPA : 109538660 109538688 109538720
AGRG : 126743567 126743568
ATD : 109605737 109605738 109605745
CSET : 123310894 123310895
LDC : 111507382 111507383 111507384 111513329
DVV : 114324460 114324462 114324464
NVL : 108562887 108562888 108562894
APLN : 108739725 112905435
PPYR : 116163955 116170493 116170495 116170496 116172353
BMAN : 114248386 114252062
MSEX : 115445050 115449403 119190321 119191824
DPL : KGM_211076 KGM_211220
PMAC : 106719984 106720016
PPOT : 106099638 106099799
PRAP : 110999632 111001764
ZCE : 119831691 119832929 119838119 119839558
LSIN : 126968928 126968936
AAGE : 121731215 121731811 121732177
SLIU : 111352315 111352489
ATRA : 106133564 106133592
PXY : 105380304 105380305 105382593
LGLY : 125226872 125227139
CFEL : 113372212 113372213
AGS : 114119005 114119006 114129730
ACOO : 126844922 126847893
BTAB : 109036611 109039294
DCI : 103510318 103520978 103521832 113469315
CLEC : 106665616 106668726 106672560
HHAL : 106680218 106684633(Ddc)
NLU : 111046758 111050012 120354521
TPAL : 117642684 117643101
ZNE : 110834322 110834472 110834487
CSEC : 111869595 111869603
SGRE : 126271954 126271955
BROR : 134531253 134531261
DPX : DAPPUDRAFT_212927 DAPPUDRAFT_300121
DPZ : 124320901 124337572 124343227
HAZT : 108664358 108674168 108682237
PPOI : 119102213 119104015 119108579
TUT : 107361668 107366392 107367452
CSCU : 111633872 111633880
LPOL : 106457524 106460318 106471537 106475989 106476882
PMEO : 129580691 129602224
CEL : CELE_C05D2.3(basl-1) CELE_C05D2.4(bas-1)
CBR : CBG_08967(Cbr-bas-1)
CRQ : GCK72_006042 GCK72_010581 GCK72_010582
BMY : BM_BM1969(Bma-basl-1)
LGI : LOTGIDRAFT_181541 LOTGIDRAFT_201667
PVUL : 126814770 130010397
CANU : 128166335 128191681
CVN : 111110396 111111022 111125148
OED : 125645967 125647889 125680273
PMAX : 117322087 117336550
MCAF : 127705512 127728088
MMER : 123537430 123551151
DPOL : 127837897 127840003 127840771 127843523
MAEA : 128224449 128235966 128241039
OBI : 106872848 106872850 106872852
LAK : 106162865 106180504 106181427
SMM : Smp_130860 Smp_171580
OVI : T265_00374 T265_03298 T265_10507 T265_12524
HMG : 100212300 100214389 100215034
CRB : 17892661 17892851 17893074
CSAT : 104701856 104710884 104747835 104747838 104750587 104766799 104766803
EUS : EUTSA_v10001969mg EUTSA_v10011066mg
BRP : 103828182 103828183 103838003 103842606
BNA : 106357568 106357570 106365219 106365245 106365308 106387342 106445398
BOE : 106306862 106306863 106310637 106315996
RSZ : 108807212 108810635 108823578 108823579 108833165 108834205
CPAP : 110811546 110814945 110816885 110825659
CIT : 102607021 102607468 102609487 102609509 102610100 102616375 102628190 112497549
CIC : CICLE_v10000723mg CICLE_v10014992mg CICLE_v10018100mg CICLE_v10020518mg CICLE_v10025359mg CICLE_v10025447mg CICLE_v10025789mg CICLE_v10033968mg
PVY : 116108066 116121079 116129050 116136764 116143682 116144606 116144741
MINC : 123196097 123206290 123206294 123216013 123218345 123219511 123219665 123219667
TCC : 18599967 18599968 18607061 18607063 18608593 18613049
GRA : 105774012 105775561 105781176 105788558 105798535
GHI : 107895446 107922385 107928801 107934214 107952740 107953442 121203656 121232334
