KEGG   ENZYME: 4.1.2.44
Entry
EC 4.1.2.44                 Enzyme                                 
Name
2,3-epoxybenzoyl-CoA dihydrolase;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating);
BoxC;
dihydrodiol transforming enzyme;
benzoyl-CoA oxidation component C;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming);
benzoyl-CoA-dihydrodiol lyase (incorrect);
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)
Reaction(IUBMB)
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate [RN:R09556]
Reaction(KEGG)
R09556
Substrate
2,3-epoxy-2,3-dihydrobenzoyl-CoA [CPD:C19684];
H2O [CPD:C00001]
Product
(3Z)-6-oxohex-3-enoyl-CoA [CPD:C19683];
formate [CPD:C00058]
Comment
The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate.
History
EC 4.1.2.44 created 2010, modified 2015
Pathway
ec00362  Benzoate degradation
Orthology
K15513  benzoyl-CoA-dihydrodiol lyase
Genes
THIS: HZT40_02645
ADI: B5T_02167
AXE: P40_10395
MARL: HH196_07245(boxC)
VFF: VITFI_CDS1592
RPJ: N234_07050 N234_31285
REH: H16_A1410(h16_A1410) H16_B1914(h16_B1914)
CNC: CNE_1c14380(boxC) CNE_2c18750(boxC)
CUH: BJN34_07190 BJN34_32100
REU: Reut_A1325
RME: Rmet_1222
CTI: RALTA_A1323 RALTA_B1613
CBW: RR42_m1519 RR42_s3012
CGD: CR3_3378(boxC)
CCUP: BKK81_26780
CUP: BKK80_29535
CUU: BKK79_35490
CPAU: EHF44_15395
COX: E0W60_03175 E0W60_17000
CCAM: M5D45_06160(boxC)
CCAX: KZ686_17585(boxC)
CUK: KB879_07270(boxC) KB879_14625
CNAN: A2G96_10130 A2G96_24420
CUPE: KLP38_06610(boxC)
CUPP: CTP10_R12260 CTP10_R54410
BUG: BC1001_2391
BGF: BC1003_1067
BUQ: AC233_12245
BXE: Bxe_A1422(boxC) Bxe_C0892(boxC)
BXB: DR64_3586(boxC) DR64_7558(boxC)
BPH: Bphy_1540
BGE: BC1002_1977
BPX: BUPH_02967
BPY: Bphyt_2696
BUZ: AYM40_13850
BFN: OI25_2715(boxC)
BCAI: K788_0006464
PSPW: BJG93_02485(boxC)
PARB: CJU94_11395
PHS: C2L64_05435
PTER: C2L65_05220
PGP: CUJ91_12145
PCJ: CUJ87_05125
PTS: CUJ90_12210
PCAF: DSC91_004073
PMEG: FNZ07_26480
PTRO: G5S35_23225
PGIS: I6I06_01095
PACP: FAZ97_21025
PACS: FAZ98_17225
PDIO: PDMSB3_3012(boxC)
PBRY: NDK50_13970(boxC)
PSAA: QEN71_05365(boxC)
PKF: RW095_24745(boxC)
PPAI: E1956_16980
PLAD: PPGU16_10600
PAZZ: PBP221_10590(boxC)
BRH: RBRH_00497
PPK: U875_06780
PPNO: DA70_23855
PPNM: LV28_06855
PRB: X636_02795
PPUL: RO07_00940
PSPU: NA29_10725
PAPI: SG18_01115
PVE: UC34_17195
POX: MB84_21970
PTX: ABW99_07625
PFG: AB870_04235
PNR: AT302_14905
PAND: DRB87_15895
PFIB: PI93_010790
PCOM: NTU39_18895(boxC)
PANN: PanNE5_27860
PANX: OYT13_17400(boxC)
TVL: FAZ95_11610
BPT: Bpet3570
BHO: D560_2020(boxC)
BHM: D558_2005(boxC)
BHZ: ACR54_04085(boxC)
BBRO: BAU06_05175
BFZ: BAU07_21250
BPDZ: BBN53_02665
BGM: CAL15_08665
BGV: CAL12_05285
AXY: AXYL_05032(boxC)
AXO: NH44784_035131
AXN: AX27061_4851
ADT: APT56_22185
AIS: BUW96_13985
ASW: CVS48_13530
ACHB: DVB37_21280
ADY: HLG70_28655
ACHO: H4P35_20160
AMUI: PE062_16815(boxC)
APES: FOC84_20825
AAEG: RA224_07445(boxC)
ASEL: RAS12_29155(boxC)
ACHM: V6V88_20710(boxC)
ACHA: KYT87_22510(boxC)
ACHH: ABFG95_08645(boxC)
PUD: G9Q38_06770
PUS: CKA81_01050
POLL: OEG81_13630(boxC)
AKA: TKWG_07585
