KEGG   ENZYME: 4.1.1.6
Entry
EC 4.1.1.6                  Enzyme                                 
Name
cis-aconitate decarboxylase;
cis-aconitic decarboxylase;
cis-aconitate carboxy-lyase;
CAD1 (gene name);
IRG1 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
cis-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
cis-aconitate = itaconate + CO2 [RN:R02243]
Reaction(KEGG)
R02243
Substrate
cis-aconitate [CPD:C00417]
Product
itaconate [CPD:C00490];
CO2 [CPD:C00011]
Comment
The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.
History
EC 4.1.1.6 created 1961, modified 2018
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01100  Metabolic pathways
Orthology
K17724  aconitate decarboxylase
Genes
HSA730249(ACOD1)
PTR452753(ACOD1)
PPS100991677(ACOD1)
GGO101139986(ACOD1)
PON100453492(ACOD1)
NLE100580880(ACOD1)
MCC695991(ACOD1)
MCF102125305(ACOD1)
MTHB126940505
CSAB103214594(ACOD1)
CATY105597924(IRG1)
PANU101008365(ACOD1)
TGE112611077(ACOD1)
RRO104671179(ACOD1)
RBB108516640(ACOD1)
TFN117063671(ACOD1)
PTEH111522010(ACOD1)
CANG105520245(IRG1)
CJC100406137(ACOD1)
SBQ101037923(IRG1)
CSYR103254970(ACOD1)
MMUR105855853(ACOD1)
LCAT123648936(ACOD1)
PCOQ105804988(IRG1)
OGA100948824(ACOD1)
MMU16365(Acod1)
MCAL110309848(Acod1)
MPAH110325897(Acod1)
RNO306127(Acod1)
MCOC116084425(Acod1)
MUN110550935(Acod1)
CGE100764165(Acod1)
MAUA101828266(Acod1)
PLEU114690163(Acod1)
MORG121463388(Acod1)
MFOT126503154
AAMP119800295(Acod1)
NGI103724871(Acod1)
HGL101714481(Acod1)
CPOC100727062(Acod1)
CCAN109696343(Acod1)
DORD105995704(Irg1)
DSP122112687(Acod1)
NCAR124984422
OCU100343808
OPI101535418(ACOD1)
TUP102484215(ACOD1)
GVR103588559(IRG1)
CFA485496(ACOD1)
CLUD112656103(ACOD1)
VVP112934309(ACOD1)
VLG121476888(ACOD1)
AML100469289(ACOD1)
UMR103659173(ACOD1)
UAH113251432(ACOD1)
UAR123800989(ACOD1)
ELK111147125
LLV125094710
MPUF101690358(IRG1)
ORO101378779(IRG1)
EJU114211490(ACOD1)
ZCA113919335(ACOD1)
MLX118009321(ACOD1)
NSU110587667(ACOD1)
LWW102751224(ACOD1)
FCA101088973(ACOD1)
PYU121037836(ACOD1)
PBG122467303(ACOD1)
LRUF124513877
PTG102971647(ACOD1)
PPAD109264209(ACOD1)
AJU106965754(ACOD1)
HHV120245406(ACOD1)
BTA107131195(ACOD1)
BOM102266999(ACOD1)
BIU109566885(ACOD1)
BBUB102389732(ACOD1)
BBIS104999571(IRG1)
CHX102183801(ACOD1)
OAS101102743(ACOD1)
ODA120883023(ACOD1)
CCAD122447253(ACOD1)
SSC100524951(ACOD1)
CFR102510611(ACOD1)
CBAI105083631(IRG1)
CDK105103146(ACOD1)
VPC102530741(ACOD1)
BACU103015984(ACOD1)
LVE103073823(ACOD1)
OOR101289258(IRG1)
DLE111176347(ACOD1)
PCAD102995953(ACOD1)
PSIU116743142(ACOD1)
ECB100052594(ACOD1)
EPZ103554777(ACOD1)
EAI106843087(ACOD1)
MYB102253704(ACOD1)
MYD102758508(ACOD1)
MMYO118651917(ACOD1)
MLF102422057(ACOD1)
MNA107539836(ACOD1)
PKL118728829(ACOD1)
HAI109389065(ACOD1)
DRO112310240(ACOD1)
SHON118996121(ACOD1)
AJM119047862(ACOD1)
PDIC114508443(ACOD1)
PHAS123818855(ACOD1)
MMF118622202(ACOD1)
RFQ117021459(ACOD1)
