Entry
Name
4-hydroxy-3-polyprenylbenzoate decarboxylase;
ubiD (gene name);
4-hydroxy-3-solanesylbenzoate decarboxylase;
3-octaprenyl-4-hydroxybenzoate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
4-hydroxy-3-polyprenylbenzoate carboxy-lyase
Reaction(IUBMB)
a 4-hydroxy-3-polyprenylbenzoate = a 2-polyprenylphenol + CO2 [RN:
R04985 ]
Reaction(KEGG)
Substrate
4-hydroxy-3-polyprenylbenzoate [CPD:
C05848 ]
Product
Comment
The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC
2.5.1.129 , flavin prenyltransferase.
History
EC 4.1.1.98 created 2014, modified 2015
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
Orthology
K03182 4-hydroxy-3-polyprenylbenzoate decarboxylase
Genes
ECOO : ECRM13514_4914(yigC)
ECOH : ECRM13516_4694(yigC)
ECW : EcE24377A_4362(ubiD)
EDJ : ECDH1ME8569_3720(ubiD)
ECOI : ECOPMV1_04201(ubiD)
RTG : NCTC13098_06977(ubiD_2)
REE : electrica_04852(ubiD)
CLAP : NCTC11466_04386(ubiD)
KIE : NCTC12125_03554(ubiD)
METY : MRY16398_54000(ubiD)
AHN : NCTC12129_04709(ubiD)
PTF : PROFFT_A_02570(ubiD)
PSHI : SAMEA2665130_2977(ubiD)
YPG : YpAngola_A1909(ubiD)
YPI : YpsIP31758_0280(ubiD)
SMW : SMWW4_v1c02600(ubiD)
SFJ : SAMEA4384070_0232(ubiD_1)
SOF : NCTC11214_02054(ubiD)
PAQU : DMB82_0019355(ubiD)
DIC : Dpoa569_003725(ubiD)
EHD : ERCIPSTX3056_309(ubiD)
TPTY : NCTC11468_03465(ubiD)
PHEI : NCTC12003_00588(ubiD)
PRJ : NCTC6933_00645(ubiD)
LRI : NCTC12151_00203(ubiD)
PDAG : 4362423_01130(ubiD)
ALIG : NCTC10568_01777(ubiD)
AVT : NCTC3438_01741(ubiD)
PAET : NCTC13378_00604(ubiD)
LLZ : LYB30171_00479(ubiD)
DJI : CH75_00705 CH75_23785
VAU : VANGNB10_cI0195(ubiD)
VSR : Vspart_03119(ubiD_2)
VPL : SA104470976_02421(ubiD)
PAEB : NCGM1900_6034(ubiD)
PPUD : DW66_5462 DW66_5582
PPRC : PFLCHA0_c59370(ubiD)
PFW : PF1751_v1c53100(ubiD)
PPUU : PputUW4_05248(ubiD)
PTRT : HU722_0028445(ubiD)
PTW : TUM18999_03770(ubiD)
PTAE : NCTC10697_04353(ubiD)
SCAA : TUM17387_34370(ubiD)
SALH : HMF8227_02947(ubiD)
OSG : BST96_01680 BST96_04265 BST96_05780
LLG : 44548918_02662(ubiD)
LJR : NCTC11533_02818(ubiD)
LCJ : NCTC11976_00742(ubiD)
LWA : SAMEA4504053_3454(ubiD)
LSS : NCTC12082_01980(ubiD)
LADL : NCTC12735_01675(ubiD)
LANT : TUM19329_34660(ubiD)
MISZ : MishRS11D_02170(ubiD)
TNI : TVNIR_3824(ubiD_[H])
GAI : IMCC3135_00030(ubiD)
THIC : TspCOW1_24090(ubiD)
AEL : NCTC12917_04191(ubiD)
CDIZ : CEDIAZO_03689(ubiD)
NMM : NMBM01240149_0489(ubiD)
NMS : NMBM01240355_1621(ubiD)
NMQ : NMBM04240196_0537(ubiD)
NMZ : NMBNZ0533_1673(ubiD)
NWE : SAMEA3174300_0108(ubiD)
NZO : SAMEA4504057_0814(ubiD)
NCI : NCTC10296_00999(ubiD)
NCZ : NCTC10294_01156(ubiD)
NANI : NCTC12227_01455(ubiD)
ECOR : SAMEA4412678_1318(ubiD)
BMV : BMASAVP1_A0758(ubiD)
BML : BMA10229_A2591(ubiD)
BPM : BURPS1710b_3106(ubiD)
BPL : BURPS1106A_3075(ubiD)
PLG : NCTC10937_05085(ubiD)
LMIR : NCTC12852_02388(ubiD)
BTRM : SAMEA390648702165(ubiD)
