KEGG ENZYME: 4.1.2.43

ENZYME: 4.1.2.43

Entry

EC 4.1.2.43                 Enzyme

Name

3-hexulose-6-phosphate synthase;
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase;
3-hexulosephosphate synthase;
3-hexulose phosphate synthase;
HPS

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)

Reaction(IUBMB)

D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde [RN:R05338]

Reaction(KEGG)

R05338

Substrate

D-arabino-hex-3-ulose 6-phosphate [CPD:C06019]

Product

D-ribulose 5-phosphate [CPD:C00199];
formaldehyde [CPD:C00067]

Comment

Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].

History

EC 4.1.2.43 created 2008

Pathway

ec00030

Pentose phosphate pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K08093

3-hexulose-6-phosphate synthase

K13812

bifunctional enzyme Fae/Hps

K13831

3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase

Genes

EUM:	ECUMN_2963

STM:

STM2755

SEO:	STM14_3320

SEV:	STMMW_27231

SEY:	SL1344_2739(hxlA)

SEM:	STMDT12_C28070

SEJ:	STMUK_2743

SEB:	STM474_2890

SEF:	UMN798_2989(hxlA)

SETU:

STU288_13940

SETC:

CFSAN001921_03340

SENR:

STMDT2_26611

SEND:

DT104_27571

SENI:

CY43_14395

SEH:	SeHA_C2929(hxlA)

SHB:

SU5_03243

SENH:

CFSAN002069_18505

SEEH:

SEEH1578_22575

ECLZ:

LI64_16165

ECAN:

CWI88_05395(hxlA)

ECHG:

FY206_18835(hxlA)

KPN:

KPN_02957

KPY:	KPNIH31_18210

KMI:	VW41_11030

KOC:	AB185_13840

KLW:	DA718_10170(hxlA)

RTG:	NCTC13098_03929

CITZ:

E4Z61_22610(hxlA)

PGE:	LG71_08965

SOD:

Sant_0061

VSH:	BSZ05_17120

MCA:	MCA2738 MCA3043 MCA3049

METU:

GNH96_02035(hxlA) GNH96_02065(hxlA) GNH96_04130(hxlA)

MMEO:

OOT43_13075(hxlA) OOT43_14695(hxlA)

MMT:	Metme_0742 Metme_4080

MDN:	JT25_012675 JT25_012930

MDH:	AYM39_02470 AYM39_02740

MKO:	MKLM6_0536 MKLM6_0590

METL:

U737_21900(hxlA)

MPAD:

KEF85_01965(hxlA) KEF85_12785(hxlA)

MELL:

IVG45_20185(hxlA)

MRP:	NM686_001835(hxlA) NM686_019235(hxlA)

MAH:	MEALZ_1912(hpsi2) MEALZ_3953(hps1)

MBUR:

EQU24_11340(hxlA)

MPSY:

CEK71_00435(hxlA) CEK71_18985

MMAI:

sS8_1135 sS8_1148

MMOB:

F6R98_00315(hxlA) F6R98_00325(hxlA)

MEIN:

methR_P2885

MOZ:	MoryE10_01110 MoryE10_06560 MoryE10_07570

MISZ:

MishRS11D_06510

MESL:

KKZ03_07025(hxlA)

MEIY:

MIN45_P0982

MCAU:

MIT9_P2554

MEJ:	Q7A_2498(hxlA) Q7A_2501(hxlA)

MEC:	Q7C_1679 Q7C_1682

MPIN:

LGT42_003280(hxlA) LGT42_003295(hxlA)

MMAF:

GCM100_18860(hxlA_1) GCM100_18890(hxlA_2)

ORB:	IPMB12_08420(hxlA)

BPDZ:

BBN53_16310

ACID:

CBP33_16730

CSER:

CCO03_04105

MFA:	Mfla_0250 Mfla_1654

MMB:	Mmol_0313 Mmol_1338

MEH:	M301_0304 M301_1547

MEI:	Msip34_0268

MEP:	MPQ_0281(sgbH) MPQ_1561

MBAC:

BN1209_0202(rmpA) BN1209_0771(rmpA)

MBAT:

BN1208_0845(hps)

MEU:	ACJ67_02420 ACJ67_07420

MPAU:

ZMTM_02460 ZMTM_11880

MOH:	IHQ72_14040

MMEI:

LRP31_14175

XDI:	EZH22_21185

NOH:	G5V57_00560

ACUT:

MRB58_00780

SDO:	SD1155_05640(hxlA)

ADO:	A6F68_00105(proA_1)

GAL:	A0U94_14275

GSP:	IGS75_14265

KBA:	A0U89_15345

NSA:	Nitsa_1660

SLH:	YH65_04865

DAO:	Desac_1176

BSU:	BSU03460(hxlA)

BSR:	I33_0397(hxlA)

BSL:

A7A1_1851

BSH:	BSU6051_03460(hxlA)

BSY:	I653_01730

BSUT:

BSUB_00396(hxlA)

BSUL:

BSUA_00396(hxlA)

BSUS:

Q433_02070

BSO:	BSNT_06681(hxlA)

BSN:	BSn5_13315

BSQ:	B657_03460(hxlA)

BSX:	C663_0338(hxlA)

BSP:	U712_01790

BSS:	BSUW23_01790(hxlA)

BST:	GYO_0559(hxlA)

BIT:	BIS30_12300

BLI:	BL02045(hxlA)

BLD:	BLi02805(hxlA)

BLH:	BaLi_c29000(hxlA)

BAY:	RBAM_003630(hxlA)

