KEGG   ENZYME: 4.1.2.53
Entry
EC 4.1.2.53                 Enzyme                                 
Name
2-keto-3-deoxy-L-rhamnonate aldolase;
KDR aldolase;
2-dehydro-3-deoxyrhamnonate aldolase;
2-keto-3-deoxy acid sugar aldolase;
YfaU;
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming);
2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde [RN:R02261]
Reaction(KEGG)
R02261
Substrate
2-dehydro-3-deoxy-L-rhamnonate [CPD:C03979]
Product
pyruvate [CPD:C00022];
(S)-lactaldehyde [CPD:C00424]
Comment
Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2].
History
EC 4.1.2.53 created 2013
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K12660  2-dehydro-3-deoxy-L-rhamnonate aldolase
K18339  2-keto-3-deoxy-L-rhamnonate aldolase
Genes
QSU111990065 112019201
PPAPAS_chr1-1_0356 PAS_chr4_0341 PAS_chr4_0577
DHADEHA2C17688g DEHA2E00660g DEHA2E01056g DEHA2G19448g
PICPICST_57832 PICST_64442
PGUPGUG_00213 PGUG_03287 PGUG_03590
CTENCANTEDRAFT_124757 CANTEDRAFT_125712 CANTEDRAFT_132762 CANTEDRAFT_134482 CANTEDRAFT_97928
YLIYALI0B23100g
CLUCLUG_02928
CLUSA9F13_18g00407
CAURCJI97_002173
SLBAWJ20_3014
BNNFOA43_001684 FOA43_001969 FOA43_001972
NCRNCU05037
NTENEUTE1DRAFT69855(NEUTE1DRAFT_69855)
SMPSMAC_07611
PANPODANSg2280
TTTTHITE_2144816
MTMMYCTH_103080
CTHRCTHT_0050150
MGRMGG_00956
FGRFGSG_10210
FPUFPSE_03663
FVRFVEG_03007
FOXFOXG_05126 FOXG_17406
NHENECHADRAFT_100628
TRETRIREDRAFT_65882
TRRM419DRAFT_37122
MAJMAA_03126
PLJVFPFJ_04545
VALVDBG_07785
VDAVDAG_00197 VDAG_09650
CFJCFIO01_01164
SAPOSAPIO_CDS10762
PFYPFICI_08543 PFICI_12530
SSLSS1G_00980 SS1G_10069
BFUBCIN_03g00250 BCIN_14g02460
MBEMBM_04586
PSCOLY89DRAFT_47291 LY89DRAFT_706903
GLZGLAREA_03429
ANIAN7929.2
APUUAPUU_41632S
PNOSNOG_09634
PTEPTT_14653
BZECOCCADRAFT_2548
BSCCOCSADRAFT_37501
BORCOCMIDRAFT_88207
AALTCC77DRAFT_1048685
ZTRMYCGRDRAFT_65551
PFJMYCFIDRAFT_38913
NPAUCRNP2_7897
TMLGSTUM_00003022001
ECOb2245(yfaU)
ECJJW2239(yfaU)
ECDECDH10B_2405(yfaU)
EBWBWG_2018(yfaU)
ECOKECMDS42_1815(yfaU)
ECEZ3503
ECSECs_3130(rhmA)
ETWECSP_3120(yfaU)
ELXCDCO157_2894
ECOOECRM13514_3001(yfaU)
ECOHECRM13516_2945(yfaU)
ESLO3K_08250
ESOO3O_17385
ESMO3M_08200
ECGE2348C_2389(yfaU)
EOKG2583_2785(yfaU)
ELRECO55CA74_13785
ELHETEC_2379
ECWEcE24377A_2543
EUNUMNK88_2797
ECPECP_2288
ENAECNA114_2338(yfaU)
ECOSEC958_2583(yfaU)
ECVAPECO1_4316(yfaU)
ECOAAPECO78_15060
ECXEcHS_A2387
ECMEcSMS35_2399
ECYECSE_2507
ECQECED1_2711(yfaU)
EUMECUMN_2586(yfaU)
ECTECIAI39_2389(yfaU)
EOCCE10_2625(rhmA)
EBRECB_02171(yfaU)
EBLECD_02171(rhmA)
EBEB21_02130(yfaU)
EBDECBD_1414
ECIUTI89_C2527(yfaU)
EIHECOK1_2481
ECZECS88_2393(yfaU)
ECCc2787(yfaU)
ELOEC042_2489
ELNNRG857_11385
ESEECSF_2125
ECLEcolC_1404
EKFKO11_11445(rhmA)
EABECABU_c25790(yfaU)
EDHEcDH1_1413
EDJECDH1ME8569_2181(yfaU)
ELUUM146_05575
ELLWFL_11935(rhmA)
ELCi14_2586(yfaU)
ELDi02_2586(yfaU)
ELPP12B_c2339
ELFLF82_3041(yfaU)
ECOLLY180_11675
ECOIECOPMV1_02406(rhmA)
ECOJP423_12575
EALEAKF1_ch3735
EMAC1192_00665
ESZFEM44_01415
STYSTY2519
STTt0574
SEXSTBHUCCB_6150
SENTTY21A_02920
STMSTM2289
SEOSTM14_2826
SEVSTMMW_23131
SEYSL1344_2258
SEMSTMDT12_C23100
SEJSTMUK_2319
SEBSTM474_2385
SEFUMN798_2470
SETUSTU288_07820
SETCCFSAN001921_05350
SENRSTMDT2_22581
SENDDT104_23471
SENICY43_12270
SEENSE451236_17640
SPTSPA0574
SEKSSPA0538
