KEGG   ENZYME: 4.1.1.83
Entry
EC 4.1.1.83                 Enzyme                                 
Name
4-hydroxyphenylacetate decarboxylase;
p-hydroxyphenylacetate decarboxylase;
p-Hpd;
4-Hpd;
4-hydroxyphenylacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
(4-hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)
Reaction(IUBMB)
(4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2 [RN:R07312]
Reaction(KEGG)
R07312
Substrate
4-hydroxyphenylacetate [CPD:C00642];
H+ [CPD:C00080]
Product
4-methylphenol [CPD:C01468];
CO2 [CPD:C00011]
Comment
The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme.
History
EC 4.1.1.83 created 2005
Orthology
K18427  4-hydroxyphenylacetate decarboxylase large subunit
K18428  4-hydroxyphenylacetate decarboxylase small subunit
Genes
SUPE: P0H77_22840 P0H77_22845
DSB: LN040_05280(hpdB) LN040_05285(hpdC)
PBIZ: LWC08_09875(hpdC) LWC08_09880(hpdB)
MSIL: METEAL_10040(hpdB) METEAL_10050
MSEA: METESE_09160(hpdB) METESE_09170
TFO: BFO_0133 BFO_0134
CBK: CLL_A1723 CLL_A1724
CBT: CLH_1871 CLH_1872
CSQ: CSCA_5035 CSCA_5036
CCK: Ccar_15590 Ccar_15595
CDRK: B9W14_19635 B9W14_19640
CDY: F3K33_11510(hpdB)
CFER: D4Z93_09005 D4Z93_09010
CTAG: LL095_08525(hpdB) LL095_08530(hpdC)
CPRF: K7H06_20215(hpdC) K7H06_20220(hpdB)
CRAS: KVH43_04030(hpdB) KVH43_04035(hpdC)
SGY: Sgly_2535 Sgly_2536
TFR: BR63_07490(hpdC) BR63_07495(hpdB)
BHV: BLHYD_24210(csdC_1) BLHYD_24220(hpdB) BLHYD_31580(csdC_2) BLHYD_31590(csdB)
ABUT: Ami103574_14830(hpdB) Ami103574_14835(hpdC)
ETM: CE91St48_01600(hpdB) CE91St48_01610
CDF: CD630_01530 CD630_01540
PDC: CDIF630_00272(hpdB) CDIF630_00273(hpdC)
CDC: CD196_0165(hpdB) CD196_0166(hpdC)
CDL: CDR20291_0152(hpdB) CDR20291_0153(hpdC)
PDF: CD630DERM_01530 CD630DERM_01540
TEB: T8CH_3003(hpdC) T8CH_3004(hpdB)
THYR: P4S50_01580(hpdB) P4S50_01585(hpdC) P4S50_13145(hpdC) P4S50_13150(hpdB)
PUF: UFO1_3967 UFO1_3968
OLS: Olsu_1029 Olsu_1030
EGD: GS424_012570(hpdB) GS424_012575(hpdC)
 » show all
Reference
1  [PMID:3938267]
  Authors
D'Ari L, Barker HA.
  Title
p-Cresol formation by cell-free extracts of Clostridium difficile.
  Journal
Arch Microbiol 143:311-2 (1985)
DOI:10.1007/bf00411256
Reference
2  [PMID:11231288]
  Authors
Selmer T, Andrei PI
  Title
p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol.
  Journal
Eur J Biochem 268:1363-72 (2001)
DOI:10.1046/j.1432-1327.2001.02001.x
  Sequence
[ag:CAD65889 CAD65890]
Reference
3  [PMID:15153112]
  Authors
Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T
  Title
Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity.
  Journal
Eur J Biochem 271:2225-30 (2004)
DOI:10.1111/j.1432-1033.2004.04152.x
  Sequence
[ag:CAD65889 CAD65890]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.83
IUBMB Enzyme Nomenclature: 4.1.1.83
ExPASy - ENZYME nomenclature database: 4.1.1.83
BRENDA, the Enzyme Database: 4.1.1.83
CAS: 340137-18-0

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Gene (340)   
   MGENES (328)   
   RefGene (12)   
Protein sequence (1510)   
   UniProt (915)   
   SWISS-PROT (10)   
   RefSeq(pep) (576)   
   PDBSTR (9)   
DNA sequence (4857)   
   RefSeq(nuc) (3636)   
   GenBank (618)   
   EMBL (603)   
3D Structure (3)   
   PDB (3)   
Protein domain (8)   
   InterPro (6)   
   Pfam (2)   
All databases (6718)   

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