Entry
Name
phosphomethylpyrimidine synthase;
thiC (gene name)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
BRITE hierarchy
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine-forming)
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO [RN:
R03472 ]
Reaction(KEGG)
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:
C03373 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine [CPD:
C04556 ];
5'-deoxyadenosine [CPD:
C05198 ];
L-methionine [CPD:
C00073 ];
formate [CPD:
C00058 ];
CO [CPD:
C00237 ]
Comment
Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.
History
EC 4.1.99.17 created 2011
Pathway
Orthology
K03147 phosphomethylpyrimidine synthase
Genes
CSAT : 104700534 104749910 104786696
BNA : 106451517 106451520 125603549
HSYR : 120142019 120160028
CMOS : 111452695 111464788
MESC : 110609103 110616265
NTA : 107782237(THIC) 107810498
SSPL : 121761796 121764674 121784023
SHIS : 125188580 125202418
ATRI : 130813299 130813464
PSOM : 113310014 113321130
TAES : 123087299 123090650 123095671
TUA : 125517650 125527215 125550248
MFLO : 136521779 136543548
PVIR : 120648344 120690201
SMO : SELMODRAFT_120890 SELMODRAFT_152730 SELMODRAFT_418436
TPS : THAPSDRAFT_41733(THI1)
ECOO : ECRM13514_5115(thiC)
ECOH : ECRM13516_4851(thiC)
ECW : EcE24377A_4536(thiC)
EDJ : ECDH1ME8569_3854(thiC)
ECOI : ECOPMV1_02795(thiC)
REE : electrica_04811(thiC)
RTG : NCTC13098_06932(thiC)
CLAP : NCTC11466_04345(thiC)
KIE : NCTC12125_03509(thiC)
AHN : NCTC12129_04655(thiC_2)
METY : MRY16398_53660(thiC)
PSHI : SAMEA2665130_3037(thiC)
MPHG : MPHASIOC01_005172(thiC)
YPG : YpAngola_A0455(thiC)
YPI : YpsIP31758_3853(thiC)
SMW : SMWW4_v1c02900(thiC)
SFJ : SAMEA4384070_0273(thiC)
SOF : NCTC11214_02091(thiC)
SSAR : SSARUM_000254(thiC)
PAQU : DMB82_0001045(thiC)
PARL : PEC302110_37540(thiC)
EHD : ERCIPSTX3056_681(thiC)
TPTY : NCTC11468_00198(thiC_1)
PHEI : NCTC12003_00404(thiC)
PRJ : NCTC6933_00460(thiC)
LRI : NCTC12151_00411(thiC)
XFU : XFF4834R_chr12000(thiC)
XPH : XppCFBP6546_16960(thiC)
XHD : LMG31886_09270(thiC)
LLZ : LYB30171_00549(thiC)
VAU : VANGNB10_cI2689c(thiC)
VPL : SA104470976_02680(thiC)
VIB : VspSTUT11_00220(thiC)
VIS : VspSTUT16_00250(thiC)
PAEB : NCGM1900_5720(thiC)
PAEU : BN889_05518(thiC_2)
PVD : CFBP1590__4794(thiC)
PPRC : PFLCHA0_c05470(thiC)
PMUD : NCTC8068_00493(thiC)
PFW : PF1751_v1c04610(thiC)
PPUU : PputUW4_00421(thiC)
PTRT : HU722_0003375(thiC)
PTW : TUM18999_55280(thiC)
PTAE : NCTC10697_04100(thiC)
PBEZ : SBP02_02465(thiC) SBP02_04445(thiC)
MSHE : MAALD49_07890(thiC)
PSYC : DABAL43B_0104(thiC)
MCAT : MC25239_00055(thiC)
MCUN : NCTC10297_00492(thiC)
SCAA : TUM17387_19010(thiC)
SALH : HMF8227_02263(thiC)
CBS : COXBURSA331_A0437(thiC)
MISZ : MishRS11D_04070(thiC)
TIB : THMIRHAM_10910(thiC)
TSE : THMIRHAS_12190(thiC)
TFRI : Thiofri_00471(thiC)
TNI : TVNIR_3762(thiC_[H])
THIC : TspCOW1_20660(thiC)
