KEGG   ENZYME: 4.1.1.96
Entry
EC 4.1.1.96                 Enzyme                                 
Name
carboxynorspermidine decarboxylase;
carboxyspermidine decarboxylase;
CANSDC;
VC1623 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
carboxynorspermidine carboxy-lyase (bis(3-aminopropyl)amine-forming)
Reaction(IUBMB)
(1) carboxynorspermidine = bis(3-aminopropyl)amine + CO2 [RN:R09082];
(2) carboxyspermidine = spermidine + CO2 [RN:R09081]
Reaction(KEGG)
R09081 R09082
Substrate
carboxynorspermidine [CPD:C18174];
carboxyspermidine [CPD:C18172]
Product
bis(3-aminopropyl)amine [CPD:C03375];
CO2 [CPD:C00011];
spermidine [CPD:C00315]
Comment
A pyridoxal 5'-phosphate enzyme. Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae [1]. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro [3].
History
EC 4.1.1.96 created 2012
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K13747  carboxynorspermidine decarboxylase
Genes
PMUPM0371(nspC)
PMVPMCN06_0390(nspC)
PULNT08PM_0945
PMPPmu_04350
PMULDR93_1146(nspC)
PDAG4362423_00506(nspC)
PSKYA6B44_03430
PATLKGI96_05565(nspC)
PCAIK7G93_000953(nspC)
MSEPCEP49_04765(nspC)
VCHVC_1623
VCFIR04_13340
VCSMS6_1405
VCEVch1786_I1123(nspC)
VCQEN18_11310
VCJVCD_002752
VCIO3Y_07885
VCOVC0395_A1230(nspC)
VCRVC395_1741(nspC)
VCMVCM66_1563(nspC)
VCLVCLMA_A1413
VCXVAA049_1180(nspC)
VCZVAB027_2271(nspC)
VVUVV1_3048(nspC)
VVYVV1238
VVMVVMO6_01980
VVLVV93_v1c11580
VPAVP1940
VPBVPBB_1782
VPKM636_12130
VPFM634_11910
VPHVPUCM_1278
VHAVIBHAR_02739
VCAM892_17170
VAGN646_1022
VEXVEA_003103
VDBAL552_18360(nspC)
VHRAL538_03270(nspC)
VNAPN96_04025
VOWA9237_14590
VROBSZ04_17200
VSPVS_1945
VEJVEJY3_10180
VFUvfu_A01726
VNIVIBNI_A2070
VANVAA_01988
LAGN175_09065
VAUVANGNB10_cI1168(nspC)
VCYIX92_08255
VCTJV59_30260
VTUIX91_08415
VEUIXK98_17035(nspC)
VSIMTO69_05990(nspC)
VFLAL536_12660(nspC)
VMIAL543_17375(nspC)
VBRA6E01_05855
VSCVSVS12_01828(nspC)
VGABSQ33_00505
VSHBSZ05_00390
VQICCZ37_05960(nspC)
VTAA0393(nspC)
VAFD1115_09530(nspC)
VNLD3H41_10615(nspC)
VCCFAZ90_05965(nspC)
VASGT360_07750(nspC)
VAQFIV01_08105(nspC)
VSRVspart_01603(nspC)
VKABTD91_00720(nspC)
VZIG5S32_08260(nspC)
VNVIF132_09430(nspC)
VGIMID13_09675(nspC)
VSLLTQ54_14805(nspC)
VPLSA104470976_01355(nspC)
VJPNP165_05965(nspC)
VPGLZI70_01370(nspC)
VOSKNV97_10200(nspC)
VTICEQ48_10955(nspC)
VCRAIS519_00200(nspC)
VNPKW548_09385(nspC)
VLEISX51_07310(nspC)
VSYK08M4_18320(nspC)
VRURND59_14145(nspC)
VMTQYQ96_06080(nspC)
VSAVSAL_I2136(nspC)
AWDAWOD_I_1744(nspC)
PPRPBPRA2228(BP0731)
PGBH744_2c1554
PDSCAY62_17315
PGHFH974_09545(nspC)
PHOTL4174_006745(nspC)
GHOAL542_15070(nspC)
GKDK6Q96_11280(nspC)
PMAICF386_00305(nspC)
ELUXBTN50_0369
PMYPmen_0987
PMKMDS_3853
