KEGG ENZYME: 4.1.2.63

ENZYME: 4.1.2.63

Entry

EC 4.1.2.63                 Enzyme

Name

2-hydroxyacyl-CoA lyase;
HACL1 (gene name);
2-hydroxyphytanoyl-CoA lyase;
2-HPCL

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

2-hydroxy-3-methyl fatty-CoA formyl-CoA lyase (2-methyl branched fatty aldehyde-forming)

Reaction(IUBMB)

(1) a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA = a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA [RN:R12799];
(2) a (2R)-2-hydroxy-Cn-long-chain fatty acyl-CoA = a Cn-1-long-chain fatty aldehyde + formyl-CoA [RN:R12800]

Reaction(KEGG)

R12799 R12800

Substrate

2-hydroxy-3-methyl-Cn-fatty-acyl-CoA;
(2R)-2-hydroxy-Cn-long-chain fatty acyl-CoA

Product

2-methyl-branched Cn-1-fatty aldehyde;
formyl-CoA [CPD:C00798];
Cn-1-long-chain fatty aldehyde

Comment

Requires Mg2+ and thiamine diphosphate. This peroxisomal enzyme, found in animals, is involved in the alpha-oxidation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids.

History

EC 4.1.2.63 created 2021

Orthology

K12261

2-hydroxyacyl-CoA lyase

Genes

HSA:	26061(HACL1)

PTR:	743738(HACL1)

PPS:	100982158(HACL1)

GGO:	101130205(HACL1)

PON:	100457302(HACL1)

PPYG:

129033966(HACL1)

NLE:	100589385(HACL1)

HMH:	116462043(HACL1)

SSYN:

129491329(HACL1)

MCC:	694261(HACL1)

MCF:	102130550(HACL1)

MTHB:

126946855

MNI:	105490407(HACL1)

CSAB:

103241708(HACL1)

CATY:

105578325(HACL1)

PANU:

101016987(HACL1)

TGE:	112617609(HACL1)

MLEU:

105538148(HACL1)

RRO:	104656450(HACL1)

RBB:	108535627(HACL1)

TFN:	117084204(HACL1)

PTEH:

111539503(HACL1)

CANG:

105505757(HACL1)

CJC:	100385052(HACL1)

SBQ:	101042137(HACL1)

CIMI:

108299907(HACL1)

ANAN:

105727097(HACL1)

CSYR:

103249270(HACL1)

MMUR:

105872704(HACL1)

LCAT:

123628571(HACL1)

PCOQ:

105826259(HACL1)

OGA:	100942962(HACL1)

MMU:	56794(Hacl1)

MCAL:

110309041(Hacl1)

MPAH:

110325771(Hacl1)

RNO:	85255(Hacl1)

MCOC:

116084402(Hacl1)

ANU:	117706255(Hacl1)

ASYL:

127690588(Hacl1)

MUN:	110551269(Hacl1)

CGE:	100767514(Hacl1)

MAUA:

101844934(Hacl1)

PROB:

127217007(Hacl1)

PLEU:

114708165(Hacl1)

MORG:

121455236(Hacl1)

MFOT:

126499145

AAMP:

119827425(Hacl1)

NGI:	103747520(Hacl1)

HGL:	101706829(Hacl1)

CPOC:

100731806(Hacl1)

CCAN:

109694810(Hacl1)

DORD:

105989902(Hacl1)

DSP:	122107948(Hacl1)

DMER:

138824648(Hacl1)

PLOP:

125358624(Hacl1)

NCAR:

124968501

MMMA:

107149652(Hacl1)

ITI:	101961946(Hacl1)

OCU:

100342558

OPI:	101524332(HACL1)

TUP:	102488706(HACL1)

GVR:	103595212(HACL1)

CFA:

608697

CLUD:

112660940(COLQ)

VVP:	112925619(HACL1)

VLG:	121478711(HACL1)

NPO:	129507342(HACL1)

AML:	100483076(HACL1)

UMR:	103679362(HACL1)

UAH:	113253912(HACL1)

UAR:	123788357(HACL1)

ELK:

111155096

LLV:

125104689

MPUF:

101679744(HACL1)

MNP:	132011775(HACL1)

MLK:	131824518(HACL1)

NVS:	122908996(HACL1)