GAB : 108457905 108458473 108463634 108481301 108482315
HSYR : 120113919 120119754 120123808 120134113 120149396 120160506 120160507 120161136 120164917 120171021 120188940 120201709
DZI : 111282679 111286961 111294646 111297134 111305353 111306300 111306301 111306582 111308429
EGR : 104425218 104425219 104444870 104456668
GMX : 100787822 100791074 100795274 100802993
GSJ : 114367137 114387038 114406968 114418337
PVU : PHAVU_001G165600g PHAVU_010G051300g
CCAJ : 109788945 109792523 109804590
APRC : 113851345 113853237 113861307
MTR : 11419480 11423672 11423811 25486293 25486294
PSAT : 127076037 127125965
VVO : 131612418 131616562 131618309 131618310 131622290
LJA : 130726388 130730483 130746221
ADU : 107472983 107478509 107491713
AIP : 107628116 107634365 107636006 107647850
AHF : 112695153 112726397 112733223 112737957 112742213 112758797 112770115 112778706
LANG : 109334832 109355740
PCIN : 129288978 129304604
QSA : O6P43_000647 O6P43_006833 O6P43_013049 O6P43_013050 O6P43_013053 O6P43_013055 O6P43_029135
FVE : 101305252 101305546 101314251
RCN : 112168244 112168752 112173098 112181755 112203105
PPER : 18766828 18774593 18779575 18779803 18782580
PMUM : 103325211 103325216 103329555 103334400 103335900
PAVI : 110747040 110755508 110760942 110771329 110772230
PDUL : 117621945 117624086 117624087 117624088 117624265 117624266 117626583 117631996 117637095
MDM : 103406477 103422211 103448183
MSYL : 126587365 126628141
PXB : 103927974 103954165 103966072
ZJU : 107413947 107416944 107434246 107434923
CSAV : 115696858 115700874 115715119 115721792 115721880 115721881 115721908 115721923 115721953 115723206 115725218 115725219
CMAX : 111466833 111490414 111495556
CMOS : 111434399 111456790 111463789
CPEP : 111783313 111802303 111811913
MEAN : 126656504 126671377
JCU : 105633447 105644464 105645127 105650426
HBR : 110641015 110642708 110652017 110652027 110660093
MESC : 110627254 110628599
POP : 18104108 7459533 7466062 7489641 7490797
PEU : 105108487 105119834 105125654 105132564
PALZ : 118036529 118037453 118047365 118050027 118053337
PNZ : 133668960 133668975 133668990 133692603 133698517
JRE : 108986911 108990273 109011099 109011101 109020052 109020549
CILL : 122275558 122276834 122277235 122279686 122279855 122279964 122305406 122308416
CAVE : 132165824 132166494 132169493 132169494 132171402 132171816 132171964 132181322
QSU : 111984346 111984363 111987515 111987526 111987527 111994300 111994303 111995075 112005716 112006134 112013050 136070715
QLO : 115953605 115957769 115960144 115968103 115988756 115989056 115989354 115991838 115992179 115992366 115992571
TWL : 119990777 120012386 120013678 120013766
VVI : 100240846 100251450 100254909 100263224 100266935
VRI : 117912423 117912433 117912437 117912480 117917492 117923377 117923425
SLY : 101244707 101251901 101263431
SPEN : 107024623 107024697 107031654
SOT : 102587268 102588273 102592946 102600956
SSTN : 125870159 125876172 125876574
CANN : 107842494 107877290 107878308
NTA : 107788484 107792430 107816983 107821692
ITR : 116003616 116010113 116011296
SIND : 105163472 105167277 105175765