PALE102890891(ACOD1)
PGIG120621518(ACOD1)
PVP105304174(ACOD1)
RAY107513078(ACOD1)
MJV108398686(ACOD1)
TOD119258495(ACOD1)
SARA101545999(IRG1)
LAV100662839(ACOD1)
TMU101345689
ETF101639135(ACOD1)
MDO100012559(ACOD1)
GAS123241843(ACOD1)
SHR100930346(ACOD1)
PCW110198810(ACOD1)
OAA100084560 100088444(ACOD1)
GGA418812(ACOD1) 422307(IRG1L)
PCOC116229463 116238891(ACOD1)
MGP100546964 100548788(ACOD1)
CJO107308047(ACOD1) 107312866
NMEL110403338 110408455(ACOD1)
APLA101794037(ACOD1) 101794721
ACYG106043926(ACOD1) 106047514
AFUL116494478 116499701(ACOD1)
TGU100226594 101232923(ACOD1)
LSR110477957 110480221(ACOD1)
SCAN103812269(ACOD1) 103816324
PMOA120504791(ACOD1) 120512600
OTC121344195(ACOD1) 121346469
PRUF121355646(ACOD1) 121362793
GFR102032832(ACOD1) 102041070
FAB101810292 101810708(ACOD1)
PHI102102295(IRG1) 102107906
PMAJ107201919(ACOD1) 107203748
CCAE111928603(ACOD1) 111929257
CCW104691709 104695876(ACOD1)
CBRC103622107 103624423(ACOD1)
ETL114062112 114062620(ACOD1)
ZAB102060470 102068328(ACOD1)
ACHL103810815
FPG101916577(ACOD1) 101922011
FCH102045907(ACOD1) 102047977
CLV102094294(ACOD1) 102098383
EGZ104127050(IRG1) 104127973
NNI104018830(IRG1) 104021092
PLET104622545(IRG1)
PCRI104025612(IRG1)
PCAO104040309(IRG1)
ACUN113480159 113480630(ACOD1)
TALA104355633(ACOD1) 104360232
PADL103923687(IRG1) 103925885
AFOR103900937(ACOD1)
ACHC115333923 115350548(ACOD1)
HALD104322338(IRG1)
HLE104838492(IRG1)
AGEN126045183
GCL127026135
CCRI104164930(IRG1)
CSTI104551429(IRG1)
EHS104509264(IRG1)
CMAC104480716(IRG1)
MUI104548241(IRG1)
FGA104071077(IRG1) 104076834
GSTE104255772(IRG1)
LDI104342598(IRG1)
MNB103773582(IRG1)
OHA104333407 104336655(IRG1)
NNT104409041(IRG1)
DPUB104297848 104310316(IRG1)
PGUU104464282 104466032(IRG1)
ACAR104519240(ACOD1)
CPEA104393968(IRG1)
AVIT104273696(IRG1)
CVF104294423(IRG1)
CUCA104054960(IRG1) 104066237
TEO104370825(IRG1)
BRHI104491115(IRG1)
AAM106489846 106491683(ACOD1)
AROW112971758(ACOD1) 112975807
NPD112947125 112951767(ACOD1)
TGT104570868(IRG1)
DNE112983281 112995731(ACOD1)
SCAM104147457(IRG1)
ASN102369682(ACOD1) 102377148
AMJ102567064(ACOD1) 102576357
CPOO109306430(ACOD1) 109313741
GGN109300352 109303394(ACOD1)
PSS102460085(ACOD1)
CMY102939148 102943113(ACOD1)
CPIC101937974 101939682(ACOD1)
TST117870883(ACOD1) 117882931
CABI116831679 116836329(ACOD1)
MRV120371377 120391174(ACOD1)
ACS100561493(acod1) 100567429
PVT110073869(ACOD1) 110080151
SUND121923666 121926277(ACOD1)
PBI103049799
PMUR107303131(ACOD1)
CTIG120318197(ACOD1)
TSR106547865(IRG1)
PGUT117665305(ACOD1)
VKO123027203(ACOD1)
GJA107108495 107120147(ACOD1)
STOW125431603(ACOD1) 125443008
XLA108698345 108698346 108708498(acod1.L) 108708981(acod1.S) 398116(acod1lb.L)
XTR100125311(acod1lb) 100490060(acod1la) 100490699(acod1)
NPR108794354(ACOD1) 108802827
RTEM120921925 120929693(ACOD1)
BBUF120977264 120995873(ACOD1)
BGAR122919376 122919379 122919799 122932267(ACOD1)
