Entry
Name
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase;
NanA;
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Reaction(IUBMB)
aceneuramate = N-acetyl-D-mannosamine + pyruvate [RN:
R12768 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme is involved in the degradation of N-acetylneuraminate. It is specific for the open form of the sugar. It also acts on N-glycoloylneuraminate and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
History
EC 4.1.3.3 created 1961, modified 2021
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K01639 N-acetylneuraminate lyase
Genes
NGI : 103743787 103745142(Npl)
OAS : 101104513(NPL) 114118360
MYB : 102241283(NPL) 102248929
MRV : 120371163(NPL) 120394268
XLA : 495191(npl.S) 734827(npl.L)
SANH : 107676614 107700206
SGH : 107548793 107585862(npl)
CCAR : 109095363 109095474
CAUA : 113069900 113107207 113107991
CGIB : 127963889 128018773
CHAR : 105910765(npl) 122131288
ELY : 117253436(npl) 117253462
MSAM : 119900855 119916767
PSPA : 121327333 121330747
BBEL : 109471487 109479995
SCLV : 120326117 120327152
APLC : 110982687 110987397
ARUN : 117300791 117302174
SKO : 100377673 102804820 102808009 102808494
PFLL : 139136742 139137670
CCAT : 101456942 101457136 101457317
BOD : 106615285 106615328 106615344
BDR : 105225310 105225311 105225313
AOQ : 129247447 129247857 129248105
ASTE : 118508922 118517012
AALB : 109409320 115259985
CNS : 116340872 116340926 116341840 116344459 116347819 116347961 116350255
BCOO : 119066250 119067238 119077911
SOC : 105194749 105194750 105194751
MPHA : 105829081 105831372
ACEP : 105627882 105627883
PBAR : 105422463 105425148
COBS : 139102237 139104657 139104799
NVI : 100115260 100121176 100124084 100679680
CSOL : 105360966 105360967 105368225
TPRE : 106648290 106653796 106653830 106654583
LBD : 127286749 127286750 127288319
AROA : 105687131 105687132
TMOL : 138123500 138123696(l(2)05714)
DPA : 109536458 109542574 109545176
ESIM : 136411154 136416112 136419915
EFOR : 136341431 136345601 136348138
SOY : 115887278 115889117 115889118
AGRG : 126734084 126743186 126747898
CSET : 123306537 123306924
HAXR : 123687695 123688919
LDC : 111507692 111511184 111515642
DVV : 114329298 126881119 126889633
APLN : 108739482 108739511 108743640 112903957
PPYR : 116160535 116160536 116160538
BMOR : 101739376 101739517 101739659 101743965 101744495
BMAN : 114243906 114243926 114243932 114243963 114243964
MSEX : 115446799 115446800 115446809 115446822
PRAP : 110997526 110997529 111003276
PNAP : 125054173 125054501
CCRC : 123699661 123699870
LSIN : 126964874 126967029
TNL : 113504787 113504858 113504859
SLIU : 111350366 111350513 111350581 111350632 111350641
ATRA : 106136224 106136225 106136268
GMW : 113511988 113519674 113519846
PXY : 105380730 105381854 119691183
PGW : 126375296 126375305 126375309 126375312
LGLY : 125225639 125232401 125232404
CSTB : 134748184 134748644 134755730
CVS : 136972379(l(2)05714)
PMEO : 129585958 129586736
LGI : LOTGIDRAFT_176288 LOTGIDRAFT_230121
PCAN : 112562614 112563490
LSAX : 138958647 138980479
HASI : 137276805 137285131
CRG : 105326247 105326248 105330010 117681851 136269805 136269843 136269844
CANU : 128156872 128166782 128168030 128184579