OEU : 111370052 111370494 111412252
EGT : 105948748 105948776 105956484
SSPL : 121743435 121745638 121752808 121754257 121757235 121811197 121811678
SMIL : 130985151 130985153
SHIS : 125186894 125187762 125193721 125217952
APAN : 127247165 127249458 127259200
HAN : 110877880 110883291 110898120
ECAD : 122582179 122585360
LSV : 111882896 111882900 111891441 111912552 111916905
CCAV : 112512074 112520219 112520220 112525584
DCR : 108208280 108208398 108208429 108210421 108213431 108213777 108224080
CSIN : 114271054 114306345 114317494
AEW : 130750947 130752079 130762224 130774220 130774279
BVG : 104883300 104899307 104900602 104908309
SOE : 110778374 110797808 110797809 110802302 130470605
CQI : 110689692 110693700 110697752 110711866 110728031
ATRI : 130805690 130813930 130816146 130817294
MOF : 131143848 131143850 131144546 131144558 131144559 131149655 131155814
NNU : 104588789 104600990 104607790 104610815 104612241
MING : 122060463 122064110 122067500 122089879
TSS : 122647191 122651458 122669313
PSOM : 113275368 113282258 113282799 113285898 113286311 113286782 113286784 113286785 113289816 113300024 113300033 113300401 113300565 113315171 113317135 113317142 113328604 113328798 113335689 113336160 113336161 113336168 113336188 113336203 113342821 113347922 113348283 113349080 113349082 113349848 113355340 113355837
OSA : 4343080(TDC2) 4344636 4344637 4348564
OBR : 102709875 102711454 102711724 102717726
OGL : 127753017 127780496 127781273 127782501
BDI : 100822828 100832473 100832786 100833411 100833475 100833712 112271623
ATS : 109734067 109739063 109745201 109748394 109749033 109749204 109751651 109754049 109756139 109756159 109758274 109759289 109759294 109760837 109781101 109782055 109783548 109783549
TDC : 119270969 119272440 119272443 119272550 119279789 119280487 119281836 119289785 119294315 119294322 119294339 119300823 119301313 119301322 119308289 119331582 119331801 119343285 119343286 119344493 119356858 119356859 119358473 119366655 119368619 119368620
TAES : 123039787 123042444 123042445 123050141 123050388 123050389 123056615 123058891 123066046 123067144 123067684 123073661 123075095 123075096 123076403 123082934 123083250 123083251 123086460 123086471 123089769 123089776 123100821 123101854 123103024 123111194 123120269 123133131 123140705 123140709 123150173 123152136 123152137 123152529 123164297 123164463 123165942 123168788 123169195 123170723 123186363 123186364 123186365
TUA : 125508366 125511644 125513004 125519537 125521192 125521529 125522835 125534329 125534331 125534332 125534642 125541537 125547056 125547057 125547470 125547601 125547628 125548916 125549528
LPER : 127307779 127314475 127314479 127314480 127314481 127320993 127333114 127333506
LRD : 124654969 124654976 124654986 124654996 124658894 124677694 124678760 124680876 124683164 124686961 124689943
SBI : 8057946 8067546 8067812 8067813 8072417 8072418
ZMA : 100274380 100279950 100383025 103655034 103655219
MFLO : 136454465 136454468 136472271 136472329 136472331 136472332 136472333 136472335 136480633 136480655 136481126 136482861 136483131 136489473 136489494 136501529 136501733 136501827 136502034 136532582 136541697