DRE562007(irg1l) 795305(acod1)
SRX107705150 107724458 107746176 107746319
SANH107658213 107661550 107663091 107668871
SGH107568925 107570155 107573949 107573956 107597428
CCAR109060025 109060032 109066072 109089282 109094805 109096956
CAUA113053376 113108796 113109355 113113525 113114446
PPRM120477370(acod1) 120494889(irg1l)
MAMB125259309(irg1l) 125270508(acod1)
IPU108266835(acod1) 108269388(irg1l)
PHYP113525153(acod1) 113542690
SMEO124383128(acod1) 124385668(irg1l)
TFD113637990(irg1l) 113654169(acod1)
AMEX103038985(acod1)
EEE113577118(acod1) 113591167
TRU101063714(acod1) 101076857 115252431
TNGGSTEN00017050G001 GSTEN00027937G001
LCO104921461(acod1) 104938224
NCC104958621(irg1)
CGOB115015081 115026778(acod1)
ELY117248431(acod1) 117261307(irg1l)
EFO125894490(irg1l) 125899838(acod1)
PLEP121948499(irg1l) 121948870(acod1)
SLUC116043133(acod1) 116064279 116064477 116064502
ECRA117952294(irg1l) 117952295 117952395(acod1)
ESP116697019 116698380(acod1)
PFLV114564608(acod1)
GAT120817036 120818364 120833795(acod1)
PPUG119210421(irg1l) 119211007 119228799(acod1)
MSAM119888190(irg1l) 119904342(acod1)
CUD121516772(irg1l) 121522444(acod1)
ALAT119006893(irg1l) 119025712(acod1)
MZE101483061(acod1) 101486456
ONL100692168 100711765(acod1)
OAU116316166(acod1) 116324629(irg1l)
OLA101163093 101169074(acod1)
OML112153498(irg1l) 112155293(acod1)
XMA102219194 102219456 102237340(acod1)
XCO114139414 114139415 114148736(acod1)
XHE116713906 116714496 116723571(acod1)
PRET103479303(acod1)
PFOR103134734(acod1) 103135609 103135613
PLAI106940818 106955405 106962435(irg1)
PMEI106925652 106925655 106927798(irg1)
GAF122837589(irg1l) 122839526(acod1)
CVG107089035 107089037 107092943(irg1)
CTUL119792514 119792523 119792524 119794734(acod1)
GMU124860059 124860060 124860907 124860946 124871233(acod1)
NFU107389734(acod1)
KMR108232367(acod1) 108240560 108240568
ALIM106514372 106518098 106527121(irg1)
NWH119408268 119408522(irg1l) 119419281(acod1)
AOCE111576374(acod1) 111587042
MCEP125008626 125008627 125018095(acod1)
CSEM103391176 103391931(acod1)
POV109630690 109646774
SSEN122778343(irg1l) 122785792(acod1)
HHIP117755244(acod1) 117769644(irg1l)
HSP118112454(irg1l) 118119803(acod1)
LCF108882906 108901242
SDU111218684(acod1) 111226511 111226512
SLAL111658568 111658573 111673038(acod1)
XGL120785573(irg1l) 120801545(acod1)
HCQ109531250(acod1)
BPEC110164034 110170567(acod1)
MALB109954119 109965329(acod1)
BSPL114847387(acod1) 114865084(irg1l)
SASA106581286 106581616(acod1) 106591804
STRU115156248(acod1) 115163980 115190476
OTW112225047(acod1) 112234848 112241585(irg1l) 121846965
OMY110501238(acod1) 110507150 110515535 118946052
OGO123992255 124011404 124011570 124014416(acod1)
ONE115119987 115130721(acod1)
SALP111959409(acod1) 112074778
SNH120018496 120018497 120036101 120036508 120064474(acod1)
CCLU121546846(acod1) 121558036 121558037 121567020
