Entry
Name
phosphoenolpyruvate carboxylase;
phosphopyruvate (phosphate) carboxylase;
PEP carboxylase;
phosphoenolpyruvic carboxylase;
PEPC;
PEPCase;
phosphate:oxaloacetate carboxy-lyase (phosphorylating)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
phosphate:oxaloacetate carboxy-lyase (adding phosphate, phosphoenolpyruvate-forming)
Reaction(IUBMB)
phosphate + oxaloacetate = phosphoenolpyruvate + HCO3- [RN:
R00345 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme replenishes oxaloacetate in the tricarboxylic acid cycle when operating in the reverse direction. The reaction proceeds in two steps: formation of carboxyphosphate and the enolate form of pyruvate, followed by carboxylation of the enolate and release of phosphate.
History
EC 4.1.1.31 created 1961, modified 2011
Pathway
ec00710 Carbon fixation by Calvin cycle
ec00720 Other carbon fixation pathways
ec01120 Microbial metabolism in diverse environments
Orthology
K01595 phosphoenolpyruvate carboxylase
Genes
ATH : AT1G53310(PPC1) AT1G68750(PPC4) AT2G42600(PPC2) AT3G14940(PPC3)
ALY : 9316063 9318970 9323269 9326740 9327804
CRB : 17887798 17893851 17894524 17897085 17898308
CSAT : 104699409 104742851 104743532 104745776 104750713 104750720 104756949 104758678 104767516 104776677 104778268 104779660 104785107 104787928
EUS : EUTSA_v10006672mg EUTSA_v10011967mg EUTSA_v10016192mg EUTSA_v10018058mg EUTSA_v10019997mg
BRP : 103830950 103832677 103840598 103859599 103865958 103866650 103869972
BNA : 106347139 106347257 106357095 106360421 106377292 106389197 106391718 106391948 106397771 106401322 106402989 106409956 106439388 106447588 106450613 125575183
BOE : 106295413 106298591 106299044 106330245 106334995 106341751 106341866 106343581
RSZ : 108808926 108816352 108822275 108831926 108832273 108854419 108861345 130495043 130505820
THJ : 104802255 104804737 104808410 104815570 104822563 104823477
CPAP : 110810919 110814687 110824156
CIT : 102607204 102608170 102616036
CIC : CICLE_v10014164mg CICLE_v10018719mg CICLE_v10030580mg
PVY : 116110243 116124997 116132097 116143123
MINC : 123196822 123201910 123209371 123216754
TCC : 18594176 18610565 18612050
GRA : 105763582 105764585 105778235 105782238 105792815 105798019
GHI : 107888527 107895337 107909179 107915834 107917197 107920383 107928294 107934792 107946467
GAB : 108456860 108464465 108469879 108478774 108479688 108483247
HSYR : 120118583 120122779 120122890 120127864 120140233 120149762 120155432 120174492 120177628 120187330 120190405
DZI : 111275904 111282170 111292011 111298852 111299714 111317769
EGR : 104433317 104441293 104448531
GMX : 100785020 100805069(PPC1) 100807407 100812219 100820574 547456(PEPC7) 547755(PEPC17) 547756(PEPC4) 547769(PEPC16)
GSJ : 114369607 114375715 114376254 114380060 114380170 114380578 114388461 114414168 114416788 114417103
