Entry
Name
1,4-dihydroxy-2-naphthoyl-CoA synthase;
naphthoate synthase;
1,4-dihydroxy-2-naphthoate synthase;
dihydroxynaphthoate synthase;
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing);
MenB;
o-succinylbenzoyl-CoA dehydratase (cyclizing)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing)
Reaction(IUBMB)
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O [RN:
R04150 ]
Reaction(KEGG)
Substrate
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA [CPD:
C03160 ]
Product
1,4-dihydroxy-2-naphthoyl-CoA [CPD:
C15547 ];
H2O [CPD:
C00001 ]
Comment
This enzyme is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments.
The coenzyme A group is subsequently removed from the product by EC
3.1.2.28 , 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.
History
EC 4.1.3.36 created 1992, modified 2010
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
CSAT : 104703642 104752723 104787117
MINC : 123207366 123213369
VVO : 131617202 131641572 131641581
AIP : 107608279 107620643 107631326
AHF : 112723928 112723936 112733898 112746950 112758438 112784500 112791785 114927663
MSYL : 126596531 126607945
CILL : 122308757 122309482
SSPL : 121755527 121769832 121793768 121799383
SMIL : 130993610 130993615 131025297
SHIS : 125207534 125207684 125216131 125223951
CSIN : 114299218 114310242 114310243
PSOM : 113294836 113311179 113311995 113312695 113324423 113336749 113339487 113339488 113339490 113357305 113361944
TAES : 123061656 123070278 123078727
PVIR : 120675207 120710075
ZOF : 122027177 122029932 122032657 122035083
SMO : SELMODRAFT_170069 SELMODRAFT_229493
ECOO : ECRM13514_3019(menB)
ECOH : ECRM13516_2964(menB)
ECW : EcE24377A_2558(menB)
EDJ : ECDH1ME8569_2199(menB)
ECOI : ECOPMV1_02424(menB)
REE : electrica_01487(menB)
RTG : NCTC13098_02012(menB)
CLAP : NCTC11466_01327(menB)
KIE : NCTC12125_00421(menB)
AHN : NCTC12129_01548(menB)
METY : MRY16398_16360(menB)
PSHI : SAMEA2665130_2005(menB)
MPHG : MPHASIOC01_002593(menB)
YPG : YpAngola_A1783(menB)
YPI : YpsIP31758_1484(menB)
SMW : SMWW4_v1c33910(menB)
SFJ : SAMEA4384070_3397(menB)
SOF : NCTC11214_03405(menB)
SSAR : SSARUM_003260(menB)
PAQU : DMB82_0014815(menB)
PARL : PEC302110_10930(menB)
PHEI : NCTC12003_01573(menB)
PRJ : NCTC6933_02321(menB)
LRI : NCTC12151_01277(menB)
HIC : NTHIC486_00006(menB)
HPIT : NCTC13334_00882(menB)
HHZ : NCTC10839_00720(menB)
HAEG : NCTC8502_00027(menB)
PDAG : 4362423_01241(menB)
ADP : NCTC12871_01436(menB)
ALIG : NCTC10568_02203(menB)
ASEG : NCTC10977_00852(menB)
AVT : NCTC3438_00057(menB)
RPNE : NCTC8284_00963(menB_1)
PAET : NCTC13378_00198(menB)
VAU : VANGNB10_cI1809c(menB)
VPL : SA104470976_01678(menB)
VIB : VspSTUT11_21000(menB)
VIS : VspSTUT16_22060(menB)
PPR : PBPRB1048(PMM0608) PBPRB1049(LL0729)
SCAA : TUM17387_38890(menB)
TFRI : Thiofri_02989(menB)
TNI : TVNIR_1663(menB_[H])
HAAH : HALA3H3_490060(menB)
AEL : NCTC12917_00431(menB)
SDF : ACG33_00440 ACG33_11765
CDIZ : CEDIAZO_00454(menB)
POLY : PSHI2_11210(menB_1) PSHI2_17860(menB_2)
POLN : PSHI8_11210(menB_1) PSHI8_17870(menB_2)
AZI : AzCIB_1513 AzCIB_2502
THAG : CKCBHOJB_02419(menB)
DOV : DSCO28_47480(menB_2)
OBG : Verru16b_02465(menB)
ABIW : Abiwalacus_05990(menB)
BTHO : Btheta7330_03285(menB)
BHF : C3V43_02835 C3V43_12205(menB)
BFC : BacF7301_14150(menB)
PCRE : NCTC12858_01270(menB)
TFO : BFO_1953(menB_1) BFO_3199(menB_2)