PPSEBN5_0984(nspC)
PPUPP_2929(nspC)
PPFPput_2763
PPGPputGB1_2843
PPWPputW619_2126
PPTPPS_2986
PPBPPUBIRD1_2806(nspC)
PPIYSA_10079
PPXT1E_3816
PPUHB479_14845
PPUTL483_12870
PPUNPP4_28800(nspC)
PPUDDW66_3252
PFVPsefu_0874
PMONX969_14300
PMOTX970_13945
PPJRK21_01669
PMOLCLJ08_02035(nspC)
PALDLU682_016000(nspC)
PIXRIN61_24655
PMOSO165_007045
PFLPFL_3538(nspC)
PPRCPFLCHA0_c35790(nspC)
PPROPPC_3684
PFEPSF113_3833
PZAHU749_013610(nspC)
PFNHZ99_00805
PFSPFLU_3579
PFCPflA506_3051(nspC)
PPZH045_10660
PFBVO64_5667
PTVAA957_26340
PVRPverR02_17605
PAZOAYR47_24960
POIBOP93_10960
PRXHRH33_16245
PMUDNCTC8068_02897
PTOLI7845_16270
PMABU0037_17890
PFWPF1751_v1c30140(nspC)
PFFPFLUOLIPICF721125
PFXA7318_14280
PENPSEEN2366(nspC)
PBAPSEBR_a2444
PSVPVLB_10890
PSKU771_19065
PCHEY04_10510
PCZPCL1606_38620
PCPJM49_19385
PCHPC4K32_2272
PFZAV641_10425
PALKPSAKL28_20430
PRHLT40_06300
PSWLK03_17135
PPVNJ69_05920
PSESPSCI_2686
PSEMTO66_11435
PSECCCOS191_3090(nspC)
PPSYAOC04_07625
PSOSPOS17_3666
PFKPFAS1_26160
PANRA7J50_2513
PSILPMA3_12700
PYMAK972_3337
PADEC3B55_00503(nspC)
PALLUYA_18505
PUMHGP31_13590
PPSHG5J76_15820
PSEJHNQ25_06965
PEZHWQ56_17395
PBZGN234_01080
PKHJLK41_19670
PTYJWV26_04775
PDWBV82_3577(nspC)
PZEHU754_014580
PMOEHV782_015355
PSEPC4K39_5520
PPIIQL104_18825(nspC)
PVWHU752_011900(nspC)
PTRTHU722_0017340
PXAKSS93_14350
PSAMHU731_003550
PQIKH389_13930(nspC)
PSHHHU773_011605
PXNHU772_015040(nspC)
PPRGHU725_009885
PANHHU763_011705(nspC)
PASGKSS96_17235
PFAKKSS94_16675
PMUYKSS95_17745
PMAMKSS90_10525(nspC)
PORYEJA05_18140
PWZJ7655_16280
PTKEXN22_16955(nspC)
PWYHU734_014645(nspC)
PTAENCTC10697_02716
PGFJ0G10_15945
PJUL1P09_14155
PHFNLY38_04995
PPHNHU825_01285
PPEGKUA23_17460
PSIHLOY51_17520
PASILG197_20510(nspC)
PKMPZ739_12825
PTAIICN73_20855(nspC)
PKKQQ992_13945(nspC)
PKJQ1W70_20895
PHYGJTY93_10455
PCHEQYM18_02270
PCUCPSH97_15990(nspC)
PPAELDL65_22565
PSJYAA098_12735
PSLPBHQ29_04125
PSAPST_3242(nspC)
PSZPSTAB_3291(nspC)
PSRPSTAA_3406(nspC)
PSCA458_04455
PSJPSJM300_14975
PSHPsest_1054
PSTUUIB01_16705
PSEDDM292_02420
PCHLLLJ08_04375
PBMCL52_04840
PKGLW136_05045
SDEGGOM96_06710
PZDKQ248_10160
HPEGEAO82_04110(nspC)
HAESLO767_14255
HARRHV822_06560
PNNKEM63_14940(nspC)
PPHABVH74_02600
DCEO6P33_07745(nspC)
PBAUOS670_17665
MBSMRBBS_0908(lysA)
MPQABA45_04695
PARPsyc_0913
PCRPcryo_1502
PRWPsycPRwf_1716
PSOPSYCG_07870
PURAOC03_00040
PALIA3K91_1513
PSPGAK823_05820
PSYGAK825_05905
PSYCDABAL43B_1233(nspC)
PSYAAOT82_577
PSYYDLE54_07980(nspC)
PSYPE5677_05820
PKYPKHYL_17500(nspC)
PCIAQ6344_07860
PRAEMN210_11605(nspC)
MCTMCR_0902(nspC)
MCSDR90_977
MCATMC25239_00906
MOIMOVS_04605
MBLAAX09_04140
MCUNNCTC10297_01743
MNCLU297_00875
MHACLU276_04325