HAK : KO116_03278 KO116_03282
HAAH : HALA3H3_30280(thiC)
HOL : HORIV_16720 HORIV_16730
HAXI : HAALTHF_49560n HAALTHF_49570n HAALTHF_49580n HAALTHF_49650n
ALCA : ASALC70_02889(thiC_2)
AEL : NCTC12917_00352(thiC)
CDIZ : CEDIAZO_00459(thiC)
NMM : NMBM01240149_0142(thiC)
NMS : NMBM01240355_1975(thiC)
NMQ : NMBM04240196_1982(thiC)
NMZ : NMBNZ0533_1972(thiC)
NMX : NMA510612_0422(thiC)
NWE : SAMEA3174300_1885(thiC)
NZO : SAMEA4504057_0041(thiC)
NCI : NCTC10296_00899(thiC)
NCZ : NCTC10294_01358(thiC)
NANI : NCTC12227_01382(thiC)
CCAH : DWG20_00055 DWG20_05660
PSE : NH8B_1623(thiC) NH8B_4048(thiC)
BMV : BMASAVP1_A1197(thiC)
BML : BMA10229_A0670(thiC)
BPM : BURPS1710b_1528(thiC)
BPL : BURPS1106A_1401(thiC)
POLT : TUM22923_07800(thiC)
PLG : NCTC10937_00723(thiC)
BUO : BRPE64_ACDS09690(thiC)
BUE : BRPE67_ACDS08630(thiC)
VTR : MYVALT_H_00060(thiC)
BTRM : SAMEA390648701489(thiC)
AXX : ERS451415_05833(thiC)
METR : BSY238_1342(thiC) BSY238_2217(thiC)
URU : DSM104443_00050(thiC)
UPL : DSM104440_00049(thiC)
THU : AC731_010940 AC731_016195
THAG : CKCBHOJB_00728(thiC)
AZQ : G3580_04320(thiC) G3580_04435(thiC)
ACOM : CEW83_03215 CEW83_18680
FPHO : SHINM1_021790(thiC)
ERW : ERWE_CDS_03030(thiC)
ERG : ERGA_CDS_02970(thiC)
MESJ : MJ8_15100 MJ8_40620
MESU : LHFGNBLO_006473(thiC)
AMIS : Amn_09970 Amn_46720
RBS : RHODOSMS8_02176(thiC)
SMEL : SM2011_b20615(thiC)
SFD : USDA257_c22940(thiC)
SAME : SAMCFNEI73_pC1978(thiC)
AGR : AGROH133_08712(thiC)
ALF : CFBP5473_02495(thiC)
AVV : RvVAT039_42130(thiC)
AVF : RvVAR031_34620(thiC)
ASAL : CFBP5507_11620(thiC)
RPUS : CFBP5875_11270(thiC)
ALEG : CFBP4996_11660(thiC)
REC : RHECIAT_PC0000245(thiC)
REL : REMIM1_PA00091(thiC)
REP : IE4803_PD00418(thiC)
REI : IE4771_PE00435(thiC)
RTR : RTCIAT899_PC03455(thiC)
RGA : RGR602_PC01292(thiC)
RPHA : AMC79_PD00257(thiC)
RJG : CCGE525_27675(thiC) CCGE525_34925(thiC)
RAD : CO657_22740 CO657_33130(thiC)
RHID : FFM81_028080(thiC) FFM81_031410(thiC)
RBQ : J2J99_29650(thiC) J2J99_33755(thiC)
RLN : J0663_22235(thiC) J0663_29810(thiC)
RBAN : J2J98_27535(thiC) J2J98_29880(thiC)
RAW : NE851_02190(thiC) NE851_08335(thiC)
BSEP : HAP48_0003245(thiC)
BCAN : BcanWSM471_29345(thiC)
VGO : GJW-30_1_02431(thiC)
BHS : BM1374165_00470(thiC)
BBK : BARBAKC583_0446(thiC)
BTX : BM1374166_00709(thiC)
BEZ : NCTC12898_00427(thiC)
MAQU : Maq22A_c04380(thiC)
METI : DK427_04385 DK427_13760
MMES : MMSR116_14955(thiC)
FIL : BN1229_v1_0273(thiC)
FIY : BN1229_v1_0277(thiC)
BVY : NCTC9239_02730(thiC)
TSV : DSM104635_00080(thiC)
DSH : Dshi_3681(thiC) Dshi_3877(thiC) Dshi_4080(thiC)
PHP : PhaeoP97_00875(thiC)
PPIC : PhaeoP14_00830(thiC)
MALG : MALG_03661 MALG_04801
RMM : ROSMUCSMR3_03600(thiC)
RID : RIdsm_01492(thiC_1) RIdsm_05439(thiC_2)
LVS : LOKVESSMR4R_00067(thiC)
SBIN : SBA_ch1_04910(thiC)
SPHB : EP837_01600(thiC) EP837_03765
SPAG : sphantq_02108(thiC)
