Entry
Name
diaminobutyrate decarboxylase;
DABA DC;
L-2,4-diaminobutyrate decarboxylase;
L-2,4-diaminobutanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming)
Reaction(IUBMB)
L-2,4-diaminobutanoate = propane-1,3-diamine + CO2 [RN:
R07650 ]
Reaction(KEGG)
Substrate
L-2,4-diaminobutanoate [CPD:
C03283 ]
Product
Comment
A pyridoxal-phosphate protein that requires a divalent cation for activity [1]. N4-Acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates. Found in the proteobacteria Haemophilus influenzae and Acinetobacter baumannii. In the latter, this enzyme is cotranscribed with the dat gene that encodes EC
2.6.1.76 , diaminobutyrate---2-oxoglutarate transaminase, which can supply the substrate for this enzyme.
History
EC 4.1.1.86 created 2006
Pathway
ec00260 Glycine, serine and threonine metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K13745 L-2,4-diaminobutyrate decarboxylase
Genes
EAS : Entas_2874 Entas_4601
REE : electrica_02557(ddc)
RTG : NCTC13098_03727(ddc)
CLAP : NCTC11466_04272(ddc)
KIE : NCTC12125_01063(ddc)
SFJ : SAMEA4384070_2485(ddc_1)
SOF : NCTC11214_04450(ddc_2)
SGRI : SGBXF1_02443(ddc_1)
RAH : Rahaq_1995 Rahaq_4873
RACE : JHW33_06785 JHW33_24850
RAQ : Rahaq2_2140 Rahaq2_4837
ROX : BV494_04395 BV494_22645
RVC : J9880_19425 J9880_24050
RIU : I2123_11515 I2123_22355
EAME : GXP68_08290 GXP68_09670
RBAD : H2866_01220 H2866_21225
CARU : P0E69_09250 P0E69_22735
NIG : C1N62_07670 C1N62_18615
EAM : EAMY_0466(ddc) EAMY_3238(dfoJ)
EAY : EAM_0361 EAM_2959(ddc)
ETA : ETA_04470(ddc) ETA_30280
EPY : EpC_04510(ddc) EpC_32410
EPR : EPYR_00474(ddc) EPYR_03489(dfoJ)
EBI : EbC_22090(ddc) EbC_24990
ERJ : EJP617_07260 EJP617_16150(ddc)
EPI : Q3V30_10110 Q3V30_11785
ETO : RIN69_11265 RIN69_13270
PAM : PANA_0635(ddc) PANA_4109(ddc)
PLF : PANA5342_3680(ddc) PANA5342_p10266(ddc)
PAJ : PAJ_3770(ddc) PAJ_p0181(ddc)
PAQ : PAGR_g3563 PAGR_p196
PVA : Pvag_pPag30241(ddc) Pvag_pPag30339(dfoJ)
PAGG : AL522_01830 AL522_02235
PANT : PSNIH1_p00670 PSNIH1_p00945
PANP : PSNIH2_00035 PSNIH2_06440
PSTW : DSJ_21105 DSJ_26105
PALH : B1H58_02415 B1H58_16090
PEY : EE896_20725 EE896_21120
PER : LAC65_16960 LAC65_17225
PJI : KTJ90_20240 KTJ90_20635
PANO : OJ965_01155 OJ965_01585
PALF : K6R05_20700 K6R05_21135
PGZ : C2E15_12185 C2E15_19605
PCD : C2E16_12425 C2E16_19040
MHAN : K6958_05230 K6958_11960
TPTY : NCTC11468_01910(ddc)
TATU : EFZ10_10210 EFZ10_15520
HPIT : NCTC13334_01173(ddc)
HAEG : NCTC8502_00048(ddc)
ALIG : NCTC10568_02370(ddc)
VSA : VSAL_I0134 VSAL_I2138
ACAL : BUM88_13765 BUM88_14430
AVZ : HWI77_18155 HWI77_18435
MCUN : NCTC10297_00065(ddc)
TVI : Thivi_2187 Thivi_4128
PAQI : KW060_10740 KW060_10745
MYM : A176_000052 A176_005296
PAUU : E8A73_013310 E8A73_041040
BLI : BL01335 BL01735 BL02887
BLD : BLi00416 BLi01014 BLi01184(rhbB)
BLH : BaLi_c04280 BaLi_c11190 BaLi_c13160(rhbB)
BSON : S101395_03655 S101395_03818(gadB) S101395_04615
BPUM : BW16_03860 BW16_05845
BPUS : UP12_03940 UP12_05455
BSM : BSM4216_1261 BSM4216_1894
BGY : BGLY_0426 BGLY_1045 BGLY_1215
BXI : BK049_02805 BK049_04340
BALT : CFN77_03815 CFN77_05445
BAER : BAE_11355 BAE_13005