MCAHU0021_00390
PANMD3795_05500(nspC)
PINPing_2290
PSYPCNPT3_08255
MVSMVIS_2444(nspC)
MYAMORIYA_0603(nspC)
MMAAFR932_05525(nspC)
MOQHWV03_09920(nspC)
SAGAM5M_18900
STAWNCG89_14215(nspC)
MCAMCA2593(nspC)
METUGNH96_00095
MMEOOOT43_15860
MEEFJWZ97_17520
MMTMetme_2585
MDNJT25_017045
MDHAYM39_13315
MKOMKLM6_2729
METLU737_07860
MPADKEF85_07105
MELLIVG45_07355
MMOTQZJ86_06660
MAHMEALZ_1374
MBUREQU24_06175
MPSYCEK71_03265
MMAIsS8_3332
MSZEMSZNOR_2815
MMOBF6R98_19250
MEINmethR_P2531
MOZMoryE10_28350
MISZMishRS11D_29700
MESLKKZ03_00640 KKZ03_08080(nspC)
ALVAlvin_2059
ATEPAtep_21560(nspC)
TTPE6P07_08185(nspC)
CJAPGWK36_04025(nspC)
MMWMmwyl1_1381
MPCMar181_2468
MPRIMP3633_2670
MARDIBG28_05705(nspC)
MFOIJSY38_04090(nspC)
MPRFJ8N69_13435(nspC)
MRHIKDW99_06010(nspC)
MPONMACH16_09690(nspC)
OAIOLEAN_C24180
MARLHH196_04325(nspC)
NIKF5I99_08620
BACZKFF03_16055(nspC)
OMEOLMES_0540
OCEGU3_02800
OPEPU634_16440
OCMCBP12_09730
OPFCBP31_08085
ZDFAN401_18475
SDFACG33_09820
BMABMAA0795
BMVBMASAVP1_0550
BMLBMA10229_0661
BMNBMA10247_A1615
BMALDM55_4647
BMAEDM78_3410
BMAQDM76_3600
BMAIDM57_11645
BMAFDM51_4493
BMAZBM44_4639
BMABBM45_3219
BPSBPSS1453
BPMBURPS1710b_A0479(nspC)
BPLBURPS1106A_A1968
BPDBURPS668_A2063
BPSEBDL_4760
BPSMBBQ_4695
BPSUBBN_4898
BPSDBBX_3922
BPZBP1026B_II1541
BPQBPC006_II1949
BPKBBK_4063
BPSHDR55_3822
BPSABBU_4583
BPSOX996_3609
BUTX994_5665
BTDBTI_3942
BHGI6G56_20760
BUDAQ610_23530
BULBW21_5936
PLGNCTC10937_02024
LMIRNCTC12852_02063(lysA_2)
BPEBP0731(nspC)
BPCBPTD_0733(nspC)
BPERBN118_0074(nspC)
BPETB1917_3093(nspC)
BPEUQ425_33180(nspC)
BPARBN117_0994(nspC)
BPABPP3684(nspC)
BBHBN112_4285(nspC)
BBRBB4118(nspC)
BBMBN115_3807(nspC)
BBXBBS798_3911(nspC)
BTRMSAMEA390648701673(nspC)
BOJCBF45_11375
PUTPT7_0645
POLLOEG81_07405
AKATKWG_19695
AMIMMIM_c30960(nspC)
AALNQ3V95_00815
ODIODI_R2668
BOZDBV39_02525
OUEI6G29_00290(nspC)
KGYEHF36_11620
HARHEAR0832(nspC)
THUAC731_002530
THAUC4PIVTH_3182(nspC)
THKCCZ27_03510
ATWC0099_00410
DDZDSYM_24080
NIYFQ775_07435 FQ775_11415
CHEAPVE73_08740
ORMHTY61_09095
SMESM_b21631(nspC)
SMKSinme_4194
SMQSinmeB_4690
SMXSM11_pD0072(nspC)
SMIBN406_05157(nspC)
SMEGC770_GR4pD0072
SMELSM2011_b21631(nspC)
SMERDU99_25820
SMDSmed_4156
SIXBSY16_2357
ESJSJ05684_c25100
EAKEKH55_2457
SKMPZL22_000754(nspC)
ECAAJ3R84_19990
ENPJVX98_32005
ATUAtu4169(nspC)
ATAAWN88_05025
AGRAGROH133_13055
ATFAch5_39410(nspC)
AGCBSY240_4310
AGTEYD00_20125(nspC)
ALFCFBP5473_18730(nspC)
ARUIG6M88_06065(nspC)
AVQHRR99_12920(nspC)
AVVRvVAT039_41560(nspC)
AVFRvVAR031_34050(nspC)
ASALCFBP5507_18170(nspC)
RIRBN877_II1299(nspC)
RPUSCFBP5875_20340(nspC)
ACUCKZ699_21135(nspC)
ALEGCFBP4996_21910(nspC)
AVIAvi_5843(nspC)
RHVBA939_20275
ROYG3A56_23010(nspC)
