KEGG ENZYME: 4.1.3.44

ENZYME: 4.1.3.44

Entry

EC 4.1.3.44                 Enzyme

Name

tRNA 4-demethylwyosine synthase (AdoMet-dependent);
TYW1

Class

Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases

Sysname

tRNAPhe N1-methylguanine,pyruvate acetaldehyde-lyase (tRNAPhe 4-demethylwyosine-forming, decarboxylating, dehydrating)

Reaction(IUBMB)

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O [RN:R10552]

Reaction(KEGG)

R10552

Substrate

N1-methylguanine37 in tRNAPhe;
pyruvate [CPD:C00022];
S-adenosyl-L-methionine [CPD:C00019]

Product

4-demethylwyosine37 in tRNAPhe;
L-methionine [CPD:C00073];
5'-deoxyadenosine [CPD:C05198];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters [3,4]. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine [3]. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine.

History

EC 4.1.3.44 created 2013

Orthology

K15449

tRNA wybutosine-synthesizing protein 1

Genes

HSA:	441250(TYW1B) 55253(TYW1)

PTR:	472401(TYW1B) 744965

PPS:	100969148 117978806(TYW1B)

GGO:	101126070 129534728

PON:	100171721(TYW1)

PPYG:

129040477

NLE:

100607540

HMH:

116811966

SSYN:

129489808

MCC:

703026

MCF:

102133005

MTHB:

126950294

MNI:

105466335

CSAB:

103246597

CATY:

105593325

PANU:

101000797

TGE:

112620166

MLEU:

105548711

RRO:

104657346

RBB:	108543844 108543845

TFN:

117072911

PTEH:

111547030

CANG:

105504691

CJC:	100389730(TYW1)

SBQ:	101051520(TYW1)

CIMI:

108290025

ANAN:

105714933

CSYR:

103260329

MMUR:

105870997

LCAT:

123632647

PCOQ:

105806992

OGA:

100942622

MMU:	100929(Tyw1)

MCAL:

110294411

MPAH:

110313163

RNO:	304423(Tyw1)

MCOC:

116068498

ANU:

117698323

MUN:

110560874

CGE:

100751910

MAUA:

101841209

PROB:

127236882

PLEU:

114693659

MORG:

121446069

MFOT:

126504186

AAMP:

119825386

NGI:	103738938(Tyw1)

HGL:	101713541(Tyw1)

CPOC:

100721498(Tyw1)

CCAN:

109685928

DORD:

105998465

DSP:

122114884

PLOP:

125338536

NCAR:

124970805

MMMA:

107147020

OCU:

100354908

OPI:

101535365

TUP:	102485198(TYW1)

GVR:	103598925(TYW1)

CFA:

479708

CLUD:

112643346

VVP:

112934119

VLG:

121487539

NPO:

129519965

AML:

100474580

UMR:

103670173

UAH:

113267757

UAR:

123784713

ELK:

111146247

LLV:

125090423

MPUF:

101692945

MNP:

132026653

MLK:

131819907

NVS:

122896102

ORO:

101386988

EJU:

114214540

ZCA:

113933655

MLX:

117999523

NSU:

110589767

LWW:

102743782

FCA:

101083473

PYU:

121017776

PCOO:

112859877

PBG:

122471375

PVIV:

125154480

LRUF:

124519297

PTG:	102960991(TYW1)

PPAD:

109250645

PUC:

125928480

AJU:

106972846

HHV:

120235688

BTA:	533109(TYW1)

BOM:	102274921(TYW1)

BIU:

109578619

BBUB:

102406545

BBIS:

104986716

CHX:

102188999

OAS:

101111335

BTAX:

128070359 128071308

CSUM:

138076148

ODA:

120878061

CCAD:

122433093

MREE:

136160736

MBEZ:

129545594

SSC:	100516854(TYW1)

CFR:

102511835

CBAI:

105082748

CDK:	105089694 116151342 116152013

VPC:

102537787

BACU:

103017871(TYW1)

BMUS:

118881561

LVE:	103068508(TYW1B)

OOR:

101274335

DLE:

111182070

PCAD:

102977187

PSIU:

116740611

NASI:

112412445

ECB:

100062082

EPZ:

103558201

EAI:

106831846

MYB:	102260719(TYW1)

MYD:	102774018(TYW1)

MMYO:

118655875

MLF:

102421459

MDT:

132233155

PKL:

118703683

EFUS:

103286268

MNA:

107546685

DRO:

112314803

SHON:

118984017

AJM:

119042035

PDIC:

114503588

PHAS:

123806514

MMF:

118641781

PPAM:

129083751

HAI:

109393965

RFQ:

117024741

PALE:

102896817

PGIG:

120591729

PVP:

105296721

RAY:

107507429

MJV:

108394392

TOD:

119241486

SARA:

101550358

SETR:

126031217

LAV:

100671588

TMU:

101344394

ETF:

101654926

DNM:

101442617

MDO:	100010958(TYW1)

GAS:

123244524

SHR:

100918039

AFZ:

127558739

PCW:	110222093(TYW1)

TVP:

118858765

PBRV:

138162044

OAA:	100076834(TYW1)

GGA:	417478(TYW1)

PCOC:

116228206

MGP:	100550560 104913893

CJO:

107322608

TPAI:

128083354

LMUT:

125703072

NMEL:

110407591(TYW1)

APLA:

101796264

ACYG:

106041074(TYW1B)

CATA:

118254048

AFUL:

116497463

TGU:

116809154

LSR:	110472027(TYW1)

SCAN:

103820232

PMOA:

120513426

OTC:

121346893

PRUF:

121362977

GFR:	102036314(TYW1)

FAB:	101816854(TYW1)

OMA:

130260813

PHI:	102104404(TYW1)

PMAJ:

107212950

CCAE:

111937628(TYW1)

CCW:

104695778

CBRC:

103616349

ACOE:

138120436(TYW1B)

ETL:	114063777(TYW1)

ZAB:	102061748(TYW1)

ZLE:

135456008

SVG:	106856259(TYW1)

MMEA:

130580248 130586624

HRT:

120761387

SATI:

136369970(TYW1B)

FPG:	101914662(TYW1)

FCH:	102051986(TYW1)

CCRI:

104159307(TYW1)

SHAB:

115601888

ACUN:

113487377

TALA:

104363693

ACHC:

115347096

HALD:

104317200(TYW1)

HLE:

104843146

AGEN:

126039943

HHAR:

128149121

GCL:

127024504

CSTI:

104557189(TYW1)

MNB:

103776734

DPUB:

104300243

PPUS:

135187429

AVIT:

104267821

BRHI:

104494815(TYW1)

EGZ:

104131883

NNI:

104012424

PCRI:

104023982

PCAO:

104043065

PADL:

103912867

AFOR:

103896533(TYW1)

FGA:	104075597(TYW1)

GSTE:

104250719

CLV:	102089530(TYW1)

MUI:	104543474(TYW1)

PGUU:

104457748(TYW1)

PLET:

104620310(TYW1)

EHS:	104506909(TYW1)

CMAC:

104477575(TYW1)

CUCA:

104064672

BREG:

104636345

OHA:

104338588

CPEA:

104390049

CVF:

104289840

RTD:

128912415

AAM:	106482279(TYW1)

AROW:

112965005(TYW1)

NPD:	112956734(TYW1)

TGT:

104578103

DNE:	112987355(TYW1)

SCAM:

104146214

ASN:	102369756(TYW1)

AMJ:	102576049(TYW1)

CPOO:

109317050

GGN:

109293449

PSS:	102458161(TYW1)

CMY:

102929958

CCAY:

125623967

DCC:

119844693

CPIC:

101940317

TST:

117867745

CABI:

116821319

MRV:

120387402

ASAO:

132763436(TYW1)

PVT:	110084529(TYW1)

SUND:

121916880(TYW1)

PBI:

103057465

PMUR:

107288563(TYW1)

CTIG:

120309242

TSR:

106540770

PGUT:

117667548

APRI:

131188874

PTEX:

113441556(TYW1)

NSS:

113414681

VKO:	123036666(TYW1)

PMUA:

114585394

PRAF:

128403116

ZVI:

118097152

HCG:

128335903

GJA:	107112490(TYW1)

STOW:

125445750

EMC:

129345067

XLA:	735035(tyw1.S)

XTR:	100124832(tyw1)

NPR:

108801186

RTEM:

120926629

BBUF:

120995543

BGAR:

122932614

MUO:

115456489

GSH:

117348989

DRE:	562076(tyw1)

SRX:	107716137 107727925

SANH:

107659913 107659914 107672403

SGH:	107554250 107582638

CCAR:

109103514

CAUA:

113115197

CGIB:

127972624

PTET:

122359449(tyw1)

LROH:

127177332(tyw1)

OMC:	131520260(tyw1)

PPRM:

120478599(tyw1)

RKG:	130077782(tyw1)

MAMB:

125248380(tyw1)

CIDE:

127495614

CERY:

137005095(tyw1)

MASI:

127422338

TROS:

130564511(tyw1)

TDW:	130428512(tyw1)

MANU:

129437833 129437834

IPU:	108278267(tyw1)

IFU:	128621043(tyw1)

PHYP:

113533033

SMEO:

124394702(tyw1)

TFD:	113636625(tyw1)

TVC:	132857653(tyw1)

TRN:	134334408(tyw1)

AMEX:

103036157(tyw1)

CMAO:

118799634(tyw1)

EEE:	113586519 113591750

CHAR:

105907801(tyw1)

TRU:

101075019

TFS:	130534595(tyw1)

TNG:	GSTEN00035174G001

LCO:

104934297

TBEN:

117471068(tyw1)

CGOB:

115018126(tyw1)

PGEO:

117457436

GACU:

117555638(tyw1)

EMAC:

134880670(tyw1)

ELY:	117259885(tyw1)

EFO:	125889485(tyw1)

PLEP:

121943724(tyw1)

SLUC:

116039820(tyw1)

ECRA:

117941809(tyw1)

ESP:

116686969

PFLV:

114553284(tyw1)

GAT:	120815876(tyw1)

PPUG:

119214575(tyw1)

AFB:	129113201(tyw1)

CLUM:

117741501(tyw1)

PSWI:

130210366(tyw1)

CANA:

137790597(tyw1)

CVE:	137874556(tyw1)

MSAM:

119882935(tyw1)

SCHU:

122879617(tyw1)

CUD:	121527119(tyw1)

ALAT:

119004619(tyw1)

ASTR:

137597217(tyw1)

MZE:

101477816

ONL:

100691054

OAU:	116320363(tyw1)

