Entry |
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Name |
phosphomevalonate decarboxylase
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Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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Sysname |
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
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Reaction(IUBMB) |
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN: R10561]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.
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History |
EC 4.1.1.99 created 2014, modified 2018
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Pathway |
ec00900 | Terpenoid backbone biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K17942 | phosphomevalonate decarboxylase |
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Genes |
» show all
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Reference |
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Authors |
Dellas N, Thomas ST, Manning G, Noel JP |
Title |
Discovery of a metabolic alternative to the classical mevalonate pathway. |
Journal |
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Reference |
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Authors |
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM |
Title |
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. |
Journal |
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Sequence |
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Reference |
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Authors |
Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP |
Title |
Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.1.99 |
ExPASy - ENZYME nomenclature database: | 4.1.1.99 |
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