SPQSPAB_00694
SEISPC_1422
SECSCH_2292(yfaU)
SEHSeHA_C2529
SHBSU5_02884
SENHCFSAN002069_20400
SEEHSEEH1578_20720
SEESNSL254_A2474
SENNSN31241_33940
SEWSeSA_A2517
SEASeAg_B2425
SENSQ786_11285
SEDSeD_A2633
SEGSG2317
SELSPUL_0602
SEGASPUCDC_0602
SETSEN2271
SENAAU38_11480
SENOAU37_11490
SENVAU39_11490
SENQAU40_12865
SENLIY59_11805
SEECCFSAN002050_18370
SEEBSEEB0189_008125
SEEPI137_02775
SENBBN855_23700
SENEIA1_11400
SENCSEET0819_18535
SFXS2460
SFVSFV_2317
SFESFxv_2569(yfaU)
SFNSFy_3311
SFSSFyv_3386
SFTNCTC1_02560(yfaU)
SSNSSON_2306
SBOSBO_2049
SDYSDY_2440
SDZAsd1617_03289
SHQA0259_15045
KPNKPN_02650(yfaU)
KPUKP1_3885(yfaU)
KPMKPHS_37160
KPPA79E_1453
KPHKPNIH24_10070
KPZKPNIH27_17760
KPVKPNIH29_18550
KPWKPNIH30_18770
KPYKPNIH31_17700
KPGKPNIH32_19100
KPCKPNIH10_18140
KPQKPR0928_18160
KPTVK055_4865
KPOKPN2242_16345
KPRKPR_2060(rhmA)
KPJN559_1604
KPID364_13505
KPAKPNJ1_01698
KPSKPNJ2_01666
KPXPMK1_00148(rhmA)
KPBFH42_09370
KPNEKU54_007825
KPNULI86_07830
KPNKBN49_3867(rhmA)
KVAKvar_1403
KPEKPK_1500
KPKA593_03110
KVDKR75_00770
KVQSP68_07305
KOXKOX_26185
KOEA225_4137
KOYJ415_11455
KOMHR38_24315
KOKKONIH1_20395
KOCAB185_15925
KQUAVR78_22520
KQVB8P98_08530
KLLBJF97_20360
KLWDA718_08655 DA718_10630
KARLGL98_07530(yfaU)
KGRJJJ10_08360(yfaU)
RORRORB6_01260
RONTE10_20120
RAODSD31_07640
RTGNCTC13098_02025(rhmA)
CROROD_26581
CFQC2U38_16750
CSEDJY391_07570(yfaU)
CAMAF384_12025
CAFAL524_10870
CFARCI104_17360 CI104_21505
CIRC2U53_27210
CTELGBC03_08335 GBC03_13105
CITZE4Z61_01500
CARSE1B03_18185
ESCEntcl_1475
KLEAO703_14490
METYMRY16398_16460(rhmA)
KINAB182_07085
PDZHHA33_10160(yfaU)
IZHFEM41_11730
EBCC2U52_17620
EBUCUC76_23155
SERASer39006_021735
SERQCWC46_21745
DDADd703_3301
BIZHC231_20920(yfaU)
PANSFCN45_18205
MINTC7M51_03756(rhmA)
MTHIC7M52_03270(rhmA)
MSUMS2103(pykF)
BSUNA4G13_07710
MVEX875_8900
ASUAsuc_1651
APORDDU33_03045
BTOWQG_700
BTREF542_20870
BTRHF543_23150
BTRAF544_720
ABERBSR55_00525
TAUTola_1177
NEIBG910_01270
BGPBGL_2c06920
BPLAbpln_2g07770
PEWKZJ38_24500
SIXBSY16_5483
CMETK6K41_20475
MLUTJET14_17725
PKBB4V02_12650
FPLAA4U99_15650
PFAAMM59RIKEN_19820(rhmA)
BPROPMF13cell1_02925(rhmA)
VRM44547418_01808(rhmA)
CIUG4D55_19965
ERBA4V01_00845
BRIFDF13_04545
PAUSNCTC13651_02073(rhmA)
ASGFB03_05450
RLCK227x_22900(rhmA)
AMOBHG15A2_21150(garL_2)
SDYNMal52_00510(rhmA_1)
ABACLuPra_05015(rhmA_2)
FVAFV113G1_31050(rhmA)
FULC4N20_08390
MCOSGM418_26085
CMRCycma_2067
SPIBG8759_32850
SRHOHH216_13985
PSEZHME7025_02113(rhmA)
DFEDfer_4324
AALGAREALGSMS7_03944
HALYHYG82_19310
 » show all
Reference
1  [PMID:18754693]
  Authors
Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA
  Title
Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.
  Journal
Biochemistry 47:9944-54 (2008)
DOI:10.1021/bi800914r
  Sequence
[eco:b2245]
Reference
2  [PMID:18754683]
  Authors
Rea D, Hovington R, Rakus JF, Gerlt JA, Fulop V, Bugg TD, Roper DI
  Title
Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12.
  Journal
Biochemistry 47:9955-65 (2008)
DOI:10.1021/bi800943g
  Sequence
[eco:b2245]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.53
IUBMB Enzyme Nomenclature: 4.1.2.53
ExPASy - ENZYME nomenclature database: 4.1.2.53
BRENDA, the Enzyme Database: 4.1.2.53

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