KEGG ENZYME: 4.2.1.100

ENZYME: 4.2.1.100

Entry

EC 4.2.1.100                Enzyme

Name

cyclohexa-1,5-dienecarbonyl-CoA hydratase;
cyclohexa-1,5-diene-1-carbonyl-CoA hydratase;
dienoyl-CoA hydratase;
cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect);
6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)

Reaction(IUBMB)

6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O [RN:R05597]

Reaction(KEGG)

R05597

Substrate

6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749]

Product

cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
H2O [CPD:C00001]

Comment

Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).

History

EC 4.2.1.100 created 2000, modified 2001

Pathway

ec00362

Benzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K07537

cyclohexa-1,5-dienecarbonyl-CoA hydratase

Genes

SHD:	SUTH_01654(dch)

EBA:	ebA5296(dch)

ABRE:

pbN1_04270(dch)

APET:

ToN1_49000(dch)

AZA:	AZKH_2147(dch)

AZI:	AzCIB_1612 AzCIB_4483

AZD:	CDA09_12110 CDA09_21775

TMZ:	Tmz1t_2952

TCL:	Tchl_2146 Tchl_3416

TAK:	Tharo_1304

DDZ:	DSYM_16330

RVA:

Rvan_0036

RLAC:

QMO75_01830

BLAG:

BLTE_16520

MAGX:

XM1_2897

MAGN:

WV31_08595

MAG:

amb2142

GME:	Gmet_2150(bamR)

GPI:	GPICK_09515

GEM:

GM21_2822

GEO:	Geob_0098(bamR)

GBM:	Gbem_1432(bamR)

GBN:	GEOBRER4_29900

GSUB:

KP001_01875

DTO:	TOL2_C38220

DOV:	DSCO28_67900

DWD:	DSCW_14370(fadB)

DALK:

DSCA_13400

DML:	Dmul_24930(dch)

DMM:	dnm_055580

SAT:

SYN_01653

DTI:	Desti_1480

DMP:

FAK_11290

CVL:	J8C06_06855

CHLO:

J8C02_03570

MSEM:

GMB29_14650

PNP:	IJ22_33340

PABS:

JIR001_03910(echA8)

DGI:	Desgi_1968

KBB:	ccbrp13_51030

FPL:

Ferp_1031

GAC:

GACE_0804

OMR:	OXIME_001145

» show all

Reference

1 [PMID:9738901]

Authors

Laempe D, Eisenreich W, Bacher A, Fuchs G

Title

Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica.

Journal

Eur J Biochem 255:618-27 (1998)
DOI:10.1046/j.1432-1327.1998.2550618.x

Sequence

[ag:CAA12246]

Reference

2 [PMID:8990279]

Authors

Harwood CS, Gibson J.

Title

Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?

Journal

J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997