Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy

L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming)

(1) L-threonine = glycine + acetaldehyde [RN:R00751];
(2) L-allo-threonine = glycine + acetaldehyde [RN:R06171]

R00751 R06171
Reaction

L-threonine [CPD:C00188];
L-allo-threonine [CPD:C05519]

Requires pyridoxal phosphate. The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine [1,2]. The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.49, L-allo-threonine aldolase.

EC 4.1.2.48 created 2011