BAQ:	BACAU_0303(hxlA)

BYA:	BANAU_0305(hxlA)

BAMP:

B938_01575

BQY:	MUS_0325(hxlA)

BAML:

BAM5036_0322(hxlA)

BAMA:

RBAU_0337(hxlA)

BAMN:

BASU_0321(hxlA)

BAMB:

BAPNAU_0307(hxlA)

BAMT:

AJ82_01980

BAMY:

V529_03250(hxlA)

BMP:	NG74_00345(hxlA)

BAO:	BAMF_0310(hxlA)

BAZ:	BAMTA208_01555(hxlA)

BQL:	LL3_00318(hxlA)

BXH:	BAXH7_00321(hxlA)

BAMI:

KSO_017855

BAMC:

U471_03230

BAMF:

U722_01860

BSIA:

CWD84_20190(hxlA)

BAE:	BATR1942_20410

BVM:	B9C48_01845

BSON:

S101395_01722(hxlA)

BHT:	DIC78_08240(hxlA)

BMOJ:

HC660_03860(hxlA)

BTEQ:

G4P54_01945(hxlA)

BIQ:	AN935_01795

BSTR:

QI003_01970(hxlA)

BPU:

BPUM_2333

BPUM:

BW16_12650

BPUS:

UP12_11780

BIF:	N288_21395 N288_22430

BMET:

BMMGA3_06845(hps)

BSM:	BSM4216_0641

BGY:	BGLY_3090(hxlA)

BXI:	BK049_15320

BALT:

CFN77_12450(hxlA)

BAER:

BAE_00125(hxlA)

BSAF:

BSL056_12835

BFD:	NCTC4823_01217(hxlA_1) NCTC4823_03793(hxlA_2)

BSHI:

LGQ02_03485(hxlA)

BCAB:

EFK13_02150(hxlA)

BRY:	M0696_02000(hxlA)

BJS:

MY9_0361

GST:	HW35_08370

BACW:

QR42_11740

BACP:

SB24_07990

BACB:

OY17_04480

BACY:

QF06_00690

BACL:

BS34A_04030(hxlA)

BALM:

BsLM_0362

BACS:

AUL54_09010

BACQ:

DOE78_03635(hxlA)

BACA:

FAY30_22685 FAY30_23225(hxlA)

BHAI:

KJK41_04665

BAEI:

RE735_08075(hxlA)

BHK:	B4U37_02010

BCIR:

C2I06_12975(hxlA) C2I06_17420

NTX:	NQZ71_05645(hxlA)

BMQ:	BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)

BMD:	BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)

BMH:	BMWSH_3691 BMWSH_4350(hxlA)

BMEG:

BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)

BEO:	BEH_06020 BEH_12940

BFX:	BC359_14510 BC359_19735

PKS:	IE339_01975(hxlA)

BKW:	BkAM31D_07120(hxlA_1) BkAM31D_16315(hxlA_2)

BCL:	ABC3351(hxlA)

BGI:	BGM20_16795

BON:	A361_15685 A361_15780 A361_26060

CGOT:

J1899_06860 J1899_20250 J1899_21665(hxlA)

CFIR:

NAF01_02050 NAF01_14215(hxlA)

CPSS:

M5V91_23200

OIH:	OB2697 OB2806

OCN:	CUC15_15170(hxlA)

OON:	NP440_00980(hxlA) NP440_16420(hxlA)

GTK:	GT3570_09830

GLI:	GLN3_03390

GTN:

GTNG_1490

GMC:	GY4MC1_3093

GGH:	GHH_c21400(hxlA)

GJF:	M493_16830

GEA:	GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)

GEL:	IB49_02240

GSR:	GS3922_12380

GEJ:	A0V43_08225

GZA:	IC807_06470(hxlA)

GTH:	Geoth_3109

PTL:	AOT13_07080

PTB:	DER53_08130(hxlA)

PARG:

PspKH34_30140(hxlA)

ANM:

GFC28_662

ANL:

GFC29_964

AND:	GRQ40_09545

ACAI:

ISX45_01330(hxlA) ISX45_06735

LAGR:

FJQ98_01550

HMN:	HM131_14425

HLI:

HLI_12660

HNZ:	P9989_20140

HSAN:

MUN89_03260

HSHI:

MUO14_10365(hxlB)

VIG:	BKP57_09220

VNE:	CFK40_05180

VPT:	KBP50_20725

VNT:	OLD84_16675(hxlA)

VIK:	KFZ58_14350

FAR:	ABE41_010275

FEC:	QNH15_11620 QNH15_16515 QNH15_20745(hxlA)

SJE:	AAV35_011130

APAK:

AP3564_06145

PBUT:

DTO10_07700

PPSR:

I6J18_02975(hxlA) I6J18_08150(hxlA)

PFRI:

L8956_21565

GRC:	GI584_10025(hxlA)

GCS:	MUN88_10555(hxlA)

GSM:	MUN87_08195(hxlA)

NMK:	CHR53_10820(hxlA)

NTM:	BTDUT50_14180(hxlA)

NDT:	L1999_02995 L1999_22990(hxlA)

NCM:	QNK12_20395 QNK12_22135(hxlA)

NNV:	QNH39_12220

MEKU:

HUW50_04030(hxlA) HUW50_16935

MSEM:

GMB29_08440

MDG:	K8L98_13980(hxlA) K8L98_15450

MLIT:

KDJ21_025570(hxlA) KDJ21_026155(hxlA)

AIA:	AWH56_012125

BLEN:

NCTC4824_00834(hxlA_1) NCTC4824_02164(hxlA_2)

