KEGG ENZYME: 4.1.1.74

ENZYME: 4.1.1.74

Entry

EC 4.1.1.74                 Enzyme

Name

indolepyruvate decarboxylase;
indol-3-yl-pyruvate carboxy-lyase;
3-(indol-3-yl)pyruvate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]

Reaction(IUBMB)

3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2 [RN:R01974]

Reaction(KEGG)

R01974

Substrate

3-(indol-3-yl)pyruvate [CPD:C00331]

Product

2-(indol-3-yl)acetaldehyde [CPD:C00637];
CO2 [CPD:C00011]

Comment

Thiamine diphosphate- and Mg2+-dependent. More specific than EC 4.1.1.1 pyruvate decarboxylase

History

EC 4.1.1.74 created 1999

Pathway

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K04103

indolepyruvate decarboxylase

Genes

STY:

STY2646

STT:

t0452

SEX:	STBHUCCB_4850

SENT:

TY21A_02305

STM:

STM2405

SEO:	STM14_2958

SEV:	STMMW_24291

SEY:	SL1344_2373

SEM:	STMDT12_C24280

SEJ:	STMUK_2436

SEB:	STM474_2506

SEF:	UMN798_2596

SETU:

STU288_08415

SETC:

CFSAN001921_04750

SENR:

STMDT2_23731

SEND:

DT104_24631

SENI:

CY43_12870

SEEN:

SE451236_18240

SPT:

SPA0455

SEK:

SSPA0422

SPQ:	SPAB_00555

SEI:

SPC_1250

SEC:	SCH_2408(dciP)

SEH:	SeHA_C2663

SHB:

SU5_03012

SENH:

CFSAN002069_19740

SEEH:

SEEH1578_21365

SEE:	SNSL254_A2597

SENN:

SN31241_35150

SEW:	SeSA_A2639

SEA:	SeAg_B2548

SENS:

Q786_11880

SEG:

SG2441

SEL:

SPUL_0473

SEGA:

SPUCDC_0473

SET:

SEN2391

SENA:

AU38_12100

SENO:

AU37_12115

SENV:

AU39_12115

SENQ:

AU40_13575

SENL:

IY59_12435

SENJ:

CFSAN001992_21525

SEEB:

SEEB0189_007540

SENB:

BN855_24940

SENE:

IA1_12005

SENC:

SEET0819_19470

SES:	SARI_00479

SBG:

SBG_2213

SBZ:

A464_2540

SBV:	N643_10720

SALZ:

EOS98_06945

ENC:

ECL_03728

ENL:	A3UG_16365

ECLG:

EC036_31850

ECLE:

ECNIH2_16335

ECLN:

ECNIH4_06815

ECLI:

ECNIH5_15275

ECLX:

LI66_15680

ECLY:

LI62_17180

ECLZ:

LI64_15110

ECLO:

ENC_38590

EHM:	AB284_09740

EXF:	BFV63_15500

ECLA:

ECNIH3_15365

ECLC:

ECR091_15300

EAU:	DI57_03295

EKB:	BFV64_16045

ENO:	ECENHK_15930

EEC:	EcWSU1_03228(ipdC)

ELG:	BH714_12275

ECAN:

CWI88_06420(ipdC)

ERN:	BFV67_15815

ECLS:

LI67_017200

ECHG:

FY206_17670(ipdC)

ESH:	C1N69_16200(ipdC)

EPT:	HWQ17_20045(ipdC)

ENT:	Ent638_2923

EAS:	Entas_3129

ENR:	H650_07700

ENX:	NI40_015950

ENF:	AKI40_1502

LNI:	CWR52_19090(ipdC)

EBG:	FAI37_13135(ipdC)

END:	A4308_20595

ENZ:	G0034_16545(ipdC)

ENS:	HWQ15_01260(ipdC)

ENK:	LOC22_03820(ipdC)

EHU:	D5067_0006810(ipdC)

EMOR:

L6Y89_15500(ipdC)