ORO:	101380715(HACL1)

EJU:	114205724(HACL1)

ZCA:	113915823(HACL1)

MLX:	118003367(HACL1)

NSU:	110570751(HACL1)

LWW:	102734410(HACL1)

FCA:	101093708(HACL1)

PYU:	121033647(HACL1)

PCOO:

112849332(HACL1)

PBG:	122492011(HACL1)

PVIV:

125175574(HACL1)

LRUF:

124526159

LGF:	123611588(HACL1)

AJU:

106971590

PTG:	102951290(HACL1)

PPAD:

109258811(HACL1)

PUC:

125921333

PLEZ:

122229710(HACL1)

HHV:	120238469(HACL1)

BTA:	512676(HACL1)

BOM:	102283180(HACL1)

BIU:	109561790(HACL1)

BBUB:

102399404(HACL1)

BBIS:

105000735(HACL1)

CHX:	102182450(HACL1)

OAS:	101119009(HACL1)

BTAX:

128046078(HACL1)

CSUM:

138078184(HACL1)

ODA:	120880360(HACL1)

CCAD:

122445507(HACL1)

MREE:

136173630(HACL1)

MBEZ:

129549457(HACL1)

SSC:	100518218(HACL1)

CFR:	102508961(HACL1)

CBAI:

105077623(HACL1)

CDK:	105096613(HACL1)

VPC:	102525121(HACL1)

BACU:

103005299(HACL1)

BMUS:

118893900(HACL1)

LVE:	103081479(HACL1)

OOR:	101278567(HACL1)

LALB:

132520839(HACL1)

GMF:	115863478(HACL1)

DLE:	111168157(HACL1)

PCAD:

102980162(HACL1)

PSIU:

116753296(HACL1)

PPHC:

136122525(HACL1)

NASI:

112401406(HACL1)

ECB:	100063920(HACL1)

EPZ:	103561485(HACL1)

EAI:	106842763(HACL1)

MYB:	102259094(HACL1)

MYD:	102760568(HACL1)

MMYO:

118668201(HACL1)

MLF:	102419042(HACL1)

MDT:	132215583(HACL1)

MYUM:

139022336(HACL1)

PKL:	118715364(HACL1)

EFUS:

103296694(HACL1)

MNA:	107542410(HACL1)

DRO:	112309688(HACL1)

SHON:

118997591(HACL1)

AJM:	119048308(HACL1)

PDIC:

114501580(HACL1)

PHAS:

123830654(HACL1)

MMF:	118633385(HACL1)

PPAM:

129088236(HACL1)

HAI:	109395823(HACL1)

RFQ:	117037187(HACL1)

PALE:

102884140(HACL1)

PGIG:

120582055(HACL1)

PVP:	105288363(HACL1)

RAY:	107508452(HACL1)

MJV:	108390849(HACL1)

TOD:	119256849(HACL1)

SARA:

101543974(HACL1)

SFUM:

130037739(HACL1)

SETR:

125997954(HACL1)

LAV:	100667352(HACL1)

TMU:

101354112

ETF:	101648042(HACL1)

DNM:	101437479(HACL1)

MDO:	100030500(HACL1)

GAS:	123250584(HACL1)

SHR:	100916928(HACL1)

AFZ:

127539116

PCW:	110209056(HACL1)

TVP:	118850418(HACL1)

PBRV:

138161655(HACL1)

MLAO:

141494504(HACL1)

OAA:	100084023(HACL1)

TACU:

119921985(HACL1)

GGA:	420638(HACL1)

PCOC:

116227085(HACL1)

MGP:	100542074(HACL1)

CJO:	107309164(HACL1)

TPAI:

128086214(HACL1)

LMUT:

125696480(HACL1)

NMEL:

110394950(HACL1)

APLA:

101798319(HACL1)

ACYG:

106030248(HACL1)

CATA:

118252779(HACL1)

AFUL:

116486217(HACL1)

TGU:	100232217(HACL1)

LSR:	110474620(HACL1)

SCAN:

103812914(HACL1)

PMOA:

120502665(HACL1)

OTC:	121339586(HACL1)

PRUF:

121352912(HACL1)

ATRC:

139591096(HACL1)

GFR:	102037543(HACL1)

FAB:	101821112(HACL1)