OLA:

101161427

OML:	112149728(tyw1)

CSAI:

133441997(tyw1)

XMA:

102221516

XCO:

114133240

XHE:	116713346 116737657

PRET:

103475137

PFOR:

103138280(tyw1)

PLAI:

106947655

PMEI:

106921600(tyw1)

GAF:	122833033(tyw1)

PPRL:

129358696(tyw1)

CVG:	107093288(tyw1)

CTUL:

119784091(tyw1)

GMU:	124884542(tyw1)

NFU:	107379807(tyw1)

KMR:	108248398(tyw1)

ALIM:

106533050(tyw1)

NWH:	119411025(tyw1)

AOCE:

111581734(tyw1)

EJA:	138205340(tyw1)

MCEP:

125014050(tyw1)

CSEM:

103377870(tyw1)

POV:	109630290(tyw1)

SSEN:

122773626(tyw1)

HHIP:

117772375(tyw1)

HSP:	118106075(tyw1)

PPLT:

128439922(tyw1)

SMAU:

118299106(tyw1)

LCF:

108876212

SDU:	111216985(tyw1)

SLAL:

111662268(tyw1)

XGL:	120791984(tyw1)

HCQ:	109510815(tyw1)

SSCV:

125972883(tyw1)

SBIA:

133504803(tyw1)

PEE:	133405389(tyw1)

PTAO:

133482279(tyw1)

BPEC:

110163600(tyw1)

MALB:

109963274(tyw1)

BSPL:

114868028(tyw1)

SJO:	128360158(tyw1)

SASA:

106581026

OTW:	112266128(tyw1)

OMY:	110507120(tyw1)

ONE:

115137769

OKI:

109904841

OKE:

118396861

SNH:	120018556(tyw1)

ELS:	105029063(tyw1)

SFM:

108922478

PKI:

111847129

AANG:

118209583(tyw1)

LOC:

102694972

PSPA:

121308574 121308578(tyw1)

ARUT:

117429105 117963254

PSEX:

120531515(tyw1)

LCM:	102355797(TYW1)

CMK:	103188458(tyw1)

RTP:	109913706(tyw1)

CPLA:

122564083(tyw1)

HOC:	132830485(tyw1)

LERI:

129710793(tyw1)

PMRN:

116950312

LRJ:

133348933

BFO:

118425802

BBEL:

109462785

CIN:

100183917

SCLV:

120340176

SPU:

577163

LPIC:

129253662 129254981

APLC:

110982000

ARUN:

117290844

AJC:

117121898

SKO:

100366909

RZE:

108374610

CLON:

129617861

CLEC:

106661607

HHAL:

106691501

NLU:

111046699

HVI:

124361851

MQU:

128990613

PHU:	Phum_PHUM437860

ZNE:

110840811

CSEC:

111864679

SGRE:

126350217

BROR:

134527582

IEL:

124159093

FCD:

110858705

DPX:	DAPPUDRAFT_189816

DMK:

116919613

DPZ:

124342317

AFRA:

136039441

EAF:

111712626

LSM:

121127660

TCF:

131887351

DSV:

119446042

RSAN:

119390120

RMP:

119173604

TUT:

107361238

DPTE:

113794424 113796780 113797569

DFR:

124500543

CSCU:

111618399

CVS:

136969039

PTEP:

107439423

ABRU:

129965673

UDV:

129220472

SDM:

118194614

LPOL:

106457440

PMEO:

129581383

TSP:

Tsp_01543

HRO:	HELRODRAFT_189252

LGI:	LOTGIDRAFT_135774

PVUL:

126823507

PCAN:

112562727

GAE:

121369519

HRF:

124133414

HRJ:	124271959 124273085

HASI:

137293931

CRG:

105331497

CANU:

128191179

CVN:

111128345

OED:

125645803

MYI:

110449607

PMAX:

117332696

AIRR:

138331898

MCAF:

127711984

MMER:

123535476

RPHI:

132742714 132749430

DPOL:

127854415

MAEA:

128232580

OBI:

106880685

OSN:

115224455

LJP:

135476487

LAK:	106151340 106181776

LLON:

135483429

NVE:

5516601

EPA:

110234939

ATEN:

116286746

ADF:

107334523

AMIL:

114976302

MCAZ:

138047580

MFOO:

137974700

PDAM:

113670269

SPIS:

111327688

DGT:

114523871

XEN:

124435220

HMG:

100207086

HSY:

130624267

RES:

135683626

TAD:	TRIADDRAFT_28630

AQU:

100633002

ATH:

AT1G75200

ALY:

9323642

CRB:

17895808

CSAT:

104702257 104713164 104751391

EUS:	EUTSA_v100183040m

BRP:	103830661 103831979

BNA:	106353668 106354510 106406196

BOE:	106296548 106300204

RSZ:	108814199 108818191 108831658 130507637

THJ:

104809061

CPAP:

110816733

CIT:

102607821

CIC:	CICLE_v10003946mg

PVY:	116119455 116122051

MINC:

123230044

TCC:

18591380

GRA:

105785067

GHI:	107917904 107922369

GAB:

108480112

HSYR:

120195315

DZI:

111315354

EGR:

104449025

GMX:	100791920 100799430

GSJ:	114384963 114393739

PVU:

137815338

VRA:

106763782

VAR:

108338328

VUN:

114194476

VUM:

124843795

CCAJ:

109791884

APRC:

113846615 113846891

MTR:

25482134

TPRA:

123886375

CAM:

101511336

PSAT:

127096684

VVO:

131596597

LJA:

130717818

ADU:

107495947

AIP:	107631952 107631972 107647819

AHF:	112697963 112734880 112756272

LANG:

109358695

PCIN:

129303377

QSA:	O6P43_016167

FVE:

101300215

AANS:

126782806

RCN:

112168925

PPER:

18792105

PMUM:

103320843

PAVI:

110767288

PDUL:

117625506

MDM:	103440486 103450485

MSYL:

126603484 126631717

PXB:	103928945 103942715 103954679 103955407

ZJU:

107420298

MNT:	112095079 21386868

CSAV:

115697450

CSV:

101217239

CMO:

103487965

BHJ:

120075547

MCHA:

111014045

CMAX:

111492394

CMOS:

111462691

CPEP:

111805516

RCU:

111946220

MEAN:

126664335

JCU:

105633788

HBR:

110655596

MESC:

110606652

POP:

112326647

PEU:

105125606

PALZ:

118056209

PNZ:

133692192

JRE:

108991714

CILL:

122299373

CAVE:

132184061

AGLU:

133867009

QSU:

112021799

QLO:

115974331

TWL:	119999358 120009905

VVI:

100255870

VRI:

117906421

SLY:

109120154

SPEN:

107018052

SOT:

102581860

SSTN:

125842510 125854755

SDUL:

129902377

CANN:

107867003

LBB:

132629140

NTA:	107774094 107805091

NSY:

104247356

NTO:

104090695

NAU:

109224889

INI:

109153124

ITR:

116027736

SIND:

105166143

OEU:

111389064

EGT:

105965981

SSPL:

121753338 121766086

SMIL:

131009772 131010520

SHIS:

125223543

APAN:

127257084

HAN:

110916962

ECAD:

122608327

LSV:

111876260

CCAV:

112511224

DCR:

108227093

CSIN:

114322726

RVL:

131333415

AEW:

130758157

BVG:

104905281

SOE:

110802801

CQI:	110720515 110721525

ATRI:

130809882

MOF:

131163016

NNU:

104601869

MING:

122073940

TSS:

122661615

PSOM:

113287835 113288631

OSA:	4334285(TYW1)

DOSA:

Os03g0775300

OBR:

102705710

BDI:

100846034

ATS:

109766020

TDC:	119303328 119310248

TAES:

123105194 123113472 123122993

TUA:

125510737

LPER:

127292620

LRD:	124688359 124702791

SBI:

8083950

ZMA:

100273754

MFLO:

136536097 136536102

SITA:

101760526

SVS:

117839948

PVIR:

120648981 120688642

PHAI:

112876845

PAUA:

133910783

PDA:	103702720 103705365

EGU:

105060806

MUS:

135612034

ZOF:	122040681 122045223

DCT:	110115136 110115495

PEQ:

110038318

AOF:

109848558

MSIN:

131218490

ACAK:

137951506

NCOL:

116251219

ATR:	105421309 18445816

CJF:

131077572

SMO:	SELMODRAFT_169856

PPP:

112286177

CRE:	CHLRE_14g623300v5

VCN:	VOLCADRAFT_118097

CSL:	COCSUDRAFT_26989

OLU:	OSTLU_12352

OTA:	OT_ostta03g03140

BPG:	Bathy09g03290

MIS:	MICPUN_78848

MPP:	MICPUCDRAFT_1250

SCE:	YPL207W(TYW1)

SEUB:

DI49_5261

SPAO:

SPAR_P00690

AGO:	AGOS_AFL099W

ERC:

Ecym_2196

LTH:	KLTH0H04026g

VPO:	Kpol_1002p48

ZRO:	ZYRO0C13398g

CGR:	2887518(GVI51_E05401)

NCS:	NCAS_0A01070(NCAS0A01070)

NDI:	NDAI_0F01620(NDAI0F01620)

TPF:	TPHA_0J02420(TPHA0J02420)

TBL:	TBLA_0B05360(TBLA0B05360)

TGB:	HG536_0E05390

TDL:	TDEL_0E05290(TDEL0E05290)

KAF:	KAFR_0K00300(KAFR0K00300)

KNG:	KNAG_0D01110(KNAG0D01110)

ZMK:	HG535_0B00890

SLUD:

SCDLUD_001107

DHA:	DEHA2C04180g

PIC:	PICST_67514(YPO7)

PGU:	PGUG_05777

SPAA:

SPAPADRAFT_143744

LEL:	PVL30_005589(YPO7)

LBG:	92209343(LODBEIA_P41470)

CAL:	CAALFM_C602290CA(CaO19.3470)

CTP:	CTRG_02817

COT:	CORT_0F02380

CDU:	CD36_62480

CLU:	CLUG_05085

CLUS:

A9F13_03g01518

CAUR:

CJI96_0002246

PKZ:	C5L36_0E03280

YLI:	2912065(YALI2_F00406g)

SLB:	AWJ20_2863(TYW1)

NCR:

NCU16769

NTE:	NEUTE1DRAFT59896(NEUTE1DRAFT_59896)

SMP:	10803976(SMAC4_04759)

PAN:	PODANSg7352

PBEL:

QC761_601910(YPO7)

PPSD:

QC762_601910(YPO7)