PVU : PHAVU_003G024800g PHAVU_005G066400g PHAVU_005G095300g PHAVU_007G101300g PHAVU_011G130400g PHAVU_011G160200g
VRA : 106753186 106756025 106760805 106770762 106777342 106778590
VAR : 108325999 108334122 108334199 108335310 108340321 108340357
VUN : 114169289 114169911 114173162 114185191 114186204 114191463
VUM : 124822808 124828634 124829588 124836697 124848039 124848707
CCAJ : 109792814 109805576 109810364 109810580 109811930 109815935
APRC : 113856059 113856485 113857392 113865560 113869612 113872516
MTR : 11405385 11407264 11409065 11413239 25479382 25502534
TPRA : 123893968 123895064 123904469 123906435 123920091
CAM : 101494422 101496857 101497901 101500264 101510288 101514127
PSAT : 127075353 127086214 127086986 127094322 127101245 127119003
VVO : 131602367 131620382 131626761 131632205 131643770 131648736 131653424 131653798
LJA : 130717831 130739612 130742533 130745877 130748280
ADU : 107462399 107468012 107478041 107478413 107491025
AIP : 107612799 107617655 107624747 107630016 107630060 107641982
AHF : 112703613 112707195 112712697 112726646 112737759 112737922 112750510 112771402 112775370 112789888 112790064 112802704
LANG : 109325302 109334133 109336179 109345927 109348106 109351866 109351938 109355083 109357617
PCIN : 129297958 129311240 129313078 129315499 129315500
QSA : O6P43_000822 O6P43_001035 O6P43_025653 O6P43_028914 O6P43_029178 O6P43_032811
FVE : 101292407 101300243 101307132 101309134
RCN : 112185773 112185818 112199861 112201512
PPER : 18779393 18781777 18791377
PMUM : 103326102 103328478 103341411
PAVI : 110757730 110758170 110764337
PDUL : 117614974 117621199 117621224 117626410
MDM : 103402738 103427458 103431561 103432220 103432225 103448757 103451698
MSYL : 126582449 126589924 126594878 126608729 126612062 126615261
PXB : 103926889 103929215 103932207 103934290 103940054 103945414 103946931 103947929
ZJU : 107417169 107429574 107432540
MNT : 21393637 21401626 21408511
CSAV : 115697730 115699459 115701041
CSV : 101208202(PPC2) 101208329 101216256(PPC3)
CMO : 103495501 103501810 103504604
BHJ : 120077815 120085745 120092921
MCHA : 111016801 111016802 111023897 111025911
CMAX : 111468110 111468898 111476821 111480367 111485935
CMOS : 111435692 111437177 111443191 111446002 111455185
CPEP : 111787976 111793177 111796737 111808554 111811405
RCU : 8269491 8285021 8287235
MEAN : 126667617 126673823 126676614
JCU : 105635703 105639215 105641960
HBR : 110642491 110649758 110654250 110665035 110670314
MESC : 110600619 110601178 110609524 110612300 110616611
POP : 18095497 7458241 7472353 7485946 7489379
PEU : 105111755 105114056 105116468 105119321 105123436 105129276
PALZ : 118039984 118043397 118044184 118047465
PNZ : 133672496 133692441 133696830 133703319 133704817
JRE : 108981819 108982573 108992417 109012286 109015115
CILL : 122281705 122289642 122304106 122310971 122313529
CAVE : 132175815 132177372 132180458