AMIM: MIM_c27180(boxC)
CDN: BN940_14761
PIG: EGT29_17295
PARK: LSG25_10595(boxC)
NARM: N7E01_12345(boxC)
RFR: Rfer_0220
RHF: EUB48_04945
RLH: MIZ03_2344
POL: Bpro_1628
PNA: Pnap_2944
POS: DT070_17680
POO: F7R28_12905
PVAC: HC248_01623(boxC)
ACK: C380_20160
ACIV: EXV95_12235
VEI: Veis_0732
DAC: Daci_0074
DEL: DelCs14_0075
DTS: BI380_22100
DHK: BO996_02625
DLA: I6G47_22050
VAP: Vapar_0093
VPE: Varpa_0109
VPD: VAPA_1c00950(boxC)
VBO: CKY39_00540
VAM: C4F17_18560
VAZ: H7F35_12420
VAV: IG196_31310
VAE: RZE79_00570(boxC)
VAX: H7F36_05980
CTT: CtCNB1_0067
CTES: O987_00315
CRJ: QMY55_00240(boxC)
RTA: Rta_22310
OTD: J1M35_05280
LIM: L103DPR2_00829(boxC)
LIH: L63ED372_02247(boxC)
HYR: BSY239_634(boxC)
HYB: Q5W_16390
HYL: LPB072_05885
HYC: E5678_00690
HPSE: HPF_06700(boxC)
HYN: F9K07_05875
HTN: KI616_07620(boxC) KI616_12825(boxC)
HCZ: G9Q37_21445
HYY: JNX00_17205
HYDR: SOM08_17425(boxC)
HYDA: ABSY19_08120(boxC)
DIH: G7047_17815
DRG: H9K76_04130
CBAA: SRAA_0584
SAQA: OMP39_14380(boxC)
SNN: EWH46_00455
SMIO: CATMQ487_11290
ATER: MW290_08060(boxC)
LCH: Lcho_3659
THI: THI_0468
SHD: SUTH_01643(boxC)
EBA: ebA2763(boxC)
ABRE: pbN1_17400(boxC)
APET: ToN1_26670(boxC)
AZO: azo3056
AOA: dqs_3190
AZA: AZKH_4518(boXC)
AZI: AzCIB_4636
AZD: CDA09_22735
AZR: CJ010_18905
TMZ: Tmz1t_3907
TCL: Tchl_1104 Tchl_2239
TAK: Tharo_1135 Tharo_1403
DDZ: DSYM_19380
NIY: FQ775_02925(boxC)
MESO: BSQ44_18035
RPOD: E0E05_11145(boxC)
KMN: HW532_10730(boxC)
ABAW: D5400_06465(boxC)
BJA: blr1080(blr1080)
BJU: BJ6T_11100
BJP: RN69_05420
BRA: BRADO6789
BBT: BBta_0749
BRS: S23_67360
AOL: S58_06710
BRC: BCCGELA001_34215
BIC: LMTR13_36355
BRO: BRAD285_6937
BRK: CWS35_10180
BOT: CIT37_08875(boxC)
BRQ: CIT40_30015(boxC)
BGQ: X265_34640
BGZ: XH91_33025
BSYM: CIT39_29130(boxC)
BBET: F8237_13010
BARH: WN72_46145
BVZ: BRAD3257_8646(boxC)
BEL: BE61_90300(boxC)
BDG: LPJ38_02115(boxC)
BSEP: HAP48_0011935(boxC)
BQB: J4P68_0015775(boxC)
BSEI: KMZ68_03455(boxC)
BBAN: J4G43_003785(boxC)
BCAN: BcanWSM471_35430(boxC)
BAUT: QA635_04855(boxC)
BBRA: QA636_04330(boxC)
BGK: IC762_32490
BCOU: IC761_34610
BPAH: QA639_04275(boxC)
BXN: I3J27_37560(boxC)
BROS: QUH67_33650(boxC)
BRAZ: LRP30_42135(boxC)
BOY: LQG66_27075(boxC)
BRAY: ML401_32625(boxC)
RPA: TX73_003500(boxC)
RPB: RPB_4654
RPD: RPD_0880
RPE: RPE_0585
RPT: Rpal_0743
RPX: Rpdx1_4110
RBK: E0H22_11690
RHOR: ONR75_03755(boxC)
RHOL: RBJ75_18375(boxC)
VGO: GJW-30_1_01039(boxC)
TRB: HB776_18410
TARD: RSO67_12280(boxC)
PTAW: DW352_26115(boxC)
RHZ: RHPLAN_60820
PSIN: CAK95_09710
RBM: TEF_07965
CAUL: KCG34_06225
SIL: SPO3700
JAN: Jann_0671(boxC)
RPON: G3256_16610(boxC)
RFU: ROLI_036860(boxC)
SUAM: BOO69_15575
SULZ: C1J03_02540
SMED: JNX03_11405(boxC)
SPSE: SULPSESMR1_02746(boxC)
TOM: BWR18_14115
RID: RIdsm_00625(boxC)
AHT: ANTHELSMS3_04344(boxC)
SAGU: CDO87_17730
SSTL: ABFK29_08850(boxC)
THAA: CFI11_22015
OCD: FHY55_19205(boxC)
MALU: KU6B_38060
TGL: HFZ77_06795(boxC)
TRY: QF118_10490(boxC)
ASCA: QEZ52_02765(boxC)
PTP: RCA23_c19080(boxC)
MALC: QQG91_02035(boxC)
SEDI: EBB79_19930(boxC)
PPSO: QPJ95_08520(boxC)