PPSP:

QC763_601910(YPO7)

PPSA:

QC764_601910(YPO7)

TTT:	THITE_2114929

MTM:	MYCTH_2298553

CTHR:

CTHT_0034610

MGR:

MGG_06096

PPEI:

PpBr36_02923

PGRI:

PgNI_01776

TMN:	UCRPA7_3023

SSCK:

SPSK_07025

FGR:	FGSG_09818

FPU:	FPSE_00823

FPOA:

FPOAC1_011819

FVN:	FVRRES_12883

FVR:	FVEG_06435

FOX:	FOXG_08238

NHE:	NECHADRAFT_33081

FFC:	NCS54_00267300

FKR:	NCS57_00263000

FMU:	J7337_004357

TRE:	TRIREDRAFT_120172

TRR:	M419DRAFT_5677

TATV:

25785392(TrAtP1_001409)

TASP:

36614292(TrAFT101_001063)

MAW:	19250720(YPO7)

MAJ:

MAA_05065

MBRN:

26237587(TYW1)

PCHM:

VFPPC_09046

CMT:

CCM_04269

AMUS:

LMH87_006326

PLJ:	28883012(PLICBS_000974)

PTKZ:

JDV02_007780(YPO7)

VAL:	VDBG_00924

VDA:	VDAG_00534

CFJ:	CFIO01_10351

CLUP:

CLUP02_15255

CHIG:

CH63R_04795

CDET:

87941864(CDEST_05361)

ELA:	UCREL1_2645

PFY:	PFICI_05678

SSL:	SS1G_08491

BFU:	BCIN_12g03860(Bctyw1)

MBE:

MBM_01987

PSCO:

LY89DRAFT_707658

GLZ:	GLAREA_09520

ANI:	ANIA_00502

AFM:	AFUA_6G11510

ACT:	ACLA_085180

NFI:	NFIA_057200

AOR:	AO090023000426

AFV:	AFLA_006773

ALUC:

AKAW2_10443S

ACHE:

ACHE_60035S

APUU:

APUU_11542S

POU:	POX_d04860

TMF:	EYB26_008374

TRG:	TRUGW13939_00173

CIM:	CIMG_09814

CPW:	9694575(D8B26_002546)

URE:	UREG_04729

ABE:

ARB_02787

TVE:

TRV_02645

PBL:	PAAG_05255

PBN:	PADG_11875

AJE:	HCAG_09003

BGH:	BDBG_01654

PNO:	SNOG_08510

PTE:

PTT_19371

PTRR:

6347330(PtrM4_035240)

BZE:	COCCADRAFT_93041

BSC:	COCSADRAFT_166747

BOR:	COCMIDRAFT_81183

AALT:

CC77DRAFT_94049

ARAB:

EKO05_0009341

ZTR:	MYCGRDRAFT_11076

PFJ:	MYCFIDRAFT_96081

FFU:	CLAFUR5_10806

CBET:

CB0940_07363

BCOM:

BAUCODRAFT_299626

NPA:	UCRNP2_228

TML:	GSTUM_00004263001

SPO:	2539172(tyw1)

SOM:	SOMG_04367(tyw1)

PGR:	PGTG_08343

PTRC:

PtA15_14A445

PSTR:

Pst134EA_025450

MLR:	MELLADRAFT_87318

RIE:	OCT59_000074

MBR:	MONBRDRAFT_14102

SRE:	PTSG_11079

PFA:	PF3D7_0524900

PFD:	PFDG_04372

PFH:	PFHG_02982

PREI:

PRSY57_0524000

PGAB:

PGSY75_0524900

PLAG:

39740554(PADL01_0523900)

PYO:	PY17X_1242900

PCB:	PCHAS_1240100

PBE:	PBANKA_1239700

PVV:	PVVCY_1204040

PKN:	PKNH_1007900

PVX:	PVX_080000

PCY:	PCYB_101670

PMAL:

PMUG01_10019600

PBRS:

92371235(MKS88_003148)

PREL:

PRELSG_1006800

PCOT:

PCOAH_00029110

TAN:

TA18985

TPV:

TP01_0125

TOT:	TOT_010000114

BEQ:	BEWA_033500

BBO:	BBOV_IV001010

BMIC:

BMR1_02g00125

BBIG:

BBBOND_0402570

TGO:	TGME49_272270 TGME49_315958

BBES:

BESB_038150

PTI:	PHATRDRAFT_21682

FCY:	FRACYDRAFT_181471

TPS:	THAPS_13378

AAF:	AURANDRAFT_21732

PIF:	PITG_03633

PSOJ:

PHYSODRAFT_260361

BLAC:

94352138(CCR75_008415)

SPAR:

SPRG_10595

TBR:	Tb09.160.3520 Tb927.7.7130

TBG:	TbgDal_IX2650 TbgDal_VII8390

TCR:	504175.9 508277.60

LMA:	LMJF_05_0750 LMJF_15_1540

LIF:	LINJ_05_0750 LINJ_15_1610

LDO:	LDBPK_050750 LDBPK_151610

LMI:	LMXM_05_0750 LMXM_15_1540

LMAT:

92517623(LSCM1_07752)

LBZ:	LBRM_05_0730 LBRM_15_1540

LPAN:

LPMP_050730 LPMP_151500

LOI:	92363159(LSCM4_07330) 92363890(LSCM4_08080)

LEIS:

94183208(GH5_07988)

LENR:

94174801(CUR178_07650)

LEIN:

94190128(JIQ42_06520) 94191631(JIQ42_08063)

PHET:

94292215(JKF63_06188) 94293419(JKF63_07403)

EHX:	EMIHUDRAFT_426304 EMIHUDRAFT_428437

GTT:	GUITHDRAFT_52860 GUITHDRAFT_85567

CVL:	J8C06_07250

MJA:

MJ_0257

MFE:	Mefer_0099

MVU:	Metvu_1462

MFS:	MFS40622_0488

MIF:	Metin_0264

MJH:	JH146_0167

MESG:

MLAUSG7_1543(taw)

MESA:

MLASG1_1131(taw)

MIG:	Metig_1762

MMP:

MMP1440

MMQ:	MmarC5_0138

MMX:	MmarC6_1233

MMZ:	MmarC7_0685

MMD:

GYY_08035

MMAK:

MMKA1_16640

MMAO:

MMOS7_15470

MMAD:

MMJJ_13990

MAE:

Maeo_0492

MVN:	Mevan_0751

MVO:

Mvol_1482

MOK:	Metok_1517

METF:

CFE53_04985

MTH:

MTH_1039

MMG:	MTBMA_c14260

MWO:	MWSIV6_1425(taw1)

MTEE:

MTTB_03830

METC:

MTCT_0947

METE:

tca_01003

METZ:

METMT2_1065

METK:

FVF72_06395

MTHM:

FZP57_06815

METJ:

FZP68_03825

MST:

Msp_1383

METB:

AW729_08595

MEIS:

PXD04_00190(twy1)

MRU:

mru_1823

MSI:

Msm_0922

MEB:

Abm4_0333

MMIL:

sm9_1868

MEYE:

TL18_08800

MOL:

YLM1_1283

MARO:

MarbSA_17110

METV:

K4897_06865(twy1)

MEL:	Metbo_2402

MEW:	MSWAN_0226

METH:

MBMB1_0221(taw1)

MFC:	BRM9_2078(tyw1)

MFI:	DSM1535_1603(taw1)

MCUB:

MCBB_0240(taw1)

MSUB:

BK009_10905

METN:

BK008_06550

METT:

CIT01_02945

METO:

CIT02_05910

MEME:

HYG87_04310

MFEG:

GCM10025860_10420

MEER:

NKF70_07860(twy1)

MFV:

Mfer_0037

MKA:

MK0055

AFU:

AF_2261

AFG:	AFULGI_00025560

APO:	Arcpr_1826

AVE:	Arcve_1060

AST:	Asulf_00938

FPL:

Ferp_2027

GAC:

GACE_0583

GAH:

GAH_01794

PFU:

PF1718

PFI:

PFC_10015

PHO:	PH1705(PH1705)

PAB:

PAB2039

PYN:

PNA2_0299

PYA:	PYCH_02060

PYS:

Py04_1597

PYC:	TQ32_08265

TKO:

TK1671

TON:

TON_1905

TGA:

TGAM_0775

TSI:

TSIB_0033

TBA:	TERMP_02019

THE:

GQS_05660

THA:

TAM4_564

THM:

CL1_0765

TLT:

OCC_01529

THS:

TES1_1969

TNU:

BD01_1513

TEU:

TEU_04000

TGY:	X802_06495

THV:	ADU37_CDS22050

TCH:	CHITON_1941

TPEP:

A0127_06875

TPIE:

A7C91_05545

TGG:	A3K92_06635

TCE:	A3L02_01590

TBS:	A3L01_00200

THH:	CDI07_00245

TSL:	A3L11_03940

TTD:	A3L14_01510

TPRF:

A3L09_08615

TRL:	A3L10_09910

TPAF:

A3L08_03350

THY:	A3L12_03240

TIC:	FH039_02310

TCQ:	TIRI35C_0260(taw)

THEM:

FPV09_07040

THEI:

K1720_03225(twy1)

PPAC:

PAP_00750

MBA:	Mbar_A1006

MBY:	MSBRM_3488

MBW:	MSBRW_3713

MBAR:

MSBR2_3440

MBAK:

MSBR3_3448

MAC:

MA_0040

MMA:

MM_1346

MMAZ:

MmTuc01_1393

MMJ:	MSMAS_3317

MMAC:

MSMAC_3340

MVC:	MSVAZ_3447

MEK:	MSKOL_3407

MLS:	MSLAZ_3118

METM:

MSMTP_3213

MEF:	MSWH1_3165

MEQ:	MSWHS_3376

MSJ:	MSSAC_4358

MSZ:	MSSIH_3859

MSW:	MSSIT_3929

MTHR:

MSTHT_1849

MTHE:

MSTHC_1437

MHOR:

MSHOH_4064

MFZ:	AOB57_008520

MBU:

Mbur_1737

MMET:

MCMEM_0004

MELO:

J7W08_10060(twy1)

MMH:

Mmah_0004

MHAZ:

BHR79_03445

MPOT:

BKM01_10455

MEV:	Metev_0006

MZH:	Mzhil_0004

MPY:

Mpsy_1671

MZI:	HWN40_00835

MMAV:

RE476_09515(twy1)

MSEB:

RE474_06450(twy1)

MHZ:	Metho_0038

MEHF:

MmiHf6_09890

MEES:

MmiEs2_00290

MTP:

Mthe_0408

MCJ:

MCON_1878

MHI:

Mhar_1521

MHU:

Mhun_2838

MRTJ:

KHC33_02765(twy1)

MLA:

Mlab_0538

MEM:	Memar_2214

MBG:	BN140_1448

MEMA:

MMAB1_1854(taw)

MCHK:

MchiMG62_25310

MSUM:

OH143_05350(twy1)

MRC:	R6Y96_03555(twy1)

MPI:

Mpet_0613

MEND:

L6E24_05490(twy1)

MEFW:

F1737_08060(twy1)

MAQE:

RJ40_06810(twy1)

MFK:	E2N92_07000(twy1)

MOU:	OU421_07560(twy1)

MESB:

L1S32_10930(twy1)

MANQ:

L1994_08355(twy1)

MBN:

Mboo_0272

MFO:	Metfor_2842

MESK:

METHP_00775

MPL:

Mpal_0289

MPD:

MCP_0744

MEZ:

Mtc_1521

RCI:

RRC421

MJK:	N2V74_00145 N2V74_05705

HAL:

VNG_2128C

HSL:	OE_3967R(taw1)

HANR:

LJ422_08555(twy1)

HDL:	HALDL1_15550

HHB:	Hhub_3415(taw1)

HAGS:

JT689_09905

HABO:

JRZ79_08285(twy1)

HNO:	LT974_13890(twy1)

HLU:	LT972_00825(twy1)

HALH:

HTSR_1795

HHSR:

HSR6_1864

HSU:	HLASF_0218

HSF:	HLASA_0218

HAHS:

HSRCO_0352(tYW1)

SALR:

FQU85_05555

HALR:

EFA46_002485

HJE:	HacjB3_01965

HALX:

M0R89_07045(twy1)

HAXZ:

M0R88_07250(twy1)

HAYC:

NGM10_09140(twy1)

HAXY:

NGM07_12975(twy1)

SALI:

L593_06145

SAIM:

K0C01_05745(twy1)

HARA:

AArcS_0241(tyw1)

HMA:

rrnAC3075

HHI:

HAH_0331

HHN:	HISP_01740

HAB:	SG26_09555

HTA:	BVU17_01595

HALJ:

G9465_01125

HSIN:

KDQ40_12035(twy1)

NPH:	NP_0070A(taw1)

NMO:	Nmlp_1366(taw1)

NHO:	HWV23_06305

NSAL:

HWV07_07520

HUT:

Huta_2016

HTI:

HTIA_1658

HALA:

Hrd1104_00310

HASV:

SVXHr_2622(tyw1)

HABN:

HBNXHr_2498(tyw1)

HMU:

Hmuk_1206

HALZ:

E5139_09205

HALL:

LC1Hm_0432(tyw1)

HAZP:

GBQ70_09200

HALI:

BV210_09080

HSN:	DV733_03140

HDS:	HSR122_1883(tyw1)

HRR:	HZS55_01535

HPEL:

HZS54_02000

HLT:	I7X12_10750

HARC:

HARCEL1_10435

SSAI:

N0B31_12085(twy1)

HTU:

Htur_2970

HSAL:

JMJ58_13570

HAKZ:

J0X25_01730(twy1)

NMG:	Nmag_0940(taw1)

HXA:	Halxa_2288

NAT:

NJ7G_1701

NPE:	Natpe_1019

NVR:	FEJ81_05280

NPL:	FGF80_08420

NAY:	HYG81_04885(twy1)

HALY:

HYG82_08360

HJT:	DVR14_14395

HLO:	J0X27_11550

NGE:	Natgr_2254

HRU:	Halru_0983

SAWL:

NGM29_09915(twy1)

HALV:

NGM15_02110(twy1)

NOU:	Natoc_2635

HLR:	HALLA_07315

HLC:	CHINAEXTREME09155

NAJ:	B1756_12395

NAG:	AArcMg_2902

NAN:	AArc1_0801

NARA:

QQ977_00065(twy1)

NBG:	DV706_10830

NAS:	GCU68_01250

HDA:	BB347_08800

MELU:

MTLP_03470

MEAM:

MU439_01090(twy1)

MEAE:

QEN48_01495(twy1)

TAC:

Ta1275

TVO:	TVG0493454(TVG0493454)

OMR:	OXIME_001199(twy1)

PTO:

PTO1196

FAC:	FACI_IFERC01G0622

FAI:

FAD_1512

CDIV:

CPM_0443

TAR:	TALC_00886

MAX:	MMALV_08220

MER:	MMINT_12640

MEAR:

Mpt1_c04620(taw1)

MEUZ:

KRP56_04075(twy1)

MARC:

AR505_0827

ABI:

Aboo_0476

ACF:	AciM339_0566

APE:

APE_1059

ACJ:

ACAM_0688

SMR:

Smar_0198

SHC:	Shell_0626

IHO:

Igni_1433

IIS:

EYM_06765

IPC:

IPA_09115

DKA:

DKAM_0657

DFD:	Desfe_0853

DMU:	Desmu_0388

TAG:

Tagg_0499

IAG:

Igag_1166

THG:	TCELL_0841

HBU:

Hbut_1116

PFM:	Pyrfu_0840

PDL:	Pyrde_1181

PABI:

PABY_10400(twy1)

PARE:

PYJP_10460(twy1)

STO:

STK_12820

SOH:	D1869_07415

SSO:

SSO0956

SOL:

Ssol_1932

SSOA:

SULA_1964

SSOL:

SULB_1965

SSOF:

SULC_1963

SSHI:

J5U23_02522

SCAS:

SACC_08400

SAI:

Saci_1331

SACN:

SacN8_06490

SACR:

SacRon12I_06480

SACS:

SUSAZ_06360

SIS:	LS215_1357

SIA:	M1425_1270

SIM:	M1627_1320

SID:

M164_1254

SIY:	YG5714_1255

SIN:	YN1551_1593

SII:

LD85_1382

SIH:

SiH_1215

SIR:

SiRe_1133

SIC:

SiL_1130

SULA:

BFU36_01655

SULE:

GFS03_07130

SULO:

GFS33_12540

SULL:

EWF20_08590

MSE:

Msed_1738

MEMJ:

MJ1HA_1983

MCN:

Mcup_0490

MHK:	DFR87_09970

MPRU:

DFR88_09545

MTEN:

GWK48_02305

MJN:	MjAS7_2866

AHO:

Ahos_1403

AMAN:

B6F84_11475

ABRI:

DFR85_10830

ASUL:

DFR86_09790

AAMB:

D1866_01950

ACIH:

HS5_28150

SACD:

HS1genome_1020

SAZO:

D1868_04180

CSTY:

KN1_24250

STEP:

IC006_1164

SMET:

RQ359_000746(twy1)

SAHS:

HS7_19270

PAI:

PAE0164

PIS:

Pisl_0084

PCL:

Pcal_0866

PAS:

Pars_2206

PYR:

P186_0927

POG:

Pogu_2678

TNE:

Tneu_1016

PYW:	PYWP30_01136

CMA:

Cmaq_1372

TTN:

TTX_2026

TUZ:

TUZN_1483

VDI:

Vdis_1354

VMO:

VMUT_2175

VSO:	Vsou_05720

TPE:

Tpen_0853

THB:	N186_05985

TCB:	TCARB_0257

THEL:

IG193_02975

ASC:

ASAC_0257

ACIA:

SE86_02145

CLG:	Calag_1311

FFO:	FFONT_0345

KCR:

Kcr_0998

NMR:

Nmar_1529

NIR:	NSED_08410

NKR:	NKOR_08320

NID:	NPIRD3C_0002

NIN:	NADRNF5_0362

NIW:	Nisw_06270

NCL:	C5F47_08015

NOX:	C5F49_07900

NUE:	C5F50_11240

NIP:	NsoK4_00635

NZT:	NZOSNM25_000260

NCT:	NMSP_0232(taw1)

NIC:	DSQ20_08925

NGA:	Ngar_c01490

NVN:	NVIE_013560

NEV:

NTE_02755

TAA:	NMY3_01903(moaA_2)

NFN:	NFRAN_2712(taw)

NCV:	NCAV_0874(taw)

NDV:	NDEV_0268(taw)

CSU:	CSUB_C1598

NBV:	T478_0225(twy1)

TAH:	SU86_004455

NIU:	DSQ19_01615

CCAI:

NAS2_0571

NEQ:

NEQ382

NAA:

Nps_02670

NAER:

MJ1_0608

MARH:

Mia14_0979

FLT:	Sv326_0984

MIY:	Micr_00149(taw1_2)

LOKI:

Lokiarch_15360(taw1_1) Lokiarch_18480(taw1_2)

LOB:	NEF87_001421

PSYT:

DSAG12_03640

AGW:	QT03_C0001G0956

» show all

Reference

1 [PMID:17881823]

Authors

Goto-Ito S, Ishii R, Ito T, Shibata R, Fusatomi E, Sekine SI, Bessho Y, Yokoyama S

Title

Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis.

Journal

Acta Crystallogr D Biol Crystallogr 63:1059-68 (2007)
DOI:10.1107/S0907444907040668

Sequence

[pho:PH1705]

Reference

2 [PMID:17727881]

Authors

Suzuki Y, Noma A, Suzuki T, Senda M, Senda T, Ishitani R, Nureki O

Title

Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA.

Journal

J Mol Biol 372:1204-14 (2007)
DOI:10.1016/j.jmb.2007.07.024

Sequence

[mja:MJ_0257]

Reference

3 [PMID:22026549]

Authors

Young AP, Bandarian V

Title

Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.

Journal

Biochemistry 50:10573-5 (2011)
DOI:10.1021/bi2015053

Reference

4 [PMID:23043105]

Authors

Perche-Letuvee P, Kathirvelu V, Berggren G, Clemancey M, Latour JM, Maurel V, Douki T, Armengaud J, Mulliez E, Fontecave M, Garcia-Serres R, Gambarelli S, Atta M

Title

4-Demethylwyosine synthase from Pyrococcus abyssi is a radical-S-adenosyl-L-methionine enzyme with an additional [4Fe-4S](+2) cluster that interacts with the pyruvate co-substrate.

Journal

J Biol Chem 287:41174-85 (2012)
DOI:10.1074/jbc.M112.405019

Other DBs

ExplorEnz - The Enzyme Database:

4.1.3.44

IUBMB Enzyme Nomenclature:

4.1.3.44

ExPASy - ENZYME nomenclature database:

4.1.3.44

BRENDA, the Enzyme Database:

4.1.3.44

DBGET integrated database retrieval system