KEGG   ENZYME: 4.1.2.51
Entry
EC 4.1.2.51                 Enzyme                                 

Name
2-dehydro-3-deoxy-D-gluconate aldolase;
Pto1279 (gene name);
KDGA;
KDG-specific aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde [RN:R08570]
Reaction(KEGG)
R08570;
(other) R10616
Substrate
2-dehydro-3-deoxy-D-gluconate [CPD:C00204]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.51 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18127  2-dehydro-3-deoxy-D-gluconate aldolase
Genes
TAC: Ta1157
TVO: TVG1289977(TVG1289977)
PTO: PTO1279
MARH: Mia14_0299
Reference
1  [PMID:20023024]
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
  Sequence
[pto:PTO1279]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.51
IUBMB Enzyme Nomenclature: 4.1.2.51
ExPASy - ENZYME nomenclature database: 4.1.2.51
BRENDA, the Enzyme Database: 4.1.2.51

DBGET integrated database retrieval system