SEDD:

ERJ70_14580 ERJ70_18455(hxlA)

BVQ:	FHE72_04710 FHE72_17335(hxlA)

RMF:	D5E69_06120(hxlA)

BAG:

Bcoa_0968

BBEV:

BBEV_0241(hxlA)

ALKG:

MOJ78_20470

PHJ:	LC071_09115(hxlA) LC071_13710(hxlA)

DOM:	RRU94_05940(hxlA) RRU94_11550(hxlA) RRU94_24155(hxlA)

STEA:

C0679_04045

PUK:	PU629_11120(hxlA) PU629_11395

SA0528

SAV:

SAV0570

SAW:

SAHV_0568

SAH:	SaurJH1_0607 SaurJH1_2812

SAJ:	SaurJH9_0593 SaurJH9_2736

SAM:

MW0525

SAS:

SAS0528

SAR:

SAR0574

SAC:

SACOL0617

SAX:	USA300HOU_0564

SAA:	SAUSA300_0555

SAO:	SAOUHSC_00553

SAE:

NWMN_0533

SAD:	SAAV_0533(hxlA)

SUU:	M013TW_0558(hxlA)

SUV:	SAVC_02440

SUE:

SAOV_0605

SUJ:	SAA6159_00524(hxlA)

SUK:	SAA6008_00578(hxlA)

SUC:	ECTR2_524(hxlA)

SUT:	SAT0131_00631

SUQ:	HMPREF0772_12618(hxlA)

SUZ:	MS7_0560(hxlA)

SUD:	ST398NM01_0645

SUX:	SAEMRSA15_04970

SUW:	SATW20_06400

SUG:	SAPIG0645(hxlA)

SUF:	SARLGA251_05060

SAUA:

SAAG_00991

SAUE:

RSAU_000524(hps)

SAUN:

SAKOR_00559

SAUS:

SA40_0511

SAUU:

SA957_0526

SAUG:

SA268_0524

SAUZ:

SAZ172_0572

SAUT:

SAI1T1_2004400

SAUJ:

SAI2T2_1004420

SAUK:

SAI3T3_1004410

SAUQ:

SAI4T8_1004400

SAUV:

SAI7S6_1004410

SAUW:

SAI5S5_1004370

SAUX:

SAI6T6_1004380

SAUY:

SAI8T7_1004410

SAUF:

X998_0612(hxlA)

SAB:

SAB0520

SUY:	SA2981_0547

SAUB:

C248_0645

SAUM:

BN843_5640

SAUC:

CA347_586(hxlA)

SAUR:

SABB_00621

SAUI:

AZ30_02885

SAUD:

CH52_02905

SAMS:

NI36_02840

SUH:	SAMSHR1132_05140

SER:

SERP0216

SEP:

SE_0341

SEPP:

SEB_00262

SEPS:

DP17_1647(hxlA)

SHA:

SH2420

SHH:	ShL2_02215(hxlA)

SSP:	SSP1619 SSP1626 SSP2148

SCA:	SCA_0226 SCA_0711

SLG:	SLGD_02315

SLN:	SLUG_22330

SSD:	SPSINT_0249

SDT:	SPSE_2213(hxlA)

SDP:	NCTC12225_02420(hxlA)

SWA:	A284_00525 A284_10445 A284_12317

SPAS:

STP1_1658

SXY:	BE24_00590

SXL:	SXYLSMQ121_2137

SXO:	SXYL_02291

SHU:	SHYC_10795(hxlA)

SCAP:

AYP1020_2319

SSCH:

LH95_10395

SSCZ:

RN70_11130

SAGQ:

EP23_11365(hxlA)

SEQO:

SE1039_03970

SSIF:

AL483_08720(hxlA)

SCV:	A4G25_06550

SPET:

CEP67_09865(hxlA)

SCOH:

BZ166_02680

SNL:	BJD96_12035

SKL:	C7J89_12605(hxlA)

SFQ:	C7J90_01805(hxlA)

SHOM:

EGX58_03330(hxlA)

SMUS:

C7J88_08345(hxlA)

SCAR:

DWB96_11675(hxlA) DWB96_13070(hxlA)

SCHR:

DWB92_10940(hxlA)

SARL:

SAP2_21950

SPIC:

SAMEA4384060_1853 SAMEA4384060_2297

SSH:	NCTC13712_00522

SSIM:

SAMEA4384339_0522

SDB:	CNQ82_05285(hxlA) CNQ82_12845(hxlA)

SLLO:

ISP08_10875(hxlA)

SAUL:

I6G39_01920(hxlA)

SSAC:

I6I31_05635(hxlA)

SRAI:

LN051_10085(hxlA)

SPSD:

JMB28_11605(hxlA)

STAS:

HYI43_10895(hxlA)

SURY:

MUA21_01500(hxlA)

SEDA:

MNY58_11550(hxlA)

SCAQ:

QMO72_11445(hxlA) QMO72_13360 QMO72_13455(hxlA)

SDEV:

Q2T90_08145(hxlA)

SSCU:

CEP64_01020(hxlA)

SFF:	FOB90_09055(hxlA)

MLEN:

H3V22_07285(hxlA)

MVT:	I6J10_09650(hxlA)

MCL:

MCCL_0037

MCAK:

MCCS_00640

MACR:

BHM04_10305

MBRU:

MGG13_01510(hxlA)

MEPI:

KFV12_00630(hxlA)

MEQU:

KFV11_01600(hxlA)

SHV:	AAT16_06530 AAT16_11280

ESI:

Exig_2372

EAN:

Eab7_2216

EXM:	U719_13055

EXU:	ESP131_15165

EACE:

KKI46_12995(hxlA)

PJD:	Pjdr2_1185

GYM:	GYMC10_3885

PPY:

PPE_04673

PPM:	PPSC2_24305(hxlA)

PPO:	PPM_4826(hxlA)

PPOL:

X809_40845

PPQ:	PPSQR21_049250(sgbH)

PPOY:

RE92_12975

PMS:	KNP414_07885(hxlA)

PMQ:	PM3016_7402

PMW:

B2K_37330

PTA:	HPL003_05880

PSAB:

PSAB_01345 PSAB_23295

PDU:	PDUR_01610 PDUR_26635

PBD:	PBOR_34755

PGM:	PGRAT_31065

POD:	PODO_29415

PAEN:

P40081_36070

PAEF:

R50345_29525

PAEQ:

R50912_32680

PSTE:

PSTEL_02005 PSTEL_26045

PAEA:

R70723_31470

PAEE:

R70331_30230

PAEH:

H70357_33735

PAEJ:

H70737_29170

PBJ:	VN24_01055 VN24_04705

PRI:	PRIO_3567 PRIO_6499(hxlA)

PSON:

JI735_07210(hxlA)

PPEO:

ABE82_24515

PNP:	IJ22_01440 IJ22_02540 IJ22_02590 IJ22_07980

POW:	IJ21_08240

PBV:	AR543_06015 AR543_17150

PXL:	BS614_16300

PYG:	AWM70_20320

PSWU:

SY83_08105

PDH:	B9T62_30300(hxlA)

PIB:	BBD41_28040

PCX:	LPB68_19235

PKB:	B4V02_00905

PAIH:

ASL14_13410

PVO:	PVOR_20959

PLW:	D5F53_10835(hxlA)

PALB:

EJC50_17680 EJC50_19855(hxlA)

PCHI:

PC41400_00765(hxlA)

PPRT:

ET464_10965(hxlA)

PBAC:

HUB98_29030(hxlA)

PRZ:	GZH47_09140(hxlA) GZH47_10845

PLYC:

GXP70_05785 GXP70_07130(hxlA)

PSOP:

KP014_02000(hxlA) KP014_04755

PTRI:

KDC22_31575(hxlA)

PALO:

E6C60_2213

PCEL:

HUB94_23390(hxlA)

PTJ:	JRJ22_27900(hxlA)

PKA:	PQ456_03510 PQ456_14780(hxlA)

PUI:	PUW25_10540(hxlA) PUW25_26985(hxlA)

PMAH:

PTQ21_17645(hxlA)

PAMY:

P9222_25085(hxlA)

PMAE:

LMZ02_07715(hxlA) LMZ02_12175(hxlA)

PSPN:

L1F29_07045(hxlA) L1F29_21075

COHN:

KCTCHS21_15480

CCHL:

FPL14_29080(hxlA)

CHEB:

HH215_35310(hxlA)

SACA:

FFV09_02170(hxlA)

AFX:	JZ786_23545

AACO:

K1I37_20295(hxlA)

ACUR:

JZ785_20925

ADAU:

NZD86_18890(hxlA) NZD86_23130(hxlA)

AFAS:

NZD89_03510(hxlA) NZD89_04475 NZD89_05660(hxlA) NZD89_15165

EFF:	skT53_30650(hxlA)

PRT:	AUC31_15190

PANA:

BBH88_04830 BBH88_17520

PMAR:

B0X71_02090

PLX:	CW734_09535(hxlA) CW734_13380(hxlA)

PMAT:

BBI11_12880

PDEC:

H1Q58_12160(hxlA)

JEO:	JMA_08740 JMA_29170

SPSY:

AZE41_09415

PANC:

E2636_12245

PLAY:

DNR44_005605

TVU:	AB849_007475

LKL:	DKL58_01400 DKL58_07350

LCZ:	LCAZH_0412

LCS:	LCBD_0422 LCBD_0453

LCE:	LC2W_0417 LC2W_0448

LCW:	BN194_04270 BN194_04560

LCL:	LOCK919_0475

LPQ:	AF91_01140

LPI:	LBPG_03035

LPAP:

LBPC_0348

LCB:	LCABL_04190 LCABL_04490(hps)

LCX:	LCA12A_2395

LCHI:

KG086_13075

LZE:	KG087_13955

LHN:	LHUE1_000947

LMU:	LBLM1_00435

LSN:

LSA_03490

LLE:	AYR59_00780

FIX:	M8332_02210(hxlA)

FCLI:

M3M38_02180

FHIN:

M3M39_06525(hxlA)

FMT:	M3M35_07060

FCP:	M3M37_03825

LBN:	LBUCD034_0077(hxlA)

LCU:	PL11_004190

LKF:	DNL43_05240

LHIL:

G8J22_00758

LLAO:

LHL71_06165

LBR:

LVIS_0442

LBK:	LVISKB_0449

LCY:	LC20004_14635

AAPI:

MOO46_01980(hxlA)

LPD:	AYR62_06120

PCE:

PECL_1750

PACI:

A4V11_00360

LROS:

LROSL1_0262

LALW:

BTM29_04245

LALI:

LA20249_07465

LHB:	D1010_15415

OOE:

OEOE_0131

OEN:	DSM07_06150

LMM:

MI1_09731

LGC:	A9176_08390

WCB:	AO080_07995 AO080_11070

WJO:	FOL01_0737

WCF:	C6P13_08480

WSO:	WSWS_00759(hxlA)