QSU : 112001951 112006698 112032494
QLO : 115957493 115957646 115981904
TWL : 119982176 119988729 119989540 120016862
VVI : 100233103 100247335 100267525
VRI : 117908640 117914506 117927252
SLY : 101245149 101248407 101260311 101261166 101267723(ppc2)
SPEN : 107002302 107007110 107018204 107024206 107025804
SOT : 102585000 102586589 102599595 102603323(PEPC) 102605963(ppc)
SSTN : 125856414 125865689 125866682 125876884 125877954
SDUL : 129870169 129871749 129876011 129891265 129893184
CANN : 107845307 107854728 107870777 107878436 107878607
LBB : 132613835 132616931 132617220 132629056 132636424
NTA : 107759530 107762239 107763355 107777405(PEPC) 107798381 107799672 107807412 107825450 107830003 107830408
NSY : 104214281 104214918 104217758 104232293 104242254
NTO : 104093879 104098299 104099403 104101422 104107812
NAU : 109218126 109226677 109229179 109229245 109240245
INI : 109150577 109155834 109171706 109176046 109187459 109188085
ITR : 115996577 116001969 116011350 116022709 116025020 116026800
SIND : 105156431 105165441 105176938 105178436
OEU : 111365313 111368882 111370829 111372068 111372069 111391584 111398959
EGT : 105953805 105968070 105970377 105974698
SSPL : 121741783 121744283 121757026 121768063 121768276 121770805 121775059 121777107 121802665 121809756
SMIL : 130986903 131009160 131012072 131024455
SHIS : 125187701 125194475 125196034 125204763 125210258 125215187
APAN : 127240407 127261393 127265902 127266159
HAN : 110872125 110885880 110897458 110909114 110912914 110921549 110929879
ECAD : 122592649 122596052 122598452 122600164 122600661
LSV : 111889306 111893411 111910462 111913734
CCAV : 112500213 112506520 112516575 112523572 112525386
DCR : 108200258 108217635 108223042 108227406
CSIN : 114257092 114260553 114262823 114268510 114292998 114302707
RVL : 131300866 131321745 131323397 131331530
AEW : 130751866 130755241 130765894
BVG : 104891399 104896344 104903486
SOE : 110782664 110789583 110804099
CQI : 110685976 110686221 110691154 110720234 110735356 110737782
ATRI : 130806734 130807487 130817473 130821049
MOF : 131146517 131147704 131154103
NNU : 104600964 104603083 104611594 104613119
MING : 122059564 122064831 122079882 122088283
TSS : 122641100 122650321 122664089
PSOM : 113275659 113277292 113297019 113302232 113344429 113354474
OSA : 4325309 4325531 4326138 4328859 4345387 4346699
OBR : 102700381 102703887 102708123 102709305 102711100
OGL : 127761861 127762280 127781743 127782455 127782709 127784473
BDI : 100821713 100829108 100836533 100842943 100843249 100845336
ATS : 109749320 109758293 109770097 109776770 109783802 109787299
TDC : 119267516 119269045 119275450 119277043 119280409 119301282 119308818 119316795 119322500 119332058 119338038
TAES : 123057453 123060630 123062103 123064236 123069256 123070833 123073572 123077770 123079223 123103489 123121238 123127443 123137097 123144536 123147894 123156484 123164058 543328