CVN : 111099829 111100777 111121053 111123254
OED : 125671938 125682368 130051586
MYI : 110459656 110467336 110467362
PMAX : 117322128 117337144
AIRR : 138320880 138322860
MMER : 123550380 123554638 123564450 123564451
RPHI : 132713679 132740774 132740784 132752447 132752449 132752450 132758979
DPOL : 127839255 127845375 127866776
MAEA : 128216028 128224102 128242187 128242692 128244913
LLON : 135502132 135502274
ATEN : 116291644 116307528
EHX : EMIHUDRAFT_367275 EMIHUDRAFT_437491
ECOO : ECRM13514_4178(nanA)
ECOH : ECRM13516_3982(nanA)
ECW : EcE24377A_3707(nanA)
ECOS : EC958_3301 EC958_3618(nanA)
ECQ : ECED1_3876(nanA) ECED1_4911
EUM : ECUMN_3385 ECUMN_3699(nanA)
EAB : ECABU_c33100(nanA1) ECABU_c36330(nanA2)
EDJ : ECDH1ME8569_3113(nanA)
ELC : i14_3334 i14_3663(nanA)
ELD : i02_3334 i02_3663(nanA)
ECOI : ECOPMV1_03530(nanA)
ECOJ : P423_16505 P423_18060
KOY : J415_00050 J415_05870
KOM : HR38_02445 HR38_08345
KOK : KONIH1_03340 KONIH1_26405
KOC : AB185_07270 AB185_32840
KLL : BJF97_03885 BJF97_26075
KLW : DA718_02970(nanA) DA718_25185
KGR : JJJ10_24620 JJJ10_27805
KPAS : LUW96_06555 LUW96_09850
KLC : K7H21_24795 K7H21_28005
KLM : BWI76_00060 BWI76_03425
KLP : GUC22_23850 GUC22_27205
RTG : NCTC13098_00644(nanA)
BAGE : BADSM9389_04580(nanA) BADSM9389_35140
AHN : NCTC12129_00607(nanA_1) NCTC12129_01122(nanA_2)
METY : MRY16398_05560(nanA)
MTHI : C7M52_02889(nanA_1) C7M52_03382(nanA_2)
ETE : ETEE_2868(nanA) ETEE_3370(nanA)
ETR : ETAE_0928 ETAE_1381(nanA)
ETC : ETAC_04430 ETAC_06530
EDW : QY76_13035 QY76_15530
EDL : AAZ33_04925 AAZ33_07185(nanA)
EHO : A9798_07330 A9798_12130
HIC : NTHIC486_00889(nanA)
HPIT : NCTC13334_00449(nanA)
HHZ : NCTC10839_01816(nanA)
HAEG : NCTC8502_01096(nanA)
PDAG : 4362423_02038(nanA)
AIO : EXH44_00115(nanA) EXH44_10990(nanA)
ALIG : NCTC10568_02130(nanA)
ASEG : NCTC10977_01722(nanA)
AVT : NCTC3438_00944(nanA_1)
RPNE : NCTC8284_03395(nanA)
VNI : VIBNI_A2737 VIBNI_A2738
VIO : AB2S62_18760 AB2S62_18765
CHJ : NCTC10426_00701(nanA)
SMEL : SM2011_b20299(nanA)
SFD : USDA257_c27920(nanA)
ELUT : CKA38_02920 CKA38_09985
TMV : OH491_06305 OH491_12845 OH491_16545 OH491_18270
OBT : OPIT5_06590 OPIT5_13835
ABIW : Abiwalacus_24360(nanA)
BVO : Pan97_06100(nanA_1) Pan97_29170(nanA_2)
BREM : PSR63_07635 PSR63_08040
SMAM : Mal15_18480(nanA_1)
AMUC : Pan181_22370(nanA_2) Pan181_32020(nanA_3)
PND : Pla175_38950(dapA_3)
AMOB : HG15A2_20960(nanA_1) HG15A2_21470(nanA_2)
PLH : VT85_14820(nanA_1) VT85_16675(nanA_2)
LRS : PX52LOC_04163 PX52LOC_04976
VBC : C5Q97_07890 C5Q97_09125
SGP : SpiGrapes_1317 SpiGrapes_1517
SASS : MUG09_03280 MUG09_09030
BFS : BF9343_1631 BF9343_3612
BFG : BF638R_1716 BF638R_3788
BFB : VU15_07240 VU15_17665
BOA : Bovatus_00650(nanA_1) Bovatus_01544(nanA_2)
BCAC : CGC64_11145 CGC64_15635
BZG : C4H11_08870 C4H11_13195
BFC : BacF7301_16375 BacF7301_17650 BacF7301_22365
PET : PEIBARAKI_5999 PEIBARAKI_6558
PROJ : KDN43_02275 KDN43_05420 KDN43_10300 KDN43_16255
PGOL : K6V26_14075 K6V26_22080
PFAI : NXY11_08195 NXY11_20990
PARY : A4V02_00025 A4V02_10370
POC : NCTC13071_00096(nanA)
CPOL : WJU16_08320 WJU16_23115
NSO : NIASO_04185 NIASO_17350
ATEE : K9M52_02680 K9M52_03445
PGS : CPT03_08040 CPT03_13140