COPR : Cop2CBH44_15580(menB)
CFAS : Cfast33896_10000(menB)
PMZ : HMPREF0659_A6050(menB)
PDN : HMPREF9137_1704(menB)
PHER : prwr041_26270(menB)
POC : NCTC13071_01463(menB)
PSEZ : HME7025_01489(menB)
FOK : KK2020170_22420(menB)
PHG : KCTC32516_02364(menB)
AALG : AREALGSMS7_04308(menB)
KOS : KORDIASMS9_04144(menB)
KAN : IMCC3317_11950(menB)
SPON : HME9304_03107(menB)
OHM : MSHRCOH1_06175(menB)
CGLE : NCTC11432_00905(menB)
CTAI : NCTC12078_00666(menB)
CTAK : 4412677_00521(menB)
CHRJ : CHRYMOREF3P_0675(menB)
CJG : NCTC13459_00784(menB)
CANT : NCTC13489_00847(menB)
PTAN : CRYO30217_01751(menB)
PROC : Ptc2401_01968(menB)
BAZ : BAMTA208_15075(menB)
BSON : S101395_01271(menB)
BFD : NCTC4823_01168(menB)
BKO : CKF48_15560 CKF48_22850(menB)
VIK : KFZ58_11995(menB) KFZ58_13910(menB)
LEX : Len3610_08545(menB) Len3610_09275(menB)
PERI : RE409_12325(menB) RE409_24385(menB)
NNV : QNH39_15010(menB) QNH39_20965(menB)
BLEN : NCTC4824_03196(menB)
ALKG : MOJ78_15870(menB) MOJ78_19125
PARG : PspKH34_06280(menB)
SAX : USA300HOU_0993(menB)
SUQ : HMPREF0772_12189(menB)
SUX : SAEMRSA15_08770(menB)
SUF : SARLGA251_09600(menB)
SAUV : SAI7S6_1007400(menB)
SAUW : SAI5S5_1007360(menB)
SAUX : SAI6T6_1007370(menB)
SAUY : SAI8T7_1007400(menB)
SDP : NCTC12225_02003(menB)
SPIC : SAMEA4384060_1910(menB)
SSH : NCTC13712_00991(menB)
SSIM : SAMEA4384339_0960(menB)
SSTE : SAMEA4384403_1817(menB_2)
LMOC : LMOSLCC5850_1736(menB)
LMW : LMOSLCC2755_1685(menB)
LMX : LMOSLCC2372_1738(menB)
LMZ : LMOSLCC2482_1737(menB)
LMON : LMOSLCC2376_1632(menB)
LMOS : LMOSLCC7179_1646(menB)
LMOO : LMOSLCC2378_1694(menB)
LMOY : LMOSLCC2479_1736(menB)
LMOT : LMOSLCC2540_1756(menB)
LMOA : LMOATCC19117_1688(menB)
LGZ : NCTC10812_01203(menB)
ADAU : NZD86_10080(menB) NZD86_19035(menB)
ACYC : JI721_02370(menB) JI721_14585(menB)
LRU : HMPREF0538_22148(menB)
LOR : AYI71_14090 AYI71_15585
ECEC : NCTC12421_02107(menB)
VRM : 44547418_00397(menB)
VDN : NCTC11831_00358(menB)
MBO : BQ2027_MB0562C(menB)
MAVM : MAA44156_04038(menB)
MSA : Mycsm_00662 Mycsm_04680
MMAE : MMARE11_08450(menB)
MBAI : MB901379_00764(menB_2)
MHEK : JMUB5695_04096(menB_3)
MBRD : MBRA_08010(menB_1) MBRA_10860(menB_2)
MPAA : MKK62_01625 MKK62_21015
MKY : IWGMT90018_08810(menB)
MSM : MSMEG_1075(menB) MSMEG_4114(menB)
MPHL : MPHLCCUG_04425(menB_2)
MTHN : 4412656_00640(menB_1)
MHAS : MHAS_04047(menB_2) MHAS_04922(menB_3)
MAUU : NCTC10437_00760(menB_1)
MANY : MANY_01630(menB_1) MANY_47990(menB_3)
MFLV : NCTC10271_04404(menB_4)
MHOL : K3U96_07070 K3U96_22780
MSAL : DSM43276_03757(menB)
MTER : 4434518_00536(menB)
MHER : K3U94_03135 K3U94_16755
CDIP : ERS451417_00343(menB)
CUN : Cul210932_0353(menB)
CUQ : Cul210931_0341(menB)
CUJ : CUL131002_0338c(menB)
CMIN : NCTC10288_02193(menB)
CRL : NCTC7448_01181(menB)
CCYS : SAMEA4530656_2136(menB)
CCOE : CETAM_02040(menB1) CETAM_10660(menB2)
CGF : CGUA_01785(menB1) CGUA_02180(menB2)
NFR : ERS450000_04749(menB_3)
NAD : NCTC11293_00051(menB_1)
NWL : NWFMUON74_65400(menB)
NSPU : IFM12276_57050(menB)
RHA : RHA1_ro02003 RHA1_ro02630 RHA1_ro11181(menB)
ROP : ROP_16770(menB) ROP_45870(menB) ROP_pROB02-01530
ROA : Pd630_LPD04481 Pd630_LPD06176 Pd630_LPD06931
RRZ : CS378_08545 CS378_10755
RRT : 4535765_03654(menB_3)
RCR : NCTC10994_03604(menB_3)
RKO : JWS14_10240 JWS14_13755 JWS14_14475(menB) JWS14_40285
ROZ : CBI38_08060 CBI38_28055 CBI38_34335