TUA : 125512544 125517428 125520902 125542213 125544794 125547463
LPER : 127300633 127313955 127320969 127340731 127341737 127343950
LRD : 124653768 124658089 124658931 124659281 124660494 124661280 124664571 124691492 124692117 124692779
SBI : 8058886 8065472 8069872 8078313 8079083 8079221
ZMA : 100191460 100384708 103649899 542372 542393 542479
MFLO : 136450465 136450586 136466901 136466952 136476140 136476197 136502327 136519769 136526705 136541847 136549750
SITA : 101752877(PPC1) 101754610 101764206 101776545 101778256
SVS : 117835252 117843888 117854270 117858341 117858575
PVIR : 120655242 120670681 120672408 120675608 120695745 120703648 120708105 120710501
PHAI : 112883000 112889660 112893376 112894832 112903677
PDA : 103701209 103705833 103709462 103724317
EGU : 105040616 105047390 105058702
MUS : 103969201 103980906 103987812 103989174 103992398 103997092
ZOF : 121971691 121975962 121981604 121981606 121985478 122001100 122002305 122002596 122005383 122006563 122006839 122009821 122010374 122014573 122016838 122020858 122024294 122040435
AOF : 109839875 109845743 109848266
MSIN : 131235429 131237767 131241000 131245379
NCOL : 116259498 116260312 116262155 116266835
SMO : SELMODRAFT_111216 SELMODRAFT_115610 SELMODRAFT_117085 SELMODRAFT_122213 SELMODRAFT_148941 SELMODRAFT_269944 SELMODRAFT_443218 SELMODRAFT_447920
PPP : 112282298 112282764 112283440 112286857 112292080 112293719
CRE : CHLRE_11g476325v5 CHLRE_16g673852v5
VCN : VOLCADRAFT_56464 VOLCADRAFT_59445
CSL : COCSUDRAFT_15132 COCSUDRAFT_52173
CVR : CHLNCDRAFT_37051 CHLNCDRAFT_58769
PLAG : 39744205(PADL01_1426500)
PMAL : PMUG01_13033400(PEPC)
PBRS : 92373055(MKS88_004968)
PREL : PRELSG_1324500(PEPC)
PTI : PHATRDRAFT_51136(PEPCase_2)
FCY : FRACYDRAFT_259279(PEPC1)
TPS : THAPSDRAFT_34543(PPC2)
EHX : EMIHUDRAFT_521922 EMIHUDRAFT_66604
GTT : GUITHDRAFT_105170 GUITHDRAFT_121941
ECOO : ECRM13514_5074(ppc)
ECOH : ECRM13516_4810(ppc)
EDJ : ECDH1ME8569_3824(ppc)
REE : electrica_04941(ppc)
RTG : NCTC13098_07088(ppc)
CLAP : NCTC11466_04481(ppc)
KIE : NCTC12125_03655(ppc)
AHN : NCTC12129_04815(ppc_2)
METY : MRY16398_54920(ppc)
PSHI : SAMEA2665130_2840(ppc)
YPI : YpsIP31758_0125(ppc)
SFJ : SAMEA4384070_4717(ppc)
SOF : NCTC11214_01518(ppc)
PARL : PEC302110_01210(ppc)
TPTY : NCTC11468_03676(ppc_1)
PHEI : NCTC12003_03837(ppc)
PRJ : NCTC6933_03861(ppc_1)
LRI : NCTC12151_00114(ppc)
HPIT : NCTC13334_01698(ppc)
HHZ : NCTC10839_01235(ppc)
HAEG : NCTC8502_01356(ppc)
ALIG : NCTC10568_01184(ppc)
RPNE : NCTC8284_02224(ppc_2)
PAET : NCTC13378_00999(ppc)
XFU : XFF4834R_chr08120(ppc)
XPH : XppCFBP6546_07410(ppc)
LAQ : GLA29479_2594(ppc) GLA29479_5014
DJI : CH75_00475 CH75_23560
VAU : VANGNB10_cI2399(ppc)
VPL : SA104470976_00185(ppc)
VIB : VspSTUT11_02450(ppc)
VIS : VspSTUT16_02730(ppc)
PPUD : DW66_1103 DW66_1437
PPRC : PFLCHA0_c11670(ppc)