OMA:	130249060(HACL1)

PHI:	102104383(HACL1)

PMAJ:

107199916(HACL1)

CCAE:

111923442(HACL1)

CCW:	104689075(HACL1)

CBRC:

103614161(HACL1)

ACOE:

138106516(HACL1)

ETL:	114055681(HACL1)

ZAB:	102070040(HACL1)

ZLE:	135443843(HACL1)

ACHL:

103801685(HACL1)

SVG:	106864264(HACL1)

MMEA:

130573229(HACL1)

HRT:	120760589(HACL1)

SATI:

136361502(HACL1)

CCIC:

134045937(HACL1)

FPG:	101915302(HACL1)

FCH:	102057939(HACL1)

CCRI:

104160177

NNT:	104408971(HACL1)

SHAB:

115618352(HACL1)

ACUN:

113476794(HACL1)

TALA:

104358157(HACL1)

ACHC:

115339770(HACL1)

HALD:

104313638(HACL1)

HLE:	104843120(HACL1)

AGEN:

126038077

HHAR:

128146956(HACL1)

GCL:

127013652

LDI:

104349001

MNB:	103771331(HACL1)

DPUB:

104307537(HACL1)

PPUS:

135187986(HACL1)

AVIT:

104275262(HACL1)

BRHI:

104498511(HACL1)

EGZ:	104126084(HACL1)

NNI:	104013970(HACL1)

PCRI:

104032401(HACL1)

PCAO:

104050212(HACL1)

PADL:

103918430(HACL1)

AFOR:

103906681(HACL1)

FGA:	104074755(HACL1)

GSTE:

104257112(HACL1)

CBOY:

140648273(HACL1)

CLV:	102085572(HACL1)

CNIC:

135984837(HACL1)

MUI:	104539747(HACL1)

PGUU:

104461122(HACL1)

PLET:

104616668(HACL1)

EHS:	104510634(HACL1)

CMAC:

104473038(HACL1)

CUCA:

104059184(HACL1)

TEO:	104375456(HACL1)

BREG:

104637546

OHA:	104333338(HACL1)

ACAR:

104518009(HACL1)

CPEA:

104397634(HACL1)

CVF:	104289911(HACL1)

RTD:	128905283(HACL1)

CRID:

134511338(HACL1)

AAM:	106483474(HACL1)

AROW:

112977277(HACL1)

NPD:	112957212(HACL1)

TGT:	104568401(HACL1)

DNE:	112985274(HACL1)

SCAM:

104145126(HACL1)

ASN:	102372627(HACL1)

AMJ:	102569780(HACL1)

CPOO:

109310399(HACL1)

GGN:	109291599(HACL1)

PSS:	102457478(HACL1)

CMY:	102946745(HACL1)

CCAY:

125631589(HACL1)

DCC:	119850377(HACL1)

CPIC:

101939557(HACL1)

TST:	117872359(HACL1)

CABI:

116837022(HACL1)

MRV:	120398934(HACL1)

ACS:	100557174(hacl1)

ASAO:

132778718(HACL1)

PVT:	110072147(HACL1)

SUND:

121934086(HACL1)

PBI:	103048759(HACL1)

PMUR:

107282910(HACL1)

CTIG:

120307310(HACL1)

TSR:	106545060(HACL1)

PGUT:

117655106(HACL1)

APRI:

131196703(HACL1)

PTEX:

113441307(HACL1)

NSS:	113415958(HACL1)

VKO:	123033833(HACL1)

PMUA:

114607097(HACL1)

PRAF:

128398463(HACL1)

ZVI:	118092350(HACL1)

HCG:	128330448(HACL1)

GJA:	107126170(HACL1)

STOW:

125441283(HACL1)

EMC:	129337493(HACL1)

XLA:	446657(hacl1.L)

XTR:	550086(hacl1)

NPR:	108802925(HACL1)

ACAT:

141144469(HACL1)

BBUF:

121002206(HACL1)

BGAR:

122938311(HACL1)

DTC:	141053688(HACL1)

PWL:	138262234(HACL1)

MUO:	115469822(HACL1)

GSH:	117354009(HACL1)

DRE:	406358(hacl1)

SRX:	107743162 107745383

SANH:

107684560 107685543

SGH:	107550801 107596724(hacl1)

