Entry
Name
4-hydroxyphenylacetate decarboxylase;
p-hydroxyphenylacetate decarboxylase;
p-Hpd;
4-Hpd;
4-hydroxyphenylacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(4-hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)
Reaction(IUBMB)
(4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2 [RN:
R07312 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme.
History
EC 4.1.1.83 created 2005
Orthology
K18427 4-hydroxyphenylacetate decarboxylase large subunit
K18428 4-hydroxyphenylacetate decarboxylase small subunit
Genes
PBIZ : LWC08_09875(hpdC) LWC08_09880(hpdB)
CCK : Ccar_15590 Ccar_15595
CDRK : B9W14_19635 B9W14_19640
CFER : D4Z93_09005 D4Z93_09010
CTAG : LL095_08525(hpdB) LL095_08530(hpdC)
CPRF : K7H06_20215(hpdC) K7H06_20220(hpdB)
CRAS : KVH43_04030(hpdB) KVH43_04035(hpdC)
CDF : CD630_01530 CD630_01540
PDC : CDIF630_00272(hpdB) CDIF630_00273(hpdC)
CDC : CD196_0165(hpdB) CD196_0166(hpdC)
CDL : CDR20291_0152(hpdB) CDR20291_0153(hpdC)
PDF : CD630DERM_01530 CD630DERM_01540
TEB : T8CH_3003(hpdC) T8CH_3004(hpdB)
TFR : BR63_07490(hpdC) BR63_07495(hpdB)
ABUT : Ami103574_14830(hpdB) Ami103574_14835(hpdC)
ETM : CE91St48_01600(hpdB) CE91St48_01610
EGD : GS424_012570(hpdB) GS424_012575(hpdC)
» show all
Taxonomy
Reference
Authors
D'Ari L, Barker HA.
Title
p-Cresol formation by cell-free extracts of Clostridium difficile.
Journal
Reference
Authors
Selmer T, Andrei PI
Title
p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol.
Journal
Sequence
Reference
Authors
Andrei PI, Pierik AJ, Zauner S, Andrei-Selmer LC, Selmer T
Title
Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.83
ExPASy - ENZYME nomenclature database: 4.1.1.83