PGJ : QG516_01250 QG516_02910
SHT : KO02_01195 KO02_14005
SMIZ : 4412673_03729(nanA)
SPHZ : E3D81_00300 E3D81_09390
SDJ : NCTC13534_05184(nanA)
STHA : NCTC11429_02640(nanA_1) NCTC11429_04304(nanA_2)
SFAE : MUK51_04785 MUK51_17750
ZGA : ZOBELLIA_1041(nanA1) ZOBELLIA_1049(nanA3)
AALG : AREALGSMS7_02038 AREALGSMS7_04068
BKW : BkAM31D_08250(nanA_2)
BLEN : NCTC4824_03976(nanA_2)
SAX : USA300HOU_0335(nanA)
SUQ : HMPREF0772_10180(nanA)
SAUT : SAI1T1_2002410(nanA)
SAUJ : SAI2T2_1002410(nanA)
SAUK : SAI3T3_1002410(nanA)
SAUQ : SAI4T8_1002410(nanA)
SAUV : SAI7S6_1002410(nanA)
SAUW : SAI5S5_1002400(nanA)
SAUX : SAI6T6_1002410(nanA)
SAUY : SAI8T7_1002410(nanA)
SSD : SPSINT_0893 SPSINT_1949
SDP : NCTC12225_00612(nanA_1) NCTC12225_01855(nanA_2)
SSCZ : RN70_03060 RN70_08390
SPIC : SAMEA4384060_0098(nanA)
SSH : NCTC13712_00263(nanA)
SFF : FOB90_04965 FOB90_11620
SSTE : SAMEA4384403_0482(nanA_1)
GMO : NCTC11323_01670(nanA)
GHA : NCTC10459_01746(nanA_4)
POD : PODO_12995 PODO_25225
PAEF : R50345_13165 R50345_24870
PAEJ : H70737_12550 H70737_24850
PIB : BBD41_09015 BBD41_12065
PLW : D5F53_23920 D5F53_26920
PLUT : EI981_21725 EI981_28030
PALR : HGI30_14275 HGI30_19585
CCHL : FPL14_15555 FPL14_18070 FPL14_19830
PLIG : NAG76_01915 NAG76_11050
SPYM : M1GAS476_1739(nanH)
SPH : MGAS10270_Spy0217(nanH)
SPI : MGAS10750_Spy0212(nanH)
SPJ : MGAS2096_Spy0235(nanH)
SPK : MGAS9429_Spy0218(nanH)
STG : MGAS15252_0244(nanH)
SNV : SPNINV200_07980(nanA) SPNINV200_14990(nanH)
SNE : SPN23F12210(nanA) SPN23F16770(nanH)
SNM : SP70585_1374 SP70585_1716
SNI : INV104_07440(nanA) INV104_14270(nanH)
SPNG : HMPREF1038_01317 HMPREF1038_01658
SNB : SP670_0947 SP670_1763
SPNE : SPN034156_05600(nanH)
SPNU : SPN034183_14700(nanH)
SPNM : SPN994038_14590(nanH)
SPNO : SPN994039_14600(nanH)
SMEN : SAMEA4412692_1535(nanA)
SPSU : NCTC13786_01400(nanH)
SPOC : NCTC10925_01773(nanH)
SAUP : NCTC3168_00681(nanH)
SURN : NCTC13766_00157(nanA)
SVF : NCTC3166_00092(nanH)
SMIE : NCTC11169_00091(nanA)
ECEC : NCTC12421_02415(dapA_2)
GSG : CYJ72_003335 CYJ72_009975
JDA : BW727_101433(nanA_2)
CBUT : ATN24_15415 ATN24_16080
ACOL : K5I23_15575 K5I23_15940
LASA : L9O85_00730 L9O85_08760
BPRO : PMF13cell1_01603(nanA)
BLUI : Blut17040_00650(nanA) Blut17040_00720
BHV : BLHYD_31030(nanA_2) BLHYD_32770(nanA_3)
LACY : A4V08_12025 A4V08_13205
CSCI : HDCHBGLK_02030(nanA)
CBOL : CGC65_03385 CGC65_04275 CGC65_12465 CGC65_24010
ECLF : QMP25_24760 QMP25_26030
MFOR : NQ534_11205 NQ534_12010
PDF : CD630DERM_22400(nanA)
PHX : KGNDJEFE_01745(nanA)
MMYI : mycmycITA_00593(nanA)
MCAP : MCCPF38_00504(nanA)
MCAR : MCCPILRI181_00501(nanA)
MNU : NCTC10166_00256(nanA)
MOE : NCTC10151_00204(nanA)
PCAT : Pcatena_01330(dapA_2)
ABAO : BEQ56_03135 BEQ56_05775
» show all
Taxonomy
Reference
Authors
COMB DG, ROSEMAN S.
Title
The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid.
Journal
J Biol Chem 235:2529-37 (1960)
Reference
Authors
Schauer R.
Title
Chemistry, metabolism, and biological functions of sialic acids.
Journal
Reference
Authors
Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.
Title
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.3
ExPASy - ENZYME nomenclature database: 4.1.3.3
BRENDA, the Enzyme Database: 4.1.3.3