ENB:	ELK40_16340(ipdC)

EQU:	OM418_15805(ipdC)

EPU:	QVH39_16580(ipdC)

EDY:	F0320_15470(ipdC)

ESA:

ESA_00851

CSK:	ES15_1112(ipdC)

CSZ:	CSSP291_04140

CSJ:	CSK29544_02057

CCON:

AFK62_14225

CDM:	AFK67_14625

CSI:	P262_01617

CMJ:	AFK66_005195

CUI:	AFK65_14100

CMW:	AFK63_04175

CTU:	CTU_29970(ipdC)

KPN:

KPN_02740

KPU:

KP1_3993

KPM:	KPHS_38120

KPP:

A79E_1361

KPH:	KPNIH24_09625

KPZ:	KPNIH27_18210

KPV:	KPNIH29_19025

KPW:	KPNIH30_19245

KPY:	KPNIH31_18445

KPG:	KPNIH32_19575

KPC:	KPNIH10_18585

KPQ:	KPR0928_18605

KPT:	VK055_4773(ipdC)

KPO:	KPN2242_16790

KPR:	KPR_1964(ipdC)

KPJ:

N559_1511

KPI:	D364_13960

KPA:	KPNJ1_01595

KPS:	KPNJ2_01565

KPX:	PMK1_00237(ipdC)

KPB:	FH42_09815

KPNE:

KU54_007350

KPNU:

LI86_07355

KPNK:

BN49_3956(ipdC)

KVA:

Kvar_1310

KPE:	KPK_1400(ipdC)

KPK:	A593_03955

KVD:	KR75_01250

KVQ:	SP68_07780

KOX:

KOX_26745

KOE:

A225_4252

KOY:	J415_10885

KOM:	HR38_24875

KMI:	VW41_16130

KOK:	KONIH1_20955

KOC:	AB185_15375

KQU:	AVR78_23265

EAE:

EAE_00275

EAR:

CCG28866

KQV:	B8P98_08020

KLL:	BJF97_20915

KLW:	DA718_08065

KAR:	LGL98_06985

KGR:	JJJ10_07820

KPAS:

LUW96_27380

KLC:	K7H21_07810

KLM:	BWI76_20520

REE:	electrica_01381(ipdC)

ROR:	RORB6_00760

RON:	TE10_20660

RPLN:

B1209_06820

RAO:	DSD31_07120

RTG:	NCTC13098_01877(ipdC)

CRO:

ROD_28081

CKO:

CKO_00409

CFD:	CFNIH1_23390

CBRA:

A6J81_24390

CWE:	CO701_05905

CYO:	CD187_07330

CPOT:

FOB25_18495

CFQ:	C2U38_17710

CSED:

JY391_07050

CAMA:

F384_13285

CAF:	AL524_10160

CIF:	AL515_16230

CFAR:

CI104_17990

CIR:	C2U53_28235

CPAR:

CUC49_12300

CTEL:

GBC03_12025

CITZ:

E4Z61_23790

CARS:

E1B03_18930

CIX:	M4I31_07160

CIB:	HF677_007055

CENS:

P2W74_06985

EBT:	EBL_c11250

CNT:	JT31_18750

CEM:	LH23_22180

CEN:	LH86_20710

CLAP:

NCTC11466_01206(ipdC)

PGE:	LG71_11480

ESC:	Entcl_1355

KLE:	AO703_15060

KSA:	C813_22760

KOR:	AWR26_07600

KRD:	A3780_16360

KPSE:

IP581_15955

KOO:	O9K67_07425

KOU:	C0557_17880

KIE:	NCTC12125_00318(ipdC)

KAS:	KATP_12520

KLU:	K7B04_22615

KCY:	RIN60_06870

LAX:	APT61_06465

LEI:	C2U54_21570(ipdC)

LEH:	C3F35_18455(ipdC)

LEE:	DVA44_06580(ipdC)

LER:	GNG29_16180(ipdC)