GCE: KYE46_09680(boxC)
GYJ: AADW23_12630(boxC)
MAGX: XM1_1069(boxC)
MAGN: WV31_13520
FER: FNB15_18635(boxC)
AALU: ABWI00_00645(boxC)
MAG: amb0174
NACI: NUH88_09985(boxC)
SNEA: NBZ79_15025(boxC)
APAU: AMPC_37380
VIN: AKJ08_1017
SCL: sce1061(boxC)
SCU: SCE1572_07650
CCRO: CMC5_025760
PAUU: E8A73_043345(boxC)
MRM: A7982_06573
SAMY: DB32_002624
LLU: AKJ09_05633
HOH: Hoch_5224
NANN: O0S08_50215(boxC)
PBAP: Pla133_22010(boxC)
MFJ: MFLOJ_46040(paaG_5)
MLW: MJO58_22410(boxC)
MMOR: MMOR_02890(paaG_1)
RANT: RHODO2019_00985(boxC)
GOQ: ACH46_13385
GOI: LK459_15650(boxC)
TOY: FO059_00800
SBAT: G4Z16_02400
SSPN: LXH13_30050(boxC)
JLI: EXU32_11265
JCR: O9K63_16290(boxC)
JAI: V1351_03605(boxC)
JTR: V3C34_06610(boxC)
NPS: KRR39_16235(boxC)
SAIU: J4H86_15065
AMAZ: LUW76_06995(boxC)
ACIR: OG979_34105(boxC)
ACTQ: OG417_22050(boxC)
NOA: BKM31_25135
NGN: LCN96_23785(boxC)
NFS: OIE67_25005(boxC)
BSD: BLASA_2557(boxC)
BBRG: U6N30_14655
AMD: AMED_8611(paaG)
AMN: RAM_44195
AMM: AMES_8480(paaG)
AMZ: B737_8481(paaG)
AOI: AORI_7397(paaG)
AJA: AJAP_02015
AMQ: AMETH_6480(paaG)
AMYC: CU254_35740
AMYB: BKN51_30390
AMYY: YIM_21140(boxC)
AORI: SD37_03475
AACD: LWP59_36015(boxC)
APRT: MUY14_40650(boxC)
AROO: NQK81_28600(boxC)
ATHM: L1857_34455(boxC)
ARHD: VSH64_04770(boxC) VSH64_32960(boxC)
AMOG: QRX60_15600(boxC)
ACYN: ORV05_36105(boxC)
ACOR: LCL61_08980(boxC)
AMYZ: HUW46_04986(boxC)
ACAB: QRX50_11945(boxC)
ANW: QP939_17835(boxC)
AMYD: K1T34_14095(boxC) K1T34_34865(boxC)
ABAR: AMYBAR_006845(boxC)
AMYE: MJQ72_12620(boxC)
AMYS: CVV72_32705
PDX: Psed_1490
PSEE: FRP1_20440
PSEH: XF36_05455
PSEQ: AD006_27855
PECQ: AD017_07450
PHH: AFB00_18005
PAUT: Pdca_13950(paaG_3)
PBRO: HOP40_01900
PPEL: H6H00_02550
PSDS: K1T35_07625(boxC)
KUT: JJ691_02590(paaG_1)
KBR: Q4V65_40835(boxC)
KPHY: AOZ06_19785
PMAD: BAY61_05965
ACTY: OG774_01095(boxC)
CAI: Caci_2008
EKE: EK0264_08365
JCY: M6B22_14595(boxC)
VAB: WPS_02280
 » show all
Reference
1  [PMID:15916608]
  Authors
Gescher J, Eisenreich W, Worth J, Bacher A, Fuchs G
  Title
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme.
  Journal
Mol Microbiol 56:1586-600 (2005)
DOI:10.1111/j.1365-2958.2005.04637.x
  Sequence
[ag:AAN39375]
Reference
2  [PMID:20452977]
  Authors
Rather LJ, Knapp B, Haehnel W, Fuchs G
  Title
Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation.
  Journal
J Biol Chem 285:20615-24 (2010)
DOI:10.1074/jbc.M110.124156
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.44
IUBMB Enzyme Nomenclature: 4.1.2.44
ExPASy - ENZYME nomenclature database: 4.1.2.44
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.2.44
BRENDA, the Enzyme Database: 4.1.2.44

  All links  
Gene (4245)   
   MGENES (3493)   
   RefGene (752)   
Protein sequence (4476)   
   UniProt (433)   
   SWISS-PROT (1)   
   RefSeq(pep) (4042)   
DNA sequence (7894)   
   RefSeq(nuc) (6759)   
   GenBank (582)   
   EMBL (553)   
Protein domain (3)   
   InterPro (3)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (16619)   

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