SITA : 101762761 101763102 101764227 101765061 101770354 101771186 101780238
SVS : 117833813 117833839 117833892 117834374 117836991 117839863 117845966 117850323 117860074 117860148 117860275 117860289 117866230 117866231 117866385 117866447 117866448 117866450 117866621
PVIR : 120644608 120645130 120645703 120651124 120667347 120677273 120677403 120677426 120677441 120677829 120684476 120693269 120697103 120711361 120713868
PHAI : 112878703 112888143 112897228 112897682 112897684 112901937 112901938 112902810 112903284
PDA : 103709887 103722148 103723655
EGU : 105032787 105043195 105049782 105052686
MUS : 103971698 103990339 103999582
DCT : 110099016 110112714 110115752
PEQ : 110031349 110031367 110034561 110038897
AOF : 109840915 109844790 109849678
MSIN : 131220401 131220753 131237178 131243410 131243583 131244384 131245748
NCOL : 116248435 116251327 116263521 116263822 116265509 116267273
ATR : 18427198 18427200 18444147
SMO : SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
PPP : 112278648 112280792 112280879 112281945
NTE : NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
SMP : 10807560(SMAC4_00940)
FPU : FPSE_07198 FPSE_07361
FVR : FVEG_04215 FVEG_12988
NHE : NECHADRAFT_50494 NECHADRAFT_55523 NECHADRAFT_87083
FFC : NCS54_01275900 NCS54_01379200
FMU : J7337_004217 J7337_013749
TATV : 25778400(TrAtP1_001069)
TASP : 36607869(TrAFT101_001387)
MAW : 19251048(J3458_020515)
PLJ : 28882866(PLICBS_001107)
CDET : 87941882(CDEST_05379)
APUU : APUU_20708A APUU_20727S
PTRR : 6348250(PtrM4_084710)
ZTR : MYCGRDRAFT_108932 MYCGRDRAFT_85159
FFU : CLAFUR5_02598 CLAFUR5_06503
CDEP : 91090119(L203_105911)
KMG : 30161950(I203_107385)
KNE : 92183166(IAR55_005908)
CCAC : CcaHIS019_0511140(CcaverHIS019_0511140)
ABP : AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV : AGABI2DRAFT185212(AGABI2DRAFT_185212)
SCM : SCHCO_02688731(SCHCODRAFT_02688731)
LMAT : 92513912(LSCM1_03867)
LOI : 92358135(LSCM4_02167)
LEIN : 94187209(JIQ42_03532)
PHET : 94289131(JKF63_03032) 94289136(JKF63_03037)
GAI : IMCC3135_01190(ddc_1)
UCY : RF679_06490 RF679_17875
MLN : A9174_03650 A9174_22115
MCI : Mesci_0744 Mesci_4037 Mesci_4422
MCIC : A4R28_04945 A4R28_06845 A4R28_24685
MOP : Mesop_0767 Mesop_4201 Mesop_4873
MAM : Mesau_00744 Mesau_03967
MAMO : A6B35_18470 A6B35_26655
MESW : A9K65_003820 A9K65_022490 A9K65_024435
MESM : EJ066_07305 EJ066_22835
MHUA : MCHK_2408 MCHK_5795
MJR : EB229_03745 EB229_21915
MERD : EB233_03790 EB233_14525 EB233_19095
MOH : IHQ72_03800 IHQ72_20410
MESJ : MJ8_35200 MJ8_50920
EAH : FA04_27405 FA04_32555
RTR : RTCIAT899_CH00080 RTCIAT899_CH03350
RJG : CCGE525_00085 CCGE525_04205
RHR : CKA34_02930 CKA34_06430
RLS : HB780_25900 HB780_29050
RHIB : I8E17_01360 I8E17_17040
BRAD : BF49_5786 BF49_5796
BOY : LQG66_17615 LQG66_29415 LQG66_35925
MAQU : Maq22A_c11740(gadB)
MOC : BB934_25625 BB934_44785
LABT : FIU93_03720(ddc1) FIU93_12310(ddc2)
TSV : DSM104635_00811(ddc_1)
RCON : K3740_16575 K3740_17880
PGA : PGA1_c21340 PGA1_c31390
PGL : PGA2_c01300 PGA2_c20290
PHP : PhaeoP97_00144 PhaeoP97_02098 PhaeoP97_03878
PPIC : PhaeoP14_00109 PhaeoP14_01943