RROSD4A92_20590
AROB0909_16965(nspC)
NEOCYG48_17400(nspC)
NENNCHU2750_24250(nspC)
NPMQEO92_24470(nspC)
RHTNT26_2996
RFVRFYW14_03078
LASCLIBASIA_03140(nspC)
LAAWSI_02280
LATCGUJ_03140(nspC)
LSOCKC_00770
LCCB488_12960
LARlam_217(lysA)
LAUG293_02010
SHZshn_03305
SZOK8M09_02955
SOJK6301_02075
SSUMQ9314_07215
ABAWD5400_05200(nspC)
PDESFE840_016485
HOEIMCC20628_00636
BMEBMEI1589
BMELDK63_1901(nspC)
BMIBMEA_A0371(nspC)
BMZBM28_A0365(nspC)
BMGBM590_A0362
BMWBMNI_I0359
BMEEDK62_1051(nspC)
BMFBAB1_0363(nspC)
BMBBruAb1_0360(nspC)
BMCBAbS19_I03330
BAABAA13334_I03388
BABODK55_380(nspC)
BABRDO74_1507(nspC)
BABTDK49_143(nspC)
BABBDK48_1747(nspC)
BABUDK53_370(nspC)
BABSDK51_1094(nspC)
BABCDO78_287(nspC)
BMSBR0334(nspC)
BSIBS1330_I0335(nspC)
BSFBSS2_I0330(nspC)
BSUIBSSP1_I0353(nspC)
BSUPBSPT1_I0358(nspC)
BSUVBSPT2_I0354(nspC)
BSUCBSSP2_I0354(nspC)
BMTBSUIS_A0365(nspC)
BSZDK67_1274(nspC)
BSVBSVBI22_A0335(nspC)
BSWIY71_01770
BSGIY72_01495
BOVBOV_0351(nspC)
BCSBCAN_A0343(nspC)
BSKBCA52141_I1151
BOLBCOUA_I0334(nspC)
BCARDK60_427(nspC)
BCASDA85_01630
BMRBMI_I339(nspC)
BPPBPI_I368(nspC)
BPVDK65_1011(nspC)
BCETV910_101611
BCEEV568_101805
BVLBF3285c1_0345(nspC)
BRUBFS01_01730
BRJBKD03_09115
OINIAR37_04880(nspC)
BIOBR141012304_10215(nspC)
OANOant_0437
OAHDR92_2502(nspC)
OPSA8A54_01425
BPSNNIK97_11125(nspC)
BRUCLJ361_01960(nspC)
OCRHGK82_01465(nspC)
OCLGTN27_01940(nspC)
OCCKMS41_01665(nspC)
OCHCES85_0374(nspC)
PSCQKHQ08_01840
BHEBH16480(nspC)
BHNPRJBM_01635(nspC)
BHSBM1374165_01703(nspC)
BQUBQ13380(nspC)
BQRRM11_1233
BBKBARBAKC583_0029(nspC)
BTRBT_2672(nspC)
BTXBM1374166_02313(nspC)
BGRBgr_20080(nspC)
BCDBARCL_1374(nspC)
BAUSBAnh1_12710(nspC)
BVNBVwin_15050(nspC)
BANCPU02_0428
BAPIBBC0122_024450
BARTBJB15x_012040
BARABA1379B_012160
BARWBWD162_014530
BARRBra60_013280
BAROB11Cv2_012850
BARJBJB63x_011830
BEZNCTC12898_01599
BARND1092_08585
BKYD1093_01245
BALSHWV54_03855
BTAYLAJ60_06115
BMACLNM86_11955
BHARNMK50_09695
BAPABBC0178_022850
CHELAL346_22650
CDQBOQ54_17145
PHLKKY_931
PEMOF122_14295
DEIC4375_14635
DSALK1X15_12295
DEVOH4N61_11910(nspC)
DRHJI748_03915
MHARL1P08_00060
MEYTM49_04750
MAADAZF01_20160
MMEDMame_00758(nspC)
MLUTJET14_00375(nspC)
JIEOH818_09325(nspC)
THDBHV28_00480(nspC)
NOHG5V57_11230(nspC)
PPHRAPZ00_18870
LAPACP90_26430
LABRCHH27_13405
LABPFJ695_05535
LABTFIU93_04190(nspC)
LAGGB0E33_10480
RPOPK1718_07800(nspC)
KVLKVU_1623(nspC)
KVUEIO_2057
KROBVG79_01674(nspC)
CIDP73_1348
CMARIMCC12053_1392
CEHCEW89_16970(nspC)
CBAKDA792_03570
MALGMALG_01297
YPACCEW88_20785
YANAYJ57_22530
TPROGa0080559_TMP1792
PABYGa0080574_TMP5140
SULDB5M07_13510
SPOTG6548_13705(nspC)
SINLDSM14862_00723(nspC)
SFAVPL335_03480
SDUBR1T39_07650