CCAR:

109106433(hacl1)

CAUA:

113116276(hacl1)

CGIB:

127975224

PTET:

122360337(hacl1)

LROH:

127178744(hacl1)

GRF:	141342399(hacl1)

OMC:	131521729(hacl1)

PPRM:

120495103(hacl1)

RKG:	130070141(hacl1)

MAMB:

125243141(hacl1)

CIDE:

127496887

CERY:

137031336(hacl1)

MASI:

127454326

TROS:

130557861(hacl1)

TDW:	130433557(hacl1)

MANU:

129448009(hacl1)

PDAB:

135743551(hacl1)

IPU:

108267388

IFU:	128609235(hacl1)

PHYP:

113542549(hacl1)

SMEO:

124385334(hacl1)

TFD:	113644391(hacl1)

TVC:	132846001(hacl1)

CGAR:

128520941(hacl1)

NGRA:

132886755(hacl1)

TRN:	134310734(hacl1)

AMEX:

125802460(hacl1)

CMAO:

118816486(hacl1)

EEE:	113571243(hacl1)

CHAR:

105891974(hacl1)

SPIL:

134082386(hacl1)

TRU:	101061718(hacl1)

TFS:	130532614(hacl1)

TNG:	GSTEN00034133G001

LCO:	104927751(hacl1)

NCC:	104944968(hacl1)

TBEN:

117480344(hacl1)

CGOB:

115021252(hacl1)

PGEO:

117461424(hacl1)

GACU:

117554061(hacl1)

EMAC:

134861315(hacl1)

ELY:	117265388(hacl1)

EFO:	125893706(hacl1)

PLEP:

121945760(hacl1)

SLUC:

116049391(hacl1)

ECRA:

117946488(hacl1)

ESP:	116691366(hacl1)

PFLV:

114557200(hacl1)

GAT:	120811025(hacl1)

PPUG:

119198104(hacl1)

AFB:	129109251(hacl1)

CLUM:

117745899(hacl1)

PSWI:

130212618(hacl1)

CANA:

137781607(hacl1)

CVE:	137891523(hacl1)

MSAM:

119897754(hacl1)

SCHU:

122881383(hacl1)

CUD:	121513857(hacl1)

SPUL:

138584351(hacl1)

LMIX:

132984104(hacl1)

ALAT:

119006461(hacl1)

ASTR:

137601971(hacl1)

MZE:	101465513(hacl1)

ONL:	100690060(hacl1)

OAU:	116325395(hacl1)

OLA:	101156193(hacl1)

OML:	112143126(hacl1)

CSAI:

133429710(hacl1)

XMA:	102223303(hacl1)

XCO:	114142081(hacl1)

XHE:	116717578(hacl1)

PRET:

103478561(hacl1)

PFOR:

103150389 103150392

PLAI:

106941218 106955235

PMEI:

106922205(hacl1)

GAF:

122831424

PPRL:

129371152(hacl1)

CVG:	107103875(hacl1)

CTUL:

119772782(hacl1)

GMU:	124865949(hacl1)

NFU:	107378691(hacl1)

KMR:	108241945(hacl1)

ALIM:

106517744(hacl1)

NWH:	119409454(hacl1)

AOCE:

111588844(hacl1)

EJA:	138194334(hacl1)

BFRE:

138619584(hacl1)

MCEP:

125015938(hacl1)

CSEM:

103388412(hacl1)

POV:	109633118(hacl1)

SSEN:

122774464(hacl1)

SSOE:

131471501(hacl1)

HHIP:

117777286(hacl1)

HSP:	118114372(hacl1)

PPLT:

128449439(hacl1)

SMAU:

118313967(hacl1)

LCF:

108891319

SDU:	111238787(hacl1)

SLAL:

111652800(hacl1)

XGL:	120784806(hacl1)

HCQ:	109525685(hacl1)

SSCV:

125975603(hacl1)

SBIA:

133501329(hacl1)

PEE:	133401696(hacl1)

PTAO:

133479457(hacl1)

BPEC:

110171659(hacl1)

ENY:	140346043 140374245(hacl1) 140375886

MALB:

109967232(hacl1)

BSPL:

114843450(hacl1)

SJO:	128366484(hacl1)

SSCO:

133983063(hacl1)