PHQ : D1820_06120 D1820_13830
OCT : FTO60_03345 FTO60_08855
LMD : METH_06295 METH_18575
LEJ : ETW24_07495 ETW24_18115
LAQU : R2C4_11090 R2C4_19610
LEV : ETW23_00040 ETW23_12250
LCAE : K3721_06125 K3721_16370
SINL : DSM14862_01910(ddc_1) DSM14862_02721(ddc_2)
SPSE : SULPSESMR1_00270(ddc)
AHT : ANTHELSMS3_01295 ANTHELSMS3_04336
MALU : KU6B_02650 KU6B_37640
HAT : RC74_15790 RC74_17915
TSCO : R1T40_07880 R1T40_17590
TAW : EI545_00360 EI545_06265
SEDI : EBB79_00445 EBB79_13735
PPSO : QPJ95_06735 QPJ95_15470
PAMO : BAR1_07255 BAR1_13630
THAS : C6Y53_05615 C6Y53_07310
HDH : G5B40_02020 G5B40_02800
GCE : KYE46_05285 KYE46_11645
AORY : AMOR_06780 AMOR_44450
MSD : MYSTI_02418 MYSTI_03144 MYSTI_05417 MYSTI_07043
MLAN : JY572_10720 JY572_32110 JY572_40165
PPAK : JY651_05880 JY651_49080
AGE : AA314_07520 AA314_09087
CFUS : CYFUS_008685 CYFUS_008887
MRM : A7982_09968 A7982_11023 A7982_13446
LLU : AKJ09_09123 AKJ09_09585
HOH : Hoch_1305 Hoch_4065 Hoch_4339 Hoch_6192
SDP : NCTC12225_00163(ddc)
SPIC : SAMEA4384060_0034(ddc)
NAH : F5544_09000 F5544_17480
STRE : GZL_02222 GZL_08019
STRC : AA958_04320 AA958_07535
SNR : SNOUR_09905 SNOUR_10015
SALL : SAZ_01240 SAZ_09825
SVR : CP971_03670 CP971_24285
SBY : H7H31_00060 H7H31_25475
SARM : DVA86_03430 DVA86_05170
KAU : B6264_18860 B6264_28035
KIT : CFP65_1951 CFP65_6901
STRI : C7M71_002030 C7M71_006600 C7M71_029515
AUW : AURUGA1_00257(ddc_1)
PHW : G7075_07170 G7075_09080
AGRA : AGRA3207_000813 AGRA3207_000885
SPIQ : OHA34_00145 OHA34_21380
ACTQ : OG417_27950 OG417_29015
NOA : BKM31_24305 BKM31_57535
NGN : LCN96_22410 LCN96_43325
SACG : FDZ84_04735 FDZ84_08315
AORI : SD37_09875 SD37_28835
PAUT : Pdca_29360 Pdca_29860
KPHY : AOZ06_08735 AOZ06_21715 AOZ06_21970
KBS : EPA93_12700 EPA93_18330 EPA93_30965 EPA93_33925 EPA93_38370 EPA93_44025
UAM : UABAM_02889 UABAM_05662
ABA : Acid345_0934 Acid345_1282 Acid345_2160
ABAC : LuPra_00260(ddc_1) LuPra_06070(ddc_2)
SCOR : J3U87_03535 J3U87_10415 J3U87_24490
GPH : GEMMAAP_10160 GEMMAAP_11960 GEMMAAP_15770
GGR : HKW67_04555 HKW67_17125 HKW67_19605
GBA : J421_0826 J421_5147 J421_5589 J421_6040
PSPC : Strain318_000374 Strain318_002802
FLA : SY85_00410 SY85_10205
ALGO : GYM62_17050 GYM62_17400
MSAA : QYS49_32175 QYS49_32365
CHK : D4L85_02700 D4L85_24115
FUA : LVD17_17005 LVD17_25625
FBC : FB2170_14043 FB2170_15768
ZGA : ZOBELLIA_3227(tyrDC)
MRS : Murru_1972 Murru_2654
FBE : FF125_05270 FF125_13515
CJG : NCTC13459_00607(ddc)
» show all
Taxonomy
Reference
Authors
Christenson JG, Dairman W, Udenfriend S.
Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
Journal
Reference
Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
Title
Aromatic L-amino acid decarboxylase.
Journal
J Biol Chem 237:89-93 (1962)
Reference
Authors
McGILVERY RW, COHEN PP
Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
Journal
J Biol Chem 174:813-6 (1948)
Reference
Authors
SEKERIS CE
Title
[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE].
Journal
Reference
Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
Journal
J Biol Chem 227:617-24 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.28
ExPASy - ENZYME nomenclature database: 4.1.1.28