PFC : PflA506_1134 PflA506_1202(ppc)
POI : BOP93_05930 BOP93_13200
PMUD : NCTC8068_01152(ppc)
PFW : PF1751_v1c11870(ppc)
PANR : A7J50_1285 A7J50_2326
PTAE : NCTC10697_03484(ppc)
ABER : BSR55_01180 BSR55_20960
SCAA : TUM17387_02370(ppc)
LCJ : NCTC11976_01245(capP)
NWR : E3U44_08410 E3U44_09630
HHK : HH1059_01660(ppc_1) HH1059_13220(ppc_2)
ALCA : ASALC70_00977(ppc_2)
AEL : NCTC12917_03636(ppc)
CHJ : NCTC10426_01670(ppc)
NMQ : NMBM04240196_2003(ppc)
NWE : SAMEA3174300_1524(ppc)
NZO : SAMEA4504057_1936(ppc)
NCI : NCTC10296_00116(ppc)
NCZ : NCTC10294_01383(ppc)
NANI : NCTC12227_00288(ppc)
ECOR : SAMEA4412678_0168(ppc)
CHIZ : HQ393_08185(ppc) HQ393_17405(ppc)
BPM : BURPS1710b_1228(ppc)
BPL : BURPS1106A_1075(ppc)
BUE : BRPE67_ACDS06220(ppc)
BCAI : K788_0001578 K788_0008096
PHS : C2L64_12250 C2L64_21710
PTER : C2L65_11370 C2L65_26285 C2L65_32970
PSAA : QEN71_24950(ppc) QEN71_33980
PPAI : E1956_14365 E1956_20565
PLG : NCTC10937_01440(ppc)
BUO : BRPE64_ACDS06830(ppc)
LIMN : HKT17_00375(ppc) HKT17_09240
LTO : RGQ30_00670(ppc_1) RGQ30_18890(ppc_2)
BTRM : SAMEA390648701557(ppc)
AXX : ERS451415_05637(ppc)
HCZ : G9Q37_01155(ppc) G9Q37_03295(ppc)
METP : C1M51_04615 C1M51_05900
RBN : RBXJA2T_10514 RBXJA2T_17554
SMIO : CATMQ487_44600(ppc)
JAZ : YQ44_10920 YQ44_18010
JAL : BZG29_09910 BZG29_16665
JSV : CNX70_10520 CNX70_16995
JAS : FJQ89_06110 FJQ89_27005
JLV : G3257_10260(ppc) G3257_17365(ppc)
JAH : JAB4_021240(ppc_1) JAB4_034150(ppc_2)
JRI : P9875_10600(ppc) P9875_17285(ppc)
MALI : EYF70_10595 EYF70_19275
MUM : FCL38_07965 FCL38_29870
PLUE : EWM63_01135 EWM63_04050
TMJ : P0M04_16990(ppc) P0M04_31835(ppc)
METR : BSY238_254 BSY238_2762
URU : DSM104443_04252(ppc)
UPL : DSM104440_03774(ppc)
APET : ToN1_34430(ppc1) ToN1_43410(ppc2)
AZA : AZKH_0912(ppc) AZKH_2722
AZR : CJ010_06005 CJ010_11970
THAG : CKCBHOJB_01054(ppc)
RBS : RHODOSMS8_02631(ppc)
BCAN : BcanWSM471_14060(ppc)
LNE : FZC33_03925 FZC33_34205
MEA : Mex_1p1732(ppc) Mex_1p4982
MDI : METDI2484(ppc) METDI5584
MZA : B2G69_04640 B2G69_16665
MRD : Mrad2831_3664 Mrad2831_5111
META : Y590_08610 Y590_23210
MAQU : Maq22A_c00515 Maq22A_c19255(ppc)
MPHY : MCBMB27_03146 MCBMB27_04553
METD : C0214_10375 C0214_24940
METX : A3862_05585 A3862_13165
METI : DK427_05705 DK427_15550
MMES : MMSR116_21310 MMSR116_28840
MTEA : DK419_14285 DK419_20550
MIND : mvi_14300 mvi_28870
MOG : MMB17_01145 MMB17_06405
MTAD : M6G65_20425 M6G65_30175
MTUN : MTUNDRAET4_3197(ppc) MTUNDRAET4_3403(ppc)
MEDK : QEV83_00365(ppc) QEV83_04545
METG : HT051_02840 HT051_06790
MSC : BN69_1172(ppc) BN69_1789(ppc)
MBRY : B1812_17540 B1812_20705
MROS : EHO51_00335 EHO51_12190
MHEY : H2LOC_011810 H2LOC_017280
MPAR : F7D14_03445 F7D14_09170
MIWA : SS37A_06310(ppc) SS37A_07180
MTW : CQW49_05095 CQW49_12230
MECQ : MSC49_04620 MSC49_21690(ppc)
HDI : HDIA_0056(ppc_1) HDIA_4146(ppc_2)
PZU : PHZ_c1154(ppc) PHZ_p0099
BVY : NCTC9239_03132(ppc_1) NCTC9239_03133(ppc_2)