GMH:	115554133(hacl1)

SASA:

106592607(hacl1) 106596819

STRU:

115187725 115187759

OTW:	112225223(hacl1)

OMY:	110505030(hacl1) 110515045 118936608

OGO:	124019490 124023920

OKI:	109876961 116365063

OKE:	118380248(hacl1)

OMM:	135538528(hacl1)

OCLA:

139387186 139404897 139404925

SALP:

111971452(hacl1)

SNH:	120038022 120040290

CCLU:

121577404 121586943(hacl1)

ELS:	105018820(hacl1)

OEP:	134024211(hacl1)

SFM:	108927371(hacl1)

PKI:	111839032(hacl1)

AANG:

118212187(hacl1)

AROT:

135261805(hacl1)

CCOG:

133133750(hacl1)

LOC:	102687234(hacl1)

PSPA:

121315127(hacl1)

ARUT:

117394717(hacl1)

PSEX:

120515400(hacl1)

LCM:	102362798(HACL1)

CMK:	103181261(hacl1)

RTP:	109933345(hacl1)

CPLA:

122549928(hacl1)

HOC:	132816078(hacl1)

LERI:

129710056(hacl1)

HAKA:

140732166(hacl1)

PMRN:

116948202(HACL1)

LRJ:	133345175(HACL1)

BFO:

118407296

BBEL:

109468963

CIN:

100178631

SCLV:

120341709

SPU:

586415

LPIC:

129274217

AJJ:

139958863

APLC:

110973383

ARUN:

117299838

AAMU:

139948701

AFIL:

140151434 140151587

AJC:

117104185

SKO:	100370616(HACL1)

PFLL:

139148198

DME:	Dmel_CG11208(Hacl)

DER:

6547754

DSE:

6610038

DSI:	Dsimw501_GD25296(Dsim_GD25296)

DYA:	Dyak_GE13819

DAN:

6496000

DSR:

110183103

DPO:

4805546

DPE:

6600980

DMN:	108160101 117192789

DWI:

6640896

DGR:

6568724

DMO:	Dmoj_GI18529

DAZ:

108616686

DNV:

108654972

DHE:

111594678

DVI:	6625321(Hacl)

CCAT:

101448871

BOD:

106624777

BDR:

105224676

RZE:

108367644

AOQ:

129244539

ALUD:

128868517

TDA:	119680124 119685324

SCAC:

106096256

LCQ:

111684644

LSQ:

119608012

CVJ:	135960208(Hacl)

GFS:

119641353

ECOE:

129950059

CLON:

129614126

HIS:

119654366

AGA:

1272675

ACOZ:

120956444

AARA:

120902070

AMER:

121599382 121602677

ASTE:

118506300

AMAP:

126557577

AFUN:

125771062

AMOU:

128299765

AMRS:

128710177

AALI:

118465009

ACOS:

131271185

AAG:	5565030 5572369

AALB:

109398509

ASUA:

134220414

CQU:	CpipJ_CPIJ014172 CpipJ_CPIJ017705

CPII:

120417246

CBRI:

134827298 134836448

CNS:

116340071

BCOO:

119066566

LLL:

129797288

PPAP:

129799177

AME:

552738

ACER:

107995125

ALAB:

122717988

ADR:

102673058

AFLR:

100867800

BIM:

100744016

BBIF:

117207092

BVK:

117237409

BVAN:

117160978

BHUN:

126863363

BTER:

100644973

BAFF:

126917186

BPYO:

122572768

BPAS:

132906822

FVI:

122535468

CCAL:

108629887

OBB:

114878797

OLG:

117602462

MGEN:

117229721

NMEA:

116434819

CGIG:

122404927

SOC:

105194976

MPHA:

105836739

AEC:

105154992

ACEP:

105626893

ACOC:

108688382

MZT:	108729186(Hacl)

PBAR:

105426340

VEM:

105566829

COBS:

139104639(Hacl)

TLN:	139814446(Hacl)

HST:

105189078

DQU:

106750369

CFO:

105255983

FEX:

115243773

PMEC:

138942410(Hacl)

LHU:	105669841(Hacl)

PGC:

109857866

OBO:

105282994

PCF:

106784580

PFUC:

122516260

VPS:

122627482

VCRB:

124422523

VVE:

124947528

NVI:

100123260

CSOL:

105361881

TPRE:

106658765

LHT:

122501395

LBD:

127283454

MDL:

103573582

CGLO:

123270220

CTYP:

141533596(Hacl)

FAS:

105272077

DAM:

107038575

AGIF:

122855352

CINS:

118066738 118066746 118069709

VCAN:

122408023

CCIN:

107263840

DSM:

124415425

NPT:	124215150(Hacl)

NFB:

124178108

NLO:

107219405

NVG:

124300342

AROA:

105684491

TCA:

664029

TMOL:

138138240(Hacl)

DPA:

109536893

ESIM:

136416833(Hacl)

EFOR:

136347411(Hacl)

SOY:

115884215

AGRG:

126737969

ATD:

109596968

CSET:

123317367

HAXR:

123683509

AGB:

108903720

LDC:

111511260

DVV:

126888127

NVL:

108560626

APLN:

108742675

PPYR:

116180506

OTU:

111426368

BMOR:

692884

BMAN:

114245011

MSEX:

115455821

DPL:	KGM_216038

BANY:

112045363

MJU:

123874087

NIQ:

126771840

VCD:

124536716

MCIX:

123660708

PMAC:

106707335 106712100

PPOT:

106110820

PXU:

106126854

BPHI:

137918623(Hacl)

PRAP:

110998130

PBX:

123713017

PNAP:

125060876

ZCE:

119839860

CCRC:

123697728

LSIN:

126966229

AAGE:

121735380

HAW:

110380221

HZE:

124638887

TNL:

113492403

SLIU:

111353800

OFU:

114354508

ONU:

135078882

ATRA:

106142233

GMW:

113515963

PXY:

105381789

PGW:

126373626

LGLY:

125230822

CSTB:

134746602

CFUM:

141441005(Hacl)

CFEL:

113377167

CCRN:

123300906

API:

100165444

DNX:

107163705

AGS:

114132285

RMD:

113551822

ACOO:

126847115

DVT:

126895664

BTAB:

109042181

DCI:

103515657

CLEC:

106674218

HHAL:

106686454(Hacl)

NLU:

111047026

HVI:

124362007

MQU:

128990225

PHU:	Phum_PHUM529400

FOC:

113211311

TPAL:

117654372

ZNE:

110831053

CSEC:

111868986

PAME:

138700261 138700262

SGRE:

126335352

BROR:

134542661

IEL:

124164359

HAMR:

139696717 139698310

FCD:

110848423

DPX:	DAPPUDRAFT_253560 DAPPUDRAFT_306512

DMK:

116930937

DPZ:

124348925

AFRA:

136026541

PVM:	113829823(Hacl)

PJA:

122259379

PCHN:

125032303

PMOO:

119597108

HAME:

121861697

PCLA:

123761322

CQD:	128689615(Hacl)

PTRU:

123499102

ESN:

127009089

MNZ:

135207748

MRJ:	136830645(Hacl)

PORN:

139756546

EAF:

111696878

TCF:

131884062

PPOI:

119105814 119106411

DSV:

119442762

RSAN:

119387927 119387928

RMP:

119188213

VDE:

111248283

VJA:

111271184

GOE:

100905806

CSCU:

111629264

CVS:	136976171(Hacl)

PTEP:

107455176

ABRU:

129956781

UDV:

129223799

SDM:	118180287 118202574

LPOL:

106471573

CEL:	CELE_B0334.3(hacl-1)

CBR:

CBG_02874

CRQ:	GCK72_005332

NAI:	NECAME_12882

LGI:	LOTGIDRAFT_207618

PVUL:

126831466

PCAN:

112564745

LSAX:

138981704

BGT:

106078649

GAE:

121382197

HRF:

124141592

HRJ:

124281687

HASI:

137256559

HCRA:

139470023

CRG:

105325181

CANU:

128189203

CVN:

111106696

MYI:

110449719

PMAX:

117343704

AIRR:

138314297

MCAF:

127728519

MMER:

123531889 128546649

RPHI:

132760561

DPOL:

127855304

MAEA:

128241824 128244020

OBI:

106872707

OSN:

115212767

LJP:

135478224

LAK:	106162962 106178375

LLON:

135500469

NVE:

5509052

EPA:	110232378 110241064 110251089

ATEN:

116307823

ADF:	107339514 107349360

AMIL:

114965786

PDAM:

113664752

SPIS:

111333468

DGT:

114536270

HSY:

130621646

RES:

135691295

AQU:

100641768

ATH:

AT5G17380

ALY:

9309892

CRB:

17882398

CSAT:

104706028 104735774 104770038

EUS:	EUTSA_v10013104mg

BRP:

103833165

BNA:	106445967 106445973

BOE:

106318756

RSZ:

108817706

THJ:

104820853

CPAP:

110807471

CIT:

102621022

CIC:	CICLE_v10011371mg CICLE_v10011616mg

PVY:

116111220

MINC:

123197953 123225748

TCC:

18601969

GRA:

105803616

GHI:	107912763 107912909

GAB:

108453368

HSYR:

120139211 120196639

DZI:	111305773 111314659

EGR:

104449677

RARG:

115738757

GMX:	100778257 100781584

GSJ:	114384324 114397553

PVU:

137823603

VRA:

106765165

VAR:

108338133

VUN:

114195378

VUM:

124842392

CCAJ:

109796119

APRC:

113847006

MTR:

25495093

TPRA:

123906672

CAM:

101501749

PSAT:

127118840

VVO:

131652686

LJA:

130739156

ADU:

107489982

AIP:

107644561

AHF:	112751450 112801899

LANG:

109347251

PCIN:

129322071

QSA:	O6P43_005651 O6P43_009312

FVE:

101306541

AANS:

126787447

RCN:

112195257

PPER:

18784460

PMUM:

103328654

PAVI:

110764468

PDUL:

117621238

MDM:	103405762 103421889

MSYL:

126583168 126609676

PXB:	103936009 103948272

PCOX:

137708055 137739411

ZJU:

107409054

MNT:

21409733

CSAV:

115722296

CSV:

101218890

CMO:

103487508

BHJ:

120082736

MCHA:

111024979

CMAX:

111492838

CMOS:

111452318 111457768

CPEP:

111788701 111790346

RCU:

8265016

MEAN:

126678086

JCU:

105638783

HBR:

110659002

MESC:

110631370

POP:

7477453

PEU:

105133039

PALZ:

118055950

PNZ:

133699221

JRE:

108988141

CILL:

122302852

CAVE:

132182769

AGLU:

133859324

QSU:

112028189

QLO:

115975759

TWL:	119995081 119998680

VVI:

100232933

VRI:

117930698

SLY:

101264774

SPEN:

107011723

SOT:

102604551

SSTN:

125846875

SDUL:

129872273

CANN:

107860091

LBB:

132623613

NTA:	107781829 107825460

NSY:	104211662 138886522

NTO:

104096832

NAU:

109243823

INI:

109154528

ITR:

116016327

SIND:

105176140

OEU:

111401032

EGT:

105961104

SSPL:

121746641 121750258 121779556 121783055

SMIL:

131014698

SHIS:

125214766 125214936

APAN:

127242133

HPUM:

140894613

PHUA:

140969312 140974313

PEBU:

140803430 140806074

HAN:

110868206

ECAD:

122603179

LSV:

111903096

CCAV:

112501516

DCR:

108196317

CSIN:

114315157

RVL:

131302583

AEW:

130769124

DLT:

127810071

BVG:

104906480

SOE:

110801650

CQI:	110703946 110720354

ATRI:

130802255

MOF:

131146019

NNU:

104613342

MING:

122068615

TSS:	122645871 122650155

PSOM:

113282348 113341018 113355684

OSA:	4324491(2-HPCL)

OBR:

102721129

OGL:

127773731

BDI:

100829473

ATS:

109738743

TDC:	119270248 119278317

TAES:

123063247 123072164 123080437

TUA:

125545867

LPER:

127308411

LRD:	124691323 124691726

SBI:

8056536

ZMA:

100191888

MFLO:

136461640

SITA:

101779082

SVS:

117857218

PVIR:

120672655 120705520

PHAI:

112895441

PAUA:

133888168

TANG:

140773897

PDA:	103705628 103715163

EGU:	105047067 105047158

MUS:

103992223

ZOF:	122002304 122006560 122026853 122028908

DCT:	110114604 114579507

PEQ:

110035637

AOF:

109829098

MSIN:

131234684

ACAK:

137936921

NCOL:

116248481

ATR:

18428183

CJF:

131075395

SMO:	SELMODRAFT_178690 SELMODRAFT_179619

PPP:

112279961

CSL:	COCSUDRAFT_18867

APRO:

F751_4156

GSL:	Gasu_12440

SCE:	YEL020C(PXP1)

SEUB:

DI49_1382

SPAO:

SPAR_E00510

AGO:	AGOS_AEL055C

ERC:

Ecym_1360

LTH:	KLTH0H14102g

VPO:	Kpol_1061p50

ZRO:	ZYRO0E03454g

CGR:	2891496(GVI51_M03113)

NCS:	NCAS_0G03960(NCAS0G03960)

NDI:	NDAI_0G00520(NDAI0G00520)

TPF:	TPHA_0B03940(TPHA0B03940)

TBL:	TBLA_0C01560(TBLA0C01560)

TGB:	HG536_0G03620

TDL:	TDEL_0B05520(TDEL0B05520)

KAF:	KAFR_0H02890(KAFR0H02890)

KNG:	KNAG_0H01580(KNAG0H01580)

ZMK:	HG535_0B03790

SLUD:

SCDLUD_003407

PPA:	PAS_chr1-1_0394

OPA:	HPODL_00543

YLI:	2912435(YALI2_E01615g)

SLB:

AWJ20_180

SSL:	SS1G_07774

BFU:	BCIN_15g01860

MBE:

MBM_05575

PSCO:

LY89DRAFT_234715

GLZ:	GLAREA_03030

ANI:	ANIA_10214

AFM:	AFUA_8G05230

ACT:	ACLA_058670

NFI:	NFIA_097990

AOR:	AO090005000624

ANG:	An16g07490

AFV:	AFLA_003432

ALUC:

AKAW2_70591S

ACHE:

ACHE_60592S

APUU:

APUU_21693S

CIM:	CIMG_04305

CPW:	9697376(D8B26_003681)

URE:	UREG_01556

ABE:

ARB_06558

TVE:

TRV_04424

PBL:	PAAG_11932(PAAG_04811)

PBN:	PADG_11446

AJE:	HCAG_02805

BGH:	BDBG_04203

ZTR:	MYCGRDRAFT_100226

PFJ:	MYCFIDRAFT_158085

CBET:

CB0940_11906

NPA:	UCRNP2_5114

TML:	GSTUM_00003438001

SPO:	2541142(hac1)

SOM:	SOMG_01328(hac1)

RIE:	OCT59_019746

DDI:	DDB_G0292402

DPP:	DICPUDRAFT_156484

DFA:

DFA_00674

ACAN:

ACA1_369090

TET:	TTHERM_00503839

PTM:	GSPATT00010458001

METR:

BSY238_2193

TBH:	Tbon_01510

TFLA:

O0235_12075(oxc)

» show all

Reference

1 [PMID:10468558]

Authors

Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M

Title

Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.

Journal

Proc Natl Acad Sci U S A 96:10039-44 (1999)
DOI:10.1073/pnas.96.18.10039

Sequence

[hsa:26061]

Reference

2 [PMID:15644336]

Authors

Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, Van Veldhoven PP, Casteels M.

Title

Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.

Journal

J Biol Chem 280:9802-12 (2005)
DOI:10.1074/jbc.M413362200

Reference

3 [PMID:17956236]

Authors

Casteels M, Sniekers M, Fraccascia P, Mannaerts GP, Van Veldhoven PP

Title

The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids.

Journal

Biochem Soc Trans 35:876-80 (2007)
DOI:10.1042/BST0350876

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.63

IUBMB Enzyme Nomenclature:

4.1.2.63

ExPASy - ENZYME nomenclature database:

4.1.2.63

BRENDA, the Enzyme Database:

4.1.2.63

All links

Gene (1374)   
   MGENES (1374)   
Protein sequence (3341)   
   UniProt (3324)   
   SWISS-PROT (8)   
   RefSeq(pep) (9)   
DNA sequence (15)   
   RefSeq(nuc) (12)   
   GenBank (1)   
   EMBL (2)   
Protein domain (7)   
   InterPro (7)   
All databases (4737)   

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