AXX : ERS451415_04971(ubiD)
DOE : DENOEST_0382 DENOEST_0390(ubiD)
FPHO : SHINM1_018710(ubiD)
SFD : USDA257_c38370(ubiD)
RGA : RGR602_PC02114(ubiD)
NEN : NCHU2750_38070(ubiD)
BIO : BR141012304_20675(ubiD)
BVY : NCTC9239_00803(ubiD)
HCL : NCTC13205_01169(yigC)
HSH : NHP194022_09010(ubiD)
HPUL : NCTC13154_00819(yigC)
CJV : MTVDSCj20_0563(menA)
CFV : CFVI03293_0587(menA)
CAMP : CFT03427_0594(menA)
CCOC : CCON33237_0800(menA)
CLR : UPTC16701_0780(menA)
CLM : UPTC16712_0784(menA)
CAMR : CAQ16704_0774(menA)
CHV : CHELV3228_1467(menA)
CPIN : CPIN18020_0050(menA)
CAMZ : CVIC12175_1178(menA)
GSK : KN400_0412 KN400_2026
GPI : GPICK_10910 GPICK_15540
GBZ : JZM60_06540 JZM60_10975
GEF : FO488_09495 FO488_18950
GUR : Gura_1842 Gura_2520 Gura_4281
GBN : GEOBRER4_02260 GEOBRER4_16080
GER : KP004_07515 KP004_17945
GSUB : KP001_07645 KP001_15315
GNT : KP003_07030 KP003_21005
GPL : M1B72_13370 M1B72_20795
GSB : GSUB_00530 GSUB_00725
PACE : A6070_00890 A6070_01320
PEF : A7E78_08980 A7E78_11870
DVE : DESUT3_01570 DESUT3_40200
DES : DSOUD_0197 DSOUD_0269
DMA : DMR_21400(ubiD) DMR_33530
DCB : C3Y92_05150 C3Y92_10255
MANA : MAMMFC1_00483(ubiD_2)
STED : SPTER_13600(ubiD_1)
SMAL : SMALA_0022 SMALA_4336
SLE : sle_31110(sle_31110)
SYY : SYNGTS_0301(sll0936)
SYT : SYNGTI_0301(sll0936)
SYS : SYNPCCN_0301(sll0936)
SYQ : SYNPCCP_0301(sll0936)
SYR : SynRCC307_1154(ubiD)
SYX : SynWH7803_1033(ubiD)
SYP : SYNPCC7002_A1113(ubiD)
SYNW : SynWH8103_01137(ubiD)
LET : O77CONTIG1_00845(ubiD)
NSPH : BDGGKGIB_00047(ubiD)
PEH : Spb1_07890 Spb1_29280(ubiD)
PLS : VT03_09610 VT03_28855(ubiD)
GMR : GmarT_09950 GmarT_10320(ubiD)
GIM : F1728_09505 F1728_09690
GPN : Pan110_09880 Pan110_10240(ubiD)
SDYN : Mal52_10250 Mal52_51110(ubiD)
PLON : Pla110_12810(ubiD) Pla110_23790
DIN : Selin_1878 Selin_1952
DAP : Dacet_2592 Dacet_2708
GTL : EP073_11285 EP073_13550
TVO : TVG0397730(TVG0397730)
» show all
Taxonomy
Reference
Authors
Leppik RA, Young IG, Gibson F
Title
Membrane-associated reactions in ubiquinone biosynthesis in Escherichia coli. 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase.
Journal
Sequence
Reference
Authors
Gulmezian M, Hyman KR, Marbois BN, Clarke CF, Javor GT
Title
The role of UbiX in Escherichia coli coenzyme Q biosynthesis.
Journal
Sequence
Reference
Authors
Pfaff C, Glindemann N, Gruber J, Frentzen M, Sadre R
Title
Chorismate pyruvate-lyase and 4-hydroxy-3-solanesylbenzoate decarboxylase are required for plastoquinone biosynthesis in the cyanobacterium Synechocystis sp. PCC6803.
Journal
Sequence
Reference
Authors
Lin F, Ferguson KL, Boyer DR, Lin XN, Marsh EN
Title
Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.
Journal
Reference
Authors
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D
Title
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.98
ExPASy - ENZYME nomenclature database: 4.1.1.98