KEGG   ENZYME: 4.1.99.27
Entry
EC 4.1.99.27                Enzyme                                 
Name
cyclopenase;
asqI (gene name)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
Sysname
(-)-cyclopenine methyl-isocyanate lyase (viridicatin-forming)
Reaction(IUBMB)
(-)-cyclopenine = viridicatin + methyl isocyanate [RN:R13135]
Reaction(KEGG)
R13135
Substrate
(-)-cyclopenine [CPD:C22623]
Product
viridicatin [CPD:C22644];
methyl isocyanate [CPD:C22645]
Comment
This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (-)-4'-methoxycyclopenine.
History
EC 4.1.99.27 created 2022
Orthology
K26348  cyckopenase
Genes
ANIAN9228.2
Reference
1  [PMID:30026518]
  Authors
Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K.
  Title
Enzymatic one-step ring contraction for quinolone biosynthesis.
  Journal
Nat Commun 9:2826 (2018)
DOI:10.1038/s41467-018-05221-5
  Sequence
[ani:AN9228.2]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.27
IUBMB Enzyme Nomenclature: 4.1.99.27
ExPASy - ENZYME nomenclature database: 4.1.99.27
BRENDA, the Enzyme Database: 4.1.99.27

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