KEGG   ENZYME: 4.1.2.44
Entry
EC 4.1.2.44                 Enzyme                                 
Name
2,3-epoxybenzoyl-CoA dihydrolase;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating);
BoxC;
dihydrodiol transforming enzyme;
benzoyl-CoA oxidation component C;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming);
benzoyl-CoA-dihydrodiol lyase (incorrect);
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)
Reaction(IUBMB)
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate [RN:R09556]
Reaction(KEGG)
R09556
Substrate
2,3-epoxy-2,3-dihydrobenzoyl-CoA [CPD:C19684];
H2O [CPD:C00001]
Product
(3Z)-6-oxohex-3-enoyl-CoA [CPD:C19683];
formate [CPD:C00058]
Comment
The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate.
History
EC 4.1.2.44 created 2010, modified 2015
Pathway
ec00362  Benzoate degradation
Orthology
K15513  benzoyl-CoA-dihydrodiol lyase
Genes
THISHZT40_02645
ADIB5T_02167
AXEP40_10395
MARLHH196_07245(boxC)
VFFVITFI_CDS1592
RPJN234_07050 N234_31285
REHH16_A1410(h16_A1410) H16_B1914(h16_B1914)
CNCCNE_1c14380(boxC) CNE_2c18750(boxC)
CUHBJN34_07190 BJN34_32100
REUReut_A1325
RMERmet_1222
CTIRALTA_A1323 RALTA_B1613
CBWRR42_m1519 RR42_s3012
CGDCR3_3378(boxC)
CCUPBKK81_26780
CUPBKK80_29535
CUUBKK79_35490
CPAUEHF44_15395
COXE0W60_03175 E0W60_17000
CCAMM5D45_06160(boxC)
BUGBC1001_2391
BGFBC1003_1067
BUQAC233_12245
BXEBxe_A1422(boxC) Bxe_C0892(boxC)
BXBDR64_3586(boxC) DR64_7558(boxC)
BPHBphy_1540
BGEBC1002_1977
BPXBUPH_02967
BPYBphyt_2696
BUZAYM40_13850
BFNOI25_2715(boxC)
BCAIK788_0006464
PSPWBJG93_02485(boxC)
PARBCJU94_11395
PHSC2L64_05435
PTERC2L65_05220
PGPCUJ91_12145
PCJCUJ87_05125
PTSCUJ90_12210
PCAFDSC91_004073
PMEGFNZ07_26480
PTROG5S35_23225
PGISI6I06_01095
PACPFAZ97_21025
PACSFAZ98_17225
PDIOPDMSB3_3012(boxC)
BRHRBRH_00497
PPKU875_06780
PPNODA70_23855
PPNMLV28_06855
PRBX636_02795
PPULRO07_00940
PSPUNA29_10725
PAPISG18_01115
PVEUC34_17195
POXMB84_21970
PTXABW99_07625
PFGAB870_04235
PNRAT302_14905
PANDDRB87_15895
PFIBPI93_010790
PCOMNTU39_18895(boxC)
BPTBpet3570
BHOD560_2020(boxC)
BHMD558_2005(boxC)
BHZACR54_04085(boxC)
BBROBAU06_05175
BFZBAU07_21250
BPDZBBN53_02665
BGMCAL15_08665
AXYAXYL_05032(boxC)
AXONH44784_035131
AXNAX27061_4851
ADTAPT56_22185
AISBUW96_13985
ASWCVS48_13530
ACHBDVB37_21280
ADYHLG70_28655
ACHOH4P35_20160
PUSCKA81_01050
PUDG9Q38_06770
AKATKWG_07585
AMIMMIM_c27180(boxC)
CDNBN940_14761
PIGEGT29_17295
PARKLSG25_10595(boxC)
RFRRfer_0220
RHFEUB48_04945
POLBpro_1628
PNAPnap_2944
POSDT070_17680
POOF7R28_12905
PVACHC248_01623(boxC)
ACKC380_20160
VEIVeis_0732
DACDaci_0074
DELDelCs14_0075
DTSBI380_22100
DHKBO996_02625
DLAI6G47_22050
VAPVapar_0093
VPEVarpa_0109
VPDVAPA_1c00950(boxC)
VBOCKY39_00540
VAMC4F17_18560
CTTCtCNB1_0067
CTESO987_00315
RTARta_22310
OTDJ1M35_05280
LIML103DPR2_00829(boxC)
LIHL63ED372_02247(boxC)
HYRBSY239_634(boxC)
HYBQ5W_16390
HYLLPB072_05885
HYCE5678_00690
HPSEHPF_06700(boxC)
HYNF9K07_05875
HTNKI616_07620(boxC) KI616_12825(boxC)
HCZG9Q37_21445
DIHG7047_17815
DRGH9K76_04130
CBAASRAA_0584
SAQAOMP39_14380(boxC)
SNNEWH46_00455