TSV : DSM104635_01047(ppc)
PSAP : JHX88_17865 JHX88_20285
SYA : A6768_11120 A6768_18430
SCLO : SCLO_1020520 SCLO_1020530
SFLA : SPHFLASMR4Y_01857(ppc)
GBE : GbCGDNIH1_0054 GbCGDNIH1_1334
GBH : GbCGDNIH2_0054 GbCGDNIH2_1334
GBC : GbCGDNIH3_0054 GbCGDNIH3_1334
GBS : GbCGDNIH4_0054 GbCGDNIH4_1334
SKT : IGS68_06450 IGS68_33195(ppc)
SMUC : JL100_021150 JL100_033250(ppc)
SROE : JL101_019865 JL101_030690(ppc)
HSH : NHP194022_01780(ppc)
AVM : JQX13_14480 JQX13_35615
BKW : BkAM31D_01650(ppc_1) BkAM31D_10395(ppc_2)
BLEN : NCTC4824_01901(ppc)
GMO : NCTC11323_01031(ppc)
GHA : NCTC10459_01082(ppc)
COHN : KCTCHS21_53840(ppc)
SPH : MGAS10270_Spy0499(ppc)
SPI : MGAS10750_Spy0524(ppc)
SPJ : MGAS2096_Spy0516(ppc)
SPK : MGAS9429_Spy0495(ppc)
SNV : SPNINV200_11370(ppc)
SNC : HMPREF0837_11418(ppc)
SPNG : HMPREF1038_01112(ppc)
SPNE : SPN034156_00670(ppc)
SPNU : SPN034183_09790(ppc)
SPNM : SPN994038_09680(ppc)
SPNO : SPN994039_09690(ppc)
SMC : SmuNN2025_1290(capP)
SGG : SGGBAA2069_c15370(ppc)
SCP : HMPREF0833_10860(ppc)
SVB : NCTC12167_00759(ppc)
SMEN : SAMEA4412692_0390(ppc)
SFER : NCTC12278_01332(ppc)
SCAI : NCTC12191_02011(ppc)
SPSU : NCTC13786_01913(ppc)
SPOC : NCTC10925_01244(ppc)
SAUP : NCTC3168_01365(ppc)
SURN : NCTC13766_01454(ppc)
SMIE : NCTC11169_01178(ppc)
LPW : LpgJCM5343_08580(ppc)
ECEC : NCTC12421_00973(ppc)
AUR : HMPREF9243_1989(ppc)
MBAI : MB901379_02075(ppc)
MKY : IWGMT90018_35350(ppc)
MPHL : MPHLCCUG_02903(ppc)
MAUU : NCTC10437_02544(ppc)
MFLV : NCTC10271_02860(ppc)
MSAL : DSM43276_04564(ppc)
CDIP : ERS451417_01037(ppc)
CUJ : CUL131002_1199c(ppc)
CVT : B843_04010 B843_07405
CMIN : NCTC10288_02023(ppc)
CCYS : SAMEA4530656_1040(ppc_1) SAMEA4530656_1700(ppc_2)
NFR : ERS450000_02179(ppc)
NAD : NCTC11293_03039(ppc)
NWL : NWFMUON74_23980(ppc)
NSPU : IFM12276_42640(ppc)
ROA : Pd630_LPD03928 Pd630_LPD14015
RCR : NCTC10994_00609(ppc)
RPSK : JWS13_00925(ppc) JWS13_06605(ppc)
RANT : RHODO2019_17420(ppc)
SLE : sle_41520(sle_41520)
SGM : GCM10017557_32500(ppc)
STUI : GCM10017668_28380(ppc)
SGOB : test1122_09055(ppc)
SXT : KPP03845_103229(ppc)
AMAV : GCM10025877_20530(ppc)
AAGI : NCTC2676_1_00362(ppc)
SERW : FY030_03870 FY030_10205
DCO : SAMEA4475696_1846(ppc)
TEZ : BKM78_09020 BKM78_09690
TLA : TLA_TLA_01821(ppc_1) TLA_TLA_01957(ppc_2)
NAQU : ENKNEFLB_04037(ppc)
MSAG : GCM10017556_34230(ppc)
ACTR : Asp14428_36960(ppc)
BBV : HMPREF9228_0044(ppc)
GVG : HMPREF0421_20155(ppc)
GVA : HMPREF0424_0018(ppc)
GVH : HMPREF9231_0029(ppc)
BALA : DSM104299_05301(ppc)
SYNW : SynWH8103_02354(ppc)
TVN : NIES2134_118420(ppc)
LET : O77CONTIG1_00648(ppc)
CHON : NIES4102_00440(ppc)
SYP : SYNPCC7002_A1414(ppc)
NSPH : BDGGKGIB_00924(ppc)
RRS : RoseRS_2753 RoseRS_3110
CHL : Chy400_3413 Chy400_4202
UAM : UABAM_00251 UABAM_06334
SDJ : NCTC13534_04282(ppc)
STHA : NCTC11429_03171(ppc)
MDA : IPZ59_14760 IPZ59_16760
FGL : EM308_10415 EM308_12235