ELS105031338(acod1) 106023913 114828687
SFM108925368 108929979(acod1)
PKI111832676(acod1) 111846354
AANG118213732(acod1) 118222853(irg1l)
LOC102698241(irg1)
PSPA121295760 121295890 121304038 121308107 121308109 121308112 121310679 121310917 121310919 121311097 121311262 121311917 121312635 121312673 121312681 121317866 121318734 121320931(acod1) 121325338
ARUT117405592(acod1) 117406549 117412119 117412177 117412295 117426783 117426784 117427043 117427147 117430943
PSEX120523764(acod1)
LCM102345136(ACOD1) 102354684
CMK103177413(irg1l)
RTP109935441(acod1)
BFO118416711
BBEL109465562
LGILOTGIDRAFT_232322
PCAN112574424
BGT106062424
GAE121375653
HRF124112777
HRJ124264812
CRG105336296
MYI110454406
PMAX117325258
OBI106875446
OSN115223530
QSU111995452 112037632
PICPICST_43263(YXE1)
SLBAWJ20_2241
FGRFGSG_11140
FPUFPSE_02880
FVRFVEG_01041
FOXFOXG_00484
ELAUCREL1_1299
PFYPFICI_09702 PFICI_09813 PFICI_14898
PSCOLY89DRAFT_226528
ANIAN7940.2
AORAO090010000161
ANGANI_1_1536084(An09g06220)
AFVAFLA_013708
ALUCAKAW2_10071S AKAW2_21039S AKAW2_40624A
TRGTRUGW13939_04011
PNOSNOG_15138
PTEPTT_12667
BZECOCCADRAFT_34888
BSCCOCSADRAFT_165999
BORCOCMIDRAFT_38737
PFJMYCFIDRAFT_64126
NPAUCRNP2_8007
STEKAXG53_15375
PFZAV641_11070
MICCAUP74_02947
MAGAMag101_09955
MHYDGTQ55_10375
CUHBJN34_23340
CBWRR42_s0411
CCUPBKK81_26750
CUPBKK80_29565
CUUBKK79_35520
BUUWS70_19940
BULBW21_4874
BUDAQ610_28770
BCAIK788_0005394
PHSC2L64_29605
PTERC2L65_18775
PMEGFNZ07_05175
BHOD560_0413
BHMD558_0411
BHZACR54_00754
BPDZBBN53_18000
BEBAEM42_06585
ORMHTY61_08970
DEAFPZ08_05470
TGLHFZ77_15530
SPHDHY78_17855
THEFE1B22_01010
FRPAX769_07395
LDNH9L06_08080
 » show all
Reference
1  [PMID:13438855]
  Authors
BENTLEY R, THIESSEN CP.
  Title
Biosynthesis of itaconic acid in Aspergillus terreus.  III.  The properties and reaction mechanism of cis-aconitic acid decarboxylase.
  Journal
J Biol Chem 226:703-20 (1957)
Reference
2  [PMID:16233265]
  Authors
Dwiarti L, Yamane K, Yamatani H, Kahar P, Okabe M
  Title
Purification and characterization of cis-aconitic acid decarboxylase from Aspergillus terreus TN484-M1.
  Journal
J Biosci Bioeng 94:29-33 (2002)
DOI:10.1263/jbb.94.29
Reference
3  [PMID:18584171]
  Authors
Kanamasa S, Dwiarti L, Okabe M, Park EY
  Title
Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus.
  Journal
Appl Microbiol Biotechnol 80:223-9 (2008)
DOI:10.1007/s00253-008-1523-1
Reference
4  [PMID:23610393]
  Authors
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K
  Title
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
  Journal
Proc Natl Acad Sci U S A 110:7820-5 (2013)
DOI:10.1073/pnas.1218599110
  Sequence
[hsa:730249] [mmu:16365]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.6
IUBMB Enzyme Nomenclature: 4.1.1.6
ExPASy - ENZYME nomenclature database: 4.1.1.6
BRENDA, the Enzyme Database: 4.1.1.6
CAS: 9025-01-8

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