RPSK : JWS13_30690(menB) JWS13_31850 JWS13_32635 JWS13_35595
RGOR : NMQ04_15955 NMQ04_19415
RHOP : D8W71_24970 D8W71_26535
RHOU : KZJ41_06995 KZJ41_20195 KZJ41_22670(menB)
RHOW : A4U64_03235 A4U64_05625 A4U64_18105
RHOJ : JVH1_23110(menB) JVH1_24025 JVH1_27270
RHOY : QNA09_02710(menB) QNA09_16700
RHJS : OYT95_24845(menB) OYT95_24905 OYT95_25395 OYT95_28675
GRU : GCWB2_05095(menB2) GCWB2_06310(menB3) GCWB2_09925(menB5)
GOM : D7316_03219(menB_3) D7316_03220(menB_4) D7316_04745(menB_5)
GAV : C5O27_17795 C5O27_22235
GOD : GKZ92_04825 GKZ92_09500
GPD : GII33_11205 GII33_18545 GII33_19290 GII33_19350(menB)
GOI : LK459_04360 LK459_14730
GAMI : IHQ52_08130 IHQ52_12805
TPUL : TPB0596_07230(menB)
TSD : MTP03_06030(menB_1) MTP03_14780(menB_2)
MSUW : GCM10025863_20020(menB)
FSB : GCM10025867_40160(menB)
AMAU : DSM26151_03290(menB_2)
AMAV : GCM10025877_19590(menB)
LALL : MUN78_00780 MUN78_12300
PSEV : USB125703_00873(menB)
ARH : AHiyo8_45210 AHiyo8_45220
AAGI : NCTC2676_1_02531(menB)
KII : KocCE7_02500 KocCE7_07245
RDN : HMPREF0733_10422(menB)
RAJ : RA11412_2726 RA11412_2727
ORN : DV701_11385 DV701_14855
OFA : NF556_15325 NF556_18425
BCAU : I6G59_08455 I6G59_16645
BREB : PGC08_00185 PGC08_05875
DCO : SAMEA4475696_0696(menB)
PAK : HMPREF0675_3964(menB)
CGRN : 4412665_01029(menB)
PAUS : NCTC13651_00937(menB)
PPC : HMPREF9154_2945(menB)
NSN : EXE58_07200 EXE58_11065(menB)
NPI : G7071_04335 G7071_05770
NAQU : ENKNEFLB_00310(menB)
ACTQ : OG417_12700 OG417_30030
MHAI : OHB01_30250(menB) OHB01_31675
AMYC : CU254_01275 CU254_42395
AACD : LWP59_02240 LWP59_12820(menB)
ACYN : ORV05_10730 ORV05_30700
AMYZ : HUW46_03274(menB_3)
PAUT : Pdca_39680(menB_2) Pdca_60350(menB_3)
PPEL : H6H00_11415 H6H00_18020
ACTU : Actkin_06039(menB_2)
CROS : N8J89_13470 N8J89_39005(menB)
MCU : HMPREF0573_10976(menB)
TBW : NCTC13354_01412(menB)
ANE : ATCC27039_17210(menB)
AHW : NCTC11636_02288(menB)
AIR : NCTC12972_00129(menB)
ASLA : NCTC11923_02641(menB)
AVC : NCTC10951_01633(menB)
ACAP : MANAM107_06140(menB)
AEY : CDG81_12725 CDG81_20545
BALA : DSM104299_02596(menB_2)
PARN : NBH00_08350 NBH00_16410(menB) NBH00_19975
PARQ : DSM112329_00861(menB_1) DSM112329_02365(menB_3)
SBAE : DSM104329_02658(menB_2)
SYR : SynRCC307_1141(menB)
SYX : SynWH7803_1022(menB)
SYH : Syncc8109_1565(menB)
SYNW : SynWH8103_01129(menB)
TVN : NIES2134_125200(menB)
LET : O77CONTIG1_02418(menB)
CHON : NIES4102_29620(menB)
SYP : SYNPCC7002_A0268(menB)
SYNN : NIES970_11610(menB)
MVZ : myaer102_19640(menB)
PAGH : NIES204_39610(menB)
PRUN : PCC7821_04715(menB)
CALS : NIES3974_02570(menB)
NSPH : BDGGKGIB_00616(menB)
SCYS : NIES4073_74280(menB)
STAN : STA3757_04390(menB)
» show all
Taxonomy
Reference
Authors
Meganathan R, Bentley R.
Title
Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes.
Journal
Reference
Authors
Kolkmann R, Leistner E.
Title
4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis.
Journal
Reference
Authors
Johnson TW, Shen G, Zybailov B, Kolling D, Reategui R, Beauparlant S, Vassiliev IR, Bryant DA, Jones AD, Golbeck JH, Chitnis PR
Title
Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803.
Journal
Reference
Authors
Truglio JJ, Theis K, Feng Y, Gajda R, Machutta C, Tonge PJ, Kisker C
Title
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.36
ExPASy - ENZYME nomenclature database: 4.1.3.36