Entry
Name
tyrosine phenol-lyase;
beta-tyrosinase;
L-tyrosine phenol-lyase (deaminating)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
BRITE hierarchy
Sysname
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
L-tyrosine + H2O = phenol + pyruvate + NH3 (overall reaction) [RN:
R00728 ];
(1a) L-tyrosine = phenol + 2-aminoprop-2-enoate [RN:
R12759 ];
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous) [RN:
R11100 ];
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) [RN:
R11099 ]
Reaction(KEGG)
Substrate
Product
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC
3.5.99.10 , 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
History
EC 4.1.99.2 created 1972
Pathway
Orthology
Genes
METY : MRY16398_33370(tpl)
PLF : PANA5342_p10091(tpl)
PRAG : EKN56_08045 EKN56_12310
LRI : NCTC12151_02412(tpl)
RPNE : NCTC8284_00313(tpl)
CHJ : NCTC10426_00445(tpl)
RCP : RCAP_rcc00516(tpl) RCAP_rcc02309(tnaA)
PCRE : NCTC12858_00848(tpl_1)
PCAG : NCTC12856_00106(tpl_1)
PSOE : CE91St14_06700(tpl)
PET : PEIBARAKI_5473 PEIBARAKI_6464
PSAC : PSM36_1292 PSM36_2654(tpl)
PROJ : KDN43_00735 KDN43_09795
COY : HF329_00540 HF329_11305
SMIZ : 4412673_01210(tpl_2)
CGLE : NCTC11432_03144(tpl_1)
CTAK : 4412677_01735(tpl_2)
CSAL : NBC122_01726(tpl_2)
CCOH : SAMEA4530647_0763(tpl_2)
DFG : B0537_00095 B0537_11110
NCD : ACONDI_01191(tpl_1) ACONDI_01327(tpl_2)
MHAP : JFY71_03580 JFY71_06480
CCYS : SAMEA4530656_1651(tnaA)
AUS : IPK37_00915 IPK37_04765
BRT : J4N02_01260 J4N02_04045
NPY : NPRO_01750 NPRO_16190
OPR : Ocepr_1553 Ocepr_1720
FHW : RN87_01430 RN87_05525
FVA : FV113G1_10500 FV113G1_23210
FUL : C4N20_00420 C4N20_11335
FPOL : ERS445057_00135(tpl_1) ERS445057_01797(tpl_3)
» show all
Taxonomy
Reference
Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
Title
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
Journal
J Biol Chem 245:1767-72 (1970)
Reference
Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
Title
Tyrosine phenol lyase. II. Cofactor requrements.
Journal
J Biol Chem 245:1773-7 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.2
ExPASy - ENZYME nomenclature database: 4.1.99.2