BSAF : BSL056_03800 BSL056_05400
BACW : QR42_03760 QR42_05290
BZH : NF868_03270 NF868_04850
BCAO : LC087_02695 LC087_17620
BAEI : RE735_14140 RE735_15605
LYG : C1N55_17665 C1N55_18215
HSAN : MUN89_16870 MUN89_19010
PSYO : PB01_00865 PB01_14270
VIJ : JNUCC6_00680 JNUCC6_13590
CCOH : SAMEA4530647_1594(ddc)
MSAL : DSM43276_01547(ddc)
NFR : ERS450000_04859(ddc)
SPIN : KV203_07885 KV203_15845
SCO : SCO2017(SC7H2.31c) SCO2782(SCC105.13)
SGR : SGR_1211 SGR_4750 SGR_5512
SGB : WQO_07765 WQO_11785 WQO_29275
SANL : KZO11_11980 KZO11_31340
SCYE : R2B67_04685 R2B67_23980
SCB : SCAB_57951(desA) SCAB_68801
SVL : Strvi_1069 Strvi_7090
SHO : SHJGH_3256 SHJGH_4048
SRC : M271_20105 M271_34370 M271_36330
SMAL : SMALA_1945 SMALA_4657
SDV : BN159_5488 BN159_6448
STRP : F750_1863 F750_2608(desA)
SCI : B446_10520 B446_14675
SLV : SLIV_23765(rhbB) SLIV_27625
SGU : SGLAU_09130 SGLAU_12690
SVT : SVTN_09685 SVTN_13760
STRE : GZL_06514 GZL_06725
SCW : TU94_08670 TU94_12170
SLC : SL103_09245 SL103_10280
SXI : SXIM_06690 SXIM_09430
STRC : AA958_06035 AA958_10360
SAMB : SAM23877_2103(rhbB) SAM23877_2817(desA)
SPRI : SPRI_4760 SPRI_5511
SCZ : ABE83_04990 ABE83_24060 ABE83_28030
SCX : AS200_28455 AS200_32915
SRW : TUE45_02531(ddc_2) TUE45_03397(ddc_3)
SLE : sle_44580(desA) sle_51220(sle_51220)
SRN : A4G23_01834(ddc_1) A4G23_04772(ddc_2)
SCLF : BB341_18600 BB341_22055
SGS : AVL59_28570 AVL59_36995 AVL59_41580
STSI : A4E84_10410 A4E84_14665
SKY : D0C37_22575 D0C37_26210
SALW : CP975_08720 CP975_12495
SCAD : DN051_24645 DN051_28380
SLS : SLINC_2334 SLINC_3205
SNR : SNOUR_30315 SNOUR_31335
SALU : DC74_2284 DC74_2485
SALL : SAZ_12105 SAZ_13770
SPLU : LK06_006930 LK06_010720
STRD : NI25_24945 NI25_29080
SAUO : BV401_13205 BV401_27145
SSIA : A7J05_08200 A7J05_26835
SVU : B1H20_11030 B1H20_30140
SPUN : BFF78_26575 BFF78_31115
SGV : B1H19_11000 B1H19_11960
SALF : SMD44_02200(ddc) SMD44_03080(ddc)
SALJ : SMD11_0167(ddc) SMD11_0705
SLX : SLAV_23925(ddc1) SLAV_27505(ddc3)
STRO : STRMOE7_09825 STRMOE7_10825
SFK : KY5_1977c KY5_2921 KY5_6019 KY5_6408c
SNZ : DC008_08400 DC008_12270
SGE : DWG14_05326(ddc_1) DWG14_06337(ddc_2)
SLK : SLUN_09765 SLUN_14250
SDX : C4B68_25740 C4B68_30180
SCYA : EJ357_11800 EJ357_16800
SAST : CD934_21335 CD934_25450
SNQ : CP978_09740 CP978_12905 CP978_34520
STIR : DDW44_03265 DDW44_08995
SKA : CP970_08985 CP970_10820 CP970_27940 CP970_32690
SGZ : C0216_23095 C0216_26185
SVN : CP980_21560 CP980_24910
SHAW : CEB94_10880 CEB94_15255
SFIC : EIZ62_06210 EIZ62_21545 EIZ62_25120
SGAL : CP966_08870 CP966_13285
SSPO : DDQ41_02635 DDQ41_07465
SPAD : DVK44_10035 DVK44_14930
SFY : GFH48_25700(desA) GFH48_29950
SAQU : EJC51_13570 EJC51_19200
SGF : HEP81_05014 HEP81_05770
SCAV : CVT27_06625 CVT27_10475 CVT27_28770
SSEO : D0Z67_06910 D0Z67_10255
SRIM : CP984_30945 CP984_32060
SSUB : CP968_02830 CP968_24730
SPHV : F9278_10315 F9278_16750(desA)
SCIN : CP977_08985 CP977_12440
SPAC : B1H29_23535 B1H29_27285
SCHA : CP983_27390 CP983_32305
SGX : H4W23_10135 H4W23_14860 H4W23_33320
SCOE : CP976_11645 CP976_16210
SBAT : G4Z16_26685 G4Z16_27590
SSPB : CP982_11835 CP982_16535
