KEGG   ENZYME: 4.1.3.41
Entry
EC 4.1.3.41                 Enzyme                                 
Name
3-hydroxy-D-aspartate aldolase;
D-3-hydroxyaspartate aldolase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming)
Reaction(IUBMB)
(1) threo-3-hydroxy-D-aspartate = glycine + glyoxylate [RN:R09717];
(2) D-erythro-3-hydroxyaspartate = glycine + glyoxylate [RN:R09718]
Reaction(KEGG)
R09717 R09718
Substrate
threo-3-hydroxy-D-aspartate [CPD:C19813];
D-erythro-3-hydroxyaspartate [CPD:C19838]
Product
glycine [CPD:C00037];
glyoxylate [CPD:C00048]
Comment
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the alpha-position of the substrate, but accepts both the threo and erythro forms at the beta-position. The erythro form is a far better substrate (about 100-fold). The enzyme can also accept D-allothreonine, D-threonine, erythro-3-phenyl-D-serine and threo-3-phenyl-D-serine. Different from EC 4.1.3.14, erythro-3-hydroxy-L-aspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.
History
EC 4.1.3.41 created 2011
Orthology
K18425  3-hydroxy-D-aspartate aldolase
Genes
DTLH8F01_09325
MPQABA45_01630
MSQBKP64_01000
PARPsyc_1390(dhaa)
PCRPcryo_0979
PSOPSYCG_05135
PURAOC03_11535
PSYCDABAL43B_1129(dhaA)
SPSWSps_01098
SPSHFM037_15100
SEURFM038_011510
CPSCPS_4887
COMCMT41_17630
COLWA3Q33_19535
COLADBO93_08415
CBERB5D82_18810
NAXHC341_04380
GAIIMCC3135_14580(dhaa)
ARADKI609_02995
VAPVapar_2236
VPEVarpa_3650
VPDVAPA_1c24150
VAMC4F17_03295
RTEAHK414_23300
MESMeso_3310 Meso_4367
AAKAA2016_6017 AA2016_6438
AMIHCO731_00754(dhaa)
NIYFQ775_00515
PLAPlav_0614
PMOBHG718_10545
KMNHW532_14250
RBSRHODOSMS8_00137
SMIBN406_06800
RHINGR_b19530
SFDUSDA257_c17700
SAMESAMCFNEI73_pC1568
RELREMIM1_PF00833
REPIE4803_CH03645
NGLRG1141_CH33030
NGGRG540_CH33840
VGOGJW-30_1_01043(dhaa)
BOPAXW83_23985
BOIBLM15_30595
AZCAZC_0733
SNOSnov_2637
APRAG3A50_08360
MRDMrad2831_1540 Mrad2831_6208
MORMOC_1918
MPHYMCBMB27_01184
METXA3862_23150
METIDK427_04595
MMESMMSR116_01770 MMSR116_17135
MTEADK419_09675
CMETK6K41_18880
AALAIGS74_11750
AALMLUX29_12900
NOHG5V57_14810
PSFPSE_p0085
LAPACP90_23560
LABRCHH27_20580
LABPFJ695_09280
LABTFIU93_01315(dhaa)
LAGGB0E33_07020
ACUTMRB58_05965
CCRCC_3106
CCSCCNA_03204
CAKCaul_2681
CSECseg_0854
CHQAQ619_03160
CMBCSW64_00160
CFHC1707_13315
CAUFCSW63_05995
CAULKCG34_08885
TSVDSM104635_01638(dhaa)
SILSPOA0146
SITTM1040_2701
RUAD1823_21190
RUTFIU92_20550(dhaa)
JANJann_2604
RDERD1_2890
RLIRLO149_c015460
RPONG3256_11505
DSHDshi_0889
OATOAN307_c10710
OAROA238_c05550
OTMOSB_04160(dhaa)
OCTFTO60_12295
LMDMETH_23270
LEJETW24_21905
LAQUR2C4_20915
REDroselon_00137
MALGMALG_04359
YPACCEW88_20000
YANAYJ57_16085
SULIC1J05_15620
SULDB5M07_04180
SPSESULPSESMR1_04893(dhaa)
TOMBWR18_19320
RMMROSMUCSMR3_02249(dhaa) ROSMUCSMR3_04226(dhaa)
ROKRAK1035_0938
RIDRIdsm_04289(dhaa)
ROMEI983_03805
ROHFIU89_00860(dhaa)
AHTANTHELSMS3_04164(dhaa)
SAGUCDO87_02405
THAACFI11_05050
OCDFHY55_04770
ROTFIV09_12730(dhaa)
MALUKU6B_33590
PDEPden_3919
PAMIJCM7686_1649 JCM7686_1733
PYEA6J80_18880
PZHCX676_03985
PAROCUV01_11725
PARUCYR75_05570
PAMNJCM7685_1474
PMUTDPM13_17980
PARREOJ32_18375
PKDF8A10_04345
PPANESD82_04855
PMAUCP157_03283(dhaa)
RSUNHU_00511
RHMB5V46_15385
RHCRGUI_2046
RMBK529_013205
DAAAKL17_0565
LVSLOKVESSMR4R_00359(dhaa) LOKVESSMR4R_02474(dhaa) LOKVESSMR4R_03892(dhaa)
RBGBG454_15055
GEHHYN69_00875
GFUKM031_14105
TAWEI545_14140
BOOE2K80_10425
PSEBEOK75_08135
LITFPZ52_03800
MONG8E03_01825
POZI0K15_09135
THASC6Y53_14005
HDHG5B40_18740
GCEKYE46_06295
FAQG5B39_13615
CBOTATE48_06720
SALSala_3175
SPHKSKP52_23630
SPHPLH20_21715
SMAGAN936_22430
SMAZLH19_25475
STERAOA14_06080
SGISGRAN_0715
SPHQBWQ93_17330
SPHOC3E99_19060
SPHXE5675_02325
SPHUSPPYR_3904
SPHDHY78_29915
SPAPH3Z74_11135
SPAIFPZ24_00050
PALGHFP57_06380
SPHSETR14_06340
SANDH3309_06930
POQKZX46_15665
RMTIAI58_16675
STELSTAQ_26460
HTQFRZ44_51590
HADHFRZ61_46800
ELIOKO353_11595
NTHNther_1933
FMRFuma_06508
GMRGmarT_47500
GIMF1728_21455
GPNPan110_47400
MRIMal4_54340
SDYNMal52_06980 Mal52_53180(dhaa)
PLONPla110_02360
GOGC1280_01075
FTJFTUN_8369
CBAECOR50_08555
HHYHalhy_0113
RSIRunsl_0164
RUNDR864_24655
EOLEmtol_3040
ALSDJ013_22025
FBTD770_08405
MAQILDL77_07210
SPONHME9304_01170(dsdA)
SYISB49_03920
AQDD1816_04420
 » show all
Reference
1  [PMID:12835921]
  Authors
Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S
  Title
A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.
  Journal
Appl Microbiol Biotechnol 62:53-60 (2003)
DOI:10.1007/s00253-003-1238-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.41
IUBMB Enzyme Nomenclature: 4.1.3.41
ExPASy - ENZYME nomenclature database: 4.1.3.41
BRENDA, the Enzyme Database: 4.1.3.41

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