SPSESULPSESMR1_01760(nspC)
RMMROSMUCSMR3_00536(nspC)
ROKRAK1035_3371
ROTFIV09_04835(nspC)
RMHLVO79_11695
TGLHFZ77_03170
PALXGQA70_18190
LSALKBK07_03950
TRYQF118_17255
RSPRSP_1474(nspC)
RSHRsph17029_0125
RSQRsph17025_2883
RSKRSKD131_2865
CAZTLV780_13535(nspC)
RCPRCAP_rcc00206(nspC)
RHPLPB142_01505
RBLB6K69_09380
FYTQF092_13135
PDEPden_2956
PAMIJCM7686_2837
PYEA6J80_13685(nspC)
PCONB0A89_06660
PZHCX676_00605(nspC)
PAROCUV01_05475(nspC)
PARUCYR75_02165
PAMNJCM7685_2479
PMUTDPM13_12180(nspC)
PARSDRW48_01805
PARREOJ32_00315(nspC)
PAAKFIU66_01970(nspC)
PKDF8A10_03660(nspC)
PPANESD82_00580
PLIAE4191_14090
PSANHGN31_10315
PMAUCP157_00402(nspC)
PMEHJWJ88_20265(nspC)
PSEWJHW44_12460
PSAPJHX88_01525
PFISJHX87_16505(nspC)
PAEXJHW48_14555
PSTLJHW45_16335
PALPJHW40_05120
PVERE3U25_10745
PAEZPAE61_11610(nspC)
PALSPAF20_04300
PDIMPAF18_01250(nspC)
PFEOE3U26_18330
DAAAKL17_0549
DONBSK21_10400
RBZB9057_03205
THWBMG03_01555
TECAKL02_000350(nspC)
LVSLOKVESSMR4R_01076(nspC)
GEHHYN69_00100
GFUKM031_09665
HMLHmaOT1_06350
PSEBEOK75_07955
MONG8E03_07595
PALWPSAL_014630(nspC)
PSHQF3W81_00515
FAPGR316_07760
SINRO5O51_15225(nspC)
LVRT8T21_01820
TXITH3_02470
THACCSC3H3_02750
TIIDY252_18835(nspC)
THAIIT893_02585(nspC)
TLUR1T41_11055
TTBMACH01_05250(nspC)
HCLNCTC13205_00620
ECOMQTN59_07675(nspC)
PARHI5S86_12000
PUFUFO1_0330
PFTJBW_04291
MANAMAMMFC1_00820(nspC)
STEDSPTER_39060(nspC)
SALWCP975_34015
PRUNPCC7821_03671(yeaW)
MPROBJP34_16220
NSPHBDGGKGIB_04046(suoC)
SCYSNIES4073_42270
BSENDP114_06300
BOXDP113_06250
VAIBU251_06230
TRIDYE50_09720
EPOEpro_0512(nspC)
ETIRSTT_409(nspC)
RSDTGRD_450
LSZJCM16776_1156(nspC)
BFINBFINE_35160
PPSVPEPS_17120
KBNHYS26_00105
 » show all
Reference
1  [PMID:19196710]
  Authors
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ
  Title
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
  Journal
J Biol Chem 284:9899-907 (2009)
DOI:10.1074/jbc.M900110200
  Sequence
[vch:VC_1623] [vvu:VV1_3048]
Reference
2  [PMID:20534592]
  Authors
Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA
  Title
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
  Journal
J Biol Chem 285:25708-19 (2010)
DOI:10.1074/jbc.M110.121137
  Sequence
[cju:C8J_1418]
Reference
3  [PMID:22025614]
  Authors
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ
  Title
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
  Journal
J Biol Chem 286:43301-12 (2011)
DOI:10.1074/jbc.M111.307835
  Sequence
[cju:C8J_1418]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.96
IUBMB Enzyme Nomenclature: 4.1.1.96
ExPASy - ENZYME nomenclature database: 4.1.1.96
BRENDA, the Enzyme Database: 4.1.1.96

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