WHE:	EFA59_09465

WEI:	EQG49_01015

LBE:	MOO44_01770(hxlA)

EGV:	EGCR1_00760(hxlA) EGCR1_06790

EAV:	EH197_05785(hxlA) EH197_09440(hxlA) EH197_17130

ESG:	EsVE80_07410

ERAF:

J9537_02595(hxlA) J9537_09055

EDS:	PML78_03975

TOO:	C7K38_07925(hxlA)

VCP:	H9L18_04415

VHY:	G7082_07465

AUR:	HMPREF9243_0240(hxlA)

AMIT:

DBT49_0008965(hxlA)

CARN:

FPV25_08815(hxlA)

CAC:

CA_C0396

CAE:	SMB_G0404(sgbH)

CAY:

CEA_G0406

CBE:

Cbei_4647

CBZ:

Cbs_4647

CBEI:

LF65_06885

CSR:	Cspa_c49610

CDY:	F3K33_23655

CRW:	CROST_007110(hxlA)

CFB:	CLFE_041540(hxlA)

CAUN:

CLAUR_022850(hxlA)

CGEL:

psyc5s11_51560

ACOL:

K5I23_04770

ROB:

CK5_18950

ARF:	AR1Y2_1706 AR1Y2_3086 AR1Y2_3232

ACAC:

EYQ97_01665(hxlA) EYQ97_02425(hxlA) EYQ97_09120(hxlA)

SINT:

K5I26_01765

CMIU:

B1H56_12255

HALS:

D7D81_05785

IFN:	GM661_03240

PFT:

JBW_00828

EUC:

EC1_08720

FRO:	AALO17_19710

AARG:

Aargi30884_01890 Aargi30884_03610 Aargi30884_04650(hxlA)

ABSI:

A9CBEGH2_06030(hxlA)

LCG:	L3BBH23_22940(hxlA)

ERB:	A4V01_02795 A4V01_05815 A4V01_19475

CIU:	G4D55_04125(hxlA) G4D55_16760(hxlA) G4D55_20095

OLO:	ADJ70_05660

MDX:	BTO20_03345 BTO20_30245

MMEH:

M5I08_09490(hxlA)

MAUB:

MAUB_30940 MAUB_31120

MMAT:

MMAGJ_12220 MMAGJ_74070(hxlA)

CDX:	CDES_00570(rmpA)

CCYC:

SCMU_00950 SCMU_40760(hxlA)

RHA:	RHA1_ro11329

ROA:	Pd630_LPD04589

RKO:	JWS14_16845 JWS14_41255

ROZ:	CBI38_29950

RPSK:

JWS13_28030

SRC:	M271_24320

SXN:	IAG42_32240

PSIC:

J4E96_11815

CMI:	CMM_1123(sgaH)

CMS:	CMS1443(hps)

CMH:	VO01_04530

CMC:	CMN_01092(sgaH)

CCAP:

AES38_05195

CZH:	H9X71_05270(hxlA)

CPHA:

FGI33_07660(hxlA)

CCAF:

FGD68_07725(hxlA)

MIM:	AKG07_11695

MIH:	BJP65_05205

MICR:

BMW26_14455 BMW26_16485

MCHN:

HCR76_15235

RIA:	C7V51_11565

RFS:	C1I64_17210

RTE:	GSU10_14405

ROE:	Q0F99_06380(hxlA)

CUM:	NI26_12475

CUB:	BJK06_08985

CUG:	C1N91_12860

CQF:	GBG65_05940

CCIT:

QPK07_12930

AGY:	ATC03_10775

AGM:	DCE93_00160

ALAV:

MTO99_08415

CART:

PA27867_0095

MYL:	C3E77_13395

MSPO:

KXZ72_11835

SALC:

C2138_08145

SALA:

ESZ53_12315

PLAP:

EAO79_07240(hxlA)

FRN:	F1C15_08050

AGX:	AGREI_3079(hxlA)

NAEI:

GCM126_07680

ART:

Arth_3708

ARR:	ARUE_c04640(rmpA)

ARE:	AL755_02190 AL755_14010

ARH:	AHiyo8_33930

ARZ:	AUT26_19920

ARU:	ASPU41_06005

ARQ:	BWQ92_06605 BWQ92_09770 BWQ92_12695

ARN:	CGK93_01940(hxlA)

ARX:	ARZXY2_3983(hxlA)

ARTH:

C3B78_00800(hxlA)

ASUN:

KG104_15075(hxlA)

AOD:	Q8Z05_05505(hxlA)

AAU:	AAur_0494(hps)

PUE:	FV140_21525(hxlA)

PNV:	JMY29_02270(hxlA)

APN:	Asphe3_02200

PSUL:

AU252_12865

PSEY:

GU243_15480(hxlA)

AAI:	AARI_06580(rmpA)

GAR:	AOZ07_14970

GLU:	F0M17_03415(hxlA)

GMY:	XH9_05400(hxlA)

KPL:	KPaMU14_03840

SATK:

SA2016_1326 SA2016_3449 SA2016_3840 SA2016_3841

BRX:	BH708_07835

BRR:	C1N80_12905

BKI:	M4486_00580

BHH:	Bra3105_16385

CXIE:

NP048_00700

PAUS:

NCTC13651_01296(hxlA)

NOW:	GBF35_26640

AMQ:	AMETH_4519(hps) AMETH_4538(hps)

PSEE:

FRP1_13235 FRP1_13275

PSEQ:

AD006_20915 AD006_20955

PECQ:

AD017_00495 AD017_00535

MCRA:

ID554_24760

VER:	HUT12_22585

PFLA:

Pflav_052080

BDE:

BDP_0013

BDN:

BBDE_0013

BANG:

BBAG_0932

BGX:	ESN35_00230

BLEM:

BL8807_07050

BEU:	BE0216_04560

AEY:	CDG81_05575

ABAM:

B1s21122_01895

NHI:	B1s21160_01650

ABAO:

BEQ56_09840

TTR:

Tter_2273

PPHT:

GA004_12635

ROO:	G5S37_04785

RBA:

RB5319

PIR:	VN12_13465(hxlA)

RUL:	UC8_20370(hxlA)

RML:	FF011L_43020(hxlA)

ROL:	CA51_14720(hxlA)

AHEL:

Q31a_23230(rmpA)

RLC:	K227x_16680(hxlA)

LPAV:

PLANPX_2556

GMR:	GmarT_59230(hxlA)

GIM:	F1728_15900

GPN:	Pan110_58500(hxlA)

TIM:	GMBLW1_21350

KST:	KSMBR1_1055

BROC:

IPI25_12570

BPIT:

BPIT_02080

JET:	L3J17_12540

HBS:	IPV69_02725

UAM:	UABAM_03098

BHC:	JFL75_16590

TRS:	Terro_1472

TALB:

FTW19_05085

EDA:	GWR55_03245

ABAC:

LuPra_03104(hxlA)

STR:	Sterm_1849 Sterm_3212

MICA:

P0L94_12760

CPI:

Cpin_5671

CHIH:

GWR21_16300

ARAC:

E0W69_006905

FLN:

FLA_3348

FLC:	KJS93_07410

PEP:	AQ505_07150

PCM:	AY601_4886

PSTY:

BFS30_16375

PROE:

H9L23_01690

PMUO:

LOK61_01885

PGJ:	QG516_07765

MUP:	A0256_03165

MRUB:

DEO27_000305

MGOS:

DIU38_016630

AGD:	FRZ59_01495

CMR:	Cycma_4041

CAMU:

CA2015_3993

EVI:	Echvi_3532

EMAI:

KZP23_17980

ALM:	AO498_04580

SPIK:

EXU85_08270

SPIB:

G8759_32855

SFOL:

H3H32_02950

RHOZ:

GXP67_03990

ALS:	DJ013_10535

MAQA:

LAG90_17715

HAEI:

MUN82_08095

PKO:	PKOR_19965

ADD:	HUW48_11525

ASWU:

HUW51_20280

CLIT:

OQ292_29210

IRO:	RT717_28065

FMM:	LVD15_04435

FCR:	HYN56_16620(hxlA)

FPLU:

NLG42_16055(hxlA)

ZPR:

ZPR_1061

MARM:

YQ22_17840

CAO:	Celal_3937

CBAL:

M667_16185

CBAT:

M666_16170

ZGA:	ZOBELLIA_3942(hxlA)

ZLA:	Q5W13_18100(hxlA)

AALG:

AREALGSMS7_04556(hxlA)

LPAL:

LDL79_02280

CBEN:

EG339_11265(hxlA)

RBAR:

AWN76_010760

MPG:	Theba_2591

ALAM:

RT761_00648

DPB:	BABL1_gene_664(hxlA)

CDES:

C0J27_01395

VPM:	KG892_00070

MJA:	MJ_0644 MJ_1447

MFE:	Mefer_0259 Mefer_1012

MVU:	Metvu_0541 Metvu_1176

MFS:	MFS40622_0906 MFS40622_1056

MIF:	Metin_1286 Metin_1445

MJH:	JH146_0570 JH146_0865

MESG:

MLAUSG7_0043 MLAUSG7_1449(fae-hps)

MESA:

MLASG1_0987(fae-hps) MLASG1_1223

MIG:	Metig_0604 Metig_0664

MMP:

MMP1270

MMQ:	MmarC5_0321

MMX:	MmarC6_1403

MMZ:	MmarC7_0516

MMD:

GYY_07185

MMAK:

MMKA1_14950

MMAO:

MMOS7_13770

MMAD:

MMJJ_15750(hxlA)

MAE:	Maeo_0614 Maeo_1123

MVN:	Mevan_0582

MOK:	Metok_0605 Metok_1249

METF:

CFE53_02965 CFE53_04300

MTH:	MTH_1474 MTH_888

MMG:	MTBMA_c00570(fae_hps) MTBMA_c12830

MWO:	MWSIV6_0011(fae-hps) MWSIV6_1262(hpsA)

MTEE:

MTTB_00460 MTTB_04920

METC:

MTCT_0805 MTCT_1339

METE:

tca_00853(proA) tca_01421(fae)

METZ:

METMT2_0957 METMT2_1368

METK:

FVF72_04250 FVF72_07115

MTHM:

FZP57_00015 FZP57_06005

METJ:

FZP68_01675

MST:	Msp_1358 Msp_1498

METB:

AW729_07875 AW729_08735

MRU:	mru_0712 mru_2131

MSI:	Msm_0426 Msm_1213

MEB:	Abm4_0046 Abm4_0441

MMIL:

sm9_0074 sm9_0586

MEYE:

TL18_02745 TL18_10355

MOL:	YLM1_0353 YLM1_1686

MARO:

MarbSA_11880 MarbSA_18020

METV:

K4897_02645 K4897_05320

MEL:	Metbo_0071 Metbo_2333

MEW:	MSWAN_0017 MSWAN_0326

METH:

MBMB1_0009(fae-hps) MBMB1_0388

MFC:	BRM9_0060 BRM9_1874

MFI:	DSM1535_0057 DSM1535_1378(fae-hps)

MCUB:

MCBB_0021(fae-hps_1)

MSUB:

BK009_09760 BK009_12115

METN:

BK008_05430 BK008_07745

METT:

CIT01_02340 CIT01_05685(fae)

METO:

CIT02_04870 CIT02_07030(fae)

MEME:

HYG87_03735 HYG87_06650

MFEG:

GCM10025860_07720

MFV:	Mfer_0465 Mfer_0572

MKA:	MK0153(sgbH) MK1449(menG)

AFU:	AF_0861 AF_1305

AFG:	AFULGI_00009430 AFULGI_00014160

APO:	Arcpr_1052 Arcpr_1797

AVE:	Arcve_1411 Arcve_1683

AST:	Asulf_00326 Asulf_01087

FPL:	Ferp_2129 Ferp_2198

GAC:	GACE_0250 GACE_2158

GAH:	GAH_00051 GAH_00575

PFU:

PF0220

PFI:

PFC_00160

PHO:	PH1938(PH1938)

PAB:

PAB1222

PYN:

PNA2_0868

PYA:	PYCH_13020

PYS:

Py04_0376

PYC:	TQ32_01240

TKO:

TK0475

TON:

TON_0336

TGA:	TGAM_1891(hps)

TSI:

TSIB_0428

TBA:	TERMP_00758

THE:

GQS_03555

THA:

TAM4_82

THM:

CL1_0365

TLT:

OCC_09933

THS:

TES1_0756

TNU:

BD01_0222

TEU:

TEU_06790

TGY:	X802_02210

THV:	ADU37_CDS03570

TPEP:

A0127_02350

TPIE:

A7C91_07685

TGG:	A3K92_01750

TCE:	A3L02_00185

TBS:	A3L01_02370

THH:	CDI07_02325

TSL:	A3L11_06255

TTD:	A3L14_03835

TPRF:

A3L09_00545

TRL:	A3L10_04210

TPAF:

A3L08_04625

THY:	A3L12_06325

TIC:	FH039_04545(hxlA)

TCQ:	TIRI35C_0698

THEM:

FPV09_04565(hxlA)

THEI:

K1720_05250(hxlA)

PPAC:

PAP_05755

MBA:	Mbar_A0935 Mbar_A1170

MBY:	MSBRM_0067 MSBRM_3392

MBW:	MSBRW_0061 MSBRW_3553

MBAR:

MSBR2_2313 MSBR2_3345

MBAK:

MSBR3_2375 MSBR3_3372

MAC:	MA_4504 MA_4608

MMA:	MM_1215 MM_1279

MMAZ:

MmTuc01_1255 MmTuc01_1325

MMJ:	MSMAS_0037 MSMAS_0097

MMAC:

MSMAC_0037 MSMAC_0105

MVC:	MSVAZ_0074 MSVAZ_0103

MEK:	MSKOL_0070 MSKOL_0099

MLS:	MSLAZ_0035 MSLAZ_3053

METM:

MSMTP_0040 MSMTP_0201

MEF:	MSWH1_0036 MSWH1_3047

MEQ:	MSWHS_0037 MSWHS_1919

MSJ:	MSSAC_0046 MSSAC_4300

MSZ:	MSSIH_0039 MSSIH_3802

MSW:	MSSIT_0039 MSSIT_3879

MTHR:

MSTHT_1664 MSTHT_1787

MTHE:

MSTHC_1499 MSTHC_1625

MHOR:

MSHOH_0037 MSHOH_0117

MFZ:	AOB57_007440 AOB57_008160

MBU:	Mbur_1994(fae-hps)

MMET:

MCMEM_0222 MCMEM_0644

MELO:

J7W08_01295 J7W08_11180

MMH:	Mmah_0234 Mmah_1222

MHAZ:

BHR79_02340 BHR79_07435

MEV:	Metev_0697 Metev_1698

MZH:	Mzhil_0262 Mzhil_0311

MPY:	Mpsy_1396 Mpsy_1425

MZI:	HWN40_01665 HWN40_01805

MHZ:	Metho_0261 Metho_0283

MEHF:

MmiHf6_08380(ulaD_1) MmiHf6_11280(ulaD_2)

MEES:

MmiEs2_03010(rraA) MmiEs2_13960(ulaD)

MTP:	Mthe_0455 Mthe_0988

MCJ:	MCON_0429 MCON_1383

MHI:	Mhar_0019 Mhar_1869

MHU:	Mhun_0647 Mhun_1628

MRTJ:

KHC33_06360 KHC33_10130

MLA:	Mlab_0996 Mlab_1453

MEM:	Memar_0744 Memar_1085

MBG:	BN140_1075 BN140_1140

MEMA:

MMAB1_1386(fae-hps) MMAB1_1456(hpsA)

MCHK:

MchiMG62_08670 MchiMG62_12270(fae)

MSUM:

OH143_10440 OH143_12150

MRC:	R6Y96_06135(hxlA) R6Y96_06510

MPI:	Mpet_0679 Mpet_0801

MEND:

L6E24_05200 L6E24_11130

MAQE:

RJ40_03655 RJ40_11130

MOU:	OU421_09050 OU421_12595

MANQ:

L1994_03250 L1994_08160

MBN:	Mboo_0707 Mboo_0772

MFO:	Metfor_2057 Metfor_2503

MPL:	Mpal_1036 Mpal_2121

MPD:	MCP_0861 MCP_2904(fae_hps)