LEA:	GNG26_16025(ipdC)

LPNU:

KQ929_05630(ipdC)

LEY:	DVA43_01310(ipdC)

LAZ:	A8A57_15055

LEF:	LJPFL01_2968

LEW:	DAI21_11595(ipdC)

BUF:	D8682_22045

BAGE:

BADSM9389_11760

BFT:	MNO13_06395

BSEL:

RHD99_06300

AHN:	NCTC12129_01441(ipdC)

ASUB:

NLZ15_15730

YRE:	HEC60_11310

SGOE:

A8O29_006725

IZH:	FEM41_22835

PSHI:

SAMEA2665130_1032(ipdC)

PSGC:

G163CM_02450(ipdC)

TOE:	QMG90_07075

EBF:

D782_1263

EBU:	CUC76_22595

EBB:

F652_508

PSTS:

E05_18610

YEN:	YE1222(ipdC)

YEP:	YE105_C2890

YEY:

Y11_00891

YEW:	CH47_624(ipdC)

YET:

CH48_396

YEF:	FORC2_1242

YEE:	YE5303_09771(ipdC)

YAL:	AT01_1826 AT01_3659

YRO:

CH64_1327

YAK:	ACZ76_03060

YMA:	DA391_06555

YHI:	D5F51_15485

YCA:	F0T03_06850

YMO:	HRD69_19045

YAS:	N0H69_09555

YKI:	HRD70_01145 HRD70_10990

YEG:	PL78_16125

SMAR:

SM39_3023

SMAC:

SMDB11_2815

SMW:	SMWW4_v1c35330

SPE:

Spro_3412

SRR:	SerAS9_3605

SRL:	SOD_c33270(ipdC)

SRY:	M621_18085

SPLY:

Q5A_018035(ipdC_2)

SRS:	SerAS12_3606

SRA:	SerAS13_3607

SMAF:

D781_3193

SLQ:	M495_17545

SERF:

L085_11020 L085_12715 L085_13395

SERS:

SERRSCBI_17135

SFW:	WN53_26400

SFG:	AV650_22465

SRZ:	AXX16_1876

SERM:

CLM71_16870

SQU:	E4343_23680

SFJ:	SAMEA4384070_3544(ipdC_2)

SOF:	NCTC11214_03262(ipdC_2)

SSUR:

ATE40_014285

SURI:

J0X03_06375

SRHZ:

FO014_17375

SNEM:

NLX84_17740

SNEV:

OI978_14765 OI978_16570

SGRI:

SGBXF1_03481(ipdC_2)

SSAR:

SSARUM_003400

SFO:	Z042_04065

RAH:	Rahaq_1125

RAQ:	Rahaq2_1203

RAA:

Q7S_05405

ROX:	BV494_00920

RVC:	J9880_13470

RBON:

QNM34_05780

RIU:	I2123_07690

GQU:	AWC35_19130

EAME:

GXP68_06180

RBAD:

H2866_01975

RCB:	O1V66_01350

CARU:

P0E69_05605

NIG:	C1N62_04595

ECA:	ECA3605(ipdC)

PATR:

EV46_17890

PATO:

GZ59_36300(ipdC)

PCT:

PC1_3426

PCC:	PCC21_034320

PCV:	BCS7_17265

PPOA:

BJK05_12135

PBRA:

B5S52_04525

PPUJ:

E2566_17245(ipdC)

PARI:

I2D83_04345(ipdC)

PVZ:	OA04_36950(ipdC)

PPAV:

LOZ86_04685(ipdC)

PCAC:

OI450_13980

PACB:

M9782_19525(ipdC)

PARL:

PEC302110_31910

PPEU:

DUT67_04190(ipdC)

DDC:	Dd586_3014

CED:	LH89_04805

DFN:	CVE23_07930

BGJ:	AWC36_00415

EAM:	EAMY_2469(pdc3)

EAY:	EAM_2375(ipdC)

ETA:	ETA_11130(ipdC)

