Entry
Name
acetolactate decarboxylase;
alpha-acetolactate decarboxylase;
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase;
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming];
(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(3R)-3-hydroxybutan-2-one-forming]
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(2S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(3R)-3-hydroxybutan-2-one-forming]
Reaction(IUBMB)
(2S)-2-hydroxy-2-methyl-3-oxobutanoate = (3R)-3-hydroxybutan-2-one + CO2 [RN:
R02948 ]
Reaction(KEGG)
Substrate
(2S)-2-hydroxy-2-methyl-3-oxobutanoate [CPD:
C06010 ]
Product
History
EC 4.1.1.5 created 1961
Pathway
ec00660 C5-Branched dibasic acid metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K01575 acetolactate decarboxylase
Genes
REE : electrica_02169(alsD)
RTG : NCTC13098_03200(aldB_3)
CLAP : NCTC11466_02429(aldB_2)
KIE : NCTC12125_02731(aldB)
SFJ : SAMEA4384070_3564(aldB_2)
SOF : NCTC11214_03230(aldC) NCTC11214_03231(aldB_1)
SSAR : SSARUM_003422(budA)
SERA : Ser39006_021815(budA)
PAQU : DMB82_0003780(budA)
PARL : PEC302110_06480(budA)
DIC : Dpoa569_003305(budA)
ETA : ETA_00110(budA) ETA_pET460240(aldC)
PLF : PANA5342_p10070(budA)
PVA : Pvag_pPag10119(alsD)
TPTY : NCTC11468_01664(aldB)
ADP : NCTC12871_01444(aldC)
VAU : VANGNB10_cII0926(aldC)
VPL : SA104470976_01314(aldB)
PMAI : CF386_08780 CF386_09640 CF386_12460
LJR : NCTC11533_02249(aldB)
LSS : NCTC12082_00913(aldB)
LADL : NCTC12735_00385(aldB)
TFRI : Thiofri_02778(alsD)
GAI : IMCC3135_15705(aldB) IMCC3135_28400(alsD)
NBA : CUN60_02875(budA) CUN60_11580(budA)
BAZ : BAMTA208_18235(alsD)
BSON : S101395_00547(alsD)
SAH : SaurJH1_2275 SaurJH1_2677
SAJ : SaurJH9_2236 SaurJH9_2623
SAC : SACOL2198(budA1) SACOL2617(budA2)
SAX : USA300HOU_2201(alsD)
SAA : SAUSA300_2165(budA) SAUSA300_2536(budA)
SAO : SAOUHSC_02467 SAOUHSC_02921
SAE : NWMN_2110(alsD) NWMN_2498(aldB)
SAD : SAAV_2267(budA1) SAAV_2667(budA2)
SUU : M013TW_2173(budA) M013TW_2578(budA)
SUV : SAVC_09920 SAVC_11875
SUE : SAOV_2251c SAOV_2645c
SUJ : SAA6159_02118(budA) SAA6159_02497(budA)
SUK : SAA6008_02247(budA1) SAA6008_02658(budA2)
SUC : ECTR2_2067(budA) ECTR2_2455(budA)
SUT : SAT0131_02382 SAT0131_02833
SUQ : HMPREF0772_10591(budA) HMPREF0772_10985(budA)
SUD : ST398NM01_2267 ST398NM01_2649
SUX : SAEMRSA15_21130 SAEMRSA15_25040
SUW : SATW20_23440 SATW20_27400
SUG : SAPIG2267(budA) SAPIG2649(budA)
SUF : SARLGA251_20000 SARLGA251_23740
SAUA : SAAG_00040 SAAG_00419
SAUE : RSAU_002049(budA) RSAU_002442(budA)
SAUN : SAKOR_02174 SAKOR_02594
SAUS : SA40_1960 SA40_2355
SAUU : SA957_2044 SA957_2439
SAUG : SA268_2115 SA268_2537
SAUZ : SAZ172_2309 SAZ172_2719
SAUT : SAI1T1_2016420(budA1) SAI1T1_2019420
SAUJ : SAI2T2_1016430(budA1) SAI2T2_1019430
SAUK : SAI3T3_1016420(budA1) SAI3T3_1019420
SAUQ : SAI4T8_1016430(budA1) SAI4T8_1019430
SAUV : SAI7S6_1016420 SAI7S6_1019420
SAUW : SAI5S5_1016360 SAI5S5_1019360
SAUX : SAI6T6_1016370 SAI6T6_1019370
SAUY : SAI8T7_1016400 SAI8T7_1019400
SAUF : X998_2193(budA) X998_2583(budA)
SUY : SA2981_2143 SA2981_2539
SAUB : C248_2249 C248_2660
SAUM : BN843_22480 BN843_26370
SAUC : CA347_2295(budA) CA347_2677(budA)
SAUR : SABB_01455 SABB_02012
SAUI : AZ30_11670 AZ30_13610
SAUD : CH52_06000 CH52_07920
SAMS : NI36_10900 NI36_13035
SUH : SAMSHR1132_20370 SAMSHR1132_24160
SSD : SPSINT_0223 SPSINT_2257
SDT : SPSE_0211 SPSE_2236(budA)
SDP : NCTC12225_00259(aldC) NCTC12225_02442(budA)
SSCH : LH95_01395 LH95_10480
SSCZ : RN70_01740 RN70_11215
SCHR : DWB92_01220 DWB92_01380(budA)
SARL : SAP2_01120 SAP2_05070
SPIC : SAMEA4384060_0568(aldC)