SFLA : SPHFLASMR4Y_00474(thiC)
HSH : NHP194022_15360(thiC)
HPUL : NCTC13154_01175(thiC)
CJV : MTVDSCj20_0426(thiC)
CFV : CFVI03293_0408(thiC)
CAMP : CFT03427_0419(thiC)
CCOC : CCON33237_1230(thiC)
CLR : UPTC16701_0994(thiC)
CLM : UPTC16712_1024(thiC)
CHV : CHELV3228_0843(thiC)
CPIN : CPIN18020_0978(thiC)
CAMZ : CVIC12175_1629(thiC)
SMAB : LN246_02755(thiC) LN246_13375
GEC : GEO60473_00600(thiC_1)
GBN : GEOBRER4_33960(thiC-1)
PCA : Pcar_0337(thiC-2) Pcar_2236(thiC-1)
PACE : A6070_01735 A6070_04115
DVE : DESUT3_09890(thiC-1)
PPOR : JCM14722_06370(thiC)
DEK : DSLASN_17000(thiC_1)
DTI : Desti_0757 Desti_4402 Desti_5563
MYX : QEG98_22610(thiC) QEG98_34280
ABIW : Abiwalacus_19700(thiC)
VBS : EGM51_02060(thiC) EGM51_10905(thiC)
LCRE : Pla8534_34750(thiC)
BTHO : Btheta7330_02232(thiC)
BCEL : BcellWH2_01837(thiC)
BFC : BacF7301_19620(thiC)
PCAG : NCTC12856_00574(thiC)
PSOE : CE91St14_02960(thiC)
COPR : Cop2CBH44_00170(thiC)
CFAS : Cfast33896_08150(thiC)
PMZ : HMPREF0659_A5799(thiC)
PHER : prwr041_11050(thiC)
PEV : KYH19_04150 KYH19_21295(thiC)
SMIZ : 4412673_01360(thiC)
SDJ : NCTC13534_02117(thiC)
STHA : NCTC11429_04807(thiC)
OHM : MSHRCOH1_02790(thiC)
CGLE : NCTC11432_03031(thiC)
CHRJ : CHRYMOREF3P_2619(thiC)
PROC : Ptc2401_00650(thiC)
DTP : JZK55_01300 JZK55_10600(thiC_1)
BAZ : BAMTA208_04050(thiC)
BSON : S101395_03897(thiC)
BFD : NCTC4823_02930(thiC_2)
HSHI : MUO14_15255(thiC) MUO14_22660(thiC)
PARG : PspKH34_34510(thiC)
SCA : SCA_0594(thiC') SCA_0595(thiC'')
SDP : NCTC12225_00277(thiC)
SPIC : SAMEA4384060_1973(thiC)
BAYD : BSPP4475_07515(thiC)
PPQ : PPSQR21_007700(thiC)
PSAB : PSAB_13585 PSAB_13590
CTET : BN906_00870(thiC_2)
CACE : CACET_c37720(thiC3)
CCOH : SAMEA4530647_0684(thiC)
CGEL : psyc5s11_09750(thiC)
SMAN : C12CBH8_04160(thiC)
HMO : HM1_0202(thiC) HM1_2074(thiC)
BPRO : PMF13cell1_01239(thiC)
BLUI : Blut17040_01960(thiC)
CSCI : HDCHBGLK_01904(thiC)
ACEL : acsn021_06870(thiC)
CBAR : PATL70BA_2870(thiC)
ABUT : Ami103574_10545(thiC)
ETM : CE91St48_05450(thiC)
CDC : CD196_0058 CD196_1625(thiC)
CDL : CDR20291_0046 CDR20291_1600(thiC)
PDF : CD630DERM_17020(thiC)
MTHO : MOTHE_c13910(thiC1)
MTHZ : MOTHA_c14770(thiC1)
AAR : Acear_0757 Acear_0758 Acear_2045
PIV : NCTC13079_01336(thiC)
VRM : 44547418_01822(thiC)
MANA : MAMMFC1_02629(thiC)
SOVA : SOV_10810(thiC_1) SOV_28610(thiC_2)
SSID : SPSIL_015540(bzaF_1) SPSIL_030630(bzaF_3)
PFAC : PFJ30894_00090(thiC)
RTS : CE91St31_20470(thiC)
MBO : BQ2027_MB0431C(thiC)
MAVM : MAA44156_04174(thiC)
MMAE : MMARE11_06850(thiC)
MBAI : MB901379_00624(thiC)
MHEK : JMUB5695_04269(thiC)
MSHJ : MSHI_25760(thiC_1) MSHI_30230(thiC_2)
MKY : IWGMT90018_07390(thiC)
MSM : MSMEG_0149 MSMEG_0826(thiC)
MSG : MSMEI_0146(thiC) MSMEI_0807(thiC)
MSB : LJ00_00750 LJ00_04110
MSN : LI99_00750 LI99_04110
MSH : LI98_00750 LI98_04110
MCB : Mycch_0502 Mycch_5599
MPHL : MPHLCCUG_04614(thiC)