EPY:	EpC_11610(ipdC)

EPR:	EPYR_01238(pdc)

EBI:	EbC_32520(ipdC)

ERJ:	EJP617_35260(ipdC)

EPE:	CI789_02120

ERWI:

GN242_05845

ERP:	LJN55_16735

EPI:	Q3V30_06190

ETO:	RIN69_16145

PAM:	PANA_2745(ipdC)

PLF:	PANA5342_1305(ipdC)

PAJ:	PAJ_2029(ipdC)

PAQ:	PAGR_g1280

PVA:	Pvag_2180(ipdC)

PAGG:

AL522_17970(ipdC)

PAO:	Pat9b_2818

KLN:	LH22_08515

PANT:

PSNIH1_00855

PANP:

PSNIH2_03830

PAGC:

BEE12_01535

PALH:

B1H58_13165

PANS:

FCN45_13640

PEY:	EE896_05575(ipdC)

PDIS:

D8B20_12140

PER:	LAC65_11385

PJI:	KTJ90_05525(ipdC)

PANO:

OJ965_07855(ipdC)

KPIE:

N5580_04940

PALF:

K6R05_05630(ipdC)

PPHO:

CTZ24_14500

PDIP:

KFZ74_05930

PGZ:	C2E15_15295

PCD:	C2E16_14980

MINT:

C7M51_02237(ipdC)

MTHI:

C7M52_00620(ipdC)

MHAN:

K6958_14410

TCI:	A7K98_17870

PMAK:

PMPD1_3174

PMR:	PMI0845(ipdC)

PMIB:

BB2000_0963(ipdC)

PVL:	AOB99_06655

PVG:	CRN77_14965

PHAU:

PH4a_13540

PROT:

BTA34_05370

PCOL:

F1325_07190

PCIB:

F9282_07080

PPEE:

I6G31_02940

PAPP:

QQS39_06885

PSI:	S70_05510 S70_19930

PSX:	DR96_214 DR96_2898

PSTA:

BGK56_01980 BGK56_08375

PTHA:

OI982_03415 OI982_18295

PRG:	RB151_020410(ipdC)

PALA:

CO695_08990 CO695_09005

PHEI:

NCTC12003_00975(ipdC_1) NCTC12003_02564(ipdC_2)

PRQ:	CYG50_07000 CYG50_21130

PRJ:	NCTC6933_03065(ipdC_1) NCTC6933_03068(ipdC_2)

PVC:	G3341_04665 G3341_11360

PMAG:

JI723_11240 JI723_13475

PHAG:

PZ638_04790 PZ638_11900

PZJ:	QS795_013400 QS795_013415

MMK:

MU9_3137

EIC:	NT01EI_0305 NT01EI_1772

ETD:

ETAF_1742

ETE:	ETEE_4006(ipdC)

ETR:

ETAE_1930

ETC:	ETAC_08820

EDW:	QY76_10580

EDL:	AAZ33_09865

EHO:	A9798_15120

HAV:	AT03_07360

HPAR:

AL518_18225

OPO:	DSM2777_12635

DYE:	EO087_06490

VNI:	VIBNI_B0089

POI:	BOP93_20470

PEN:

PSEEN2115

PSAM:

HU731_009640

PANH:

HU763_022815

PMAM:

KSS90_10950

PAGR:

E2H98_15195

SAZ:

Sama_1025

SKH:	STH12_00564(ipdC)

SLIT:

JQC75_04935

IDI:	CWC33_04800

IAB:	K5X84_00755

PANM:

D3795_08275

CPS:

CPS_0688

PRR:	AT705_06545

PLZ:	S4054249_14100 S4054249_16175

PALN:

B0W48_00215

PPIS:

B1L02_22865

PSEN:

PNC201_21925(ipdC)

PVB:	J5X90_08120 J5X90_18170

PFLI:

CTT31_23575

PMAZ:

R5H13_23720

LAL:	AT746_07025

CATE:

C2869_18270

PMAW:

MACH26_07870

SAGA:

M5M_04875

FTU:	FTT_1744c(ipdC)

FTQ:

RO31_2075

FTF:	FTF1744c(ipdC)

FTW:

FTW_1982

FTR:	NE061598_10155

FTT:	FTV_1661(ipdC)

FTG:	FTU_1746(ipdC)

FTL:

FTL_0006

FTS:

F92_00035

FTO:	X557_00040

FTC:

DA46_736

FTV:

CH67_257

FTZ:

CH68_2141

FTM:	FTM_1730(idpC)

FTN:	FTN_0116(ipdC)

FTX:

AW25_84

FTD:

AS84_598

FTY:

CH70_10

FCF:	FNFX1_0108

FCN:	FN3523_0100

FHI:	FSC454_00480

FPH:

Fphi_0711

FPT:

BZ13_1316

FPI:

BF30_920

FPM:

LA56_1459

FPX:

KU46_635

FPZ:

LA55_89

FPJ:

LA02_567

FRT:	F7308_0106

FRX:	F7310_00570

FRC:

KX01_410

FAD:	CDH04_05840

FMI:	F0R74_08965

FSR:	KQR59_00530

FRL:	FIP56_00530

TSY:	THSYN_15535

RHH:	E0Z06_09145

THIP:

N838_27840 N838_29260

SEDS:

AAY24_06235

HCH:

HCH_01981

HAHE:

ENC22_20920

HAHH:

O5O45_16555

ENW:	MJO57_30755

SUTR:

L0B52_07745(ipdC)

MAER:

DAI18_11795

PDIO:

PDMSB3_1977.1

BOJ:	CBF45_08145

KGY:	EHF36_08290

RFR:

Rfer_0518

RHOA:

HZ993_13435(ipdC)

RLH:	MIZ03_2775

ACIV:

EXV95_17420(ipdC)

COF:	FOZ74_12250(ipdC)

OTD:	J1M35_15580(ipdC)

SIMP:

C6571_06705(ipdC)

PAIS:

PFX98_17030(ipdC)

SMIO:

CATMQ487_03390

MNR:	ACZ75_02305

MASY:

DPH57_05430(ipdC)

MENY:

LSQ66_21965(ipdC)

MASZ:

C9I28_16430(ipdC)

MFLA:

GO485_02350(ipdC)

EHB:	E7V67_014380(ipdC)

UPL:	DSM104440_01061(ipdC)

ARES:

IWH25_13915(ipdC)

EBA:	ebA6545(pdc)

ABRE:

pbN1_40400(pdC)

APET:

ToN1_46880(pdc)

AZA:	AZKH_2996(ipdC)

AZI:	AzCIB_1933

AZD:	CDA09_11830(ipdC)

TMZ:	Tmz1t_0101

TCL:

Tchl_0074

TAK:	Tharo_0060

APP:	CAP2UW1_2653

KMN:	HW532_21720(ipdC)

SMK:	Sinme_5681

SMQ:	SinmeB_5928

SMD:	Smed_5992 Smed_6051

RET:	RHE_PF00449

REC:	RHECIAT_PC0000672

REL:	REMIM1_PF00428

REP:	IE4803_PC00499

REI:	IE4771_PD00509

RLU:	RLEG12_10425

RGA:	RGR602_PC00349

RHN:	AMJ98_PE00527

RPHA:

AMC79_PD00665

RHK:	Kim5_PC00457

REZ:	AMJ99_PD00527

RHID:

FFM81_025020

RLN:	J0663_24040

RBAN:

J2J98_22780

RRG:	J3P73_25215

RAW:	NE851_33400

RSUL:

N2599_34600

RLW:	RlegWSM1455_25830

RHIZ:

QMO80_004890

BRA:	BRADO7016(ipdC)

BBT:	BBta_0512(ipdC)

AOL:

S58_04790

BRO:	BRAD285_7156(ipdC)

