Entry
Name
citramalate lyase;
citramalate pyruvate-lyase;
citramalate synthase;
citramalic-condensing enzyme;
citramalate synthetase;
citramalic synthase;
(S)-citramalate lyase;
(+)-citramalate pyruvate-lyase;
citramalate pyruvate lyase;
(3S)-citramalate pyruvate-lyase;
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming)
Reaction(IUBMB)
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate [RN:
R00325 ]
Reaction(KEGG)
Substrate
(2S)-2-hydroxy-2-methylbutanedioate [CPD:
C02614 ]
Product
Comment
The enzyme can be dissociated into components, two of which are identical with EC
2.8.3.11 (citramalate CoA-transferase) and EC
4.1.3.25 (citramalyl-CoA lyase).
History
EC 4.1.3.22 created 1972
Pathway
ec00660 C5-Branched dibasic acid metabolism
Reference
Authors
Barker HA.
Title
Citramalate lyase of Clostridium tetanomorphum.
Journal
Reference
Authors
Dimroth P, Buckel W, Loyal R, Eggerer H.
Title
Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.22
ExPASy - ENZYME nomenclature database: 4.1.3.22