MEZ:	Mtc_0381(fae) Mtc_1411

RCI:	RCIX1492 RCIX775(fae-hps)

HARA:

AArcS_1663

MELU:

MTLP_05990(fae_1) MTLP_12130

MEAM:

MU439_01845 MU439_06385

MEAE:

QEN48_00515 QEN48_03760

TAR:	TALC_01565

MAX:	MMALV_16840

MER:	MMINT_19420

MEAR:

Mpt1_c14440(faeB)

MEUZ:

KRP56_00255

MARC:

AR505_0014

ABI:

Aboo_0457

ACF:	AciM339_0590

APE:	APE_0952.1(hxlA)

ACJ:	ACAM_0624(hxlA)

SMR:

Smar_0492

SHC:	Shell_0310

IHO:

Igni_0269

IIS:

EYM_01130

IPC:

IPA_01560

DKA:

DKAM_1456

DFD:	Desfe_0079

DMU:	Desmu_0149

TAG:

Tagg_1068

IAG:

Igag_1921

THG:	TCELL_0740

HBU:

Hbut_0129

PFM:	Pyrfu_0648

PDL:	Pyrde_0680

PARE:

PYJP_15730(hxlA)

STO:	STK_02380(hxlA)

SOH:	D1869_00695(hxlA)

SSO:	SSO0202(hpS-2)

SOL:

Ssol_1184

SSOA:

SULA_1220

SSOL:

SULB_1221

SSOF:

SULC_1219

SSHI:

J5U23_00054

SCAS:

SACC_01190

SAI:

Saci_0802

SACN:

SacN8_03890

SACR:

SacRon12I_03880

SACS:

SUSAZ_03625

SIS:	LS215_2094

SIA:	M1425_1931

SIM:	M1627_2009

SID:

M164_1939

SIY:	YG5714_2053

SIN:	YN1551_0865

SII:

LD85_2191

SIH:

SiH_1876

SIR:

SiRe_1804

SIC:

SiL_1785

SULA:

BFU36_04900

SULE:

GFS03_10600

SULO:

GFS33_02415

SULL:

EWF20_02130(hxlA)

MSE:

Msed_0227

MEMJ:

MJ1HA_0312

MCN:

Mcup_1845

MHK:	DFR87_05610

MPRU:

DFR88_05485

MTEN:

GWK48_05945

MJN:	MjAS7_0813

AHO:

Ahos_0599

AMAN:

B6F84_07975

ABRI:

DFR85_06830

ASUL:

DFR86_07010

AAMB:

D1866_10735

ACIH:

HS5_20010

SACD:

HS1genome_0892

SAZO:

D1868_00970

CSTY:

KN1_17010

STEP:

IC006_1852

SMET:

RQ359_002366

SAHS:

HS7_17030

PAI:

PAE1679

PIS:

Pisl_1686

PCL:

Pcal_0568

PAS:

Pars_1830

PYR:

P186_0040

POG:

Pogu_0300

TNE:

Tneu_0708

PYW:	PYWP30_00751

CMA:

Cmaq_1871

TTN:	TTX_1521(hps)

TUZ:

TUZN_2015

VDI:

Vdis_1817

VMO:

VMUT_0258

VSO:	Vsou_02140

TPE:

Tpen_0372

THB:	N186_02880

TCB:	TCARB_1644

THEL:

IG193_05685

ASC:

ASAC_0959

ACIA:

SE86_04960

CLG:	Calag_0067

FFO:	FFONT_0403

NCV:

NCAV_0256

CCAI:

NAS2_0542

KCR:

Kcr_1307

BARC:

AOA65_1083(faeB-hpsB)

BARB:

AOA66_0495 AOA66_1278

FLT:	Sv326_0214 Sv326_0884

LOKI:

Lokiarch_06870 Lokiarch_17920 Lokiarch_47420

PSYT:

DSAG12_03237(faeB-hpsB)

» show all

Reference

1 [PMID:4219834]

Authors

Ferenci T, Strom T, Quayle JR

Title

Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus.

Journal

Biochem J 144:477-86 (1974)
DOI:10.1042/bj1440477

Reference

2 [PMID:564713]

Authors

Kato N, Ohashi H, Tani Y, Ogata K

Title

3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics.

Journal

Biochim Biophys Acta 523:236-44 (1978)
DOI:10.1016/0005-2744(78)90026-8

Reference

3 [PMID:8595859]

Authors

Yanase H, Ikeyama K, Mitsui R, Ra S, Kita K, Sakai Y, Kato N

Title

Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli.

Journal

FEMS Microbiol Lett 135:201-5 (1996)
DOI:10.1111/j.1574-6968.1996.tb07990.x

Sequence

[ag:BAA19967]

Reference

4 [PMID:16278835]

Authors

Yurimoto H, Kato N, Sakai Y

Title

Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism.

Journal

Chem Rec 5:367-75 (2005)
DOI:10.1002/tcr.20056

Reference

5 [PMID:16428816]

Authors

Kato N, Yurimoto H, Thauer RK

Title

The physiological role of the ribulose monophosphate pathway in bacteria and archaea.

Journal

Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10

Reference

6 [PMID:15901685]

Authors

Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N

Title

The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.

Journal

J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005

Sequence

[pho:PH1938]

Reference

Authors

Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C.

Title

3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19.

Journal

Agric Biol Chem 52:2659-2661 (1988)

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.43

IUBMB Enzyme Nomenclature:

4.1.2.43

ExPASy - ENZYME nomenclature database:

4.1.2.43

BRENDA, the Enzyme Database:

4.1.2.43

DBGET integrated database retrieval system