KEGG ENZYME: 4.1.1.99

ENZYME: 4.1.1.99

Entry

EC 4.1.1.99 Enzyme

Name

phosphomevalonate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)

Reaction(IUBMB)

ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]

Reaction(KEGG)

R10561

Substrate

ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]

Comment

The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.

History

EC 4.1.1.99 created 2014, modified 2018

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17942

phosphomevalonate decarboxylase

Genes

RRS:	RoseRS_4285

RCA:

Rcas_0936

HAL:	VNG_0593G(dmd)

HSL:	OE_1893F(mvaD)

HDL:	HALDL1_07090

HHB:	Hhub_1732(mvaD)

HJE:	HacjB3_11155

HALH:

HTSR_1043(mvaD) HTSR_1765

HHSR:

HSR6_1076(mvaD) HSR6_1831(pmd)

HSU:	HLASF_0833(mvaD)

HSF:	HLASA_0830(mvaD)

SALR:

FQU85_11735

HALR:

EFA46_007505

HMA:	rrnAC1489(dmd)

HHI:	HAH_2062(dmd)

HHN:	HISP_10500

HAB:	SG26_02805

HTA:	BVU17_10065

HALJ:

G9465_15195

NPH:	NP_1580A(mvaD)

NMO:	Nmlp_1993(mvaD)

HUT:

Huta_0691

HTI:

HTIA_0600

HALA:

Hrd1104_09580(mvaD)

HMU:

Hmuk_2128

HALZ:

E5139_13780

HALL:

LC1Hm_1696(dmd)

HALI:

BV210_02915

HSN:	DV733_13305

HRR:	HZS55_09955(mvaD)

HPEL:

HZS54_15200

HLT:	I7X12_03205

HARC:

HARCEL1_02615

HWA:	HQ_1525A(mvaD)

HWC:	Hqrw_1624(mvaD)

HVO:	HVO_1412(mvaD)

HME:	HFX_1486(dmd)

HGI:	ABY42_06940

HALE:

G3A49_10265

HBO:	Hbor_18190

HAQ:	DU484_10010

HAJ:	DU500_10255

HAER:

DU502_07420

HRA:	EI982_06245

HLM:	DV707_07860

HALM:

FCF25_13955(mvaD)

HLA:

HALP:

HALB:

HEZZ:

HALQ:

SRUB:

HAE:	halTADL_3034

HALN:

B4589_002050(mvaD)

HALG:

HUG10_06730

HALU:

HUG12_08730

HDF:	AArcSl_0776(mvaD)

HAH:	Halar_1389

HTU:

Htur_1087

HDA:	BB347_03210

HJT:	DVR14_03890

HALY:

HYG82_18705

NMG:	Nmag_3235(mvaD)

HXA:	Halxa_3857

NAT:

NJ7G_3246

NPE:	Natpe_2790

NVR:	FEJ81_12855

NPL:	FGF80_13460

NGE:	Natgr_0456

HRU:	Halru_0775

NOU:	Natoc_1020

SALI:

L593_12340

HLR:	HALLA_08960

HLC:	CHINAEXTREME19995

NAJ:	B1756_18005

NAG:	AArcMg_1739

NAN:	AArc1_1936

NBG:	DV706_01870(mvaD)

NAS:	GCU68_11880(mvaD)

CSU:	CSUB_C1629

» show all

Reference

1 [PMID:24327557]

Authors

Dellas N, Thomas ST, Manning G, Noel JP

Title

Discovery of a metabolic alternative to the classical mevalonate pathway.

Journal

Elife 2:e00672 (2013)
DOI:10.7554/eLife.00672

Reference

2 [PMID:24375100]

Authors

Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM

Title

Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway.

Journal

J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13

Sequence

[hvo:HVO_1412]

Reference

3 [PMID:31268677]

Authors

Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP

Title

Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.

Journal

ACS Chem Biol 14:1767-1779 (2019)
DOI:10.1021/acschembio.9b00322