KEGG   ENZYME: 4.1.2.53Help
Entry
EC 4.1.2.53                 Enzyme                                 

Name
2-keto-3-deoxy-L-rhamnonate aldolase;
KDR aldolase;
2-dehydro-3-deoxyrhamnonate aldolase;
2-keto-3-deoxy acid sugar aldolase;
YfaU;
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming);
2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde [RN:R02261]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-L-rhamnonate [CPD:C03979]
Product
pyruvate [CPD:C00022];
(S)-lactaldehyde [CPD:C00424]
Comment
Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2].
History
EC 4.1.2.53 created 2013
Pathway
ec00051  Fructose and mannose metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K12660  2-dehydro-3-deoxy-L-rhamnonate aldolase
K18339  2-keto-3-deoxy-L-rhamnonate aldolase
Genes
PPA: PAS_chr4_0341 PAS_chr4_0577
DHA: DEHA2E01056g DEHA2G19448g
PIC: PICST_64442
PGU: PGUG_00213 PGUG_03287 PGUG_03590
CTEN: CANTEDRAFT_124757 CANTEDRAFT_125712 CANTEDRAFT_132762 CANTEDRAFT_134482 CANTEDRAFT_97928
YLI: YALI0B23100g
CLU: CLUG_02928
CLUS: A9F13_18g00407
SLB: AWJ20_3014
NCR: NCU05037
NTE: NEUTE1DRAFT69855(NEUTE1DRAFT_69855)
MGR: MGG_00956
MAJ: MAA_03126
MBE: MBM_04586
ANI: AN7929.2
PTE: PTT_14653
ECO: b2245(rhmA)
ECJ: JW2239(yfaU)
ECD: ECDH10B_2405(yfaU)
EBW: BWG_2018(yfaU)
ECOK: ECMDS42_1815(yfaU)
ECE: Z3503
ECS: ECs3130
ETW: ECSP_3120(yfaU)
ECG: E2348C_2389(yfaU)
EOK: G2583_2785(yfaU)
ECC: c2787(yfaU)
ECP: ECP_2288
ECI: UTI89_C2527(yfaU)
ECV: APECO1_4316(yfaU)
ECY: ECSE_2507
ECQ: ECED1_2711(yfaU)
ECT: ECIAI39_2389(yfaU)
EOC: CE10_2625(rhmA)
EUM: ECUMN_2586(yfaU)
ECZ: ECS88_2393(yfaU)
ELH: ETEC_2379
ESE: ECSF_2125
ESO: O3O_17385
ESM: O3M_08200
ESL: O3K_08250
EBR: ECB_02171(yfaU)
EBD: ECBD_1414
EKF: KO11_11445(rhmA)
EAB: ECABU_c25790(yfaU)
EDJ: ECDH1ME8569_2181(yfaU)
ENA: ECNA114_2338(yfaU)
ELL: WFL_11935(rhmA)
ELC: i14_2586(yfaU)
ELD: i02_2586(yfaU)
EBL: ECD_02171(rhmA)
EBE: B21_02130(yfaU)
ELF: LF82_3041(yfaU)
ECOI: ECOPMV1_02406(rhmA)
ECOJ: P423_12575
ECOO: ECRM13514_3001(yfaU)
ECOH: ECRM13516_2945(yfaU)
ECOS: EC958_2583(yfaU)
STY: STY2519
STT: t0574
STM: STM2289
SENI: CY43_12270
SPT: SPA0574
SEK: SSPA0538
SEI: SPC_1422
SEC: SCH_2292(yfaU)
SHB: SU5_02884
SENS: Q786_11285
SED: SeD_A2633
SEG: SG2317
SEL: SPUL_0602
SET: SEN2271
SENA: AU38_11480
SENO: AU37_11490
SENV: AU39_11490
SENQ: AU40_12865
SENL: IY59_11805
SEEP: I137_02775
SENE: IA1_11400
SFX: S2460
SFV: SFV_2317
SFE: SFxv_2569(yfaU)
SFN: SFy_3311
SFS: SFyv_3386
SFT: NCTC1_02560(yfaU)
SSN: SSON_2306
SBO: SBO_2049
SDY: SDY_2440
KPN: KPN_02650(yfaU)
KPU: KP1_3885(yfaU)
KPP: A79E_1453
KPE: KPK_1500
KPR: KPR_2060(rhmA)
KPJ: N559_1604
KPX: PMK1_00148(rhmA)
KPNU: LI86_07830
KPNK: BN49_3867(rhmA)
KVA: Kvar_1403
KOX: KOX_26185
KOE: A225_4137
CRO: ROD_26581
CAMA: F384_12025
MSU: MS2103(pykF)
MVE: X875_8900
ASU: Asuc_1651
BTO: WQG_700
BTRE: F542_20870
BTRH: F543_23150
BTRA: F544_720
TAU: Tola_1177
VRM: 44547418_01808(rhmA)
FVA: FV113G1_31050(rhmA)
 » show all
Taxonomy
Reference
1  [PMID:18754693]
  Authors
Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA.
  Title
Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.
  Journal
Biochemistry 47:9944-54 (2008)
DOI:10.1021/bi800914r
  Sequence
[eco:b2245]
Reference
2  [PMID:18754683]
  Authors
Rea D, Hovington R, Rakus JF, Gerlt JA, Fulop V, Bugg TD, Roper DI.
  Title
Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12.
  Journal
Biochemistry 47:9955-65 (2008)
DOI:10.1021/bi800943g
  Sequence
[eco:b2245]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.53
IUBMB Enzyme Nomenclature: 4.1.2.53
ExPASy - ENZYME nomenclature database: 4.1.2.53
BRENDA, the Enzyme Database: 4.1.2.53

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