KEGG   ENZYME: 4.1.2.56
Entry
EC 4.1.2.56                 Enzyme                                 

Name
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase;
griI (gene name)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate L-aspartate 4-semialdehyde-lyase (glycerone phosphate-forming)
Reaction(IUBMB)
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = glycerone phosphate + L-aspartate 4-semialdehyde [RN:R10673]
Reaction(KEGG)
R10673
Substrate
2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate [CPD:C20644]
Product
glycerone phosphate [CPD:C00111];
L-aspartate 4-semialdehyde [CPD:C00441]
Comment
Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus.
History
EC 4.1.2.56 created 2014
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18287  2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
Genes
BUR: Bcep18194_C6861
BCEP: APZ15_32405 APZ15_37520
BSTL: BBJ41_35540
MCHT: MCHIJ_41750
NIE: KV110_28200
RTM: G4H71_04120
GPO: GPOL_c23170
GOC: CXX93_17250
GOM: D7316_02313(griI)
GAM: GII34_12230
SGR: SGR_4249(griI)
SBH: SBI_01604
SVE: SVEN_5126
SLD: T261_2095
SPRI: SPRI_1929
SFK: KY5_6732
MPH: MLP_27040
AMI: Amir_3141
SESP: BN6_21360(griI1) BN6_63900(griI2)
KAL: KALB_2249
ACTN: L083_5377
 » show all
Reference
1  [PMID:17003031]
  Authors
Suzuki H, Ohnishi Y, Furusho Y, Sakuda S, Horinouchi S
  Title
Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
  Journal
J Biol Chem 281:36944-51 (2006)
DOI:10.1074/jbc.M608103200
  Sequence
[sgr:SGR_4249]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.56
IUBMB Enzyme Nomenclature: 4.1.2.56
ExPASy - ENZYME nomenclature database: 4.1.2.56
BRENDA, the Enzyme Database: 4.1.2.56

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