SNF : JYK04_02654(ddc_1) JYK04_03395(ddc_3)
SPLA : CP981_08905 CP981_09925
SBRO : GQF42_12990 GQF42_17595(desA)
STUI : GCM10017668_16480 GCM10017668_25030
SATA : C5746_10960 C5746_15060
SCHF : IPT68_09425 IPT68_13600(desA)
SHUN : DWB77_04910(ddc_1) DWB77_05728(ddc_2)
SHAR : HUT13_03960 HUT13_05345
SCYG : S1361_11080(ddc1) S1361_15225(ddc2)
SFEU : IM697_07210(desA) IM697_11895
SLIA : HA039_16390 HA039_26015
SDW : K7C20_08410 K7C20_09460
SVD : CP969_11175 CP969_15020
SCAL : I6J39_07065 I6J39_11245 I6J39_29945
SAUH : SU9_006875 SU9_007905
SFB : CP974_10275 CP974_25545
SROI : IAG44_26045(desA) IAG44_30130
SGJ : IAG43_07430 IAG43_11115
SANU : K7396_07650 K7396_26920 K7396_27870
SDD : D9753_09075 D9753_22560 D9753_26585
SMAO : CAG99_23035 CAG99_24065
SGOB : test1122_03120 test1122_12325
SINE : KI385_11500 KI385_12610
SDEC : L3078_11880 L3078_16870(desA)
SYAN : NRK68_08965 NRK68_12355
SRUG : F0345_05780 F0345_08960
SAKB : K1J60_28020(desA) K1J60_33645
STAA : LDH80_25485 LDH80_29260
SNIG : HEK616_14970 HEK616_17020
SVIO : HWN34_21175 HWN34_24575
SCAE : IHE65_28455(desA) IHE65_33775
STUB : MMF93_06940 MMF93_07885
SSPN : LXH13_10560 LXH13_15500(desA)
SCIR : STRCI_002202 STRCI_003146(desA)
SXT : KPP03845_102220(ddc_1)
STUD : STRTU_005411 STRTU_005605
SGK : PET44_08825 PET44_12040
SANT : QR300_17970 QR300_31900
SYUN : MOV08_30335 MOV08_31345 MOV08_35455
SARG : HKX69_21855(desA) HKX69_25885
SJN : RI060_26950(desA) RI060_31960
SOV : QZH56_02375 QZH56_27345
SFIY : F0344_23440 F0344_28390
SHAU : K9S39_09305 K9S39_33040 K9S39_34025
SKG : KJK29_24105(desA) KJK29_28905
SCOA : QU709_27140(desA) QU709_32785
SROC : RGF97_21610 RGF97_26070 RGF97_31010
SCHG : NRO40_10260 NRO40_24120 NRO40_24145
STTN : BSL84_08660 BSL84_11940
SINN : ABB07_24145 ABB07_28295
KBU : Q4V64_12635 Q4V64_18440(desA)
SPRF : K4G22_03630 K4G22_04765
SLUO : PS467_11825 PS467_25200
STPB : QR97_06945 QR97_27375
SRPA : HEP86_10130 HEP86_11215
SCAJ : O1G22_26810(desA) O1G22_31205
STRW : QHG49_22310(desA) QHG49_26165
SCT : SCAT_1144 SCAT_p1223(rhbB)
SCY : SCATT_11410 SCATT_p05030
KAB : B7C62_06740 B7C62_10670 B7C62_31395
NAQU : ENKNEFLB_01323(ddc)
MHAI : OHB01_10480 OHB01_20060
FRA : Francci3_2711 Francci3_4055
AMYZ : HUW46_00067(ddc_1) HUW46_00215(ddc_2) HUW46_06950(hdc)
ACTA : C1701_03465 C1701_23900 C1701_24035
MCAB : HXZ27_06670 HXZ27_14010
DFU : Dfulv_32650 Dfulv_43395
PVAR : SH412_000085 SH412_002904
FLW : LVD16_14415 LVD16_17545
ATK : AUTU_07140 AUTU_12800
AQB : D1818_00965 D1818_17885
AQA : D1815_06445 D1815_13500
AQD : D1816_05105 D1816_20855
CGN : OK18_15855 OK18_17280
CGLE : NCTC11432_00671(ddc_1)
HLR : HALLA_03545 HALLA_21220
» show all
Taxonomy
Reference
Authors
Yamamoto S, Tsuzaki Y, Tougou K, Shinoda S.
Title
Purification and characterization of L-2,4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus.
Journal
Reference
Authors
Ikai H, Yamamoto S.
Title
Cloning and expression in Escherichia coli of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii.
Journal
Reference
Authors
Ikai H, Yamamoto S
Title
Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.86
ExPASy - ENZYME nomenclature database: 4.1.1.86