KEGG   ENZYME: 4.1.1.99Help
Entry
EC 4.1.1.99                 Enzyme                                 

Name
phosphomevalonate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Reaction(IUBMB)
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]
Comment
The enzyme participates in a mevalonate pathway that occurs in archaea other than the extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.110, bisphosphomevalonate decarboxylase.
History
EC 4.1.1.99 created 2014, modified 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17942  phosphomevalonate decarboxylase
Genes
HAL: VNG_0593G(dmd)
HSL: OE_1893F(mvaD)
HDL: HALDL1_07090
HHB: Hhub_1732(mvaD)
HJE: HacjB3_11155
HALH: HTSR_1043(mvaD) HTSR_1765
HHSR: HSR6_1076(mvaD) HSR6_1831(pmd)
HSU: HLASF_0833(mvaD)
HSF: HLASA_0830(mvaD)
SALR: FQU85_11735
HMA: rrnAC1489(dmd)
HHI: HAH_2062(dmd)
HHN: HISP_10500
HAB: SG26_02805
HTA: BVU17_10065
NPH: NP_1580A(mvaD)
NMO: Nmlp_1993(mvaD)
HUT: Huta_0691
HTI: HTIA_0600
HMU: Hmuk_2128
HALZ: E5139_13780
HALI: BV210_02915
HSN: DV733_13305
HARC: HARCEL1_02615
HWA: HQ_1525A(mvaD)
HWC: Hqrw_1624(mvaD)
HVO: HVO_1412(mvaD)
HME: HFX_1486(dmd)
HGI: ABY42_06940
HBO: Hbor_18190
HAQ: DU484_10010
HAJ: DU500_10255
HAER: DU502_07420
HLM: DV707_07860
HALM: FCF25_13955(mvaD)
HLA: Hlac_1434
HALP: DOS48_06945
HALB: EKH57_03095
HEZZ: EO776_08350
SRUB: C2R22_08520
HAE: halTADL_3034
HAH: Halar_1389
HTU: Htur_1087
HDA: BB347_03210
HJT: DVR14_03890
NMG: Nmag_3235(mvaD)
HXA: Halxa_3857
NAT: NJ7G_3246
NPE: Natpe_2790
NVR: FEJ81_12855
NPL: FGF80_13460
NGE: Natgr_0456
HRU: Halru_0775
NOU: Natoc_1020
SALI: L593_12340
HLR: HALLA_08960
HLC: CHINAEXTREME19995
NAJ: B1756_18005
NAG: AArcMg_1739
NAN: AArc1_1936
NBG: DV706_01870(mvaD)
CSU: CSUB_C1629
 » show all
Taxonomy
Reference
1  [PMID:24375100]
  Authors
Vannice JC, Skaff DA, Keightley A, Addo J, Wyckoff GJ, Miziorko HM.
  Title
Identification in Haloferax volcanii of Phosphomevalonate Decarboxylase and Isopentenyl Phosphate Kinase as Catalysts of the Terminal Enzymatic Reactions in  an Archaeal Alternate Mevalonate Pathway.
  Journal
J Bacteriol (2013)
DOI:10.1128/JB.01230-13
  Sequence
[hvo:HVO_1412]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.99
IUBMB Enzyme Nomenclature: 4.1.1.99
ExPASy - ENZYME nomenclature database: 4.1.1.99
BRENDA, the Enzyme Database: 4.1.1.99

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (203)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (64)   
   KEGG MGENES (100)   
   RefGene (38)   
Protein sequence (11)   
   UniProt (10)   
   SWISS-PROT (1)   
DNA sequence (21)   
   GenBank (10)   
   EMBL (11)   
All databases (250)   

Download RDF
DBGET integrated database retrieval system