| Entry |
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| Name |
D-threonine aldolase;
D-TA;
DTA;
low specificity D-TA;
low specificity D-threonine aldolase
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| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
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| Sysname |
D-threonine acetaldehyde-lyase (glycine-forming)
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| Reaction(IUBMB) |
(1) D-threonine = glycine + acetaldehyde [RN: R08195];
(2) D-allothreonine = glycine + acetaldehyde [RN: R08196]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein that is activated by divalent metal cations (e.g. Co2+, Ni2+, Mn2+ or Mg2+) [1,2]. The reaction is reversible, which can lead to the interconversion of D-threonine and D-allothreonine [1]. Several other D-beta-hydroxy-alpha-amino acids, such as D-beta-phenylserine, D-beta-hydroxy-alpha-aminovaleric acid and D-beta-3,4-dihydroxyphenylserine, can also act as substrate [1].
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| History |
EC 4.1.2.42 created 2007
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Kataoka M, Ikemi M, Morikawa T, Miyoshi T, Nishi K, Wada M, Yamada H, Shimizu S. |
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| Title |
Isolation and characterization of D-threonine aldolase, a pyridoxal-5'-phosphate-dependent enzyme from Arthrobacter sp. DK-38. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S, Yamada H. |
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| Title |
A novel metal-activated pyridoxal enzyme with a unique primary structure, low specificity D-threonine aldolase from Arthrobacter sp. Strain DK-38. Molecular cloning and cofactor characterization. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Liu JQ, Odani M, Dairi T, Itoh N, Shimizu S, Yamada H. |
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| Title |
A new route to L-threo-3-[4-(methylthio)phenylserine], a key intermediate for the synthesis of antibiotics: recombinant low-specificity D-threonine aldolase-catalyzed stereospecific resolution. |
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| Journal |
Appl Microbiol Biotechnol 51:586-91 (1999) |
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| Reference |
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| Authors |
Liu JQ, Odani M, Yasuoka T, Dairi T, Itoh N, Kataoka M, Shimizu S, Yamada H. |
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| Title |
Gene cloning and overproduction of low-specificity D-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug. |
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| Journal |
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| Sequence |
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| Reference |
5 |
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| Authors |
Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. |
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| Title |
Diversity of microbial threonine aldolases and their application. |
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| Journal |
J Mol Catal B 10:107-115 (2000) |
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| Reference |
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| Authors |
Paiardini A, Contestabile R, D'Aguanno S, Pascarella S, Bossa F. |
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| Title |
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.2.42 |
| ExPASy - ENZYME nomenclature database: | 4.1.2.42 |
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