KEGG   ENZYME: 4.1.1.99
Entry
EC 4.1.1.99                 Enzyme                                 
Name
phosphomevalonate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Reaction(IUBMB)
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]
Reaction(KEGG)
R10561
Substrate
ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]
Comment
The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.
History
EC 4.1.1.99 created 2014, modified 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17942  phosphomevalonate decarboxylase
Genes
HAL: VNG_0593G(dmd)
HSL: OE_1893F(mvaD)
HANR: LJ422_02475(mvaD)
HDL: HALDL1_07090
HHB: Hhub_1732(mvaD)
HAGS: JT689_03750(mvaD)
HABO: JRZ79_02255(mvaD)
HNO: LT974_03595(mvaD)
HLU: LT972_09845(mvaD)
HANX: ABSL23_08625(mvaD)
HALH: HTSR_1043(mvaD) HTSR_1765
HHSR: HSR6_1076(mvaD) HSR6_1831(pmd)
HSU: HLASF_0833(mvaD)
HSF: HLASA_0830(mvaD)
HAHS: HSRCO_1219(mvd1)
SALR: FQU85_11735
HALR: EFA46_007505
HJE: HacjB3_11155
HDO: MUK72_12405(mvaD) MUK72_18300
HALX: M0R89_12935(mvaD)
HAXZ: M0R88_13290(mvaD)
HAYC: NGM10_03025(mvaD)
HAXY: NGM07_00490(mvaD)
SALI: L593_12340
SAIM: K0C01_09265
HARA: AArcS_1922(mvd1)
HMA: rrnAC1489(dmd)
HSIN: KDQ40_03130
HHI: HAH_2062(dmd)
HHN: HISP_10500
HAB: SG26_02805
HTA: BVU17_10065
HALJ: G9465_15195
NPH: NP_1580A(mvaD)
NMO: Nmlp_1993(mvaD)
NHO: HWV23_04855
NSAL: HWV07_03955(mvaD)
HUT: Huta_0691
HTI: HTIA_0600
HALA: Hrd1104_09580(mvaD)
HASV: SVXHr_0902(mvaD)
HABN: HBNXHr_0894(mvaD)
HMU: Hmuk_2128
HALZ: E5139_13780
HALL: LC1Hm_1696(dmd)
HAZP: GBQ70_13795
HALI: BV210_02915
HSN: DV733_13305
HDS: HSR122_1854(mvd1)
HRR: HZS55_09955(mvaD)
HPEL: HZS54_15200
HLT: I7X12_03205
HARC: HARCEL1_02615
SSAI: N0B31_03695(mvaD)
HAAD: MW046_05125(mvaD)
HWA: HQ_1525A(mvaD)
HWC: Hqrw_1624(mvaD)
HVO: HVO_1412(mvaD)
HALE: G3A49_10265
HLN: SVXHx_1378(mvad)
HME: HFX_1486(dmd)
HGI: ABY42_06940
HLS: KU306_11920
HBO: Hbor_18190
HAQ: DU484_10010
HAJ: DU500_10255
HAER: DU502_07420
HRA: EI982_06245
HLM: DV707_07860
HALM: FCF25_13955(mvaD)
HLA: Hlac_1434
HALP: DOS48_06945
HALB: EKH57_03095
HEZZ: EO776_08350
HALQ: Hrr1229_014665
HSS: J7656_08105
HSAI: HPS36_13615
HAZZ: KI388_06040
SRUB: C2R22_08520
HAE: halTADL_3034
HALN: B4589_002050(mvaD)
HALG: HUG10_06730
HALU: HUG12_08730
HMP: K6T50_02775
HRE: K6T36_02605
HRM: K6T25_11895
HACB: Hbl1158_11835
HDF: AArcSl_0776(mvaD)
HAAA: AArcCO_2522(mvd1)
HAH: Halar_1389
HTU: Htur_1087
HSAL: JMJ58_03305(mvaD)
HAKZ: J0X25_09245 J0X25_13120(mvaD)
NMG: Nmag_3235(mvaD)
HXA: Halxa_3857
NAT: NJ7G_3246
NPE: Natpe_2790
NVR: FEJ81_12855
NPL: FGF80_13460
NAY: HYG81_17075
HALY: HYG82_18705
HJT: DVR14_03890
HLO: J0X27_03355
NGE: Natgr_0456
HLC: CHINAEXTREME19995
HRU: Halru_0775
SAWL: NGM29_17685(mvaD)
HALV: NGM15_08900(mvaD)
NOU: Natoc_1020
HLR: HALLA_08960
NAJ: B1756_18005
NAG: AArcMg_1739
NAN: AArc1_1936
NARA: QQ977_00285(mvaD)
NBG: DV706_01870(mvaD)
NAS: GCU68_11880(mvaD)
HDA: BB347_03210
CSU: CSUB_C1629
 » show all
Reference
1  [PMID:24327557]
  Authors
Dellas N, Thomas ST, Manning G, Noel JP
  Title
Discovery of a metabolic alternative to the classical mevalonate pathway.
  Journal
Elife 2:e00672 (2013)
DOI:10.7554/eLife.00672
Reference
2  [PMID:24375100]
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
  Sequence
[hvo:HVO_1412]
Reference
3  [PMID:31268677]
  Authors
Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP
  Title
Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
  Journal
ACS Chem Biol 14:1767-1779 (2019)
DOI:10.1021/acschembio.9b00322
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.99
IUBMB Enzyme Nomenclature: 4.1.1.99
ExPASy - ENZYME nomenclature database: 4.1.1.99
BRENDA, the Enzyme Database: 4.1.1.99

  All links  
Gene (136)   
   MGENES (98)   
   RefGene (38)   
Protein sequence (734)   
   UniProt (72)   
   SWISS-PROT (1)   
   RefSeq(pep) (661)   
DNA sequence (1057)   
   RefSeq(nuc) (972)   
   GenBank (50)   
   EMBL (35)   
Protein domain (7)   
   InterPro (7)   
All databases (1934)   

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