Entry |
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Name |
aldehyde oxygenase (deformylating);
decarbonylase;
aldehyde decarbonylase;
octadecanal decarbonylase;
octadecanal alkane-lyase
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Class |
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
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Sysname |
a long-chain aldehyde alkane-lyase
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Reaction(IUBMB) |
a long-chain aldehyde + O2 + 2 NADPH + 2 H+ = an alkane + formate + H2O + 2 NADP+ [RN: R03728]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Contains a diiron center. Involved in the biosynthesis of alkanes. The enzyme from the cyanobacterium Nostoc punctiforme PCC 73102 is only active in vitro in the presence of ferredoxin, ferredoxin reductase and NADPH, and produces mostly C15 and C17 alkanes [2,3]. The enzyme from pea (Pisum sativum) produces alkanes of chain length C18 to C32 and is inhibited by metal-chelating agents [1]. The substrate for this enzyme is formed by EC 1.2.1.80, acyl-[acyl-carrier protein] reductase.
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History |
EC 4.1.99.5 created 1989, modified 2011, modified 2013
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Pathway |
ec00073 | Cutin, suberine and wax biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K14331 | fatty aldehyde decarbonylase |
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Genes |
» show all
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Reference |
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Authors |
Cheesbrough TM, Kolattukudy PE. |
Title |
Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a particulate preparation from Pisum sativum. |
Journal |
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Reference |
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Authors |
Schirmer A, Rude MA, Li X, Popova E, del Cardayre SB |
Title |
Microbial biosynthesis of alkanes. |
Journal |
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Sequence |
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Reference |
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Authors |
Warui DM, Li N, Norgaard H, Krebs C, Bollinger JM Jr, Booker SJ |
Title |
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase. |
Journal |
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Sequence |
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Reference |
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Authors |
Li N, Chang WC, Warui DM, Booker SJ, Krebs C, Bollinger JM Jr |
Title |
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.99.5 |
ExPASy - ENZYME nomenclature database: | 4.1.99.5 |
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