KEGG ENZYME: 4.1.1.83

ENZYME: 4.1.1.83

Entry

EC 4.1.1.83                 Enzyme

Name

4-hydroxyphenylacetate decarboxylase;
p-hydroxyphenylacetate decarboxylase;
p-Hpd;
4-Hpd;
4-hydroxyphenylacetate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

(4-hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)

Reaction(IUBMB)

(4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2 [RN:R07312]

Reaction(KEGG)

R07312

Substrate

4-hydroxyphenylacetate [CPD:C00642];
H+ [CPD:C00080]

Product

4-methylphenol [CPD:C01468];
CO2 [CPD:C00011]

Comment

The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme.

History

EC 4.1.1.83 created 2005

Orthology

K18427

4-hydroxyphenylacetate decarboxylase large subunit

K18428

4-hydroxyphenylacetate decarboxylase small subunit

Genes

PBIZ:

LWC08_09875(hpdC) LWC08_09880(hpdB)

CBK:	CLL_A1723 CLL_A1724

CBT:	CLH_1871 CLH_1872

CSQ:	CSCA_5035 CSCA_5036

CCK:	Ccar_15590 Ccar_15595

CDRK:

B9W14_19635 B9W14_19640

CDY:	F3K33_11510(hpdB)

CFER:

D4Z93_09005 D4Z93_09010

CTAG:

LL095_08525(hpdB) LL095_08530(hpdC)

CPRF:

K7H06_20215(hpdC) K7H06_20220(hpdB)

CRAS:

KVH43_04030(hpdB) KVH43_04035(hpdC)

CDF:	CD630_01530 CD630_01540

PDC:	CDIF630_00272(hpdB) CDIF630_00273(hpdC)

CDC:	CD196_0165(hpdB) CD196_0166(hpdC)

CDL:	CDR20291_0152(hpdB) CDR20291_0153(hpdC)

PDF:	CD630DERM_01530 CD630DERM_01540

TEB:	T8CH_3003(hpdC) T8CH_3004(hpdB)

SGY:	Sgly_2535 Sgly_2536

TFR:	BR63_07490(hpdC) BR63_07495(hpdB)

ABUT:

Ami103574_14830(hpdB) Ami103574_14835(hpdC)

ETM:	CE91St48_01600(hpdB) CE91St48_01610

PUF:	UFO1_3967 UFO1_3968

EGD:	GS424_012570(hpdB) GS424_012575(hpdC)

OLS:	Olsu_1029 Olsu_1030

TFO:	BFO_0133 BFO_0134

» show all

Reference

1 [PMID:3938267]

Authors

D'Ari L, Barker HA.

Title

p-Cresol formation by cell-free extracts of Clostridium difficile.

Journal

Arch Microbiol 143:311-2 (1985)
DOI:10.1007/bf00411256

Reference

2 [PMID:11231288]

Authors

Selmer T, Andrei PI

Title

p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol.

Journal

Eur J Biochem 268:1363-72 (2001)
DOI:10.1046/j.1432-1327.2001.02001.x

Sequence

[ag:CAD65889 CAD65890]

Reference

3 [PMID:15153112]

Authors

Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T

Title

Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity.

Journal

Eur J Biochem 271:2225-30 (2004)
DOI:10.1111/j.1432-1033.2004.04152.x

Sequence

[ag:CAD65889 CAD65890]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.83

IUBMB Enzyme Nomenclature:

4.1.1.83

ExPASy - ENZYME nomenclature database:

4.1.1.83

BRENDA, the Enzyme Database:

4.1.1.83

CAS:	340137-18-0

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