| Entry |
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| Name |
carboxynorspermidine decarboxylase;
carboxyspermidine decarboxylase;
CANSDC;
VC1623 (gene name)
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
carboxynorspermidine carboxy-lyase (bis(3-aminopropyl)amine-forming)
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| Reaction(IUBMB) |
(1) carboxynorspermidine = bis(3-aminopropyl)amine + CO2 [RN: R09082];
(2) carboxyspermidine = spermidine + CO2 [RN: R09081]
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| Reaction(KEGG) |
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| Substrate |
carboxynorspermidine [CPD: C18174];
carboxyspermidine [CPD: C18172]
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| Product |
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| Comment |
A pyridoxal 5'-phosphate enzyme. Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae [1]. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro [3].
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| History |
EC 4.1.1.96 created 2012
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
| K13747 | carboxynorspermidine decarboxylase |
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| Genes |
» show all
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| Reference |
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| Authors |
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ. |
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| Title |
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA |
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| Title |
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ |
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| Title |
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.96 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.96 |
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