Entry |
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Name |
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase;
5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase;
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase;
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)
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Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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Sysname |
(3E,5R)-5-carboxy-2-oxohept-3-enedioate carboxy-lyase [(4Z)-2-oxohept-4-enedioate-forming]
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Reaction(IUBMB) |
(3E,5R)-5-carboxy-2-oxohept-3-enedioate = (4Z)-2-oxohept-4-enedioate + CO2 (overall reaction) [RN: R04133];
(1a) (3E,5R)-5-carboxy-2-oxohept-3-enedioate = (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate + CO2;
(1b) (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate = (4Z)-2-oxohept-4-enedioate
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Reaction(KEGG) |
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Substrate |
(3E,5R)-5-carboxy-2-oxohept-3-enedioate;
(2Z,4Z)-2-hydroxyhepta-2,4-dienedioate
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Product |
(4Z)-2-oxohept-4-enedioate;
CO2 [CPD: C00011];
(2Z,4Z)-2-hydroxyhepta-2,4-dienedioate
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Comment |
Requires Mg2+ [2,3]. Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli.
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History |
EC 4.1.1.68 created 1984
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Pathway |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K05921 | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
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Genes |
» show all
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Reference |
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Authors |
Garrido-Peritierra A, Cooper RA |
Title |
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. |
Journal |
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Reference |
2 |
Authors |
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P. |
Title |
Characterization of a dienol intermediate in the 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase reaction. |
Journal |
J Am Chem Soc 114:11001-11003 (1992) |
Reference |
3 |
Authors |
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P. |
Title |
Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications. |
Journal |
J Am Chem Soc 117:8719-8726 (1995) |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.1.68 |
ExPASy - ENZYME nomenclature database: | 4.1.1.68 |
UM-BBD (Biocatalysis/Biodegradation Database): | 4.1.1.68 |
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