KEGG   ENZYME: 4.1.1.53
Entry
EC 4.1.1.53                 Enzyme                                 
Name
phenylalanine decarboxylase;
L-phenylalanine decarboxylase;
aromatic L-amino acid decarboxylase (ambiguous);
L-phenylalanine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-phenylalanine carboxy-lyase (phenylethylamine-forming)
Reaction(IUBMB)
L-phenylalanine = phenylethylamine + CO2 [RN:R00699]
Reaction(KEGG)
R00699
Substrate
L-phenylalanine [CPD:C00079]
Product
phenylethylamine [CPD:C05332];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also acts on tyrosine and other aromatic amino acids.
History
EC 4.1.1.53 created 1972
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
Orthology
K22427  phenylalanine decarboxylase
Genes
LSM121118260 121121568
SLY101248029 101248320 101248599 101249664 101263045 101264847 101265155 101265461 101265757 101268488 544085(hdc) 778254(AADC1A) 778255(AADC1B) 778256(AADC2)
SPEN107026800 107026802 107027073 107027079 107027080 107027236 107027252 107027311 107027331 107027771 107027995 107028163
SOT102579202 102579840 102580376 102581292 102581308 102581623 102581954 102582616 102591703 102591875 102592044 102594070
CANN107845032 107848433 107854628 107879725
NTA107760316(hdc) 107768931 107789682 107795329 107800126 107800924 107804556 107809914 107812155
NSY104220279 104224399 104228428 104237302
NTO104095303 104095606 104096073 104097046 104097306 104103394 104112462 104113710 108946339
NAU109206779 109206798 109219573 109221082 109231394 109234461 109239718
INI109171915 109171916
ITR116024766 116024849
EGT105967006
 » show all
Reference
1  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J Biol Chem 237:89-93 (1962)
Reference
2  [PMID:6034195]
  Authors
Schulz AR, Oliner L.
  Title
The possible role of thyroid aromatic amino acid decarboxylase in thyroxine biosynthesis.
  Journal
Life Sci 6:873-80 (1967)
DOI:10.1016/0024-3205(67)90291-3
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.53
IUBMB Enzyme Nomenclature: 4.1.1.53
ExPASy - ENZYME nomenclature database: 4.1.1.53
BRENDA, the Enzyme Database: 4.1.1.53
CAS: 9075-72-3

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