SSH : NCTC13712_02156(aldC_1) NCTC13712_02554(aldC_2)
SSIM : SAMEA4384339_2399(aldC)
SLLO : ISP08_00605(budA) ISP08_00725(budA)
SCAQ : QMO72_00245(budA) QMO72_02250(budA)
SROT : ML435_10590(budA) ML435_12525(budA)
SFF : FOB90_06395 FOB90_08965(budA)
LGZ : NCTC10812_00836(aldB)
PPQ : PPSQR21_021290(alsD)
PSTE : PSTEL_13915 PSTEL_13920
PNK : AASFL403_13945(budA)
LLA : L0321(aldB) L0322(aldC)
LLK : LLKF_1134(aldC) LLKF_1271(aldB)
LLT : CVCAS_1080(aldC) CVCAS_1194(aldB)
LLS : lilo_1010(aldC) lilo_1117(aldB)
LLD : P620_06015 P620_06980(budA)
LLX : NCDO2118_1110(aldC) NCDO2118_1238(aldB)
LLJ : LG36_1172(aldB) LG36_1271(aldC)
LLM : llmg_1275(aldB) llmg_1464(aldC)
LLN : LLNZ_06580 LLNZ_07545
LLI : uc509_1108(aldC) uc509_1244(aldB) uc509_p8046(aldC)
LACT : D7I46_03690 D7I46_03795(budA)
LACK : FLP15_08710 FLP15_08815(budA)
LTI : JW886_05475 JW886_05870(budA)
LPET : lgb_00881(aldC_1) lgb_01057(aldC_2)
LFO : LMK00_04995 LMK00_05890(budA)
SNV : SPNINV200_12360(aldB)
SNC : HMPREF0837_11155(budA)
SPNG : HMPREF1038_01380(aldB)
SPNE : SPN034156_03110(aldB)
SPNU : SPN034183_12230(aldB)
SPNM : SPN994038_12120(aldB)
SPNO : SPN994039_12130(aldB)
SMC : SmuNN2025_0654(aldB)
SGG : SGGBAA2069_c08150(aldB)
SCP : HMPREF0833_10830(budA)
SVB : NCTC12167_00911(alsD)
SFER : NCTC12278_00725(alsD) NCTC12278_00729(aldC)
SPSU : NCTC13786_00438(aldB)
SPOC : NCTC10925_00760(aldB)
SAUP : NCTC3168_01395(aldB)
SURN : NCTC13766_01367(aldB)
SVF : NCTC3166_01353(aldB)
SMIE : NCTC11169_00575(aldB)
LPW : LpgJCM5343_10360(alsD)
LRU : HMPREF0538_21279(budA)
LBN : LBUCD034_0051(aldB1) LBUCD034_0198(aldB2)
LPAR : FAM21731_00816 FAM21731_00979
LKF : DNL43_05285(budA) DNL43_05890(budA)
LHO : LOOC260_108560(aldB)
LSU : A6B45_02665 A6B45_04570
LPSE : FGL85_05265(budA) FGL85_07280(budA)
WCB : AO080_04355 AO080_07135
WJO : FOL01_1292 FOL01_1600
WPA : CO680_00830(budA) CO680_02445(budA)
LBE : MOO44_00955(budA) MOO44_04085(budA)
EFU : HMPREF0351_11759(alsD)
ECEC : NCTC12421_00476(aldC)
PTH : PTH_2318(AlsD) PTH_2358(AlsD)
AWI : CHL1_001620(budA) CHL1_002792
SRI : SELR_pSRC100420 SELR_pSRC101200(aldB) SELR_pSRC200150(aldB) SELR_pSRC200220(aldB)
SATR : SATRI_v1c12390(alsD)
SERI : SERIO_v1c12100(alsD)
SPRN : S100390_v1c10220(alsD)
SPIT : STU14_v1c10220(alsD)
SCHI : SCHIN_v1c02870(alsD)
SPLT : SPLAT_v1c05040(alsD)
CDIP : ERS451417_00893(alsD)
COI : CPCIP5297_04115(budA)
CUN : Cul210932_0874(alsD)
CUQ : Cul210931_0836(alsD)
CUJ : CUL131002_0852c(alsD)
CMIN : NCTC10288_01976(alsD)
CRL : NCTC7448_01655(alsD)
CART : PA27867_0370 PA27867_0967
CRY : B7495_01835(budA) B7495_04925(budA)
RDN : HMPREF0733_10018(budA)
PAUS : NCTC13651_01348(aldB)
PPC : HMPREF9154_3152(budA)
BBV : HMPREF9228_1697(budA)
SYR : SynRCC307_1716(alsD)
LCRE : Pla8534_37060(aldB)
AGV : OJF2_44260(aldB) OJF2_77410(alsD)
PCOR : KS4_36180(aldB_1) KS4_36230(aldB_2)
GRW : FTO74_09590(budA) FTO74_10605(budA)
ELB : VO54_00112(aldB) VO54_02747(alsD)
EGM : AYC65_04995 AYC65_18175
MBA : Mbar_A2915 Mbar_A2916
MAC : MA_3744(aldC) MA_3746(aldC)
MCHK : MchiMG62_09560(alsD)
» show all
Taxonomy
Reference
1
Authors
Hill RK, Sawada S, Arfin SM.
Title
Stereochemistry of valine and isoleucine biosynthesis. IV. Synthesis, configuration, and enzymatic specificity of alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate.
Journal
Bioorg Chem 8:175-189 (1979)
Reference
Authors
Stormer FC.
Title
Isolation of crystalline pH 6 acetolactate-forming enzyme from Aerobacter aerogenes.
Journal
J Biol Chem 242:1756-9 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.5
ExPASy - ENZYME nomenclature database: 4.1.1.5
BRENDA, the Enzyme Database: 4.1.1.5