KEGG   ENZYME: 4.1.2.54
Entry
EC 4.1.2.54                 Enzyme                                 
Name
L-threo-3-deoxy-hexylosonate aldolase;
GAAC;
LGA1
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde [RN:R10550]
Reaction(KEGG)
R10550
Substrate
2-dehydro-3-deoxy-L-galactonate [CPD:C20680]
Product
pyruvate [CPD:C00022];
L-glyceraldehyde [CPD:C02426]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
History
EC 4.1.2.54 created 2013
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18103  L-threo-3-deoxy-hexylosonate aldolase
Genes
SLB: AWJ20_3293
NCR: NCU09532
NTE: NEUTE1DRAFT115768(NEUTE1DRAFT_115768)
SMP: 10803507(SMAC4_06596)
PAN: PODANSg8696
PBEL: QC761_208470(LGA1)
PPSD: QC762_208470(LGA1)
PPSP: QC763_208470(LGA1)
PPSA: QC764_208470(LGA1)
TTT: THITE_2107318
MTM: MYCTH_87557
CTHR: CTHT_0029160
RTHE: 98127127(VTJ83DRAFT_5839)
MGR: MGG_07462
PPEI: PpBr36_02373
PGRI: PgNI_02406
TMN: UCRPA7_6928
SSCK: SPSK_00854 SPSK_04450
FGR: FGSG_05128
FPU: FPSE_06524
FPOA: FPOAC1_008572(LGA1)
FVN: FVRRES_09164
FVR: FVEG_04796
FOX: FOXG_07874
NHE: NECHADRAFT_96312
FFC: NCS54_01160200
FKR: NCS57_01150600
FMU: J7337_006830(LGA1)
TRE: TRIREDRAFT_60067
TRR: M419DRAFT_7860
TATV: 25782249(TrAtP1_011499)
TASP: 36616285(LGA1)
MAW: 19246427(LGA1_1)
MAJ: MAA_01503
MBRN: 26244562(lga1)
PCHM: VFPPC_06071 VFPPC_06385
UVI: 66067658(UV8b_06881)
CMT: CCM_03105
AMUS: LMH87_002635
PLJ: 28890278(PLICBS_009615)
PTKZ: JDV02_004939(LGA1)
DCON: 63715391(DCS_02748)
VAL: VDBG_00212
VDA: VDAG_08496
CFJ: CFIO01_06981
CLUP: CLUP02_08125
CHIG: CH63R_04290
CDET: 87941332(CDEST_04829)
ELA: UCREL1_9196
PFY: PFICI_07764
SSL: SS1G_00738
BFU: BCIN_03g01490(Bclga1)
MBE: MBM_04252
PSCO: LY89DRAFT_579725
GLZ: GLAREA_12881
ANI: ANIA_02859
AFM: AFUA_3G11920
ACT: ACLA_039780
NFI: NFIA_065390
AOR: AO090003000752
ANG: An02g07720
AFV: AFLA_000931
ALUC: AKAW2_10640S
ACHE: ACHE_21180S
APUU: APUU_30710A
PCS: N7525_000919
PDP: PDIP_74980
POU: POX_b02783
PPSF: 300787332(PFLUO_LOCUS1791)
TMF: EYB26_000846
TRG: TRUGW13939_03810
ABE: ARB_05689
TVE: TRV_03692
PNO: SNOG_11734
PTE: PTT_12089
PTRR: 6338766(PtrM4_002680)
BZE: COCCADRAFT_6119
BSC: COCSADRAFT_40160
BOR: COCMIDRAFT_33737
AALT: CC77DRAFT_687369
ADAC: 96084546(ACET3X_004224)
ARAB: EKO05_0003373
BCOM: BAUCODRAFT_28953
NPA: UCRNP2_4054
FME: FOMMEDRAFT_21161
RSX: RhiXN_08390
PFP: PFL1_04596
 » show all
Reference
1  [PMID:17609199]
  Authors
Hilditch S, Berghall S, Kalkkinen N, Penttila M, Richard P
  Title
The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase.
  Journal
J Biol Chem 282:26195-201 (2007)
DOI:10.1074/jbc.M704401200
  Sequence
[ag:ABP04235]
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002
  Sequence
[ang:An02g07720]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.54
IUBMB Enzyme Nomenclature: 4.1.2.54
ExPASy - ENZYME nomenclature database: 4.1.2.54
BRENDA, the Enzyme Database: 4.1.2.54

  All links  
Gene (20)   
   RefGene (20)   
Protein sequence (29)   
   UniProt (25)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (7)   
   GenBank (4)   
   EMBL (3)   
All databases (63)   

Download RDF
DBGET integrated database retrieval system