ATERMW290_08060(boxC)
LCHLcho_3659
THITHI_0468
SHDSUTH_01643(boxC)
EBAebA2763(boxC)
ABREpbN1_17400(boxC)
APETToN1_26670(boxC)
AZOazo3056
AOAdqs_3190
AZAAZKH_4518(boXC)
AZIAzCIB_4636
AZDCDA09_22735
AZRCJ010_18905
TMZTmz1t_3907
TCLTchl_1104 Tchl_2239
TAKTharo_1135 Tharo_1403
DDZDSYM_19380
APAUAMPC_37380
VINAKJ08_1017
SCLsce1061(boxC)
SCUSCE1572_07650
CCROCMC5_025760
PAUUE8A73_043345(boxC)
SAMYDB32_002624
LLUAKJ09_05633
MRMA7982_06573
HOHHoch_5224
MESOBSQ44_18035
RPODE0E05_11145(boxC)
NIYFQ775_02925(boxC)
KMNHW532_10730(boxC)
ABAWD5400_06465(boxC)
BJAblr1080(blr1080)
BJUBJ6T_11100
BJPRN69_05420
BRABRADO6789
BBTBBta_0749
BRSS23_67360
AOLS58_06710
BRCBCCGELA001_34215
BICLMTR13_36355
BROBRAD285_6937
BRKCWS35_10180
BOTCIT37_08875
BRQCIT40_30015
BGQX265_34640
BGZXH91_33025
BSYMCIT39_29130
BBETF8237_13010
BARHWN72_46145
BVZBRAD3257_8646(boxC)
BELBE61_90300(boxC)
BDGLPJ38_02115(boxC)
BSEPHAP48_0011935(boxC)
BQBJ4P68_0015775(boxC)
BSEIKMZ68_03455(boxC)
RPARPA0676
RPBRPB_4654
RPDRPD_0880
RPERPE_0585
RPTRpal_0743
RPXRpdx1_4110
RBKE0H22_11690
VGOGJW-30_1_01039(boxC)
TRBHB776_18410
RHZRHPLAN_60820
PSINCAK95_09710
RBMTEF_07965
CAULKCG34_06225
SILSPO3700
JANJann_0671(boxC)
RPONG3256_16610(boxC)
SUAMBOO69_15575
SULZC1J03_02540
SMEDJNX03_11405(boxC)
SPSESULPSESMR1_02746(boxC)
TOMBWR18_14115
RIDRIdsm_00625(boxC)
AHTANTHELSMS3_04344(boxC)
SAGUCDO87_17730
THAACFI11_22015
OCDFHY55_19205(boxC)
MALUKU6B_38060
TGLHFZ77_06795(boxC)
PTPRCA23_c19080(boxC)
SEDIEBB79_19930(boxC)
GCEKYE46_09680(boxC)
MAGamb0174
MAGXXM1_1069(boxC)
MAGNWV31_13520
FERFNB15_18635(boxC)
NACINUH88_09985(boxC)
SNEANBZ79_15025(boxC)
MFJMFLOJ_46040(paaG_5)
MMORMMOR_02890(paaG_1)
GOQACH46_13385
GOILK459_15650(boxC)
TOYFO059_00800
SBATG4Z16_02400
JLIEXU32_11265
NPSKRR39_16235(boxC)
SAIUJ4H86_15065
NOABKM31_25135
NGNLCN96_23785(boxC)
BSDBLASA_2557(boxC)
AMDAMED_8611(paaG)
AMNRAM_44195
AMMAMES_8480(paaG)
AMZB737_8481(paaG)
AOIAORI_7397(paaG)
AJAAJAP_02015
AMQAMETH_6480(paaG)
AMYCCU254_35740
AMYBBKN51_30390
AMYYYIM_21140(boxC)
AORISD37_03475
AACDLWP59_36015(boxC)
APRTMUY14_40650(boxC)
AROONQK81_28600(boxC)
PDXPsed_1490
PSEEFRP1_20440
PSEHXF36_05455
PSEQAD006_27855
PECQAD017_07450
PHHAFB00_18005
PAUTPdca_13950(paaG_3)
PBROHOP40_01900
KPHYAOZ06_19785
PMADBAY61_05965
CAICaci_2008
EKEEK0264_08365
 » show all
Reference
1  [PMID:15916608]
  Authors
Gescher J, Eisenreich W, Worth J, Bacher A, Fuchs G
  Title
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme.
  Journal
Mol Microbiol 56:1586-600 (2005)
DOI:10.1111/j.1365-2958.2005.04637.x
  Sequence
Reference
2  [PMID:20452977]
  Authors
Rather LJ, Knapp B, Haehnel W, Fuchs G
  Title
Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation.
  Journal
J Biol Chem 285:20615-24 (2010)
DOI:10.1074/jbc.M110.124156
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.44
IUBMB Enzyme Nomenclature: 4.1.2.44
ExPASy - ENZYME nomenclature database: 4.1.2.44
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.2.44
BRENDA, the Enzyme Database: 4.1.2.44

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