BGZ:	XH91_10085

BOY:	LQG66_17730 LQG66_21040(ipdC)

RPA:	TX73_016115(ipdC)

RPB:

RPB_2425

RPD:

RPD_3027

RPT:

Rpal_3526

RPX:	Rpdx1_2308

RHOL:

RBJ75_07400(ipdC)

STAR:

G3545_10560

SNO:

Snov_3860

BID:

Bind_1794

CMB:	CSW64_09035

TRY:	QF118_13330

PAMO:

BAR1_13915(ipdC)

SPHS:

ETR14_13725

ERR:	DVR09_08065(ipdC)

ERYT:

KDC96_06945(ipdC)

ABG:	Asbog_00347

BOB:	GN304_01255 GN304_01565

PARZ:

DTQ13_05850

RAP:	RHOA_2015(ipdC)

ABS:	AZOBR_40354(ipdC)

ABQ:	ABAZ39_11295

ABF:	AMK58_11540

AZT:	TSH58p_08865(ipdC)

AARE:

D3093_12380(ipdC)

NCB:	C0V82_11605

RRU:

Rru_A2719

RRF:

F11_13965

DVN:	HQ394_02155

HTL:

HPTL_0792

DMA:

DMR_26260

DCB:	C3Y92_12130

DDE:

Dde_2331

DSA:	Desal_2664

DAS:

Daes_0883

DVM:

DvMF_0027

CLIH:

KPS_000038(ipdC)

DPS:

DP2330

APAU:

AMPC_29240

LLU:	AKJ09_08048

MSTO:

MSTO_33270

MSAK:

MSAS_54240

MKU:	I2456_01155

MAUU:

NCTC10437_03502(pdc)

MTY:	MTOK_57060(pdc1)

MSEI:

MSEDJ_11710

SGV:	B1H19_03900

SFY:	GFH48_00745

SRIM:

CP984_14945

SBRO:

GQF42_35885

SCAL:

I6J39_02285

SACT:

DMT42_01490

SCOA:

QU709_37660

AGLA:

OIE69_03795 OIE69_35025

NGV:	CDO52_11105

FRI:	FraEuI1c_3511

KRA:

Krad_0182

ACTY:

OG774_28575

SAQ:

Sare_0838

MICF:

QQG74_13040

AMS:	AMIS_17220

SYG:

sync_1491

SYX:	SynWH7803_0869(pdc)

SYND:

KR52_11410

CAN:	Cyan10605_1896

CAP:	CLDAP_36720

KBB:	ccbrp13_33530

SACI:

Sinac_1424

AGV:	OJF2_34230(ipdC_2)

PCOR:

KS4_35060(ipdC)

CPI:

Cpin_1754

CHIH:

GWR21_24215

CFIL:

MYF79_08810

CSAC:

SIO70_07755

ARAC:

E0W69_007350

MUC:

MuYL_0601

ALGO:

GYM62_19425

FJO:

Fjoh_3836

FCG:	LNP23_09395

AQB:	D1818_21015

AFLA:

FHG64_17570

MBA:	Mbar_A1429

MBY:	MSBRM_0475

MBW:	MSBRW_3298

MBAR:

MSBR2_1907

MBAK:

MSBR3_2046

MAC:	MA_0594(ipdC)

MVC:	MSVAZ_0537

MEK:	MSKOL_0516

MTHR:

MSTHT_2109

MTHE:

MSTHC_1175

MHOR:

MSHOH_3634

MFZ:	AOB57_005405

» show all

Reference

1 [PMID:7766676]

Authors

Koga J.

Title

Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis.

Journal

Biochim Biophys Acta 1249:1-13 (1995)
DOI:10.1016/0167-4838(95)00011-I

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.74

IUBMB Enzyme Nomenclature:

4.1.1.74

ExPASy - ENZYME nomenclature database:

4.1.1.74

BRENDA, the Enzyme Database:

4.1.1.74

CAS:

9074-92-4

DBGET integrated database retrieval system