Entry
Name
citrate (pro-3S)-lyase;
citrase;
citratase;
citritase;
citridesmolase;
citrate aldolase;
citric aldolase;
citrate lyase;
citrate oxaloacetate-lyase;
citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate)
Reaction(IUBMB)
citrate = acetate + oxaloacetate [RN:
R00362 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme can be dissociated into components, two of which are identical with EC
2.8.3.10 (citrate CoA-transferase) and EC
4.1.3.34 (citryl-CoA lyase). EC
3.1.2.16 , citrate lyase deacetylase, deacetylates and inactivates the enzyme.
History
EC 4.1.3.6 created 1961
Reference
Authors
DAGLEY S, DAWES EA.
Title
Citridesmolase: its properties and mode of action.
Journal
Reference
Authors
Dimroth P, Loyal R, Eggerer H.
Title
Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.6
ExPASy - ENZYME nomenclature database: 4.1.3.6
BRENDA, the Enzyme Database: 4.1.3.6